Sung Joon Lee
Affiliation: Korea University
Seo W, Lee J, Jia Y, Wu C, Lee S. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. Bioorg Med Chem Lett. 2015;25:5237-42 pubmed publisher
..Collectively, these results suggest that saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake. ..
Jia Y, Wu C, Kim J, Kim B, Lee S. Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt. J Nutr Biochem. 2016;28:9-18 pubmed publisher
..In addition to the previously reported differential regulation of PPARÎ± and PPARÎ³, inhibition of Akt activity and activation of hepatic autophagy reduced hepatic steatosis in mouse livers. ..
Thach T, Lee C, Park H, Lee S, Lee S. Syringaresinol induces mitochondrial biogenesis through activation of PPAR? pathway in skeletal muscle cells. Bioorg Med Chem Lett. 2016;26:3978-83 pubmed publisher
..Taken together, our results indicate that syringaresinol induces mitochondrial biogenesis by activating PPAR? pathway. ..
Yang M, Lee G, Si J, Lee S, You H, Ko G. Curcumin Shows Antiviral Properties against Norovirus. Molecules. 2016;21: pubmed
..Our results demonstrated that CCM may be a promising candidate for development as an anti-noroviral agent to prevent outbreaks of foodborne illness. ..
Wu C, Jia Y, Lee J, Kim Y, Sekharan S, Batista V, et al
. Activation of OR1A1 suppresses PPAR-Î³ expression by inducing HES-1 in cultured hepatocytes. Int J Biochem Cell Biol. 2015;64:75-80 pubmed publisher
..These results indicate that OR1A1 may function as a non-redundant receptor in hepatocytes that regulates the PKA-CREB-HES-1 signaling axis and thereby modulates hepatic triglyceride metabolism. ..
Hoang M, Jia Y, Mok B, Jun H, Hwang K, Lee S. Kaempferol ameliorates symptoms of metabolic syndrome by regulating activities of liver X receptor-Î². J Nutr Biochem. 2015;26:868-75 pubmed publisher
..They also suggest that kaempferol activates LXR-Î² and suppresses SREBP-1 to enhance symptoms in metabolic syndrome. ..
Thach T, Hong Y, Lee S, Lee S. Molecular determinants of the olfactory receptor Olfr544 activation by azelaic acid. Biochem Biophys Res Commun. 2017;485:241-248 pubmed publisher
..Collectively, these data indicated that a hydrogen bond between Y109 residue and AzA is a major determinant of the Olfr544-AzA interaction and activation. ..
Lee J, Jia Y, Thach T, Han Y, Kim B, Wu C, et al
. Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice. Nutr Res. 2017;43:89-99 pubmed publisher
..In conclusion, hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. ..
Kim Y, Hwang S, Jia Y, Seo W, Lee S. Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase. Food Res Int. 2017;101:209-217 pubmed publisher
..In conclusion, BSE ameliorated hepatic steatosis in a mouse model of ethanol-induced fatty liver by activating AMPK, an effect possibly mediated by the saponarin component. ..