Genomes and Genes
Young Jae Lee
Affiliation: Gachon Medical School
- Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral developmentYoung Jae Lee
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Dev Biol 347:195-203. 2010....
- Clinical and genetic analyses of three Korean families with hereditary hemorrhagic telangiectasiaMi Jung Kim
Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea
BMC Med Genet 12:130. 2011..Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1; ALK1), receptors for transforming growth factor-β (TGF-β) superfamily, have been identified as the principal HHT-causing genes...
- Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertensionKwon Ho Hong
Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida College of Medicine, Gainesville, USA
Circulation 118:722-30. 2008..The present study was designed to investigate whether endothelial Bmpr2 deletion can predispose to PAH...
- Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasiaSung Ok Park
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, 1376 Mowry Road, Room 456, Gainesville, Florida 32610, USA
J Clin Invest 119:3487-96. 2009..We believe our data provide novel insights into the pathogenetic mechanisms of HHT and potential therapeutic approaches...
- Generation of activin receptor type IIB isoform-specific hypomorphic allelesYoung Jae Lee
Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA
Genesis 44:487-94. 2006..In this study, we demonstrate that this phenomenon is most likely due to the reduction in the expressed Acvr2b(4) levels rather than to the functional deficiency of the Acvr2b(4) isoform itself...
- TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular developmentHa Long Nguyen
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, USA
Lab Invest 91:1554-63. 2011..These data reveal for the first time that αvβ8 integrin-activated TGF-βs regulate angiogenesis in the developing brain via paracrine signaling to ECs...
- Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2Eun Jung Choi
Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida, United States of America
PLoS ONE 8:e63138. 2013..We also demonstrated in vivo that Alk1-deficient ECs exhibited high migratory and invasive properties. Taken together, these data suggest that enhanced responses to angiogenic cues in ALK1-deficient ECs underlie the pathogenesis of HHT2...
- VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2Chul Han
Department of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL, 32610, USA
Angiogenesis 17:823-30. 2014..Taken together, the presented experimental model is an invaluable system for precise molecular mechanism of action of VEGF blockades as well as for preclinical screening of drug candidates for epistaxis and gastrointestinal bleedings...
- Generation of mice with a conditional and reporter allele for Tmem100Eun Hye Moon
Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Yunsu Gu, Incheon, Republic of Korea
Genesis 48:673-8. 2010..We found that Tmem100 was predominantly expressed in arterial endothelial cells of developing embryos. The conditional and reporter allele will be a useful resource to investigate the in vivo role of Tmem100, especially in angiogenesis...
- Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3Rahul N Kanadia
Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610 0267, USA
Gene Expr Patterns 3:459-62. 2003..Our studies reveal a striking overlap between the expression of Dmpk and the muscleblind genes during development of the limbs, nervous system and various muscles, including the diaphragm and tongue...
- Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in miceJeong Hoon Joo
Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Dev Dyn 236:2147-58. 2007..Taken together, the data suggest that Pnn plays important roles during mouse development through its involvement in regulation of Tcf/Lef activity...
- ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2Sung O Park
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Shands Cancer Center, Gainesville 32610, USA
Blood 111:633-42. 2008..These data indicate that neither ALK5 nor TGFBR2 is required for ALK1 signaling pertinent to the pathogenesis of HHT and suggest that HHT might not be a TGF-beta subfamily disease...
- B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signalingSean Park
Department of Physiology and Functional Genomics, University of Florida, 1600 SW Archer Rd, Room D533d, Gainesville, FL 32610, USA
Mol Cell Biol 24:10256-62. 2004..In view of the genetic evidence that reduced BMP signaling causes posteriorization of the vertebral pattern, we propose that the observed vertebral phenotype in Btg2-null mice is due to attenuated BMP signaling...