Research Topics

Woon Puay Koh



  1. Talaei M, Hosseini N, Koh A, Yuan J, Koh W. Association of "Elevated Blood Pressure" and "Stage 1 Hypertension" With Cardiovascular Mortality Among an Asian Population. J Am Heart Assoc. 2018;7: pubmed publisher
  2. Yii A, Soh A, Chee C, Wang Y, Yuan J, Koh W. Asthma, sinonasal disease, and the risk of active tuberculosis. J Allergy Clin Immunol Pract. 2018;: pubmed publisher
    ..95, 95% CI 0.68-1.31). A history of asthma or sinonasal disease may modulate immunological response to reduce incidence of active TB in the adult population. ..
  3. Dai Z, Koh W. B-vitamins and bone health--a review of the current evidence. Nutrients. 2015;7:3322-46 pubmed publisher
    ..In addition, observational and interventional studies conducted in Asia are limited and thus require more attention due to a steep rise of osteoporosis and hip fracture incidence projected in this part of the world. ..
  4. Dai Z, Jin A, Soh A, Ang L, Yuan J, Koh W. Coffee and tea drinking in relation to risk of hip fracture in the Singapore Chinese Health Study. Bone. 2018;112:51-57 pubmed publisher
    ..Future studies should corroborate these results to determine levels of optimal coffee consumption in relation to bone health. ..
  5. Lu Y, Wang Y, Ong C, Subramaniam T, Choi H, Yuan J, et al. Metabolic signatures and risk of type 2 diabetes in a Chinese population: an untargeted metabolomics study using both LC-MS and GC-MS. Diabetologia. 2016;59:2349-2359 pubmed publisher
    ..5 mmol/mol]; AUC?=?0.781). Our findings show that branched-chain amino acids and NEFA are potent predictors of diabetes development in Chinese adults. Our results also indicate the potential of lysophospholipids for predicting diabetes. ..
  6. Wang Y, Meng R, Kunutsor S, Chowdhury R, Yuan J, Koh W, et al. Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis. Sci Rep. 2018;8:406 pubmed publisher
    ..Overall evidence indicates that higher adiponectin levels are associated with decreased T2D risk in Chinese and other populations. ..
  7. Leung Y, Allen J, Noviani M, Ang L, Wang R, Yuan J, et al. Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study. Osteoarthritis Cartilage. 2015;23:41-7 pubmed publisher
    ..Results were similar for men and women. Our results provided evidence for a constant mechanical mechanism underlying BMI and KOA initiation and/or progression. ..
  8. Soh A, Chee C, Wang Y, Yuan J, Koh W. Dietary Cholesterol Increases the Risk whereas PUFAs Reduce the Risk of Active Tuberculosis in Singapore Chinese. J Nutr. 2016;146:1093-100 pubmed publisher
    ..Dietary intake of cholesterol may increase the risk of active tuberculosis, whereas marine n-3 and n-6 FAs may reduce the risk of active tuberculosis in the Chinese population. ..
  9. Lew Q, Jafar T, Koh H, Jin A, Chow K, Yuan J, et al. Red Meat Intake and Risk of ESRD. J Am Soc Nephrol. 2017;28:304-312 pubmed publisher
    ..4% (95% CI, 33.1 to 78.9; P<0.01). Our study shows that red meat intake may increase the risk of ESRD in the general population and substituting alternative sources of protein may reduce the incidence of ESRD. ..

More Information


  1. Seah J, Gay G, Su J, Tai E, Yuan J, Koh W, et al. Consumption of Red Meat, but Not Cooking Oils High in Polyunsaturated Fat, Is Associated with Higher Arachidonic Acid Status in Singapore Chinese Adults. Nutrients. 2017;9: pubmed publisher
    ..A diet high in fish, soy products and polyunsaturated cooking oil, and low in red meat may be associated with an optimal plasma profile of PUFA in this Chinese population. ..
  2. Talaei M, Pan A, Yuan J, Koh W. Dairy intake and risk of type 2 diabetes. Clin Nutr. 2018;37:712-718 pubmed publisher
  3. Wang Y, Koh W, Yuan J, Pan A. Plasma ferritin, C-reactive protein, and risk of incident type 2 diabetes in Singapore Chinese men and women. Diabetes Res Clin Pract. 2017;128:109-118 pubmed publisher
    ..037). The elevation of blood ferritin levels, in the presence of raised hs-CRP, was significantly associated with increased risk of T2D. ..
  4. Lew Q, Jafar T, Talaei M, Jin A, Chow K, Yuan J, et al. Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore population. Kidney Int. 2017;92:979-987 pubmed publisher
    ..Thus, BMI itself is a risk factor for ESRD in the general population and this association is present in those without pre-existing diabetes, hypertension, coronary heart disease, and stroke. ..
  5. Teng G, Leung Y, Ang L, Yuan J, Koh W. Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study. Osteoarthritis Cartilage. 2017;25:1962-1968 pubmed publisher
    ..016). Gout is associated with risk of severe KOA, especially in lean women, suggesting the crystal arthritis may play a role in the pathogenesis or progression of OA. ..
  6. Dai Z, Wang R, Ang L, Yuan J, Koh W. Bone turnover biomarkers and risk of osteoporotic hip fracture in an Asian population. Bone. 2016;83:171-7 pubmed publisher
    ..Our data demonstrated that higher serum levels of bone turnover biomarkers were associated with increased risk of hip fracture in an Asian population. ..
  7. Chei C, Loh J, Soh A, Yuan J, Koh W. Coffee, tea, caffeine, and risk of hypertension: The Singapore Chinese Health Study. Eur J Nutr. 2018;57:1333-1342 pubmed publisher
    ..The inverse U-shaped association with coffee suggests that at higher doses, other ingredients in coffee may offset the effect of caffeine and confer benefit on blood pressure. ..
  8. Soh A, Pan A, Chee C, Wang Y, Yuan J, Koh W. Tea Drinking and Its Association with Active Tuberculosis Incidence among Middle-Aged and Elderly Adults: The Singapore Chinese Health Study. Nutrients. 2017;9: pubmed publisher
    ..71-0.96) in daily drinkers (p for trend = 0.003). Coffee or caffeine intake was not significantly associated with tuberculosis risk. In conclusion, regular tea drinking was associated with a reduced risk of active tuberculosis. ..
  9. Koh A, Velmurugan B, Gao F, Tan R, Wong J, Teo L, et al. Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatr. 2017;17:275 pubmed publisher
    ..016). We demonstrate additional ability of suPAR, over age, to predict impaired myocardial relaxation. Identifier: NCT02791139 (Registered May 31, 2016). ..
  10. Pan A, Wang Y, Yuan J, Koh W. High-sensitive C-reactive protein and risk of incident type 2 diabetes: a case-control study nested within the Singapore Chinese Health Study. BMC Endocr Disord. 2017;17:8 pubmed publisher
    ..Previous positive findings from prospective studies might be partly due to undiagnosed T2D among the cases during blood collection. ..