Malgorzata Kloc

Summary

Affiliation: The Houston Methodist Research Institute and The Houston Methodist Hospital
Location: Houston, Texas, USA
Publications:
1. Kloc.M. (1976). Extrachromosomal DNA and RNA-synthesis in oocytes of Creophilus maxillosus (Staphylinidae, Coleoptera, Polyphaga). EXPERIENTIA 32, 375-377.

2. Matuszewski, B., Kloc, M. (1976). Gene amplification in oocytes of the rove beetle Creophilus maxillosus (Staphylinidae, Coleoptera-Polyphaga). EXPERIENTIA 32, 34-36.

3. Kloc, M. and Matuszewski, B. (1977). Extrachromosomal DNA and the origin of oocytes in the telotrophic-meroistic ovary of Creophilus maxillosus (L.) (Staphylinidae, Coleoptera-Polyphaga). WILHEM ROUX ARCH. 183, 351-368

4. Kloc, M. (1980). Extrachromosomal DNA and its activity in RNA synthesis in oogonia and oocytes in the pupal ovary of Creophilus maxillosus (Staphylinidae, Coleoptera-Polyphaga). EUR. J. CELL BIOL. 21, 328-334.

5. Kloc, M., Lee, P.E., Tajbakhsh, S., Matthie, B.D. (1983). The effect of sodium butyrate on Tipula iridescent virus synthesis in insect suspension cell cultures. J. INVERTEBR. PATHOL.42, 113-123.

6. Kloc, M., Lee, P.E., Tajbakhsh, S. (1984). The effect of two insect hormones on the replication of Tipula iridescent virus in Estigmene acrea cells in suspension culture. J. INVERTEBR. PATHOL.43, 114-123.

7. Matuszewski, B., Ciechomski, K., Nurkowska, J., and Kloc, M. (1985). The linear clusters of oogonial cells in the development of telotrophic ovarioles in polyphage Coleoptera. ROUX’S ARCH. DEV BIOL 194, 462-469.

8. Heikkila, J.J., Kloc, M., Bury, J., Schultz, G.A. and Browder, L. (1985). Acquisition of the heat shock response and thermotolerance during early development of Xenopus laevis. DEV. BIOLOGY 107, 483–489.

9. Kloc, M., Mailer, K., Stepkowski, S. (1986). Superoxide dismutase dcerese in cardiac transplants. TRANSPLANTATION 41, 794-796.

10. Browder, L.W., Pollock, M., Heikkila, J.J., Wilkes, J., Wang, T., Krone, P., Ovsenek, N. and Kloc, M. (1987) Decay of oocyte-type heat shock response of Xenopus laevis. DEV. BIOL. 124, 191-199.

11. Currie, R.W., Karmazyn, M., Kloc, M., Mailer, K. (1988). Heat-shock response is associated with enhanced postischemic ventricular recovery. CIRC. RES. 63, 543-549.

12. Miller, M., Kloc, M., Eastman, E., Dryer, E., and Etkin, L. (1989). Xlgv7: a maternal gene product localized in nuclei of the central nervous system in Xenopus laevis. GENES DEV. 3, 572–583.

13. Kloc, M., Miller, M., Carrasco, A.E., Eastman, E. and Etkin, L. (1989). The maternal store of the Xlgv7 mRNA in full grown oocytes is not required for normal development in Xenopus. DEVELOPMENT 107, 899-907.

14. Kloc, M., Miller, M., Eastman, E., Reddy, B. and Etkin, L. (1991) Xl21: A localized maternal gene product in Xenopus laevis. MOL. REPROD. DEV. 28, 341-345.

15. Miller, M., Reddy, B., Kloc, M., Li, X.X., Dreyer, C. and Etkin, L. (1991). The nuclear-cytoplasmic distribution of the Xenopus nuclear factor, xnf7, changes during early development coincident with its state of phosphorylation. DEVELOPMENT 113, 569-575.

16. Reddy, B., Kloc, M. and Etkin, L. (1991) Identification of the cDNA for xlcaax-1, a membrane associated Xenopus maternal protein. BIOCHEM. BIOPHYS. RES. COM. 179, 1635-1641.

17. Reddy, B., Kloc, M. and Etkin, L. (1991). The cloning and characterization of a maternally expressed novel zinc finger nuclear phosphoprotein (xnf7) in Xenopus laevis. DEVELOP. BIOL. 148, 107-116.

18. Kloc, M., Reddy, B., Crawford, S., Etkin, L.D. (1991). A novel 110-kDa maternal CAAX box-containing protein from Xenopus is palmitoylated and isoprenylated when expressed in baculovirus. J. BIOL. CHEM. 266, 8206-8212.

19. Cornish, J., Kloc, M., Decker, G., Reddy, B. and Etkin, L. (1992) Xlcaax-1 is localized to the basolateral membrane of polarized epithelia and to epidermally derived tissues during Xenopus development. DEVELOP. BIOL. 150, 108-120.

20. Reddy, B., Kloc, M., and L.D. Etkin (1992). The cloning and characterization of a localized maternal transcript in Xenopus laevis whose zygotic counterpart is detected in the CNS. MECH. OF DEV. 39, 143-150.

21. Kloc, M., Li, X. and Etkin, L.D. (1993) Two upstream cysteines and the CAAX motif but not the polybasic domain are required for membrane association of Xlcaax in Xenopus oocytes. BIOCHEM. 32, 8207-8212.

22. Kloc, M., Spohr, G. and Etkin, L.D. (1993) Translocation of repetitive RNA sequences with the germ plasm in Xenopus oocytes. SCIENCE 262, 1712- 1714.

23. Stepkowski, S.M., Tim, J., Kloc, M. (1993). Interlukin-2 antisense oligonucleotides inhibit T-cell function. TRANSPL. PROC. 25, 125

24. Li, X., Shou, W., Kloc, M., Reddy, B. and Etkin, L.D. (1994). Cytoplasmic retention of Xenopus nuclear factor 7 (xnf7) prior to MBT utilizes an anchoring mechanism involving a cis-acting retention domain and several phosphorylation sites. J. CELL BIOL. 124, 7-17.

25. Li, X, Shou, W., Kloc, M., Reddy, B. and Etkin, L.D. (1994). The association of Xenopus Nuclear Factor 7 with subcellular structures is dependent upon phosphorylation and specific domains. EXP. CELL RES. 213, 473-481.

26. Kloc, M. and Etkin, L.D. (1994). Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus after destruction of Xlsirt RNA. SCIENCE 265, 1101-1103.

27. Kloc, M. and Etkin, L.D. (1995) Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopus oocytes. DEVELOPMENT 121, 287-297


28. Zhang, H. , Reynaud, S., Kloc, M., Etkin, L.D. and Spohr, G. (1995) I.D. Gene activity during Xenopus embryogenesis. MECH. DEV. 50, 119-130.

29. Ghobrial. R., Hamashima T., Kloc, M., Etkin, L., Stepkowski, S.M., Kahan, B.D. (1995). Membrane-bound or soluble truncated RT1.Aa rat class I major histocompatibility antigens induce specific alloimunity. TRANSPLANTATION 60, 602-610.

30. Kloc, M., Matuszewski, B., Nurkowska, J. (1995). Ribosomal gene amplification in the oocytes of Creophilus maxillosus (Staphyliniade, Coleoptera-polyphaga)-an insect with telotrophic ovaries. FOLIA HISTOCHEM. CYTOBIOL. 33, 267-276.

31. Kloc, M., Larabell, C., and Etkin, L.D. (1996). Elaboration of the messenger transport organizer pathway (METRO) for localization of RNA to the vegetal cortex of Xenopus oocytes. DEV. BIOL. 180, 119-130.

32. Wang, M., Stepkowski, S. M., Tim, L., Langowski, J., Hebert J.S., Kloc, M., Yu, J Kahan, B.D. (1996). Nucleotide sequences of three distinct cDNA clones coding for the rat class I heavy chain RT1n antigen. IMMUNOGENETICS 45, 73-75.

33. Wang, M., Stepkowski, S. M., Tim, L., Langowski, J., Yu, J., Kloc, M., Kahan, B.D. (1997). Nucleotide sequences of rat cDNA clones coding heavy chain class I major histocompatibility complex proteins. TRANSPL. PROC. 29, 1661-1662.

34. Kloc, M. and L.D. Etkin (1998). Apparent continuity between the METRO and late RNA localization pathways during oogenesis in Xenopus. MECH. DEV. 73, 95-106.

35. Kloc, M., Larabell, C., Chan, P-Y. A., Etkin,L. (1998). Contribution of METRO pathway localized molecules to the organization of the germ cell lineage. MECH. DEV. 75, 81-93.

36. Zagrodzinska, B., Kloc, M. (1998). Direct fluorescence in situ hybridization to polytene chromosomes. BIOTECHNIQUES 24, 184-185

37. Bashirullah, A., Halsell, S.R., Cooperstock ,R.L., Kloc, M., Karaiskakis, A., Fisher, W.W., Fu, W., Hamilton, J.K., Etkin, L.D., Lipshitz, H.D. ( 1999). Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster. EMBO J. 18, 2610-2620.


38. Chan, A. P., Kloc, M., Etkin, L. D. (1999). Fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes. DEVELOPMENT 126, 4943-4953.

39. Matuszewski, B., Ciechomski, K., Kloc, M. (1999). Extrachromosomal rDNA and polarity of pro-oocytes during ovary development in Creophilus maxillosus (Coleoptera, Staphylinidae). FOLIA HISTOCHEM. CYTOBIOL. 37, 179-190.

40. Kloc, M., Bilinski, S., Chan A. P-Y., Etkin, L. (2000). The targeting of Xcat2 mRNA to the germinal granules depends on a cis-acting germinal granule localization element within the 3’ UTR. DEV. BIOL. 217, 221-229.

41. De Smedt, V, Szollosi, D, Kloc, M. (2000). The Balbiani body: Asymmetry in the mammalian oocyte. GENESIS 26, 208-212.

42. Kloc, M., Bilinski, S, Chan, A.P., Etkin, L.D. (2000). Mitochondrial ribosomal RNA in the germinal granules in Xenopus embryos revisited. DIFFERENTIATION 67, 80-83.

43. Chan, A. P., Kloc, M., Bilinski, S., Etkin, L.D. (2001). The vegetally localized mRNA fatvg is associated with the germ plasm in the early embryo and is later expressed in fat body. MECH. DEV.100, 137-140.

44. Kloc, M., Zagrodzinska, B. (2001). Chromatin elimination-an oddity or a common mechanism in differentiation and development. DIFFERENTIATION 68, 84-91.

45. Bradley, J.T., Kloc, M., Wolfe, K. G.,Estridge, B.H., Bilinski, S.M (2001). Balbiani bodies in cricket oocytes:development, ultarstructure, and presence of localized RNAs. DIFFERENTIATION 67, 117-127.

46. Rutzky, L. Kloc, M., Bilinski, S. Phan, T., Zhang, H., Stepkowski, S.M., Katz, S. (2001). Microgravity culture conditions decrease immunogenicity but maintain excellent morphology of pancreatic islets. TRANSPL. PROC. 33, 388.

47. Kloc, M., Bilinski, S., Chan, A.P., Allen, L.H., Zearfoss, N.R., Etkin, L.D. (2001). RNA localization and germ cell determination in Xenopus. INT. REV. CYTOL.203, 63-91.

48. Rutzky, L.P., Bilinski, S., Kloc, M., Phan, T., Zhang, H., Katz, S.M., Stepkowski, S.M. (2002). Microgravity culture condition reduces immunogenicity and improves function of pancreatic islets. TRANSPLANTATION 74, 13-21.

49. Bilinski, S., Kloc, M. (2002). Accessory nuclei revisited: the translocation of snRNPs from the germinal vesicle to the periphery of the future embryo. CHROMOSOMA 111, 62-68.

50. Reynaud-Deonauth, S., Zhang, H, Afouda, A., Taillefert, S., Beatus, P., Kloc, M., Etkin, L.D., Fischer-Lougheed, J., Spohr, G. (2002). Notch signaling is involved in the regulation of Id3 gene transcription during Xenopus embryogenesis. DIFFERENTIATION 69, 198-208.

51. Kloc, M., Dougherty, M., Bilinski, S, Chan, A-P., Brey, E, King, M.L. Patrick, P., Etkin, L.D.(2002). Three-dimensional ultrastructural analysis of RNA distribution in germinal granules in Xenopus. DEV. BIOL. 241, 79-93.

52. Kloc, M., Zearfoss, R., and Etkin, L.D. (2002). Mechanisms of subcellular mRNA localization. CELL 108, 533-544.

53. Kloc, M., Bilinski, S. (2002). Specification of the germ-line cells in invertebrates and vertebrates. The function of the germ plasm. POSTEPY BIOL. KOM. 29, 301-317.

54. Kloc, M., Bilinski, S. (2003). RNA localization and its role in spatially restricted protein synthesis. FOLIA. HIST. CYTOL. 41, 3-11.

55. Allen L., Kloc, M., Etkin, L. D. (2003). Identification and characterization of the Xlsirt cis-acting RNA localization element. DIFFERENTIATION. 71, 311-321.

56. Cheung, W. L., Ajiro, K., Samejima, K., Kloc, M., Cheung, P., Mizzen, C. A., Beeser, A., Etkin, L. D., Chernoff, J., Earnshaw, W. C., Allis, C. D. (2003). Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. CELL 113, 507-517.

57. Zearfoss, N. R., Chan, A. P., Kloc, M., Allen, L. H., Etkin, L. D. (2003). Identification of new Xlsirt family members in the Xenopus laevis oocyte. MECH. DEV. 120, 503-509.

58. Kloc, M., Bilinski, S., Etkin, L.D. (2004). The Balbiani body and germ cell determinants: 150 years later. CURR.TOPICS. DEV.BIOL. 59, 1-36.

59. Kloc, M., Bilinski, S., Dougherty, M.T., Brey, E.m., Etkin, L.D. (2004). Formation, architecture and polarity of female germline cyst in Xenopus. DEV. BIOL. 266, 43-61.

60. Pijanowska, J., Kloc, M. (2004). Daphnia response to predation threat involves heat-shock proteins and the actin and tubulin cytoskeleton. GENESIS 38, 81-86.

61. Bilinski, M. S., Jaglarz, M. K., Szymanska, B., Etkin, L. D., Kloc, M. (2004). Sm proteins, the constituents of the pliceosome, are components of nuage and mitochondrial cement in Xenopus oocytes. EXP. CELL RES. 2990, 171-178.

62. Wilk, K., Bilinski, S., Dougherty, M., Kloc, M. (2005). Delivery of germinal granules and localized RNAs via the messenger transport organizer pathway to the vegetal cortex of Xenopus oocytes occurs through directional expansion of the mitochondrial cloud. INT. J. DEV. BIOL. 48, 17-21.

63. Kloc, M., Etkin, L. D. (2005). RNA localization mechanisms in oocytes. J.CELL SCI. 118, 269-282.

64. Kloc, M., Wilk, K., Vargas, D., Shirato Y., Bilinski, S., Etkin L.D. (2005). Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex of Xenopus oocytes. DEVELOPMENT 132, 3445-3457.

65. Jaglarz, M. K., Bilinski, S. M., Kloc, M. (2005). Assembly and breakdown of Cajal bodies in accessory nuclei of Hymenoptera. DIFFERENTIATION 73, 99-108.

66. Stepkowski, S, M, Phan, T., Zhang, H., Bilinski, S., Kloc, M., Qi, Y., Katz, S.M, Rutzky, L, P. (2006). Immature syngeneic denditric cells (DC) potentiate tolerance to pancreatic islets allografts depleted of donor DC in microgravity condition. TRANSPLANTATION 82, 1756-1763.

67. Song, H. W., Cauffman,K., Chan, A. P., Zhou, Y., King, M. L., Etkin, L. D., and Kloc, M. (2007). Hermes RNA binding protein targets RNAs encoding proteins involved in meiotic maturation, early cleavage, and germline development. DIFFERENTIATION 75, 519-528.

68. Chan, A. P., Kloc, M., Larabell, C., LeGros, M., and Etkin, L. D. (2007). The maternally localized RNA fatvg is required for cortical rotation and germ cell formation. MECH. DEV. 124, 350-363.

69. Kloc, M., Bilinski, S., Dougherty, M. T. (2007). Organization of cytokeratin cytoskeleton and germ plasm in the vegetal cortex of Xenopus laevis oocytes depends on coding and non-coding RNAs: three-dimensional and ultrastructural analysis. EXP. CELL RES. 313, 1639-1651.

70. Zelazowska, M., Kilarski, W., Bilinski, S., Podder, D., Kloc, M. (2007). Balbiani cytoplasm in oocytes of primitive fish, sturgeon Acipenser gueldenstaedtii, and its potential homology to the Balbiani body (mitochondrial cloud) of Xenopus laevis oocytes. CELL TISSUE RES. 329, 137-145.

71. Traverso, E. E., Cho, M. S., Wu, C-F., Sater, A., Larabell, C. A., Kloc, M., Etkin, L. D. (2007). Disruption of the dynamic sub-cellular localization of Xenopus tumorhead protein causes embryonic lethality at the early gastrula transition. DIFFERENTIATION 75, 947-956.

72. Kloc, M. and Chan, A. P. (2007). Centroid, a novel putative DEAD-box RNA helicase maternal mRNA is localized in mitochondrial cloud in Xenopus laevis oocytes. INT. J. DEV. BIOL. 51, 701-706.

73. Kloc, M., Shirato, Y., Bilinski, S., Browder, L., Johnston, J. (2007) Differential subcellular sequestration of pro-apoptotic and anti-apoptotic proteins and co-localization of Bcl-xL with the germ plasm, in Xenopus laevis oocytes. GENESIS 45, 523-531.

74. Wu, C.F, Delsert, C., Traverso, E. E., Kloc, M., Kuang, J., Etkin, L. D., Morin, N. (2007). Tumorhead (TH) Distribution to Cytoplasmic Membrane of Neural Plate Cells Is Positively Regulated by Xenopus p21-Activated Kinase 1 (X-PAK1). DEV. BIOL. 308, 169-186.

75. Kloc, M., Maleszewski, M., Tarkowski, A. K. (2008). Developmental biology in Poland. INT. J. DEV. BIOL. 52, 93-96.

76. Jaglarz, M. K., Kloc, M. and Bilinski, S. M. (2008). Accessory nuclei in insect oogenesis: in search of the function of enigmatic organelles. INT. J. DEV. BIOL. 52, 179-185.

77. Kloc, M. Where Have All The Cecidomyiidae Gone or The Basic Science B. D. (Before Drosophila): Cytology at Warsaw University (2008). INT. J. DEV. BIOL. 52, 115-119.

78. Katayama, H., Sasai, K., Kloc, M., Brinkley, B. R., Sen, S. (2008). Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. CELL CYCLE 7, 2691-2704.

79. Kloc, M., Jaglarz, M., Dougherty, M., Stewart, M. D., Nel-Themaat, L., Bilinski, S. (2008). Mouse early oocytes are transiently polar: Three-dimensional and ultrastructural analysis. EXP. CELL RES. 314, 3245-3254.

80. Pan, S., Wang, R., Zhou, X., Corvera, J., Kloc, M., Sifers, R., Gallick, G. E., Lin, S. H., Kuang J. (2008). Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly. EMBO J. 27, 2077-2090.

81. Kloc, M. (2008). Emerging novel functions of RNAs, and binary phenotype? DEV. BIOL. 317, 401-404.


82. Mikulski, A., Grzesiuk, M. Kloc, M. Pijanowska, J. (2009). Heat shock proteins in Daphnia detected using commercial antibodies: description and responsiveness to thermal stress. CHEMOECOLOGY. EPUB.

83. Kloc, M. (2009). Teachings from the egg: New and unexpected functions of RNAs . MOL. REP. DEV. 76, 922–932.

84. Markowska, M., Bentkowski, P., Kloc, M., Pijanowska, J. (2009). Presence of melatonin in Daphnia magna. PINEAL RES. 46, 242–244.

85. Lisik, W., Tejpal, N., Gong, Y., Skelton, T. S., Ganachari, M., Bremer, E. G., Kloc, M., Ghobrial, R. M. (2009). Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I. PLoS ONE 4 (12), e8020.

86. Tworzydlo, W., Kloc, M., Bilinski, S. M. (2009). The Balbiani Body in the Female Germline Cells of an Earwig, Opisthocosmia silvestris. ZOOL. SCI. 26:754-757.

87. Bilinski, S. M., Jaglarz, M. K., Dougherty, M. T., Kloc, M. (2010). Electron microscopy, immunostaining, cytoskeleton visualization, in situ hybridization, and three-dimensional reconstruction of Xenopus oocytes. METHODS 51, 11–19.

88. Tworzydlo, W., Kloc, M., Bilinski, S. M. (2010). Female germline stem cell niches of earwigs are structurally simple and different from those of Drosophila melanogaster J. MORPHOL. 271, 634–640.

89. Lisik, W., Gong, Y., Tejpal, N., Skelton, T. S., Bremer E. G., Kloc, M., Ghobrial, R.M. (2010). Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model. GENESIS 48, 8-19.

90. Shin, Y. H., Choi, Y., Erdin, S. U., Yatsenko, S. A., Kloc, M., Yang, F., Wang, P. J., Meistrich, M. L., Rajkovic, A. (2010). Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS GENET. 6 (11), e1001190.

91. Cho, K., Vaught, T. G., Ji, H., Gu, D., Papasakelariou-Yared, C., Horstmann, N., Jennings, J. M., Lee, M., Sevilla, L. M., Kloc, M., Reynolds, A. B., Watt, F. M., Brennan, R. G., Kowalczyk, A. P., McCrea, P. (2010). Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. J. CELL SCI. 123, 4128-4144.

92. Skelton, T. S., Tejpal, N., Gong, Y., Kloc, M., Ghobrial, R, M. (2010). Downregulation of RhoA and changes in T cell cytoskeleton correlate with the abrogation of allograft rejection. TRNASPL. IMMUNOL. 23, 185-193.

93. Kloc, M. Editorial. METHODS. (2010) 51:1-2.

94. Dobrzynski, M., Bernatowicz, P., Kloc, M., Kubiak, J. Z. (2011). Evolution of bet-hedging-like mechanisms in cell cycle and embryo development stimulated by weak linkage of stochastic processes. Book Chapter in: Springer-Verlag GmbH Berllin Heidelberg. Stochacity in cell cycle evolution, oocyte maturation, embryo development and bet-hedging evolutionary strategy. Vol. 53, p. 11-30.

95. Jaglarz, M., Kloc, M., Jankowska, W., Szymanska, B., Bilinski, S. (2011). Nuage morphogenesis gets more complex: two translocation pathways and two forms of nuage coexist in Drosophila germline syncytia. CELL TISSUE RES. 344, 169-181.

96. Mikulski, A., Bernatowicz, P., Grzesiuk, M., Kloc, M., Pijanowska, J. (2011) Differential Levels of Stress Proteins (HSPs) in Male and Female Daphnia magna in Response to Thermal Stress: A Consequence of Sex-Related Behavioral Differences? J. CHEM. ECOLOGY. 37, 670-676.

97. Lechowska, A., Bilinski, S., Choi, Y., Shin, Y., Kloc, M., Rajkovic, A. (2011). Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown. J. ASSIST. REPROD. GENET. 28, 583-589.

98. Skelton, T. S., Tejpal, N., Gong, Y., Kubiak, J., Kloc, M., Ghobrial, R. M. (2012). Allochimeric molecules and mechanisms in abrogation of cardiac allograft rejection. J. Heart Lung Transpl. 31, 73-84

99. Lechowska A., Bilinski, S M., Rasweiler, J J., Cretekos CJ., Behringer R. Kloc M. (2011) Early oogenesis in the short-tailed fruit bat Carollia perspicillata: transient germ cell cysts and noncanonical intercellular bridges. GENESIS Genesis 50(1):18-27. PMID

100. Kloc M, Foreman V, Reddy S.A. (2011). Binary function of mRNA. BIOCHIMIE. 93, 1955-1961

101. Skelton T, Cordero AM, Nelles NJ, Ganachari M, Sidhu J, Tejpal N, Gong Y, You J, Kloc M, Ghobrial R M. (2011). Allochimeric MHC I-Conditioned T Cells Attenuate Chronic Rejection in Rat Cardiac Model System.
J CLIN CELL IMMUNOL 2:108.

102. Skelton TS, Kloc M, Ghobrial, RM (2011). Molecular and cellular pathways involved in the therapeutic functions of MHC molecules; a novel approach for mitigation of chronic rejection. OPEN J. IMMUNOL. 1, 15-26.

103. Cho K, Lee M, Gu D, Munoz WA, Ji H, Kloc M, McCrea PD. (2011). Kazrin, and its binding partners ARVCF- and delta-catenin, are required for Xenopus laevis craniofacial development. DEV. DYN. 240, 2601-2612

104. Kloc M, Dallaire P, Reunov A, Major F. (2011). Structural messenger RNA contains cytokeratin polymerization and depolymerization signals. CELL TISSUE RES. 346, 209-222.

105. Kloc M, Borsuk E, Kubiak JZ (2012). Polarity and asymmetry during mouse oogenesis and oocyte maturation. Chapter in the book: "Mouse Development: From Oocyte to Stem Cells", RESULTS and PROBLEMS in CELL DIFFERENTIATION (RPCD), Springer Publishing. 55:23-44. doi: 10.1007/978-3-642-30406-4_2. Review

106. Kloc M, Kubiak JZ, Ghobrial RM. Translationally Controlled Tumor-Associated Protein (2012). BIOCHEM RES INT. Volume 2012 Article ID 432590

107. Munoz WA, Kloc M, Cho K, Lee M, Hofmann I, Sater A, Vleminckx K, McCrea PD (2012).
Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues. PLoS ONE. 7(4):e34342. doi: 10.1371/journal.pone.0034342.

108. Kloc M, Tejpal N, Sidhu J, Ganachari M, Flores-Villanueva P, Jennings NB, Sood AK, Kubiak JZ, Ghobrial RM. (2012). Inverse correlation between TCTP/RhoA and p53/cyclin A/actin expression in ovarian cancer cells. FOLIA HISTOCHEMICA AND CYTOBIOLOGICA 50(3):358-67. doi: 10.5603/19745.

109. Jaglarz MK, Bazile F, Laskowska K, Polanski Z, Chesnel F, Borsuk E, Kloc M, Kubiak JZ. (2012) Association of TCTP with centrosome and microtubules. BIOCHEM RES INT. 2012:541906. Epub 2012 May 14.

110. Zhang L, Kloc M, Tejpal N, You J, Cordero-Reyes AM, Youker KA, Ghobrial RM. ROCK1 inhibitor abrogates chronic rejection in rat cardiac model system. OPEN J ORGAN TRANSP SURG. (2012) 2: 46-51.

111. Gabr MM, Zakaria MM, Refaie AF, Ismail AM, Abou-El-Mahasen MA, Ashamallah Sa, Khater SM, El-Halawani SM, Ibrahim RY, Uin GS, Kloc M, Calne RY, Ghoneim MA. (2013) Insulin-Producing Cells From Adult Human Bone Marrow Mesenchymal Stem Cells Control Streptozotocin-Induced Diabetes In Nude Mice. CELL TRANSPLANTATION. 22(1):133-45. doi: 10.3727/096368912X647162.

112. Kloc, M, Ghobrial RM, Kubiak JZ. (2013). Recent advances in the understanding of germ cell-specific organelles and their functions. CELL BIOLOGY RESEARCH PROGRESS. RECENT ADVANCES IN GERM CELLS RESEARCH, page 41-70. Aubry Perrotte Ed. Nova Science Publishers Inc., New York. ISBN: 978-1-62618-519-7.

113. Zhang L, You J, Sidhu J, Tejpal N, Ganachari M, Skelton TS, Kloc M, Ghobrial RM. (2013) Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways. Transplantation 96(9):782-90. doi: 10.1097/TP.0b013e3182a2034f.PMID:

114. Li X, Kloc M, Ghobrial RM. (2013). Memory T cells in Transplantation- progress and challenges. Curr Opin Organ Transplant. (4):387-92

115. Piprek RP, Pecio A, Laskowska-Kaszub K, Kloc M, Kubiak JZ, Szymura JM. (2013). Retinoic acid homeostasis regulates meiotic entry in developing anuran gonads and in Bidder's organ through Raldh2 and Cyp26b1 proteins. MECH DEV. 130, 613- 627

116. Kloc M, Kubiak JZ, Li XC, Ghobrial RM. The newly found functions of MTOC in immunological response. J Leukocyte Biol. 2013 Dec 2. [Epub ahead of print] PMID:

117. Kloc M (2014). Polarity of Xenopus oocytes and embryo. XENOPUS DEVELOPMENT, Ed. Kloc M and Kubiak JZ. WILEY & SONS INC. ISBN: 978-1-118-49281-9

118. Kloc M and RM Ghobrial (2014). Chronic allograft rejection: a significant hurdle to transplant success. BURNS &TRAUMA. 2: 3-10.

119. Munoz WA, Lee M; Miller RM; Ji H; Kloc M; McCrea PD (2014). Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor, to positively modulate gene activity. 9(1):e86784. doi: 10.1371/journal.pone.0086784. PMID:

120. Kloc M, Jedrzejowska I, Tworzydlo W, Bilinski SM. (2014). Balbiani body, nuage and sponge bodies - The germ plasm pathway players. Arthropod Struct Dev. S1467-8039(13)00108-4. doi: 10.1016/j.asd.2013.12.003. [Epub ahead of print] PMID:

121. Kloc M, LI XC, Ghobrial RM. (2014). RhoA cytoskeletal pathway to transplantation. Journal of Immunology and Clinical Research. J Immunol Clin Res 2(1): 1012.

Publications

  1. request reprint
    Song H, Cauffman K, Chan A, Zhou Y, King M, Etkin L, et al. Hermes RNA-binding protein targets RNAs-encoding proteins involved in meiotic maturation, early cleavage, and germline development. Differentiation. 2007;75:519-28 pubmed
    ..We propose that as an RNA-binding protein, Hermes may be involved in maturation, cleavage events at the vegetal pole and germ cell development by negatively regulating the expression of RINGO/Spy, Mos, and Xcat2 mRNAs. ..
  2. Munoz W, Kloc M, Cho K, Lee M, Hofmann I, Sater A, et al. Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues. PLoS ONE. 2012;7:e34342 pubmed publisher
    ..The use of two distinct morpholinos, as well as rescue approaches, indicated the specificity of these effects. Our results point to the requirement of Pkp3 in amphibian embryogenesis, with functional roles in a number of tissue types...
  3. request reprint
    Reynaud Deonauth S, Zhang H, Afouda A, Taillefert S, Beatus P, Kloc M, et al. Notch signaling is involved in the regulation of Id3 gene transcription during Xenopus embryogenesis. Differentiation. 2002;69:198-208 pubmed
    ..The data presented here suggest that Notch control of differentiation may involve activation of transcription of Id, a negative regulator of bHLH transcription factors. ..
  4. Tworzydlo W, Kloc M, Bilinski S. Female germline stem cell niches of earwigs are structurally simple and different from those of Drosophila melanogaster. J Morphol. 2010;271:634-40 pubmed publisher
    ..We also show that between somatic cells of earwig niche argosome-like vesicles and cytoneme-like extensions are present...
  5. Cho K, Vaught T, Ji H, Gu D, Papasakelariou Yared C, Horstmann N, et al. Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. J Cell Sci. 2010;123:4128-44 pubmed publisher
    ..Taken together, our study supports the essential role of Kazrin in development, and reveals the biochemical and functional association of KazrinA with ARVCF-catenin, spectrin and p190B RhoGAP...
  6. request reprint
    Kloc M, Bilinski S, Etkin L. The Balbiani body and germ cell determinants: 150 years later. Curr Top Dev Biol. 2004;59:1-36 pubmed
  7. request reprint
    Kloc M, Etkin L. RNA localization mechanisms in oocytes. J Cell Sci. 2005;118:269-82 pubmed
  8. Lisik W, Gong Y, Tejpal N, Skelton T, Bremer E, Kloc M, et al. Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model. Genesis. 2010;48:8-19 pubmed publisher
    ..These novel findings may have important clinical implications for inhibition of chronic rejection in transplant recipients. ..
  9. request reprint
    Kloc M, Bilinski S, Chan A, Allen L, Zearfoss N, Etkin L. RNA localization and germ cell determination in Xenopus. Int Rev Cytol. 2001;203:63-91 pubmed
    ..We will discuss the different aspects of RNA localization in Xenopus in the context of the differentiation of the germ cells and the development of the oocyte polarity. ..

More Information

Publications64

  1. request reprint
    Chan A, Kloc M, Etkin L. fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes. Development. 1999;126:4943-53 pubmed
    ..This element differs in sequence from previously described Vg1 localization elements, suggesting that different localization elements are involved in the localization of RNAs through the Late pathway. ..
  2. request reprint
    Reddy B, Kloc M, Etkin L. The cloning and characterization of a maternally expressed novel zinc finger nuclear phosphoprotein (xnf7) in Xenopus laevis. Dev Biol. 1991;148:107-16 pubmed
  3. Kloc M, Jedrzejowska I, Tworzydlo W, Bilinski S. Balbiani body, nuage and sponge bodies--term plasm pathway players. Arthropod Struct Dev. 2014;43:341-8 pubmed publisher
  4. Kloc M, Jaglarz M, Dougherty M, Stewart M, Nel Themaat L, Bilinski S. Mouse early oocytes are transiently polar: three-dimensional and ultrastructural analysis. Exp Cell Res. 2008;314:3245-54 pubmed publisher
    ..Based on these findings, we conclude that the polarity of early oocytes imposed by the position of the centrioles at the cytoplasmic bridges is a fundamental and ancestral feature across the animal kingdom. ..
  5. Kloc M. Emerging novel functions of RNAs, and binary phenotype?. Dev Biol. 2008;317:401-4 pubmed publisher
    ..e. depends not only on the function of the protein but also on the autonomous function of its mRNA. ..
  6. Chan A, Kloc M, Larabell C, LeGros M, Etkin L. The maternally localized RNA fatvg is required for cortical rotation and germ cell formation. Mech Dev. 2007;124:350-63 pubmed
    ..These results point to a common fundamental mechanism that is regulated by fatvg through which germ cell determinants and dorsalizing factors segregate during early development. ..
  7. Munoz W, Lee M, Miller R, Ahmed Z, Ji H, Link T, et al. Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. PLoS ONE. 2014;9:e86784 pubmed publisher
    ..Using Xenopus laevis embryos and mammalian cells, we provide evidence for the Pkp3:ETV1 complex on both biochemical and functional levels. ..
  8. Lechowska A, Bilinski S, Rasweiler J, Cretekos C, Behringer R, Kloc M. Early oogenesis in the short-tailed fruit bat Carollia perspicillata: transient germ cell cysts and noncanonical intercellular bridges. Genesis. 2012;50:18-27 pubmed publisher
    ..perspicillata suggest that the formation of germ-line cysts is an evolutionarily conserved phase in the development of the female gametes in a substantial part of the animal kingdom. ..
  9. request reprint
    Wilk K, Bilinski S, Dougherty M, Kloc M. Delivery of germinal granules and localized RNAs via the messenger transport organizer pathway to the vegetal cortex of Xenopus oocytes occurs through directional expansion of the mitochondrial cloud. Int J Dev Biol. 2005;49:17-21 pubmed
    ..On the basis of these findings, we propose here a revised model of germinal granule and localized RNAs delivery to the oocyte vegetal cortex via the METRO pathway. ..
  10. Kloc M. Teachings from the egg: new and unexpected functions of RNAs. Mol Reprod Dev. 2009;76:922-32 pubmed publisher
    ..The fact that some of the RNAs may have previously unforeseen structural functions, will change our view on traditional functions of RNAs and will open new frontiers in the field of RNA studies and therapeutic development. ..
  11. request reprint
    Allen L, Kloc M, Etkin L. Identification and characterization of the Xlsirt cis-acting RNA localization element. Differentiation. 2003;71:311-21 pubmed
    ..Further analysis of this element identified putative METRO and Late pathway localization sub-elements. Computer analysis relates the secondary structure of the 137 nt element to its ability to function as a localization element. ..
  12. request reprint
    Jaglarz M, Bilinski S, Kloc M. Assembly and breakdown of Cajal bodies in accessory nuclei of Hymenoptera. Differentiation. 2005;73:99-108 pubmed
    ..Because the morphology and behavior of ANs and their Cajal body-like inclusions are conserved in two other hymenopteran species, these features might be characteristic of all hymenopterans. ..
  13. request reprint
    Zearfoss N, Chan A, Kloc M, Allen L, Etkin L. Identification of new Xlsirt family members in the Xenopus laevis oocyte. Mech Dev. 2003;120:503-9 pubmed
  14. Bashirullah A, Halsell S, Cooperstock R, Kloc M, Karaiskakis A, Fisher W, et al. Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster. EMBO J. 1999;18:2610-20 pubmed
    ..The second pathway is activated 2 h after fertilization and functions together with the maternal pathway to ensure that transcripts are degraded by the MBT. ..
  15. request reprint
    Bilinski S, Kloc M. Accessory nuclei revisited: the translocation of snRNPs from the germinal vesicle to the periphery of the future embryo. Chromosoma. 2002;111:62-8 pubmed
    ..e., to the region where the blastoderm of the embryo develops and where there is a requirement for a high concentration of RNA-processing factors. ..
  16. request reprint
    Katayama H, Sasai K, Kloc M, Brinkley B, Sen S. Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle. 2008;7:2691-704 pubmed
    ..The findings provide the first evidence of Aurora-A, in association with INCENP and TPX2, being a key regulator of kinetochore/chromatin associated microtubule formation in human cells. ..
  17. request reprint
    Reddy B, Kloc M, Etkin L. The cloning and characterization of a localized maternal transcript in Xenopus laevis whose zygotic counterpart is detected in the CNS. Mech Dev. 1992;39:143-50 pubmed
    ..The presence of this mRNA in animal pole region which contributes to the future neural cell lineages suggests that this gene product may function either in the specification of neural cell types or in a neural specific function. ..
  18. Skelton T, Tejpal N, Gong Y, Kloc M, Ghobrial R. Downregulation of RhoA and changes in T cell cytoskeleton correlate with the abrogation of allograft rejection. Transpl Immunol. 2010;23:185-93 pubmed publisher
  19. request reprint
    Miller M, Kloc M, Reddy B, Eastman E, Dreyer C, Etkin L. xlgv7: a maternal gene product localized in nuclei of the central nervous system in Xenopus laevis. Genes Dev. 1989;3:572-83 pubmed
    ..We conclude that the xlgv7 gene product is a maternal protein that may serve several important functions, one of which may be in the development and maintanance of the CNS. ..
  20. request reprint
    Kloc M, Zearfoss N, Etkin L. Mechanisms of subcellular mRNA localization. Cell. 2002;108:533-44 pubmed
    ..This strategy of posttranscriptional gene regulation utilizes a variety of distinct mechanisms to regulate the movement and anchoring of different transcripts. ..
  21. Kloc M, Ghobrial R, Borsuk E, Kubiak J. Polarity and asymmetry during mouse oogenesis and oocyte maturation. Results Probl Cell Differ. 2012;55:23-44 pubmed publisher
    ..Curiously, the mouse oocyte becomes polarized at least twice during ontogenesis; the question of how this phenomenon is achieved and what role it might play is addressed in this chapter. ..
  22. Tworzydlo W, Kloc M, Bilinski S. The Balbiani body in the female germline cells of an earwig, Opisthocosmia silvestris. Zoolog Sci. 2009;26:754-7 pubmed publisher
    ..We also show that in the cyst cells, the Bbs are invariably located next to the fusome, a specialized cytoplasm occupying the bridge connecting sibling cells. ..
  23. Pan S, Wang R, Zhou X, Corvera J, Kloc M, Sifers R, et al. Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly. EMBO J. 2008;27:2077-90 pubmed publisher
    ..These findings demonstrate that a sub-population of Alix localizes extracellularly and regulates integrin-mediated cell adhesions and fibronectin matrix assembly. ..
  24. request reprint
    Zagrodzinska B, Kloc M. Direct fluorescence in situ hybridization to polytene chromosomes. Biotechniques. 1998;24:184-5 pubmed
  25. Kloc M, Kubiak J, Li X, Ghobrial R. The newly found functions of MTOC in immunological response. J Leukoc Biol. 2014;95:417-30 pubmed publisher
    ..In this review, we focus on the ultrastructural and molecular aspects of MTOCs in various aspects of immune cell functions, with specific emphasis on the formation of the IS and targeted cell killing. ..
  26. Li X, KLOC M, Ghobrial R. Memory T cells in transplantation - progress and challenges. Curr Opin Organ Transplant. 2013;18:387-92 pubmed publisher
    ..This situation remains a major challenge in the clinic. ..
  27. Zhang L, You J, Sidhu J, Tejpal N, Ganachari M, Skelton T, et al. Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways. Transplantation. 2013;96:782-90 pubmed publisher
    ..Selective targeting of T-cell actin cytoskeletal pathways shows potential for pathway-targeted immunosuppression therapies. ..
  28. request reprint
    Rutzky L, Bilinski S, Kloc M, Phan T, Zhang H, Katz S, et al. Microgravity culture condition reduces immunogenicity and improves function of pancreatic islets1. Transplantation. 2002;74:13-21 pubmed
    ..Microgravity condition decreases immunogenicity and significantly improves the function of secretory cells. ..
  29. Jaglarz M, Kloc M, Bilinski S. Accessory nuclei in insect oogenesis: in search of the function of enigmatic organelles. Int J Dev Biol. 2008;52:179-85 pubmed publisher
    ..In the light of recent discoveries, we discuss the role accessory nuclei play in insect oogenesis and early embryogenesis. ..
  30. Kloc M, Bilinski S, Dougherty M. Organization of cytokeratin cytoskeleton and germ plasm in the vegetal cortex of Xenopus laevis oocytes depends on coding and non-coding RNAs: three-dimensional and ultrastructural analysis. Exp Cell Res. 2007;313:1639-51 pubmed
    ..We suggest that the cytokeratin cytoskeleton plays a role in anchoring of germ plasm islands within the vegetal cortex and germinal granules within the germ plasm islands. ..
  31. request reprint
    Pijanowska J, Kloc M. Daphnia response to predation threat involves heat-shock proteins and the actin and tubulin cytoskeleton. Genesis. 2004;38:81-6 pubmed
    ..In addition, some of these effects are transgenerational, i.e., they are passed on from the mother to her offspring. ..
  32. Bilinski S, Jaglarz M, Dougherty M, Kloc M. Electron microscopy, immunostaining, cytoskeleton visualization, in situ hybridization, and three-dimensional reconstruction of Xenopus oocytes. Methods. 2010;51:11-9 pubmed publisher
  33. request reprint
    Kloc M, Zagrodzinska B. Chromatin elimination--an oddity or a common mechanism in differentiation and development?. Differentiation. 2001;68:84-91 pubmed
    ..We will discuss the possible role of the germ plasm in this process. ..
  34. Lisik W, Tejpal N, Gong Y, Skelton T, Ganachari M, Bremer E, et al. Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I. PLoS ONE. 2009;4:e8020 pubmed publisher
    ..We believe that these novel findings may have important clinical implications for organ transplantation. ..
  35. request reprint
    Kloc M, Bilinski S, Chan A, Etkin L. Mitochondrial ribosomal RNA in the germinal granules in Xenopus embryos revisited. Differentiation. 2001;67:80-3 pubmed
    ..The majority of the mtlrRNA and mtlsrRNAs was present inside the mitochondria and in the germ plasm matrix. ..
  36. Shin Y, Choi Y, Erdin S, Yatsenko S, Kloc M, Yang F, et al. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet. 2010;6:e1001190 pubmed publisher
    ..HORMAD1 is therefore a critical component of the synaptonemal complex that affects synapsis, recombination, and meiotic sex chromosome inactivation and transcriptional silencing...
  37. Jaglarz M, Bazile F, Laskowska K, Polanski Z, Chesnel F, Borsuk E, et al. Association of TCTP with centrosome and microtubules. Biochem Res Int. 2012;2012:541906 pubmed publisher
  38. request reprint
    Wang M, Stepkowski S, Tian L, Langowski J, Hebert J, Kloc M, et al. Nucleotide sequences of three distinct cDNA clones coding for the rat class I heavy chain RT1n antigen. Immunogenetics. 1996;45:73-5 pubmed
  39. request reprint
    Kloc M, Bilinski S, Dougherty M, Brey E, Etkin L. Formation, architecture and polarity of female germline cyst in Xenopus. Dev Biol. 2004;266:43-61 pubmed
    ..The dissimilarities between Drosophila and Xenopus and the uniqueness of each system probably evolved through modifications of the same fundamental design of the germline cyst. ..
  40. request reprint
    Cheung W, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen C, et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003;113:507-17 pubmed
    ..Our data provide evidence for a potential apoptotic "histone code." ..
  41. request reprint
    Kloc M, Wilk K, Vargas D, Shirato Y, Bilinski S, Etkin L. Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex of Xenopus oocytes. Development. 2005;132:3445-57 pubmed
    ..These results demonstrate a novel structural role of coding and noncoding RNAs in the organization of the vegetal cortex of Xenopus oocytes. ..
  42. Wosik J, Chen W, Qin K, Ghobrial R, Kubiak J, Kloc M. Magnetic Field Changes Macrophage Phenotype. Biophys J. 2018;114:2001-2013 pubmed publisher
  43. Chen W, Chen S, Chen W, Li X, Ghobrial R, Kloc M. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts. Transpl Immunol. 2018;50:15-25 pubmed publisher
  44. Chen W, Ghobrial R, Li X, Kloc M. Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages. Immunobiology. 2018;223:634-647 pubmed publisher
  45. Liu Y, Tejpal N, You J, Li X, Ghobrial R, Kloc M. ROCK inhibition impedes macrophage polarity and functions. Cell Immunol. 2016;300:54-62 pubmed publisher
    ..These novel findings suggest that the impediment of macrophage structure and function via interference with the RhoA/ROCK pathway has a potential to be therapeutically effective in organ transplantation. ..
  46. Liu Y, Minze L, Mumma L, Li X, Ghobrial R, Kloc M. Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3. Exp Cell Res. 2016;341:225-36 pubmed publisher
    ..These novel findings will revise/complement our understanding of RhoA pathway regulation of cell structure and polarity. ..
  47. Kloc M, Bilinski S, Kubiak J. Cytoskeleton and Cytoskeleton-Bound RNA Visualization in Frog and Insect Oocytes. Methods Mol Biol. 2016;1457:179-90 pubmed publisher
    ..In addition, we describe visualization of cytoskeleton-bound RNAs using molecular beacons in live Xenopus oocytes. ..
  48. request reprint
    Liu Y, Chen W, Minze L, Kubiak J, Li X, Ghobrial R, et al. Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference. Cell Tissue Res. 2016;366:707-720 pubmed
    ..These dramatic differences in the response of M0/M2 versus M1 macrophages to the same molecular cues ought to be important considerations in the interpretation of experimental data and therapeutic use of bone-marrow-derived macrophages. ..
  49. Liu Y, Chen W, Wu C, Minze L, Kubiak J, Li X, et al. Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts. J Heart Lung Transplant. 2017;36:340-354 pubmed publisher
    ..Our finding of codependence of chronic rejection on monocyte/macrophage CX3CR1/CX3CL1 and RhoA signaling pathways may lead to the development of novel anti-chronic rejection therapies. ..
  50. Kloc M, Kubiak J, Bilinski S. Gametic synapses, nanotubes and sperm RNAs - Redefining the origin of maternal determinants. Mech Dev. 2016;141:1-3 pubmed publisher
    ..In addition, the discovery that sperm delivers various RNAs to the egg suggests that sperm may not only epigenetically modify the egg genome but also influence or modify information contained in the maternal determinants. ..
  51. Bilinski S, Kubiak J, Kloc M. Asymmetric Divisions in Oogenesis. Results Probl Cell Differ. 2017;61:211-228 pubmed publisher
    ..In the following chapter, we summarize current knowledge on the asymmetric oogonial divisions in invertebrate (insects) and vertebrate (Xenopus) species. ..
  52. Liu Y, Kubiak J, Li X, Ghobrial R, Kloc M. Macrophages and RhoA Pathway in Transplanted Organs. Results Probl Cell Differ. 2017;62:365-376 pubmed publisher
    ..In this review we discuss the role of RhoA pathway in governance of macrophage's functions in terms of transplanted organs. ..
  53. Kloc M, Kubiak J. Exogenous Molecule and Organelle Delivery in Oogenesis. Results Probl Cell Differ. 2017;63:3-16 pubmed publisher
    ..In this chapter, we will summarize present-day knowledge on sources and presumptive functions of different types of exogenous molecules and organelles delivered to the animal oocytes and eggs. ..
  54. Chen W, Zhao Y, Li X, Kubiak J, Ghobrial R, Kloc M. Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex. Int J Biochem Cell Biol. 2017;93:12-24 pubmed publisher
  55. Chen W, Sandoval H, Kubiak J, Li X, Ghobrial R, Kloc M. The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis. Cell Immunol. 2018;324:1-7 pubmed publisher
    ..This indicates that the maintenance of mouse macrophage phenotypes depends on mitochondrial function and ATP/ADP homeostasis. ..