Affiliation: University of Tokyo
- Numata S, Iga J, Nakataki M, Tayoshi S, Taniguchi K, Sumitani S, et al. Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:527-34 pubmed publisher..Our results suggest that the PDE4B gene itself does not link to MDD but the elevated mRNA levels of PDE4B might be implicated in the pathophysiology of MDD. ..
- Numata S, Iga J, Nakataki M, Tayoshi S, Tanahashi T, Itakura M, et al. Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population. J Psychiatry Neurosci. 2009;34:195-8 pubmed..Finally, we did not show how SNPs of the PCNT gene alter its function. Our results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of MDD in the Japanese population. ..
- Numata S, Nakataki M, Iga J, Tanahashi T, Nakadoi Y, Ohi K, et al. Association study between the pericentrin (PCNT) gene and schizophrenia. Neuromolecular Med. 2010;12:243-7 pubmed publisher..In the haplotypic analysis, we could not find any significant association in our subjects, either. This gene may not play a major role independently in the etiology of SZ in the Japanese population. ..
- Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, et al. Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia. Schizophr Bull. 2014;40:1154-63 pubmed publisher..15 for schizophrenia per 1-SD increase in plasma total homocysteine. Our study suggests that increased plasma total homocysteine levels may be associated with an increased risk of schizophrenia. ..
- Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, et al. Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk. Psychiatry Res. 2016;246:833-837 pubmed publisher..Our findings suggest that common polygenic variations, which are associated with the plasma total homocysteine levels, may contribute to the risk of SCZ. ..
- Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, et al. Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. Int J Mol Sci. 2017;18: pubmed publisher..Furthermore, DNA methylation changes in the CREBBP (CREB binding protein) gene were significantly correlated with the clinical improvements. Our findings provide insights into the action of clozapine in treatment-resistant SCZ. ..
- Nishi A, Numata S, Tajima A, Zhu X, Ito K, Saito A, et al. De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity. Sci Rep. 2017;7:2887 pubmed publisher..These results suggest that a de novo TBL1XR1 point mutation could alter Wnt/?-catenin signaling activity. Further studies are required to clarify the involvement of TBL1XR1 mutations in neuropsychiatric conditions. ..
- Umehara H, Numata S, Watanabe S, Hatakeyama Y, Kinoshita M, Tomioka Y, et al. Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder. Sci Rep. 2017;7:4855 pubmed publisher..Our findings suggest that imbalances in specific metabolite levels may be involved in the pathogenesis of MDD, and provide insight into the mechanisms by which antidepressant agents work in MDD patients. ..