Affiliation: University of Tokyo
Ishikawa M, Kitayama J, Kazama S, Nagawa H. Expression of vascular endothelial growth factor C and D (VEGF-C and -D) is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma. Jpn J Clin Oncol. 2003;33:21-7 pubmed
..These observations are based only on retrospective analysis of a small case series and further evaluation with a larger number of cases is necessary. ..
Ishikawa M, Kitayama J, Kazama S, Nagawa H. The expression pattern of vascular endothelial growth factor C and D in human esophageal normal mucosa, dysplasia and neoplasia. Hepatogastroenterology. 2004;51:1319-22 pubmed
..This finding raises the possibility that VEGF-C and -D might play positive roles in the early stage of esophageal carcinogenesis. ..
Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res. 2004;10:4325-31 pubmed
..Leptin may have a promoting effect on the carcinogenesis and metastasis of breast cancer, possibly in an autocrine manner. Functional inhibition of leptin may be effective for the prevention and treatment of breast cancer. ..
Ishikawa M, Kitayama J, Kazama S, Hiramatsu T, Hatano K, Nagawa H. Plasma adiponectin and gastric cancer. Clin Cancer Res. 2005;11:466-72 pubmed
Ishikawa M, Kitayama J, Nagawa H. Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer. World J Gastroenterol. 2006;12:5517-22 pubmed
..Functional upregulation of leptin/OB-R may have a positive role in the development and initial phase of progression in gastric cancer. ..