Takashi Suzuki


Affiliation: Tohoku University
Country: Japan


  1. Suzuki T, Miki Y, Nakamura Y, Ito K, Sasano H. Steroid sulfatase and estrogen sulfotransferase in human carcinomas. Mol Cell Endocrinol. 2011;340:148-53 pubmed publisher
    ..Therefore, STS pathway and estrogen actions may play an important role in the development of these carcinomas, and further investigations are required. ..
  2. Fue M, Miki Y, Takagi K, Hashimoto C, Yaegashi N, Suzuki T, et al. Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the ?-Catenin Pathway in Endometrial Cancer. Int J Mol Sci. 2018;19: pubmed publisher
    ..These results suggest that adherens junctions in cancer cells are weakened by the breakdown of the cadherin/catenin complex, which is induced by ?-catenin phosphorylation via RLN2/RXFP1 signaling. ..
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    Suzuki T, Darnel A, Akahira J, Ariga N, Ogawa S, Kaneko C, et al. 5alpha-reductases in human breast carcinoma: possible modulator of in situ androgenic actions. J Clin Endocrinol Metab. 2001;86:2250-7 pubmed
  4. Takagi K, Miki Y, Onodera Y, Ishida T, Watanabe M, Sasano H, et al. ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens. Int J Mol Sci. 2018;19: pubmed publisher
    ..ARHGAP15 immunoreactivity is therefore considered a potent prognostic factor in human breast carcinomas. ..
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    Suzuki T, Sasano H, Takeyama J, Kaneko C, Freije W, Carr B, et al. Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol (Oxf). 2000;53:739-47 pubmed
    ..The increased level of P450c17, DHEA-ST, P450 oxidoreductase, and cytochrome b5, and the decreased level of 3betaHSD in the reticularis is likely to contribute to increased C19 steroid production during adrenarche. ..
  6. Hashimoto C, Miki Y, Tanaka S, Takagi K, Fue M, Doe Z, et al. 17?-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer. Int J Mol Sci. 2018;19: pubmed publisher
    ..These findings suggest that androgen suppresses the estrogen dependence of endometrial cancer through the induction of 17?-HSD2 in endometrial cancer. ..
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    Suzuki T, Moriya T, Darnel A, Takeyama J, Sasano H. Immunohistochemical distribution of chicken ovalbumin upstream promoter transcription factor II in human tissues. Mol Cell Endocrinol. 2000;164:69-75 pubmed
    ..The widespread expression of COUP-TFII suggests that COUP-TFII may play an important role in the function and homeostasis of various human tissues and organs. ..
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    Suzuki T, Inoue A, Miki Y, Moriya T, Akahira J, Ishida T, et al. Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor. Endocr Relat Cancer. 2007;14:279-92 pubmed
    ..These results suggest that EGR3 plays an important role in estrogen-meditated invasion and is an independent prognostic factor in breast carcinoma. ..
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    Suzuki T, Miki Y, Moriya T, Shimada N, Ishida T, Hirakawa H, et al. Estrogen-related receptor alpha in human breast carcinoma as a potent prognostic factor. Cancer Res. 2004;64:4670-6 pubmed
    ..Results from our study suggest that ERRalpha possibly modulates the expression of ERE-containing estrogen-responsive genes, and ERRalpha immunoreactivity is a potent prognostic factor in human breast carcinoma. ..

More Information


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    Suzuki T, Urano T, Tsukui T, Horie Inoue K, Moriya T, Ishida T, et al. Estrogen-responsive finger protein as a new potential biomarker for breast cancer. Clin Cancer Res. 2005;11:6148-54 pubmed
    ..Our data suggest that Efp immunoreactivity is a significant prognostic factor in breast cancer patients. These findings may account for an oncogenic role of Efp in the tumor progression of breast carcinoma. ..
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    Suzuki T, Miki Y, Moriya T, Akahira J, Ishida T, Hirakawa H, et al. 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production. Int J Cancer. 2007;120:285-91 pubmed
    ..Aromatase inhibitors may be more effective in these patients, possibly due to increasing local DHT concentration with estrogen deprivation. ..
  3. Katagiri M, Karasawa H, Takagi K, Nakayama S, Yabuuchi S, Fujishima F, et al. Hexokinase 2 in colorectal cancer: a potent prognostic factor associated with glycolysis, proliferation and migration. Histol Histopathol. 2017;32:351-360 pubmed publisher
    ..These results suggest that HK2 plays important roles in the glycolytic, proliferation and migration properties of colorectal carcinoma and, therefore, HK2 status is a potent worse prognostic factor in colorectal cancer patients. ..
  4. Miki Y, Hata S, Ono K, Suzuki T, Ito K, Kumamoto H, et al. Roles of Aryl Hydrocarbon Receptor in Aromatase-Dependent Cell Proliferation in Human Osteoblasts. Int J Mol Sci. 2017;18: pubmed publisher
    ..These findings indicated that AhR could regulate estrogen synthesis and metabolism in bone tissues through cytokine/aromatase signaling. ..