Affiliation: Shinshu University
Tsukahara T, Hanazawa S, Kobayashi T, Iwamoto Y, Murakami Murofushi K. Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor ?. Prostaglandins Other Lipid Mediat. 2010;93:126-33 pubmed publisher
..Our results identify PPAR? as a molecular mediator of cPA activity in HT-29 cells, and suggest that cPA and the PPAR? pathway might be therapeutic targets in the treatment of colon cancer. ..
Tsukahara T, Hanazawa S, Murakami Murofushi K. Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells. Biochem Biophys Res Commun. 2011;404:109-14 pubmed publisher
..These findings contribute to the participation of cPA on the lipolytic activity in 3T3-L1 adipocytes. Our studies imply that cPA might be a therapeutic compound in the treatment of obesity and obesity-related diseases. ..
Tsukahara T, Haniu H. Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation. Biochem Biophys Res Commun. 2011;406:558-63 pubmed publisher
..Taken together, these results suggest that HTT2800 specifically converts the differentiation pathway of C2C12 myoblasts to that of adipoblast-like cells. ..
Tsukahara T, Haniu H, Matsuda Y. Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells. Biochem Biophys Res Commun. 2013;433:281-5 pubmed publisher
..These findings suggest that alkyl-LPA activates PPAR? and stimulates glucose uptake in the absence of insulin in C2C12 cells. This may contribute to the plasma glucose-lowering effect in the treatment of insulin resistance. ..
Tsukahara T, Haniu H. Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells. Biochem Biophys Res Commun. 2012;424:524-9 pubmed publisher
..We observed a correlation between the level of PPAR? expression and the cells' sensitivity for proliferation...
Tsukahara T, Haniu H, Matsuda Y. PTB-associated splicing factor (PSF) is a PPAR?-binding protein and growth regulator of colon cancer cells. PLoS ONE. 2013;8:e58749 pubmed publisher
..The PSF-PPAR? axis may play a role in the control of colorectal carcinogenesis. Taken together, this study is the first to describe the effects of PSF on cell proliferation, tumor growth, and cell signaling associated with PPAR?. ..