Thomas J McHugh

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. pmc CA3 NMDA receptors are required for the rapid formation of a salient contextual representation
    Thomas J McHugh
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hippocampus 19:1153-8. 2009
  2. pmc Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory
    Toshiaki Nakashiba
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 62:781-7. 2009
  3. ncbi request reprint Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
  4. doi request reprint Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
    Toshiaki Nakashiba
    Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1260-4. 2008
  5. ncbi request reprint Spatial exploration is required for the formation of contextual fear memory
    Thomas J McHugh
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Behav Neurosci 121:335-9. 2007
  6. pmc Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
    Toshiaki Nakashiba
    Department of Biology, RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 149:188-201. 2012
  7. pmc Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus
    Ariel Kamsler
    RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1618-23. 2010
  8. doi request reprint The ins and outs of hippocampal circuits
    Susumu Tonegawa
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 57:175-7. 2008
  9. ncbi request reprint NMDA receptors, place cells and hippocampal spatial memory
    Kazu Nakazawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Nat Rev Neurosci 5:361-72. 2004

Collaborators

Detail Information

Publications9

  1. pmc CA3 NMDA receptors are required for the rapid formation of a salient contextual representation
    Thomas J McHugh
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hippocampus 19:1153-8. 2009
    ..Our results suggest CA3 contributes both speed and salience to contextual processing and support the theory of competition between multimodal and unimodal conditioned stimuli for associative learning...
  2. pmc Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory
    Toshiaki Nakashiba
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 62:781-7. 2009
    ..Collectively, these results suggest that the posttraining integrity of the trisynaptic pathway and the ripple-associated reactivation of hippocampal memory engram are crucial for memory consolidation...
  3. ncbi request reprint Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation...
  4. doi request reprint Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
    Toshiaki Nakashiba
    Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1260-4. 2008
    ..In contrast, the full trisynaptic pathway containing CA3 is required for rapid one-trial contextual learning, for pattern completion-based memory recall, and for spatial tuning of CA1 cells...
  5. ncbi request reprint Spatial exploration is required for the formation of contextual fear memory
    Thomas J McHugh
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Behav Neurosci 121:335-9. 2007
    ..Our results indicate that spatial exploration is necessary for mice to benefit from contextual preexposure...
  6. pmc Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
    Toshiaki Nakashiba
    Department of Biology, RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 149:188-201. 2012
    ..Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion...
  7. pmc Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus
    Ariel Kamsler
    RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1618-23. 2010
    ..mGluR LTD was rescued by stimulating PKC activity pharmacologically in CA3-m1KO mice. These data confirm a role for PKC activation in presynaptic induction of mGluR LTD and distinguish between the roles of mGluRs and m1 receptors...
  8. doi request reprint The ins and outs of hippocampal circuits
    Susumu Tonegawa
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 57:175-7. 2008
    ....
  9. ncbi request reprint NMDA receptors, place cells and hippocampal spatial memory
    Kazu Nakazawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Nat Rev Neurosci 5:361-72. 2004