Hiroaki Nagano

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression
    H Ota
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka E 2, Suita, Osaka 565 0871, Japan
    Br J Cancer 93:557-64. 2005
  2. ncbi request reprint Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Cancer 110:2493-501. 2007
  3. ncbi request reprint [A case of HCC with inferior caval vein tumor thrombus and multiple pulmonary metastases that remarkably responded to combination therapy of TS-1 and interferon-alpha]
    Masato Nakamura
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 32:1824-8. 2005
  4. doi request reprint Pilot study of combination chemotherapy of S-1, a novel oral DPD inhibitor, and interferon-alpha for advanced hepatocellular carcinoma with extrahepatic metastasis
    Masato Nakamura
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Cancer 112:1765-71. 2008
  5. ncbi request reprint Complete remission of hepatocellular carcinoma with portal vein tumor thrombus and lymph node metastases by arterial infusion of 5-fluorouracil and interferon-alpha combination therapy following hepatic resection
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita, Osaka, Japan
    J Gastroenterol 42:501-6. 2007
  6. ncbi request reprint Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation
    Bazarragchaa Damdinsuren
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Int J Oncol 26:319-27. 2005
  7. ncbi request reprint A case of hepatocellular carcinoma with multiple lung, spleen, and remnant liver metastasis successfully treated by combination chemotherapy with the novel oral DPD-inhibiting chemotherapeutic drug S-1 and interferon-alpha
    Masato Nakamura
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gastroenterol 41:1120-5. 2006
  8. ncbi request reprint [A case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus]
    Hisanori Hatano
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2374-6. 2009
  9. ncbi request reprint Pretreatment with S-1, an oral derivative of 5-fluorouracil, enhances gemcitabine effects in pancreatic cancer xenografts
    Shin Nakahira
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, E2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Anticancer Res 28:179-86. 2008
  10. ncbi request reprint Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565 0871, Osaka, Japan
    Oncol Rep 18:801-9. 2007

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. pmc Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression
    H Ota
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka E 2, Suita, Osaka 565 0871, Japan
    Br J Cancer 93:557-64. 2005
    ..0070). IFN-alpha/5-FU combination therapy is a promising modality for advanced HCC with tumour thrombi in the major portal branches and could significantly depend on IFNAR2 expression...
  2. ncbi request reprint Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Cancer 110:2493-501. 2007
    ..In addition, they evaluated the correlation between the response to such therapy and expression of IFN-alpha type 2 receptor (IFNAR2)...
  3. ncbi request reprint [A case of HCC with inferior caval vein tumor thrombus and multiple pulmonary metastases that remarkably responded to combination therapy of TS-1 and interferon-alpha]
    Masato Nakamura
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 32:1824-8. 2005
    ..No adverse effect was seen during this treatment. It was suggested that a combination therapy of TS-1 and interferon-alpha may be one of the most effective treatment modalities against advanced HCC with distant metastasis...
  4. doi request reprint Pilot study of combination chemotherapy of S-1, a novel oral DPD inhibitor, and interferon-alpha for advanced hepatocellular carcinoma with extrahepatic metastasis
    Masato Nakamura
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Cancer 112:1765-71. 2008
    ..In a pilot study, the results of combination therapy of S-1, a novel oral dehydropyrimidine dehydrogenase (DPD) inhibitor, and interferon-alpha (IFN-alpha) are reported for HCC patients with extrahepatic metastasis...
  5. ncbi request reprint Complete remission of hepatocellular carcinoma with portal vein tumor thrombus and lymph node metastases by arterial infusion of 5-fluorouracil and interferon-alpha combination therapy following hepatic resection
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita, Osaka, Japan
    J Gastroenterol 42:501-6. 2007
    ..The patients are alive without any recurrence more than 1 year after initial treatment. IFN-alpha/5-FU combined therapy following hepatic resection is a promising modality for the treatment of advanced HCC with LN metastasis...
  6. ncbi request reprint Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation
    Bazarragchaa Damdinsuren
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Int J Oncol 26:319-27. 2005
    ..These findings suggested that Id1, 2 and 3 might play a role in the early stages of hepatocarcinogenesis, but not in the development of advanced carcinoma, and might consequently be related to HCC dedifferentiation...
  7. ncbi request reprint A case of hepatocellular carcinoma with multiple lung, spleen, and remnant liver metastasis successfully treated by combination chemotherapy with the novel oral DPD-inhibiting chemotherapeutic drug S-1 and interferon-alpha
    Masato Nakamura
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gastroenterol 41:1120-5. 2006
    ..This outcome suggests that combination therapy with S-1 and IFN-alpha may be a promising treatment modality against advanced HCC with distant metastasis...
  8. ncbi request reprint [A case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus]
    Hisanori Hatano
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2374-6. 2009
    ..Thereafter, sustained partial remission was achieved. In case of combined hepatocellular and cholangiocarcinoma, we need to create a treatment strategy against characteristics of both components...
  9. ncbi request reprint Pretreatment with S-1, an oral derivative of 5-fluorouracil, enhances gemcitabine effects in pancreatic cancer xenografts
    Shin Nakahira
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, E2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Anticancer Res 28:179-86. 2008
    ..The purpose of this study was to evaluate the relationship between different schedules and the effects of GEM/S-1 combination therapy on pancreatic cancer xenograft models...
  10. ncbi request reprint Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565 0871, Osaka, Japan
    Oncol Rep 18:801-9. 2007
    ..The synergistic and anti-angiogenic effects may in part be attributable to the regulation of Ang-1, -2 and VEGF...
  11. ncbi request reprint Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model
    Masanori Tsujie
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, E2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Pancreas 33:142-7. 2006
    ..The purpose of the present study was to evaluate the relationship between the schedules of gemcitabine/uracil-tegafur (UFT) combination therapy and their effects in pancreatic cancer in vivo...
  12. ncbi request reprint Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Liver Int 26:414-23. 2006
    ..Angiogenesis is regulated by a balance between pro and antiangiogenic molecules. The aim of this study was to investigate the expressions of angiogenic factors and elucidate their roles in angiogenesis in HCC...
  13. ncbi request reprint Combination of IFN-alpha and 5-fluorouracil induces apoptosis through IFN-alpha/beta receptor in human hepatocellular carcinoma cells
    Motoi Kondo
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka E2, Suita, Osaka 565 0871, Japan
    Clin Cancer Res 11:1277-86. 2005
    ..In the present study, we examined whether apoptosis through IFN-alpha/beta receptor (IFN-alpha/betaR) was associated with the effects of combination therapy...
  14. ncbi request reprint Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway
    Masanori Tsujie
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, E2, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Exp Cell Res 289:143-51. 2003
    ....
  15. ncbi request reprint [A long-term survival case of hepatocellular carcinoma with lymph node metastasis on the posterior surface of the pancreas head and portal vein tumor thrombus successfully treated with hepatopancreatoduodenectomy and adjuvant interferon-alpha and 5-fluoro
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2389-91. 2009
    ....
  16. doi request reprint Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer
    Hiromitsu Hoshino
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Int J Oncol 40:1423-30. 2012
    ..Both hypoxia and TP53 deficiency increase iPC cell generation. TP53 deficiency can also result in deleterious mutations, whereas hypoxia may impact molecular targets of epigenome normalisation...
  17. ncbi request reprint [A case of long-term survivor with multiple pulmonary metastases of HCC after hepatic resection]
    Masato Nakamura
    Dept of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 31:1939-42. 2004
    ..It was suggested that a good prognosis may be expected, even in the HCC case with distant metastasis after hepatic resection, if the primary cite was curatively treated...
  18. ncbi request reprint [A case of complete response to S-1 therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection]
    Akira Tomokuni
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2383-5. 2009
    ..This case illustrates that S-1 may be an effective treatment for HCC with extrahepatic metastasis...
  19. pmc Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cells
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita 565 0871 Osaka, Japan
    BMC Cancer 9:361. 2009
    ....
  20. ncbi request reprint [A case of successful treatment of advanced hepatocellular carcinoma with tumor thrombi in the major portal branches and inferior vena cava with combined intraarterial 5-fluorouracil, adriamycin and cisplatin therapy]
    Hideo Ota
    Dept of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 30:1673-7. 2003
    ..In conclusion, some patients may obtain longer survival through this treatment, even in cases of advanced HCC with tumor thrombus in the major trunks of portal vein and/or hepatic vein...
  21. ncbi request reprint Hepatic resection followed by IFN-alpha and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Japan
    Hepatogastroenterology 54:172-9. 2007
    ..In this study, this therapy was applied for resectable advanced HCC (Vp3) as a postoperative adjuvant...
  22. ncbi request reprint CDC25A inhibition suppresses the growth and invasion of human hepatocellular carcinoma cells
    Xundi Xu
    Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Int J Mol Med 21:145-52. 2008
    ..These results suggest that CDC25A, by inhibiting HCC growth and invasion, may be a feasible therapeutic target for human HCC...
  23. ncbi request reprint Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy
    Tameyoshi Yamamoto
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Clin Oncol 12:150-4. 2007
    ..In addition to this therapy, combined modality therapy including, for example, surgical resection, can sometimes have a dramatic therapeutic effect, shown by tumor markers reverting to normal levels...
  24. doi request reprint Steroid-free living donor liver transplantation in adults: impact on hepatitis C recurrence
    Shigeru Marubashi
    Department of Surgery, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan
    Clin Transplant 23:904-13. 2009
    ..We aimed to clarify the impact of steroid-free immunosuppression on post-operative HCV recurrence after living donor liver transplantation (LDLT)...
  25. ncbi request reprint [Intra arterial infusion chemotherapy combined with interferon-alpha following palliative hepatic resection against advanced hepatoma with portal venous tumor thrombus in the major trunk and multiple nodules--a preliminary study]
    Hiroaki Nagano
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 33:1848-51. 2006
    ..In conclusion, IFN-alpha/5-FU combined therapy may be a promising modality for advanced HCC with tumor thrombi in the major trunk with multiple nodules after following palliative surgery...
  26. ncbi request reprint [A long-term survival case of hepatocellular carcinoma recurrence after the patient received a living donor liver transplantation treated by combined modality therapy]
    Naoki Hama
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 35:2092-5. 2008
    ..This case suggested that a combined modality therapy might have improved the survival of the patient after recurrence in the liver transplantation for advanced HCC...
  27. ncbi request reprint [A long-term survival case of pancreatic cancer with hepatic metastasis after pancreaticoduodenectomy successfully treated by s-1 and gemcitabine combination chemotherapy]
    Hiromitsu Hoshino
    Department of Surgery, Graduate School of Medicine, Osaka University, and Osaka National Hospital, National Hospital Organization
    Gan To Kagaku Ryoho 36:2419-21. 2009
    ..S-1 and gemcitabine combination therapy is not only effective but also well tolerated and safe. This combination therapy should be considered one of selective choices for advanced or metastatic pancreatic cancer...
  28. doi request reprint Long-term culture following ES-like gene-induced reprogramming elicits an aggressive phenotype in mutated cholangiocellular carcinoma cells
    Ken ichi Nagai
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 395:258-63. 2010
    ....
  29. ncbi request reprint Interstitial pneumonia induced by combined intraarterial 5-fluorouracil and subcutaneous interferon-alpha therapy for advanced hepatocellular carcinoma
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    J Gastroenterol 39:793-7. 2004
    ..The combination of IFN-alpha and 5-FU is a useful therapy for patients with advanced HCC, such as that with portal vein invasion or multiple metastatic foci. Thus, interstitial pneumonia in these patients should be carefully managed...
  30. ncbi request reprint [Successful treatment for advanced cholangiocellular carcinoma with intrahepatic metastasis and/or portal vein tumor thrombi by intraarterial chemotherapy combined with 5-fluorouracil, adriamycin and cisplatin (FAP)--two cases report]
    Hiroshi Wada
    Dept of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 31:1711-3. 2004
    ..They are alive for more than 1 year after chemotherapy had started. FAP hepatic arterial infusion chemotherapy might be promising as an effective therapy for non-resectable CCC without extra hepatic metastasis...
  31. ncbi request reprint [A case of complete response to interferon-α and S-1 combination therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection]
    Yoshiteru Katsura
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 38:2487-9. 2011
    ..Diagnostic imaging and tumor markers showed a marked improvement after 4 courses of S-1/IFN therapy, and he is still alive with good condition without recurrence and progression of tumors...
  32. doi request reprint Differential transcriptome patterns for acute cellular rejection in recipients with recurrent hepatitis C after liver transplantation
    Tadafumi Asaoka
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Liver Transpl 15:1738-49. 2009
    ....
  33. ncbi request reprint [A case of combined hepatocellular and cholangiocarcinoma showing tumor growth and invasion to the diaphragm during interferon-alpha and 5-fluorouracil combined intra-arterial chemotherapy]
    Takehiro Noda
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 35:2099-102. 2008
    ..This case suggested that the growth of cancer cells without sensitivity to IFN-alpha/5-FU chemotherapy and the blood supply via the diaphragm led the relapse of IFN-alpha/5-FU chemotherapy...
  34. ncbi request reprint Molecular prediction of response to 5-fluorouracil and interferon-alpha combination chemotherapy in advanced hepatocellular carcinoma
    Yukinori Kurokawa
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Clin Cancer Res 10:6029-38. 2004
    ..Combination chemotherapy with intra-arterial 5-fluorouracil and subcutaneous interferon-alpha has shown promising results for such advanced HCC, but it is important to develop the ability to accurately predict chemotherapeutic responses...
  35. ncbi request reprint Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance
    Di Tang
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565 0871, Osaka, Japan
    Oncol Rep 15:525-32. 2006
    ..Although TSP-1 may increase intrahepatic CCC metastases, neither MVD levels nor the expression of VEGF, Ang-1, or Ang-2 was associated with clinicopathological factors and prognosis...
  36. ncbi request reprint Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer
    Masanori Tsujie
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University E2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Anticancer Res 27:2241-9. 2007
    ..The purpose of this study was to find a novel biomarker to predict 5-fluorouracil (5-FU) or gemcitabine (2',2'-difluoro-deoxycytidine) sensitivity in pancreatic cancer...
  37. ncbi request reprint [S-1 treatment against advanced HCC]
    Masato Nakamura
    Dept of Surgery, Osaka University, Graduate School of Medicine, Japan
    Gan To Kagaku Ryoho 33:230-5. 2006
    ..It was suggested that a combination therapy of S-1 and interferon-alpha may be one of the most effective treatment modalities against advanced HCC with distant metastases...
  38. ncbi request reprint Phase I/II trial of hyperfractionated accelerated chemoradiotherapy for unresectable advanced pancreatic cancer
    Masanori Tsujie
    Department of Surgery and Clinical Oncology, Osaka University, Suita, Osaka, Japan
    Jpn J Clin Oncol 36:504-10. 2006
    ....
  39. ncbi request reprint Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor
    Jiro Okami
    Department of Surgery and Clinical Oncology, Osaka University, Graduate School of Medicine, Suita City, Osaka, Japan
    Clin Exp Metastasis 20:577-84. 2003
    ..Thus, COX-2-specific inhibitors may be a useful anti-invasive therapeutic option in pancreatic cancer...
  40. ncbi request reprint Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Yamadaoka, Suita City, Japan
    Oncology 66:468-75. 2004
    ..To determine the prognostic value of valosin-containing protein (VCP) expression and the Ki-67 labeling index (LI) in pancreatic endocrine neoplasms (PENs), the present analysis was employed...
  41. ncbi request reprint [Surgical treatment for peritoneal dissemination of hepatocellular carcinoma after percutaneous ethanol injection therapy--a case report]
    Hiroshi Wada
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 33:1935-7. 2006
    ..We think that this is a rare but a serious complication of PEIT and every effort should be attempted to prevent this complication, especially in the treatment of superficial and larger HCC...
  42. ncbi request reprint Quantitative tissue blood flow measurement of the liver parenchyma: comparison between xenon CT and perfusion CT
    Kazuhiko Hashimoto
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Dig Dis Sci 52:943-9. 2007
    ..8+/-13%, respectively. The measured values by the two techniques also showed a significant correlation (R (2)= 0.869, P < 0.05). We conclude that there was a good correlation between hepatic TBF quantified by xenon CT and perfusion CT...
  43. ncbi request reprint Role of the Fas/FasL pathway in combination therapy with interferon-alpha and fluorouracil against hepatocellular carcinoma in vitro
    Masato Nakamura
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Hepatol 46:77-88. 2007
    ..However, the mechanism underlying the clinical anti-tumor effects of this treatment is not well understood. The aim of this study was to determine the role of Fas/FasL signaling in the anti-tumor effect of this combination therapy...
  44. ncbi request reprint [A successful surgical treatment for solitary pulmonary and adrenal metastases after hepatic resection to hepatocellular carcinoma--a case report]
    Hiroshi Wada
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 32:1835-8. 2005
    ..Eighty one months after the first operation, he died of liver failure due to tumor progression. Surgical resection for metastases from HCC resulted in long-term survival even if there were extrahepatic metastases in two different sites...
  45. ncbi request reprint Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
    Shin Nakahira
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Int J Cancer 120:1355-63. 2007
    ..016). RRM1 should be a key molecule in gemcitabine resistance in human pancreatic cancer through both in vitro and clinical models. RRM1 may have the potential as predictor and modulator of gemcitabine treatment...
  46. doi request reprint Molecular prediction of early recurrence after resection of hepatocellular carcinoma
    Shinichi Yoshioka
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Eur J Cancer 45:881-9. 2009
    ..0001, hazard ratio=3.29). Gene expression pattern related to early intrahepatic recurrence inherited in the primary HCC tumour can be useful for the prediction of prognosis...
  47. ncbi request reprint [A case of hepatocellular carcinoma with right atrium tumor thrombus treated with combined doxorubicin and interferon-beta/intra-arterial injection chemotherapy and hepatectomy]
    Masahiro Murakami
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 34:2087-9. 2007
    ..It was suggested that the doxorubicin and interferon-beta combined chemotherapy might be the promising modality for advanced hepatocellular carcinoma as one of the multimodel treatment...
  48. ncbi request reprint [The progress of hepatic arterial infusion chemotherapy for hepatocellular carcinoma]
    Takehiro Noda
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 33:1221-5. 2006
    ..We previously reported that the beneficial effects of combination therapy of IFN-alpha/5-FU for advanced HCC. IFN-alpha/5-FU combination therapy may be a promising treatment modality for advanced HCC...
  49. ncbi request reprint Clinical and pathological features of Allen's type C classification of resected combined hepatocellular and cholangiocarcinoma: a comparative study with hepatocellular carcinoma and cholangiocellular carcinoma
    Di Tang
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Gastrointest Surg 10:987-98. 2006
    ..Surgical resection of this tumor yields results intermediate between those of HCC and CCC in character. More cases are needed to further define the characteristics of this tumor...
  50. ncbi request reprint [Long-term survival of a patient with hepatocellular carcinoma with portal vein tumor thrombus treated with interferon-α and 5-fluorouracil combination therapy]
    Yujiro Tsuda
    Dept of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 40:1804-6. 2013
    ..Therefore, even if patients have HCC with PVTT in the main branch and severe liver cirrhosis, long-term survival is possible by administration of a combination of FAIT and TACE. ..
  51. ncbi request reprint Living-donor liver transplantation with renoportal anastomosis for patients with large spontaneous splenorenal shunts
    Shigeru Marubashi
    Department of Surgery and Clinical Oncology, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan
    Transplantation 80:1671-5. 2005
    ..However, the long-term outcome, portal venous hemodynamics after liver transplantation, and the effects of altering the renal venous drainage remained unknown...
  52. ncbi request reprint Portal venous reconstruction in a living liver donor with an anomalous hepatic arterial and portal venous anatomy
    Shigeru Marubashi
    Department of Surgery and Clinical Oncology, Osaka University, Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Gastrointest Surg 9:365-8. 2005
    ....
  53. ncbi request reprint Stronger growth-inhibitory effect of interferon (IFN)-beta compared to IFN-alpha is mediated by IFN signaling pathway in hepatocellular carcinoma cells
    Bazarragchaa Damdinsuren
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Int J Oncol 30:201-8. 2007
    ....
  54. ncbi request reprint Detection of AFP mRNA-expressing cells in the peripheral blood for prediction of HCC recurrence after living donor liver transplantation
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka, Japan
    Transpl Int 20:576-82. 2007
    ..We concluded that the presence of AFP mRNA-expressing cells preoperatively could be a useful predictor of the recurrence of HCC in liver transplant patients...
  55. ncbi request reprint [A case of successful treatment with combined 5-fluorouracil, adriamycin, cisplatin (FAP) therapy followed by Gemcitabine, UFT therapy and intra-arterial FAP therapy for unresectable advanced gallbladder cancer]
    Shigeru Marubashi
    Dept of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 31:1708-10. 2004
    ..She is still alive 18 months after the first diagnosis. It may be possible to improve the prognosis by maintaining QOL using the combination of chemotherapies such as FAP, Gemcitabine, and UFT...
  56. doi request reprint Fibrin sealant with PGA felt for prevention of bile leakage after liver resection
    Shogo Kobayashi
    Department of Surgery, Osaka University, Osaka, Japan
    Hepatogastroenterology 59:2564-8. 2012
    ..We performed preliminary evaluation of fibrin sealing combined with PGA felt (PGA-FS) as hemostat and to prevent biliary leakage, in comparison with the conventional fibrin-coated collagen fleece (FC-CF), retrospectively...
  57. doi request reprint Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection
    Daisaku Yamada
    Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Ann Surg Oncol 19:S355-64. 2012
    ..One function of this demethylase is to amplify hypoxia-inducible gene expression. We hypothesized that the demethylase would be a significant marker of hepatocellular carcinoma...
  58. doi request reprint Biliary reconstruction in living donor liver transplantation: technical invention and risk factor analysis for anastomotic stricture
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Transplantation 88:1123-30. 2009
    ..The objectives of this study were to investigate the outcome of biliary reconstruction using "open-up" anastomotic technique and to clarify the risk factors for biliary stricture after LDLT...
  59. doi request reprint Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells
    Masahiro Murakami
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Ann Surg Oncol 18:589-96. 2011
    ..In this study, we showed the VEGF-related effects of IFN/5-FU therapy using VEGF-receptor (VEGFR) selective inhibitor, PTK787/ZK222584 (PTK/ZK), in HCC cells...
  60. ncbi request reprint [A case of hepatocellular carcinoma with gall bladder metastasis]
    Masahiro Murakami
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 35:2089-91. 2008
    ..So we diagnosed it as gall bladder metastasis from hepatocellular carcinoma...
  61. ncbi request reprint Clinical value of alterations in p73 gene, related to p53 at 1p36, in human hepatocellular carcinoma
    Taro Aoki
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, E2, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Oncol 24:441-6. 2004
    ..Identifying the patients with LOH of p73 in tumors could be useful to predict early recurrence and to stratify the patients who need adjuvant therapy after operation...
  62. ncbi request reprint [Pancreatic cancer showing complete pathological response to preoperative chemoradiotherapy-a case report]
    Keiko Tanizaki
    Dept of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 40:1872-4. 2013
    ..Histopathological examination revealed no cancer cells in the pancreas or the dissected lymph nodes. The pathological effect was judged as grade IV. The patient has had no recurrence for 8 months since pancreatectomy. ..
  63. doi request reprint Guanylate-binding protein 2 mRNA in peripheral blood leukocytes of liver transplant recipients as a marker for acute cellular rejection
    Shogo Kobayashi
    Department of Surgery, Osaka University, Suita, Osaka 565 0871, Japan
    Transpl Int 23:390-6. 2010
    ..Using a cut-off value of 20, the sensitivity and specificity of GBP2/GAPDH based on ROC curve analysis were 63% and 85% respectively. GBP2 in the patients with LD may be useful for diagnosis of ACR...
  64. ncbi request reprint New measurement of hepatic blood flow by xenon CT system: an animal study with PGE1
    Shouho Hayashi
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Surg Res 129:24-30. 2005
    ..In a rabbit model, we evaluated the accuracy of this system by comparing it with the electromagnetic blood flowmeter (EMBF), the pharmacological effect of PGE1 on the fractional hepatic hemodynamics...
  65. ncbi request reprint Utility of 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography in differential diagnosis of benign and malignant intraductal papillary-mucinous neoplasm of the pancreas
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Oncol Rep 24:613-20. 2010
    ..5 offered the best diagnosis of malignant IPMN. These results suggest that FDG-PET is useful for differentiation of malignant IPMN of the pancreas, and that it should be performed in combination with other conventional imaging modalities...
  66. ncbi request reprint TGF-beta1-induced cell growth arrest and partial differentiation is related to the suppression of Id1 in human hepatoma cells
    Bazarragchaa Damdinsuren
    Department of Surgery, Graduate School of Medicine, Osaka University, E2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Oncol Rep 15:401-8. 2006
    ..Our results suggest that, in some HCC cells, the pathway of suppression of Id1 by TGF-beta1 may be important in TGF-beta1-induced growth inhibition and partial differentiation...
  67. ncbi request reprint [A case of long-term survival with TAE resistant multiple recurrence HCC successfully treated by hepatic resection]
    Masato Nakamura
    Dept of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 30:1717-21. 2003
    ..It appears that this surgery may be a useful modality for TAE resistant multiple recurrence hepatoma in cases of good liver function and lesions limited to the hemi lobe...
  68. ncbi request reprint A successful resection and long-term survival of a patient with intrahepatic recurrences of combined hepatocellular-cholangiocarcinoma: report of a case
    Hidetoshi Eguchi
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Japan
    Surg Today 32:742-6. 2002
    ..To improve the poor prognosis of combined HCC-CC, clinicopathological features of this disease and the therapy selection for recurrent tumors should be discussed...
  69. doi request reprint Once-daily prolonged-release tacrolimus in de novo liver transplantation: a single center cohort study
    Shigeru Marubashi
    Department of Surgery, Osaka University, Osaka, Japan
    Hepatogastroenterology 59:1184-8. 2012
    ..The feasibility of oral administration of once-daily prolonged-release tacrolimus (TAC-PR) in de novo liver transplantation is not clear and therefore was investigated further...
  70. ncbi request reprint Molecular-based prediction of early recurrence in hepatocellular carcinoma
    Yukinori Kurokawa
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka Univeristy, Suita City, Osaka 565 0871, Japan
    J Hepatol 41:284-91. 2004
    ..As the current morphological indicators are often insufficient for therapeutic decisions, we sought to identify additional biologic indicators for early recurrence...
  71. ncbi request reprint Surgical outcomes of noninvasive and minimally invasive intraductal papillary-mucinous neoplasms of the pancreas
    Hidenori Takahashi
    Department of Gastroenterological Surgery, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Japan
    Ann Surg Oncol 13:955-60. 2006
    ..In this study, we evaluated the surgical outcome of noninvasive and minimally invasive IPMNs, concentrating particularly on the pattern of recurrences...
  72. ncbi request reprint [Management of pulmonary recurrence of hepatocellular carcinoma after receiving a living-donor liver transplantation--a case report]
    Tadafumi Asaoka
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 35:2086-7. 2008
    ..5 to 43.0 months and the median survival time was 18.9 months. Only one of the 5 patients who underwent a surgical resection of pulmonary recurrence is still alive without a new recurrence for a long period of time...
  73. ncbi request reprint [A case of postoperative multiple hepatic metastasis from gastric cancer successfully treated by percutaneous microwave coagulation therapy and hepatic arterial infusion chemotherapy]
    Tameyoshi Yamamoto
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 29:2429-32. 2002
    ..In conclusion, some cases can obtain longer survival if the multimoderate therapy including hepatic arterial infusion chemotherapy (FAP) and microwave coagulation therapy are effective...
  74. ncbi request reprint [A long-term survival case of hepatocellular carcinoma with bone metastasis and inferior vena cava tumor thrombus successfully treated with multidisciplinary therapy]
    Daisaku Yamada
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 37:2670-2. 2010
    ..This case suggests that some patients with highly progressive HCC involving inferior vena cava tumor thrombus (Vv3) and bone metastasis can gain a long-term survival by multidisciplinary therapy including TACE and Interferon-α and S-1...
  75. ncbi request reprint [A long-term survival case of hepatocellular carcinoma with portal vein and inferior vena cava tumor thrombi]
    Yasuji Hashimoto
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 37:2693-5. 2010
    ..This case suggests that some patients with advanced HCC with tumor thrombus can get a long-term survival when intrahepatic lesions are controlled by various therapies including IFN-α/5-FU combination therapy...
  76. ncbi request reprint Interferon-beta is more potent than interferon-alpha in inhibition of human hepatocellular carcinoma cell growth when used alone and in combination with anticancer drugs
    Bazarragchaa Damdinsuren
    Department of Surgery and Clinical Oncology E2, Graduate School of Medicine, Osaka University, Osaka, Japan
    Ann Surg Oncol 10:1184-90. 2003
    ..The prognosis of advanced hepatocellular carcinoma (HCC) is extremely poor, but promising effects of chemotherapies combined with interferon (IFN) have been reported...
  77. ncbi request reprint [FAIT (FU arterial infusion and interferon therapy) for hepatocellular carcinoma]
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University
    Nihon Rinsho 64:1314-8. 2006
    ..FAIT is a promising modality for advanced HCC with tumour thrombi in the major portal branches...
  78. doi request reprint Treatment of borderline cases for curative resection of biliary tract cancer
    Shogo Kobayashi
    Department of Surgery, Osaka University, Suita, Osaka, Japan
    J Surg Oncol 104:499-503. 2011
    ..To dissect the high rate of non-curative resection associated with biliary tract cancer, we compared the outcome of non-curative resection with that of inoperable cancer in patients referred for surgery...
  79. ncbi request reprint [Development and research of the new therapy for hepatocellular carcinoma--combined interferon and 5-fluorouracil therapy]
    Hiroaki Nagano
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Nihon Rinsho 60:2237-44. 2002
    ..In conclusion, combination therapy with subcutaneous IFN and intra-arterial 5-FU is therefore a promising treatment modality for intractable HCC with Vp3 or 4...
  80. ncbi request reprint Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas
    Xundi Xu
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Japan
    Clin Cancer Res 9:1764-72. 2003
    ..CDC25A and CDC25B, being oncogenes, are overexpressed in a variety of human malignancies. To investigate the potential roles of CDC25s in hepatocellular carcinoma (HCC), expression of CDC25A and CDC25B was examined in human HCC samples...
  81. ncbi request reprint Impact of graft size on postoperative thrombocytopenia in living donor liver transplant
    Shigeru Marubashi
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Arch Surg 142:1054-8. 2007
    ..Perioperative variables, including portal venous pressure (PVP) and graft size, can predict thrombocytopenia after living donor liver transplant (LDLT)...
  82. ncbi request reprint [Anti-tumor effect of interferon for hepatocellular carcinoma-from the clinical consideration]
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Japan
    Nihon Shokakibyo Gakkai Zasshi 104:654-9. 2007
  83. ncbi request reprint [Cases of postoperative hepatic metastasis from gastric cancer in which hepatic arterial infusion chemotherapy with 5-FU, adriamycin and cisplatin was performed after TS-1 chemotherapy]
    Yutaka Kimura
    Dept of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 31:1825-7. 2004
    ..It is necessary to consider combined chemotherapy in addition to systemic chemotherapy...
  84. ncbi request reprint Transarterial embolization for large hepatocellular carcinoma with use of superabsorbent polymer microspheres: initial experience
    Keigo Osuga
    Departments of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Vasc Interv Radiol 13:929-34. 2002
    ..No deterioration of liver function occurred. Our initial experience suggests that embolization with use of SAP-MS leads to extensive tumor necrosis of large nodular HCC, sparing use of chemotherapeutic agents...
  85. ncbi request reprint Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against Hepatocellular Carcinoma
    Tameyoshi Yamamoto
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka, University, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Clin Cancer Res 10:7884-95. 2004
    ....
  86. ncbi request reprint Combined intraarterial 5-fluorouracil and subcutaneous interferon-alpha therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches
    Masato Sakon
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Japan
    Cancer 94:435-42. 2002
    ..The prognosis of hepatocellular carcinoma (HCC) invading into the major branches of the portal vein (Vp3) is extremely poor...
  87. doi request reprint Evaluation of a new immunoassay for therapeutic drug monitoring of tacrolimus in adult liver transplant recipients
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    J Clin Pharmacol 50:705-9. 2010
    ..The effects of maintaining low levels of FK should be evaluated in liver transplant recipients...
  88. ncbi request reprint Intrahepatic recurrences of hepatocellular carcinoma after hepatectomy: analysis based on tumor hemodynamics
    Masato Sakon
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Arch Surg 137:94-9. 2002
    ..Surgical margin, i.e., the area of possible local intrahepatic metastasis, is controversial in hepatectomy for hepatocellular carcinoma...
  89. doi request reprint Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation
    Takahiro Tsuboyama
    Department of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiology 255:824-33. 2010
    ..To investigate the mechanism of enhancement of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) images and to characterize HCC thus enhanced...
  90. ncbi request reprint A safe protocol of intermittent hilar vascular clamping for hepatic resection in cirrhosis
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita 565 0871 Osaka, Japan
    Hepatogastroenterology 56:1439-44. 2009
    ..Postoperative liver function was assessed at days 1, 3 and 5...
  91. doi request reprint Salvage cystic duct anastomosis using a magnetic compression technique for incomplete bile duct reconstruction in living donor liver transplantation
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Liver Transpl 16:33-7. 2010
    ..A combination of the MCA technique and cystic duct anastomosis is life-saving in certain situations and should be considered as the treatment of choice...
  92. ncbi request reprint Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence
    Shinji Yamamoto
    Departments of Surgery and Clinical Oncology, and Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Clin Oncol 21:447-52. 2003
    ..In this study, association of VCP expression with recurrence of hepatocellular carcinoma (HCC) and patient survival was examined...
  93. ncbi request reprint [Influence on 5-fluorouracil metabolism by combination of interferon-alpha and 5-fluorouracil against human hepatocellular carcinoma xenografts]
    Chang De Jin
    Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 31:1511-5. 2004
    ..This suggested that antitumor activity of 5-FU and IFN-alpha in combination was not significantly involved in 5-FU metabolism in two human hepatocellular carcinoma cell lines examined...
  94. ncbi request reprint Steroid-free living-donor liver transplantation in adults
    Shigeru Marubashi
    Department of Surgery and Clinical Oncology, Osaka University, Graduate School of Medicine, Suita, Japan
    Transplantation 80:704-6. 2005
    ..Steroid avoidance was beneficial in the recipients, as both steroid side effects and recurrence of HCV could be avoided...
  95. doi request reprint Role of the liver in determining alloimmune response in vitro following donor-specific spleen cell injection
    Masaki Okuyama
    Department of Surgery, Graduate School of Medicine Osaka University, Osaka 565 0871, Japan
    Transpl Immunol 22:150-6. 2010
    ..Our findings suggest that liver and other organs may behave differently to alloantigen, suggesting the importance of an early Th1 reaction in the liver and spleen...
  96. ncbi request reprint [Hepatocellular carcinoma recurrence in PEI site--a case report]
    Hideo Ota
    Dept of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 29:2421-4. 2002
    ..In December 2000, the patient had a high AFP level, and a recurrent tumor was observed at S3 on abdominal CT. In June 2001, S3 subsegmentectomy was performed, because the recurrent tumor existed in the Glisson S3 area...
  97. ncbi request reprint Xenon-inhalation computed tomography for noninvasive quantitative measurement of tissue blood flow in hepatocellular carcinoma
    Takamichi Murakami
    Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan
    Invest Radiol 39:210-5. 2004
    ....
  98. ncbi request reprint JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1
    Hirofumi Yamamoto
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
    Gastroenterology 125:556-71. 2003
    ..The aim of this study was to assess the effects of cyclooxygenase (COX)-2 inhibition on rat experimental liver fibrogenesis...
  99. ncbi request reprint [Hepatic arterial infusion chemotherapy (HAIC)--hepatocellular carcinoma]
    Keigo Osuga
    Dept of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gan To Kagaku Ryoho 31:2114-7. 2004
    ..None of the regimens have been proved to be the standard for HAIC, and prospective multi-center clinical studies with standardized protocol are needed in the future...
  100. ncbi request reprint Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection
    Yubo Yang
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Surgery 141:196-202. 2007
    ..The aim of the present study was to determine the clinicopathologic characteristics and prognosis of patients with extrahepatic metastasis from HCC according to the recurrence pattern...
  101. ncbi request reprint [Recent progress in chemotherapy for hepatocellular carcinoma]
    Masato Sakon
    Nihon Naika Gakkai Zasshi 93:1660-5. 2004