Kazuo Yamagata


Affiliation: Nihon University
Country: Japan


  1. Yamagata K, Nakayama C, Suzuki K. Dietary ?-carotene regulates interleukin-1?-induced expression of apolipoprotein E in astrocytes isolated from stroke-prone spontaneously hypertensive rats. Neurochem Int. 2013;62:43-9 pubmed publisher
    ..Furthermore, under hypoxic stress, astrocytes isolated from SHRSP/Izm rats displayed altered regulation of Apoe compared with those from WKY/Izm rats. ..
  2. Yamagata K, Xie Y, Suzuki S, Tagami M. Epigallocatechin-3-gallate inhibits VCAM-1 expression and apoptosis induction associated with LC3 expressions in TNFα-stimulated human endothelial cells. Phytomedicine. 2015;22:431-7 pubmed publisher
    ..We thus conclude that EGCG might be beneficial for inhibiting TNF-α-mediated human endothelial disorders by affecting LC3 expression-related processes. ..
  3. Yamagata K, Miyashita A, Matsufuji H, Chino M. Dietary flavonoid apigenin inhibits high glucose and tumor necrosis factor alpha-induced adhesion molecule expression in human endothelial cells. J Nutr Biochem. 2010;21:116-24 pubmed publisher
    ..It is suggested that apigenin inhibited the expression of several genes through inhibition of IKKs. ..
  4. Yamagata K, Tagami M, Yamori Y. Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. Nutrition. 2015;31:28-37 pubmed publisher
    ..As such, there are many questions concerning their physiological mode of action. In this review, we discuss research on the effect of dietary polyphenols on cardiovascular disease and their protective effect on EC dysfunction. ..
  5. Yamagata K, Suzuki S, Tagami M. Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence. Prostaglandins Leukot Essent Fatty Acids. 2016;104:11-8 pubmed publisher
    ..TNF-α-mediated upregulation of these genes was inhibited by allopurinol and apocynin. These results indicated that DHA regulated the expression of several genes that are associated with senescence and dysfunction of EC. ..
  6. Yamagata K. Do Coffee Polyphenols Have a Preventive Action on Metabolic Syndrome Associated Endothelial Dysfunctions? An Assessment of the Current Evidence. Antioxidants (Basel). 2018;7: pubmed publisher
    ..This review describes the results of studies exploring the putative effects of coffee components, especially in protecting vascular endothelial function and preventing metabolic syndrome. ..
  7. Yamagata K, Hakata K, Maeda A, Mochizuki C, Matsufuji H, Chino M, et al. Adenosine induces expression of glial cell line-derived neurotrophic factor (GDNF) in primary rat astrocytes. Neurosci Res. 2007;59:467-74 pubmed
    ..This expression was attenuated in astrocytes of SHRSP compared with those of WKY. ..
  8. Yamagata K, Tagawa C, Matsufuji H, Chino M. Dietary apigenin regulates high glucose and hypoxic reoxygenation-induced reductions in apelin expression in human endothelial cells. J Nutr Biochem. 2012;23:929-36 pubmed publisher
    ..Furthermore, dietary apigenin might improve the expression of angiogenic genes and fatty acid uptake. ..
  9. Yamagata K, Tanaka N, Matsufuji H, Chino M. ?-carotene reverses the IL-1?-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells. Microvasc Res. 2012;84:297-305 pubmed publisher
    ..carotene may contribute to the functional maintenance of vascular endothelial cells in a manner similar to HDL, protecting them against stimuli such as IL-1?. ..

More Information


  1. Suzuki S, Nakashima N, Kageyama M, Yamagata K. A phytoestrogen supplement prevents the altered gene expression associated with pregnancy implantation induced by IL-1? in endometrial epithelial cells. Reprod Biol. 2017;17:259-267 pubmed publisher
    ..AglyMax-Sup might abrogate IL-1?-mediated changes that can affect embryo implantation via the MAPK pathway. ..
  2. Yamagata K, Ichinose S, Miyashita A, Tagami M. Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Neuroscience. 2008;153:428-35 pubmed publisher
    ..Ebselen may be effective in the prevention and/or treatment of neurodegenerative diseases associated with excessive apoptosis in patients with stroke. ..
  3. Yamagata K, Miyashita A, Chino M, Matsufuji H. Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. Microvasc Res. 2011;81:60-7 pubmed publisher
    ..Conversely, the inhibitory action of apigenin may be beneficial for the treatment of diabetic endothelial dysfunction. ..
  4. Yamagata K. Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease. Lipids Health Dis. 2017;16:118 pubmed publisher
    ..The aim of this paper was to review the effects of DHA on vascular endothelial cells and recent findings on their potential for the prevention of circulatory diseases. ..
  5. Yamagata K, Takahashi N, Akita N, Nabika T. Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats. J Neuroinflammation. 2017;14:176 pubmed publisher
    ..The data suggest that AVP attenuated the expression of MCTs in SHRSP/Izm and SHRpch1_18 astrocytes. Reduced expression of MCTs may be associated with decreased lactate production in SHRSP. ..
  6. Yamagata K, Izawa Y, Onodera D, Tagami M. Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells. Mol Cell Biochem. 2018;441:9-19 pubmed publisher
    ..In conclusion, chlorogenic acid may contribute to the polyphenolic anti-cancer effect associated with consumption of vegetables and fruits. ..