Tomihisa Takahashi

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. ncbi request reprint Autoregulatory mechanism of Runx2 through the expression of transcription factors and bone matrix proteins in multipotential mesenchymal cell line, ROB-C26
    Tomihisa Takahashi
    Department of Anatomy, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 47:199-207. 2005
  2. ncbi request reprint Cloning of the chicken immunoglobulin joining (J)-chain gene and characterization of its promoter region
    Tomihisa Takahashi
    Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan
    DNA Cell Biol 21:81-90. 2002
  3. ncbi request reprint Cloning and expression of the chicken immunoglobulin joining (J)-chain cDNA
    T Takahashi
    Department of Pathology, Nihon University School of Dentistry, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Immunogenetics 51:85-91. 2000
  4. ncbi request reprint The effect of retinoic acid on a zinc finger transcription factor, AJ18, during differentiation of a rat clonal preosteoblastic cell line, ROB-C20, into osteoblasts
    Tomihisa Takahashi
    Department of Anatomy, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    Arch Oral Biol 53:87-94. 2008
  5. doi request reprint Overexpression of Runx2 and MKP-1 stimulates transdifferentiation of 3T3-L1 preadipocytes into bone-forming osteoblasts in vitro
    Tomihisa Takahashi
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Calcif Tissue Int 88:336-47. 2011
  6. ncbi request reprint Glucocorticoids induce the differentiation of a mesenchymal progenitor cell line, ROB-C26 into adipocytes and osteoblasts, but fail to induce terminal osteoblast differentiation
    Shinsuke Ito
    Department of Anatomy, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Tokyo 101 8310, Japan
    Bone 40:84-92. 2007
  7. ncbi request reprint Effects of bone morphogenetic protein-2 and transforming growth factor beta1 on gene expression of transcription factors, AJ18 and Runx2 in cultured osteoblastic cells
    Minoru Takagi
    Department of Anatomy, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Mol Histol 35:81-90. 2004
  8. ncbi request reprint Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts
    Masato Igarashi
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    J Mol Histol 35:3-10. 2004
  9. ncbi request reprint Dexamethasone promotes DMP1 mRNA expression by inhibiting negative regulation of Runx2 in multipotential mesenchymal progenitor, ROB-C26
    Yoshikazu Mikami
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Cell Biol Int 32:239-46. 2008
  10. ncbi request reprint Cloning and expression of the turtle (Trachemys scripta) immunoglobulin joining (J)-chain cDNA
    Arihiro Iwata
    Department of Pathology, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Immunogenetics 54:513-9. 2002

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Autoregulatory mechanism of Runx2 through the expression of transcription factors and bone matrix proteins in multipotential mesenchymal cell line, ROB-C26
    Tomihisa Takahashi
    Department of Anatomy, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 47:199-207. 2005
    ....
  2. ncbi request reprint Cloning of the chicken immunoglobulin joining (J)-chain gene and characterization of its promoter region
    Tomihisa Takahashi
    Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan
    DNA Cell Biol 21:81-90. 2002
    ..These results suggest that the chicken J-chain gene consists of four exons and three introns and that the transcriptional regulatory elements may be present within 3.8 kb upstream of exon 1...
  3. ncbi request reprint Cloning and expression of the chicken immunoglobulin joining (J)-chain cDNA
    T Takahashi
    Department of Pathology, Nihon University School of Dentistry, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Immunogenetics 51:85-91. 2000
    ..These data indicated that the chicken J-chain gene displays a high degree of homology with that of other species, and is expressed at an early stage of development of the chicken immune system...
  4. ncbi request reprint The effect of retinoic acid on a zinc finger transcription factor, AJ18, during differentiation of a rat clonal preosteoblastic cell line, ROB-C20, into osteoblasts
    Tomihisa Takahashi
    Department of Anatomy, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    Arch Oral Biol 53:87-94. 2008
    ..To verify the effect of RA on osteoblast differentiation, AJ18 expression level was examined using a rat clonal preosteoblastic cell line, ROB-C20 (C20)...
  5. doi request reprint Overexpression of Runx2 and MKP-1 stimulates transdifferentiation of 3T3-L1 preadipocytes into bone-forming osteoblasts in vitro
    Tomihisa Takahashi
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Calcif Tissue Int 88:336-47. 2011
    ....
  6. ncbi request reprint Glucocorticoids induce the differentiation of a mesenchymal progenitor cell line, ROB-C26 into adipocytes and osteoblasts, but fail to induce terminal osteoblast differentiation
    Shinsuke Ito
    Department of Anatomy, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Tokyo 101 8310, Japan
    Bone 40:84-92. 2007
    ....
  7. ncbi request reprint Effects of bone morphogenetic protein-2 and transforming growth factor beta1 on gene expression of transcription factors, AJ18 and Runx2 in cultured osteoblastic cells
    Minoru Takagi
    Department of Anatomy, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Mol Histol 35:81-90. 2004
    ....
  8. ncbi request reprint Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts
    Masato Igarashi
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    J Mol Histol 35:3-10. 2004
    ..Thus, it is likely that Dex may promote osteoblastic differentiation and mineralization of FRCC by inducing the expression of Cbfa1 and Osx genes in vitro...
  9. ncbi request reprint Dexamethasone promotes DMP1 mRNA expression by inhibiting negative regulation of Runx2 in multipotential mesenchymal progenitor, ROB-C26
    Yoshikazu Mikami
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Cell Biol Int 32:239-46. 2008
    ....
  10. ncbi request reprint Cloning and expression of the turtle (Trachemys scripta) immunoglobulin joining (J)-chain cDNA
    Arihiro Iwata
    Department of Pathology, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Immunogenetics 54:513-9. 2002
    ..In addition, immunohistochemistry showed J-chain-positive plasma cells in the intestine and spleen. These results suggest the presence of a mucosal immune system mainly composed of J-chain-containing Ig in the turtle...
  11. doi request reprint Inhibition of Wnt/β-catenin signaling by dexamethasone promotes adipocyte differentiation in mesenchymal progenitor cells, ROB-C26
    Masako Naito
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyodaku, Tokyo 101 8310, Japan
    Histochem Cell Biol 138:833-45. 2012
    ..These results suggest that inhibition of β-catenin expression by Dex promotes the differentiation of mesenchymal progenitor cells into adipocytes...
  12. doi request reprint Suppression of lamin A/C by short hairpin RNAs promotes adipocyte lineage commitment in mesenchymal progenitor cell line, ROB-C26
    Masako Naito
    Department of Anatomy, Nihon University School of Dentistry, Kanda Surugadai, Chiyodaku, Tokyo, Japan
    Histochem Cell Biol 137:235-47. 2012
    ..These results suggest that decreased lamin A/C expression levels not only suppress osteoblast phenotypes but also promote adipocyte differentiation in C26 cells...
  13. doi request reprint The p75 neurotrophin receptor regulates MC3T3-E1 osteoblastic differentiation
    Yoshikazu Mikami
    Department of Anatomy, Nihon University School of Dentistry, Tokyo, Japan
    Differentiation 84:392-9. 2012
    ..Taken together, our studies demonstrated that p75(NTR) signaling through the trk tyrosine kinase pathway affects osteoblast functions by targeting osteoblast proliferation and differentiation...
  14. doi request reprint The P75 neurotrophin receptor regulates proliferation of the human MG63 osteoblast cell line
    Yuko Akiyama
    Nihon University Graduate School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Differentiation 87:111-8. 2014
    ....
  15. ncbi request reprint Component analysis of dental porcelain for assisting dental identification
    H Aboshi
    Department of Legal Medicine, Nihon University School of Dentistry, Chiyoda Ky, Tokyo, Japan
    J Forensic Odontostomatol 24:36-41. 2006
    ..The energy dispersive X-ray fluorescence (EDXRF) spectrometer was used for a pilot study of identification of porcelain composition...
  16. ncbi request reprint Role of nuclear factor-kappaB in the expression by tumor necrosis factor-alpha of the human polymeric immunoglobulin receptor (plgR) gene
    N Takenouchi-Ohkubo
    Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan
    Immunogenetics 51:289-95. 2000
    ..These data indicated that pIgR gene expression induced by TNF-alpha is transcriptionally regulated via activation of NF-kappaB. In addition, there is a possibility that another factor may act in concert with NF-kappaB...
  17. ncbi request reprint Cloning of hypoxia-inducible factor 1alpha cDNA from chick embryonic ventricular myocytes
    T Takahashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 281:1057-62. 2001
    ..These data suggest that HIF-1alpha may be involved in embryonic cardiovascular development. HIF-1alpha and EPAS1 may play distinct roles during developmental stages...
  18. doi request reprint Age estimation using microfocus X-ray computed tomography of lower premolars
    H Aboshi
    Department of Legal Medicine, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Forensic Sci Int 200:35-40. 2010
    ..The coefficients of determination for the chosen variables were 0.625 for lower first and 0.698 for lower second premolars. Pulp-tooth volume ratio is an age-dependent variable that can be used to estimate age with reasonable accuracy...
  19. doi request reprint Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells
    Masako Naito
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Cell Tissue Res 354:761-70. 2013
    ..These results suggest that Axin2 plays a key role in adipocyte and osteoblastic differentiation by controlling β-catenin expression. ..
  20. pmc Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats
    Akiko Ohashi
    Department of Anatomy, Nihon University School of Dentistry, Chiyoda, Tokyo, Japan
    PLoS ONE 11:e0164305. 2016
    ..Since a high BH2 relative to BH4 causes NOS dysfunction, the lowering of the BH4% must be avoided in practice, otherwise the desired effect of the supplementation in ameliorating NOS dysfunction would be spoiled...
  21. doi request reprint Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5
    Masako Naito
    Department of Anatomy, Nihon University School of Dentistry, Tokyo, Japan Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan Electronic address
    Mol Cell Endocrinol 417:114-23. 2015
    ..01). These results clearly indicated that PLZF promoted differentiation into hypertrophic chondrocytes and mediated dexamethasone-induced cell cycle arrest by regulating CDK inhibitors...
  22. ncbi request reprint Bacitracin upregulates mbrAB transcription via mbrCD to confer bacitracin resistance in Streptococcus mutans
    Yoshikazu Mikami
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    J Pharmacol Sci 117:204-7. 2011
    ..These results suggest that both mbrC and mbrD are required for mbrAB upregulation that confers the bacitracin-resistant phenotype on S. mutans...
  23. doi request reprint Classification and antimicrobial susceptibilities of enterococcus species isolated from apparently healthy food-producing animals in Japan
    A Kojima
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Kokubunji, Tokyo, Japan
    Zoonoses Public Health 57:137-41. 2010
    ..hirae. Isolates from cattle were more susceptible to the antimicrobials studied than those from pigs and broilers. VanA- or VanB-type vancomycin-resistant enterococci have not been found since the ban of avoparcin use 5 years ago...
  24. ncbi request reprint Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein
    K Aoki
    Department of Immunology, National Institute of Health, Shinjuku ku, Tokyo, Japan
    Genomics 43:237-41. 1997
    ..In situ hybridization and physical mapping of somatic cell hybrids allowed localization of the gene to human chromosome 2q21.1...
  25. doi request reprint Dexamethasone inhibits chondrocyte differentiation by suppression of Wnt/β-catenin signaling in the chondrogenic cell line ATDC5
    Masako Naito
    Department of Anatomy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyodaku, Tokyo, 101 8310, Japan
    Histochem Cell Biol 144:261-72. 2015
    ..These results suggest that Dex inhibits chondrocyte differentiation via down-regulation of Wnt/β-catenin signaling, which promotes chondrocyte differentiation in ATDC5 cells. ..
  26. ncbi request reprint Identification of a novel periplasmic catalase-peroxidase KatA of Legionella pneumophila
    J Amemura-Maekawa
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 176:339-44. 1999
    ..In addition, KatA has a N-terminal signal sequence and was considered to be present in the periplasm of the bacterium...
  27. ncbi request reprint Identification of the tetracycline resistance gene, tet(M), in Erysipelothrix rhusiopathiae
    K Yamamoto
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1 15 1, Tokura, Kokubunji, Tokyo, 185 8511, Japan
    J Vet Med B Infect Dis Vet Public Health 48:293-301. 2001
    ..The specific amplified DNA fragment was obtained from all 114 tetracycline-resistant strains. It was suggested that the tet(M) gene was widely present in the field isolates of E. rhusiopathiae resistant to tetracycline...
  28. ncbi request reprint Ontogeny of the murine Ig joining chain gene and protein
    M Kimura
    Nihon University School of Dentistry, Department of Pathology, Tokyo, Japan
    Scand J Immunol 54:613-8. 2001
    ..These results suggest that the expression of J chain is a later event than the mu chain in the mouse, which thus differs in embryogenesis from humans...
  29. ncbi request reprint A national surveillance of Shiga toxin-producing Escherichia coli in food-producing animals in Japan
    M Kijima-Tanaka
    National Veterinary Assay Laboratory, Tokyo, 185 8511, Japan
    J Vet Med B Infect Dis Vet Public Health 52:230-7. 2005
    ..This first national study of STEC in the Japanese veterinary field should aid our understanding of Japan's STEC status...
  30. ncbi request reprint Population-based mapping of pulmonary adenoma susceptibility 1 locus
    T A Dragani
    National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 60:5017-20. 2000
    ..001) and survival rate (log rank = 0.0014), confirming the mapping of PAS1 and pointing to the role of this locus in human lung cancer...
  31. ncbi request reprint Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces beta-adrenergic receptor desensitization and myocardial hypertrophy in vivo
    M Iwata
    Cardiology Division, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ Res 88:578-86. 2001
    ..Sustained sympathomimetic-like actions of autoantibodies against the domain may be partly responsible for these changes...
  32. ncbi request reprint The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
    A Sawano
    Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, 108, Japan
    Biochem Biophys Res Commun 238:487-91. 1997
    ..These results strongly suggest that Tyr-1169 on Flt-1 is a major binding site for PLCgamma and important for Flt-1 signal transduction within the cell...
  33. ncbi request reprint Effects of sodium hyaluronate on epithelial healing of the vesical mucosa and vesical fibrosis in rabbits with acetic acid induced cystitis
    K Takahashi
    Central Research Laboratories, Seikagaku Corp, Higashiyamato, Tokyo, Japan
    J Urol 166:710-3. 2001
    ..4% sodium hyaluronate. CONCLUSIONS: Our findings suggest that sodium hyaluronate is effective for promoting epithelial healing of the vesical mucosa and inhibiting vesical fibrosis...
  34. ncbi request reprint Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization
    N Kokudo
    Department of Surgery, Cancer Institute Hospital, Tokyo, Japan
    Hepatology 34:267-72. 2001
    ..004). We conclude that PVE increases tumor growth and probably is associated with enhanced recurrence of disease. Although PVE is effective in extending indications for surgery, patient selection for PVE should be cautious...
  35. doi request reprint A lung granuloma with partial anomalous pulmonary venous connection and bronchial atresia
    K Sumida
    Department of Thoracic Surgery, Toranomon Hospital, Tokyo, Japan
    J Thorac Cardiovasc Surg 135:449-50. 2008
  36. ncbi request reprint Lactobacillus casei acquires the binding activity to fibronectin by the expression of the fibronectin binding domain of Streptococcus pyogenes on the cell surface
    A Kushiro
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    J Mol Microbiol Biotechnol 3:563-71. 2001
    ..This L. casei also shows binding affinity to fibrinogen, indicating that fibronectin binding domain is involved in the binding to fibrinogen as well...
  37. ncbi request reprint Significance of lymphocytosis in bronchoalveolar lavage in suspected ocular sarcoidosis
    T Takahashi
    Fourth Dept of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Eur Respir J 18:515-21. 2001
    ..It should be kept in mind that a diagnostic group of patients with sarcoidosis who manifest ocular involvement and lymphocytosis in bronchoalveolar lavage exists...
  38. ncbi request reprint [A case of congenital esophagobronchial fistula discovered incidentally on esophagography]
    G Moriyama
    Fourth Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, Tokyo, Japan
    Nihon Kokyuki Gakkai Zasshi 39:888-92. 2001
    ..These findings suggested that this case could be categorized as Braimbridge type II. In this case, the chest CT showed the esophagobronchial fistula clearly, and was useful for the diagnosis...
  39. ncbi request reprint Regression of an unresectable pancreatic tumor following nonmyeloablative allogeneic peripheral-blood stem-cell transplantation
    Y Omuro
    Department of Chemotherapy, Tokyo Metropolitan Komagome Hospital, Hokomagome, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 31:943-5. 2003
    ..The observed clinical course may suggest a graft-versus-tumor effect on the pancreatic tumor following allogeneic stem-cell transplantation...
  40. ncbi request reprint Serovars of Erysipelothrix strains isolated from pigs affected with erysipelas in Japan
    T Takahashi
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    J Vet Med Sci 58:587-9. 1996
    ..8%) to serovar 5, 11 (1.1%) to serovar 21, and the remaining 26 to serovars 4, 8, 11, 12, 15, 17, or 19. Only 5 (0.5%) strains isolated from the cases of erysipelas belonged to Erysipelothrix tonsillarum and represented serovars 7 or 23...