Nakashima T, Miyazaki Y, Matsuyama Y, Muraoka W, Yamaguchi K, Oda T. Producing mechanism of an algicidal compound against red tide phytoplankton in a marine bacterium gamma-proteobacterium. Appl Microbiol Biotechnol. 2006;73:684-90 pubmed
..This bacterium and other algicidal bacteria might be concerned in regulating the blooms of harmful flagellate algae through the quorum sensing system. ..
Nakashima T, Kato Y, Yamaguchi K, Oda T. Evaluation of the anti-Trichophyton activity of a prodigiosin analogue produced by gamma-proteobacterium, using stratum corneum epidermis of the Yucatan micropig. J Infect Chemother. 2005;11:123-8 pubmed
..In spite of the lower efficiency of PG-L-1 transfer into SCE from medium than that of bifonazole, PG-L-1 transferred into SCE showed more potent antifungal activity than bifonazole, at lower concentrations. ..
Nakashima T, Tamura T, Kurachi M, Yamaguchi K, Oda T. Apoptosis-mediated cytotoxicity of prodigiosin-like red pigment produced by gamma-Proteobacterium and its multiple bioactivities. Biol Pharm Bull. 2005;28:2289-95 pubmed
Nakashima T, Nozawa A, Ito T, Majima T. Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro. J Infect Chemother. 2002;8:331-5 pubmed
..This model enables one to evaluate the activity of a topical antifungal agent that has penetrated human nail tissue, and it may facilitate research on a topical agent for onychomycosis. ..
Nakashima T, Kurachi M, Kato Y, Yamaguchi K, Oda T. Characterization of bacterium isolated from the sediment at coastal area of Omura Bay in Japan and several biological activities of pigment produced by this isolate. Microbiol Immunol. 2005;49:407-15 pubmed
..aureus, which colonized skin on atopic dermatitis as well as suppression of activated lymphocyte proliferation and superoxide generation from leucocytes. ..
Nakashima T, Sato E, Niwano Y, Kohno M, Muraoka W, Oda T. Inhibitory or scavenging action of ketoconazole and ciclopiroxolamine against reactive oxygen species released by primed inflammatory cells. Br J Dermatol. 2007;156:720-7 pubmed
..Knowledge of the inhibitory or scavenging effects of both antifungal agents on ROS released from inflammatory cells may be useful in developing a therapeutic strategy for dermatitis. ..