Toshimitsu Araki

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. doi request reprint Modified Martius flap procedure for refractory ileal pouch-vestibular fistula: a report of three cases
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Int J Colorectal Dis . 2016
  2. doi request reprint FK506-Binding Protein 5 mRNA Levels in Ileal Mucosa Are Associated with Pouchitis in Patients with Ulcerative Colitis
    Toshimitsu Araki
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Dig Dis Sci 60:1617-23. 2015
  3. doi request reprint Redo Ileal pouch-anal anastomosis combined with anti-TNF-α maintenance therapy for Crohn's disease with pelvic fistula: report of two cases
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:1982-5. 2014
  4. pmc Identification of prognostic factors and surgical indications for metastatic gastric cancer
    Yasuhiko Mohri
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    BMC Cancer 14:409. 2014
  5. doi request reprint Risk factors for surgical site infection in Japanese patients with ulcerative colitis: a multicenter prospective study
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:1072-8. 2014
  6. doi request reprint Impact of postoperative infliximab maintenance therapy on preventing the surgical recurrence of Crohn's disease: a single-center paired case-control study
    Toshimitsu Araki
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:291-6. 2014
  7. doi request reprint Full mucosal proctectomy initiated below the dentate line may prevent the development of a perianal fistula after ileal pouch-anal anastomosis for ulcerative colitis
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan
    Dig Surg 30:219-24. 2013
  8. ncbi request reprint An alternative conversion technique for salvaging a failed ileal J-pouch-anal anastomosis to a modified H-pouch
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Dig Surg 24:324-7. 2007
  9. ncbi request reprint The significance of serum hepatocyte growth factor levels in planning follow-up of postoperative jaundice-free patients with biliary atresia
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu Mie 514 8507, Japan
    J Pediatr Surg 41:1657-62. 2006
  10. doi request reprint Neutrophil dysfunction in steroid-overdosed patients with ulcerative colitis: potential relevance of macrophage migration inhibitory factor to increased postoperative morbidity
    Yoshiki Okita
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 41:1504-11. 2011

Collaborators

Detail Information

Publications81

  1. doi request reprint Modified Martius flap procedure for refractory ileal pouch-vestibular fistula: a report of three cases
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Int J Colorectal Dis . 2016
    ..This report describes the use of the modified Martius flap procedure for three patients with ulcerative colitis who developed refractory pouch-vestibular fistulae...
  2. doi request reprint FK506-Binding Protein 5 mRNA Levels in Ileal Mucosa Are Associated with Pouchitis in Patients with Ulcerative Colitis
    Toshimitsu Araki
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Dig Dis Sci 60:1617-23. 2015
    ..Although the pathogenesis of pouchitis is incompletely understood, steroid and FK506 therapy are significantly associated with pouchitis. These medical treatments are regulated by the FK506-binding protein (FKBP) 4 and FKBP5 genes...
  3. doi request reprint Redo Ileal pouch-anal anastomosis combined with anti-TNF-α maintenance therapy for Crohn's disease with pelvic fistula: report of two cases
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:1982-5. 2014
    ..Redo-IPAA was performed to normalize the twisted mesentery of the ileal pouch. No complications have been observed in either patient, both of whom have experienced good functional results after closure of the covering stomas...
  4. pmc Identification of prognostic factors and surgical indications for metastatic gastric cancer
    Yasuhiko Mohri
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    BMC Cancer 14:409. 2014
    ..This retrospective study aimed to identify the prognostic factors and clinical indications for surgery in patients with metastatic gastric cancer...
  5. doi request reprint Risk factors for surgical site infection in Japanese patients with ulcerative colitis: a multicenter prospective study
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:1072-8. 2014
    ..A prospective, multicenter, observational study was performed to investigate the risk factors of surgical site infection (SSI) in patients with ulcerative colitis (UC)...
  6. doi request reprint Impact of postoperative infliximab maintenance therapy on preventing the surgical recurrence of Crohn's disease: a single-center paired case-control study
    Toshimitsu Araki
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:291-6. 2014
    ..Preventing a recurrence of Crohn's disease is a problem that remains to be solved. We evaluated the impact of using infliximab as a postoperative therapy on preventing the surgical recurrence of Crohn's disease...
  7. doi request reprint Full mucosal proctectomy initiated below the dentate line may prevent the development of a perianal fistula after ileal pouch-anal anastomosis for ulcerative colitis
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan
    Dig Surg 30:219-24. 2013
    ..Long-term functional results of ileal pouch-anal anastomosis (IPAA) with mucosal proctectomy (MP) for ulcerative colitis (UC) are satisfactory but may be compromised by perianal fistulae...
  8. ncbi request reprint An alternative conversion technique for salvaging a failed ileal J-pouch-anal anastomosis to a modified H-pouch
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Dig Surg 24:324-7. 2007
    ..This operation achieved a satisfactory functional result and, we believe, presents an option for reconstructing ileal J-pouch-anal anastomosis...
  9. ncbi request reprint The significance of serum hepatocyte growth factor levels in planning follow-up of postoperative jaundice-free patients with biliary atresia
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu Mie 514 8507, Japan
    J Pediatr Surg 41:1657-62. 2006
    ....
  10. doi request reprint Neutrophil dysfunction in steroid-overdosed patients with ulcerative colitis: potential relevance of macrophage migration inhibitory factor to increased postoperative morbidity
    Yoshiki Okita
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 41:1504-11. 2011
    ..We studied macrophage migration inhibitory factor (MIF)-related neutrophil dysfunction in patients with ulcerative colitis (UC), under conditions of surgical stress, focusing in particular on total preoperative steroid dosages...
  11. doi request reprint Perioperative host-tumor inflammatory interactions: a potential trigger for disease recurrence following a curative resection for colorectal cancer
    Chikao Miki
    Department of Gastrointestinal and Paediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Surg Today 38:579-84. 2008
    ..Controlling surgical insults and/or regulating perioperative inflammatory responses may therefore lead to new therapeutic approaches for controlling disease recurrence...
  12. doi request reprint Predictive factors for development of chronic pouchitis after ileal pouch-anal anastomosis in ulcerative colitis
    Yoshiki Okita
    Division of Reparative Medicine, Departments of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan
    Digestion 88:101-9. 2013
    ..This study evaluated the independent predictive factors for chronic pouchitis...
  13. pmc Characteristics of extremely early-onset pouchitis after proctocolectomy with ileal pouch-anal anastomosis
    Yoshiki Okita
    Departments of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    J Gastrointest Surg 17:533-9. 2013
    ..This study aims to evaluate the clinical characteristics of patients with postoperative ulcerative colitis developing extremely early-onset pouchitis within 4 weeks of restoration of gastrointestinal continuity...
  14. doi request reprint Identification of patients with developing ulcerative colitis-associated neoplasia by nitrative DNA damage marker 8-nitroguanin expression in rectal mucosa
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Clin Gastroenterol 47:e80-6. 2013
    ..To clarify whether the expression of nitrative and oxidative DNA damage markers in the rectal mucosa of patients with ulcerative colitis (UC) could be used to predict UC-associated neoplasia...
  15. doi request reprint Intravital three-dimensional dynamic pathology of experimental colitis in living mice using two-photon laser scanning microscopy
    Yuhki Morimoto
    Department of Gastrointestinal and Pediatric Surgery, Mie University, Mie, Japan
    J Gastrointest Surg 15:1842-50. 2011
    ..Intravital three-dimensional (3D) visualization of treatment efficacy in experimental colitis in living mice using two-photon laser scanning microscopy (TPLSM) has not been described...
  16. doi request reprint Poor catch-up growth after proctocolectomy in pediatric patients with ulcerative colitis receiving prolonged steroid therapy
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Graduate School of Medicine, Mie University, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Pediatr Surg Int 26:373-7. 2010
    ..The aim of the present study was to review the complications and growth after proctocolectomy and ileal J-pouch anal anastomosis (IPAA) in pediatric ulcerative colitis (UC) patients receiving prolonged steroid therapy...
  17. ncbi request reprint Preoperative steroid-related complications in Japanese pediatric patients with ulcerative colitis
    Keiichi Uchida
    Second Department of Surgery, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Dis Colon Rectum 49:74-9. 2006
    ....
  18. pmc Factors influencing the outcome of image-guided percutaneous drainage of intra-abdominal abscess after gastrointestinal surgery
    Yoshiki Okita
    Departments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 43:1095-102. 2013
    ..To improve the selection of patients for percutaneous abscess drainage (PAD) to treat postoperative intra-abdominal abscess after gastrointestinal surgery, we investigated the factors predictive of outcome...
  19. ncbi request reprint Angiopoietin-like Protein 2 as a Predictor of Early Recurrence in Patients After Curative Surgery for Gastric Cancer
    Tadanobu Shimura
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Anticancer Res 35:4633-9. 2015
    ..Angiopoietin-like protein-2 (ANGPTL2) mediates chronic inflammation. Tumor cell-derived ANGPTL2 promotes tumor invasion and angiogenesis. ANGPTL2 expression has not been fully investigated in gastric cancer (GC)...
  20. doi request reprint Self-reported assessment of health-related quality of life in children who underwent restorative proctocolectomy with ileal J-pouch anal anastomosis for ulcerative colitis
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Pediatr Surg Int 29:287-91. 2013
    ..0 (PedsQL) was administered...
  21. doi request reprint Transumbilical single-incision laparoscopic ileocecal resection for Crohn's disease in a child
    Mikihiro Inoue
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Asian J Endosc Surg 6:48-51. 2013
    ..Single-incision laparoscopic ileocecal resection is a good procedure for uncomplicated Crohn's disease patients in childhood...
  22. doi request reprint In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 28:1822-30. 2012
    ..Time-series intravital TPLSM imaging on the metastatic tumor xenografts may be useful for screening and evaluating new chemotherapeutics with less interindividual variability...
  23. ncbi request reprint Factors predicting postoperative infectious complications and early induction of inflammatory mediators in ulcerative colitis patients
    Chikao Miki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, 514 8507, Tsu, Mie, Japan
    World J Surg 31:522-9; discussion 530-1. 2007
    ..However, there is no useful perioperative marker predicting postoperative infectious complications (PICs) in steroid overdosed patients with ulcerative colitis (UC)...
  24. doi request reprint Neutrophil-related immunoinflammatory disturbance in steroid-overdosed ulcerative colitis patients
    Shigeyuki Yoshiyama
    Department of Gastrointestinal Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu 514 8507, Japan
    J Gastroenterol 43:789-97. 2008
    ..This study aimed to assess steroid-related changes in functional profiles of neutrophils in UC patients to estimate the immunological changes under surgical stress...
  25. ncbi request reprint The expression patterns of Toll-like receptors in the ileal pouch mucosa of postoperative ulcerative colitis patients
    Yuji Toiyama
    Second Department of Surgery, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 36:287-90. 2006
    ....
  26. ncbi request reprint MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer
    Yuka Nagano
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Anticancer Res 36:6521-6526. 2016
    ..854, 95% confidence interval=1.016-3.540; p=0.044). miR-7 acts as an oncogene in CRC and is significantly associated with tumour progression and poor prognosis...
  27. doi request reprint Small intestinal perforation caused by cytomegalovirus reactivation after subtotal colectomy for ulcerative colitis: report of a case
    Hiroyuki Fujikawa
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie, 514 8507, Japan
    Clin J Gastroenterol 6:111-5. 2013
    ..This is the first report of ileal perforation due to cytomegalovirus infection confirmed pathologically in a patient with ulcerative colitis. ..
  28. doi request reprint Cytoreductive strategy for multiple intra-abdominal and abdominal wall desmoid tumors in familial adenomatous polyposis: report of three cases
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Clin J Gastroenterol 5:361-6. 2012
    ..Surgical intervention as tumor volume reduction (cytoreduction) may be useful for cases with medical treatment-refractory or symptomatic FAP-associated abdominal DTs. ..
  29. doi request reprint Erratum to: Intestinal necrosis due to norovirus enteritis
    Hiromi Yasuda
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Clin J Gastroenterol 8:253. 2015
    ..Erratum to: Clin J Gastroenterol (2015) 8:10–13,DOI 10.1007/s12328-014-0540-0. The name of the third author should be given as Hiroki Imaoka, not Yuhki Imaoka...
  30. doi request reprint Outcome and functional prognosis of pelvic sepsis after ileal pouch-anal anastomosis in patients with ulcerative colitis
    Shozo Ide
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 47:301-306. 2017
    ..We conducted this study to investigate the cause of pouch failure and evaluate defecatory function after pelvic sepsis...
  31. doi request reprint Clinical features and management of afferent limb syndrome after ileal pouch-anal anastomosis for ulcerative colitis
    Yoshiki Okita
    Division of Reparative Medicine, Departments of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 46:1159-65. 2016
    ..The aim of this study was to reveal the clinical features and management of ALS...
  32. doi request reprint Secondary pouchitis in a pediatric patient successfully treated by salvage surgery
    Yoshiki Okita
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
    Pediatr Int 58:625-8. 2016
    ..Early treatment by abdomino-anal salvage surgery might be indicated to improve quality of life in pediatric patients with secondary pouchitis caused by surgical complication unresponsive to defunctioning and local salvage surgery. ..
  33. doi request reprint Endoscopy-assisted transanal repair of afferent limb obstruction and long efferent limb with ileopexy after ileal J-pouch-anal anastomosis
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Asian J Endosc Surg 9:167-9. 2016
    ..Laparotomy view also prevented of injury to the pouch itself and entrapment of the mesentery of the afferent and efferent limbs of the pouch between the stapler anvils. ..
  34. ncbi request reprint Clinical Burden of C-Reactive Protein/Albumin Ratio Before Curative Surgery for Patients with Gastric Cancer
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan
    Anticancer Res 36:6491-6498. 2016
    ..21, p=0.011) and poor prognosis (HR=1.82, p=0.038). We show, for the first time to our knowledge, that a high CAR predicts SSI, early recurrence and poor prognosis in patients with GC treated with curative intent...
  35. ncbi request reprint Impact of sarcopenia on surgical site infection after restorative proctocolectomy for ulcerative colitis
    Hiroyuki Fujikawa
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 47:92-98. 2017
    ..We evaluated the association between sarcopenia and surgical site infection (SSI) after surgery for ulcerative colitis...
  36. doi request reprint Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer
    Yoshinaga Okugawa
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan
    J Surg Oncol 114:483-9. 2016
    ..We systemically evaluated the levels of differentially-expressed serum cytokines using array-based techniques to identify a novel and reliable serum biomarker with which to predict metastasis and poor outcomes of CRC...
  37. ncbi request reprint Clinical Characteristics of Stoma-Related Obstruction after Ileal Pouch-Anal Anastomosis for Ulcerative Colitis
    Yoshiki Okita
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    J Gastrointest Surg . 2016
    ..We defined small bowel obstruction occurring around the limbs of the ileostomy as stoma-related obstruction (SRO) and investigated the clinical characteristics and predictive factors of SRO...
  38. doi request reprint Systemic Acute-phase Response in Laparoscopic and Open Ileal Pouch Anal Anastomosis in Patients With Ulcerative Colitis: A Case-matched Comparative Study
    Yoshiki Okita
    Departments of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Surg Laparosc Endosc Percutan Tech 25:424-9. 2015
    ..The current trial was designed to study and compare the postoperative outcomes and systemic acute responses between patients undergoing laparoscopic-ileal pouch anal anastomosis (LAP-IPAA) and open IPAA for ulcerative colitis...
  39. pmc In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Oncol 2012:265487. 2012
    ..In vivo time-course imaging of tumor angiogenesis in the same living mice using time-series TPLSM could be an ideal tool for antiangiogenic drug evaluation, reducing the effects of interindividual variation...
  40. doi request reprint Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model
    Yuhki Koike
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Pediatr Surg Int 30:1199-206. 2014
    ..In sepsis, circulating free DNA (cf-DNA) is increased, and is a marker of severity and prognosis of septic patients. This study aimed to evaluate cf-DNA in a dextran sodium sulfate-induced colitis mouse model, and its clinical implications...
  41. pmc In vivo characterization of neutrophil extracellular traps in various organs of a murine sepsis model
    Koji Tanaka
    Departments of Gastrointestinal and Paediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    PLoS ONE 9:e111888. 2014
    ..NETs appeared to be associated with the formation of platelet aggregates or leukocyte-platelet aggregates. These observational findings may suggest the adverse effect of intravascular NETs on the host during a sepsis. ..
  42. pmc Sphincter-saving resection of rectal hemangioma based on Doppler transrectal ultrasonography findings: report of a case
    Hiroyuki Fujikawa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Int Surg 99:705-9. 2014
    ..Using a transanal approach, mucosectomy and intersphincteric resection were performed based on the Doppler transrectal ultrasonography results. There were no intraoperative complications, and her anemia resolved postoperatively...
  43. doi request reprint Segmental distribution in refractory ulcerative colitis: a histological evaluation in pediatric and adult patients who underwent proctocolectomy
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Inflamm Bowel Dis 20:1227-35. 2014
    ....
  44. pmc Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    PLoS ONE 9:e96410. 2014
    ..BDNF/TrkB signaling may thus be a potential target for treating peritoneal carcinomatosis arising from colorectal cancer. ..
  45. doi request reprint Trehalose does not affect the functions of human neutrophils in vitro
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:332-9. 2014
    ..We investigated whether trehalose affects the function of human polymorphonuclear neutrophils (PMNs) in vitro to assess the feasibility of its clinical application as an anti-adhesive barrier...
  46. doi request reprint Ulcerative colitis with severe backwash ileitis successfully treated by staged operation without sacrificing any involved ileum
    Yoshiki Okita
    Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan
    J Pediatr Surg 44:e37-9. 2009
    ..Our cases suggest that the underlying pathophysiologic conditions in BWI may be reversible, and the involved lesion can be salvaged in some cases...
  47. doi request reprint Surgical intervention for neonatal and infantile-onset severe colonic Crohn's disease: report of three cases
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Dis Colon Rectum 51:247-50. 2008
    ..Early induction of surgical therapy may present a better outcome and improve quality of life for medical therapy-resistant cases in neonatal and infantile severe colonic Crohn's disease...
  48. ncbi request reprint Combined measurement of hepatocyte growth factor and carcinoembryonic antigen as a prognostic marker for patients with dukes a and B colorectal cancer: results of a five-year study
    Chikao Miki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174 Tsu, Mie 514 8507, Japan
    Dis Colon Rectum 49:1710-8. 2006
    ..We evaluated the results of five years of actuarial survival data to determine whether serial monitoring of serum hepatocyte growth factor could provide prognostic information on these patients...
  49. ncbi request reprint Neutrophil priming as a surgery-related risk factor for postoperative infectious complications in patients with ulcerative colitis
    Chikao Miki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Dig Surg 23:179-85. 2006
    ..The present study was designed to assess whether preoperative neutrophil priming under surgical stress has causal effects on the postoperative clinical outcomes of ulcerative colitis (UC) patients...
  50. doi request reprint Clinical impact of preoperative albumin to globulin ratio in gastric cancer patients with curative intent
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan Electronic address
    Am J Surg 213:120-126. 2017
    ..However, there are no reports regarding the relation between pretreatment AGR and clinicopathological data, including oncological outcomes, in gastric cancer (GC) patients with curative intent...
  51. ncbi request reprint Preoperative Lower Body Mass Index Correlates with Poorer Prognosis in Patients Undergoing Curative Laparoscopic Surgery for Colorectal Cancer
    Ryo Uratani
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan
    Anticancer Res 35:5639-48. 2015
    ..The aim of this study was to investigate the correlations between clinicopathological findings, laboratory data and survival outcome in patients undergoing curative laparoscopic surgery for colorectal cancer (CRC)...
  52. doi request reprint Systemic Analysis of Predictive Biomarkers for Recurrence in Colorectal Cancer Patients Treated with Curative Surgery
    Koichiro Mori
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Dig Dis Sci 60:2477-87. 2015
    ..The molecular status of CRC, including microsatellite instability (MSI), BRAF and KRAS mutations, and tumor-infiltrating lymphocytes (TILs), has also been associated with recurrence in CRC patients treated with curative surgery...
  53. ncbi request reprint Deficiency in systemic interleukin-1 receptor antagonist production as an operative risk factor in malnourished elderly patients with colorectal carcinoma
    Chikao Miki
    Second Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
    Crit Care Med 33:177-80. 2005
    ..However, it is unclear whether this influences the outcomes of surgery. We explored the relationships between cytokines and surgical complications among patients undergoing surgery for colorectal cancer...
  54. ncbi request reprint Serum Angiopoietin-like Protein 2 Improves Preoperative Detection of Lymph Node Metastasis in Colorectal Cancer
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan
    Anticancer Res 35:2849-56. 2015
    ..We investigated whether serum markers and clinical factors could be used to preoperatively predict lymph node (LN) metastasis in colorectal cancer (CRC)...
  55. doi request reprint In vivo optical pathology of paclitaxel efficacy on the peritoneal metastatic xenograft model of gastric cancer using two-photon laser scanning microscopy
    Tadanobu Shimura
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Gastric Cancer 18:109-18. 2015
    ..In this study, we established the method for evaluating the response of peritoneal xenografts to chemotherapy of metastatic gastric cancer using intravital TPLSM...
  56. doi request reprint Infantile Crohn's disease is one of the risk factors for catheter-related bloodstream infection
    Yuhki Koike
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Pediatr Int 56:364-8. 2014
    ..This study analyzed the risk of infection with Broviac line use among these patients at a single Japanese center...
  57. doi request reprint Chemoradiotherapy followed by restorative proctocolectomy with partial intersphincteric resection for advanced rectal cancer associated with ulcerative colitis: report of a case
    Yasuhiro Inoue
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:387-90. 2014
    ..The postoperative course was uneventful, and the ileostomy was closed 6 months after the initial surgery. The patient was doing well with good pouch function and no evidence of recurrent disease 1 year after her initial surgery...
  58. doi request reprint Sexual activity after ileal pouch-anal anastomosis in Japanese patients with ulcerative colitis
    Kazue Yoshida
    Faculty of Medicine, School of Nursing, Mie University, Tsu, Japan
    Surg Today 44:73-9. 2014
    ..The aim of this study was to evaluate the sexual activity after restorative proctocolectomy with ileal J-pouch-anal anastomosis (ileoanal anastomosis) in Japanese patients with ulcerative colitis...
  59. doi request reprint Double balloon enteroscopy for pediatric inflammatory bowel disease
    Keiichi Uchida
    Department of Gastrointestinal Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Pediatr Int 54:806-9. 2012
    ..The aim of the present study was to evaluate the efficacy and safety of double balloon enteroscopy (DBE) in children with inflammatory bowel disease (IBD)...
  60. pmc Spinal epidural abscess: a rare complication of ulcerative colitis after ileal pouch anal anastomosis
    Mikio Kawamura
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Case Rep 2:128. 2016
    ..We describe herein a rare case of spinal epidural abscess as a complication of ileal pouch anal anastomosis...
  61. doi request reprint History of and current issues affecting surgery for pediatric ulcerative colitis
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 43:1219-31. 2013
    ..Surgeons treating children with UC should consider the historical experiences of pioneer surgeons to take the most appropriate next step to improve the surgical outcomes and patients' quality of life...
  62. doi request reprint Pyoderma gangrenosum occurring at the peri-ileal pouch-anal anastomosis in a patient with ulcerative colitis: report of a case
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:783-5. 2014
    ..We herein report the first published case of a patient with UC who developed peri-anastomotic PG after IPAA during the postoperative tapering of systemic corticosteroids. ..
  63. doi request reprint Intravital imaging of DSS-induced cecal mucosal damage in GFP-transgenic mice using two-photon microscopy
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Gastroenterol 45:544-53. 2010
    ..Two-photon laser-scanning microscopy (TPLSM) is a powerful diagnostic tool for real-time, high-resolution structural imaging. However, obtaining high-quality in vivo TPLSM images of intra-abdominal organs remains technically challenging...
  64. ncbi request reprint Efficacy of postoperative elective ventilatory support for leakage protection in primary anastomosis of congenital esophageal atresia
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Pediatr Surg Int 22:496-9. 2006
    ..PEVS is an effective management method to decrease anastomotic complications for EA neonates...
  65. pmc Oncologic outcome with use of sodium hyaluronate-carboxymethylcellulose barrier in gastric cancer
    Yasuhiko Mohri
    1 Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan
    Int Surg 98:271-6. 2013
    ..Our study suggests that the anti-adhesive barrier does not affect oncologic outcome, nor does it increase postoperative complications in patients undergoing surgery for gastric cancer...
  66. doi request reprint Intravital imaging of gastrointestinal diseases in preclinical models using two-photon laser scanning microscopy
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Surg Today 43:123-9. 2013
    ..This report presents the general principles and properties of TPLSM for biomedical research. In addition, the methods and the usefulness of time-series intravital TPLSM imaging for preclinical gastrointestinal diseases is discussed...
  67. doi request reprint Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 41:1442-6. 2011
    ..Hepatocellular adenomas occur due to the inactivation of hepatic nuclear factor 1α, but the mechanism underlying the malignant transformation from HCA to HCC could not be identified in this case...
  68. ncbi request reprint Total proctocolectomy and ileal J-pouch anal anastomosis for chagasic megacolon with fecaloma: report of a case
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Surg Today 36:277-9. 2006
    ..A feasible outcome has been achieved after a 1-year follow-up. A total proctocolectomy with ileal J-pouch anal anastomosis may therefore be one of the useful strategies for the surgical treatment of patients with chagasic megacolon...
  69. pmc Secondary pouchitis in a post-operative patient with ulcerative colitis, successfully treated by salvage surgery
    Yuji Toiyama
    The Second Department of Surgery, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    World J Gastroenterol 11:6888-90. 2005
    ..The postoperative course was uneventful with no sign of pouchitis. Salvage surgery may be indicated to treat secondary pouchitis when caused by surgery-related complications...
  70. ncbi request reprint Successful treatment with topical 5-aminosalicylic acid ointment and spray of refractory oral and pharyngeal ulcerations in a child with Crohn disease
    Kohei Otake
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Pediatr Gastroenterol Nutr 44:378-81. 2007
  71. doi request reprint Impact of Surgical Infection Society/Infectious Disease Society of America-recommended antibiotics on postoperative intra-abdominal abscess with image-guided percutaneous abscess drainage following gastrointestinal surgery
    Yoshiki Okita
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Surg Today 45:993-1000. 2015
    ..The aims of this study were to reveal how using the antibiotics recommended by the 2010 Surgical Infection Society (SIS) and Infectious Disease Society of America (IDSA) guidelines can affect the therapeutic outcomes...
  72. pmc Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma
    Yuji Toiyama
    Second Department of Surgery, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    World J Gastroenterol 11:5151-5. 2005
    ..A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis (UC). We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication...
  73. doi request reprint Risk factors for anastomotic leakage and favorable antimicrobial treatment as empirical therapy for intra-abdominal infection in patients undergoing colorectal surgery
    Minako Kobayashi
    Department of Innovative Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 44:487-93. 2014
    ..In addition, we evaluated the efficacy of empirical antimicrobial therapy with respect to the clinical outcomes...
  74. doi request reprint Intestinal necrosis due to norovirus enteritis
    Hiromi Yasuda
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Clin J Gastroenterol 8:10-3. 2015
    ..The patient's recovery was uneventful, and he was transferred to another hospital on the 7th post-operative day. Ileostomy closure was performed one month after the first surgery at the transfer hospital. He had no recurrent episodes. ..
  75. doi request reprint Functional and manometric outcomes after redo-ileal pouch anal anastomosis in patients with ulcerative colitis
    Toshimitsu Araki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Dig Surg 31:190-6. 2014
    ..To retrospectively analyze manometric findings in patients with ulcerative colitis who underwent redo-ileo anal anastomosis for pouch-related complications...
  76. ncbi request reprint Allogenic blood transfusion is an independent risk factor for infective complications after less invasive gastrointestinal surgery
    Shin ichi Ikuta
    Second Department of Surgery, Mie University School of Medicine, Edobashi 2 174, Tsu, Japan
    Am J Surg 185:188-93. 2003
    ..The present study aimed to clarify the predisposing factors for postoperative infectious complications after less invasive surgery...
  77. ncbi request reprint Predicting factor of quality of life in long-term jaundice-free survivors after the Kasai operation
    Keiichi Uchida
    Second Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
    J Pediatr Surg 39:1040-4. 2004
    ..The aim of this study was to determine simple predictors for quality of life (QOL) in long-term jaundice-free survivors after the Kasai operation...
  78. ncbi request reprint Huge scrotal, flank, and retroperitoneal lymphangioma successfully treated by OK-432 sclerotherapy
    Keiichi Uchida
    Second Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
    Urology 60:1112. 2002
    ..We report a case of a huge retroperitoneal lymphangioma extending to the flank and scrotum that was successfully treated by intralesional OK-432 sclerotherapy without any serious complications...
  79. ncbi request reprint The effect on morbidity of mesentery lengthening techniques and the use of a covering stoma after ileoanal pouch surgery
    Toshimitsu Araki
    Department of Digestive Surgery, Hopital Saint Antoine AP HP, University Paris VI Pierre and Marie Curie, Paris, France
    Dis Colon Rectum 49:621-8. 2006
    ..This study was designed to evaluate the influence of mesenteric lengthening techniques on the need for a stoma and on early outcomes after restorative proctocolectomy...
  80. ncbi request reprint Early postoperative application of extracorporeal leukocyte apheresis in ulcerative colitis patients: results of a pilot trial to prevent postoperative septic complications
    Chikao Miki
    J Gastroenterol 42:508-9. 2007
  81. ncbi request reprint Fulminant ulcerative colitis during pregnancy successfully treated by three-stage operation
    Yuji Toiyama
    J Gastroenterol 39:300-1. 2004