Y Naito


Affiliation: Kyoto Prefectural University of Medicine
Country: Japan


  1. Naito Y, Takagi T, Higashimura Y. Heme oxygenase-1 and anti-inflammatory M2 macrophages. Arch Biochem Biophys. 2014;564:83-8 pubmed publisher
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    Naito Y, Akagiri S, Uchiyama K, Kokura S, Yoshida N, Hasegawa G, et al. Reduction of diabetes-induced renal oxidative stress by a cantaloupe melon extract/gliadin biopolymers, oxykine, in mice. Biofactors. 2005;23:85-95 pubmed
    ..These results indicated that the oxykine reduced the diabetes-induced oxidative stress and renal mesangial cell injury. In conclusion, oxykine might be a novel approach for the prevention of diabetes nephropathy. ..
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    Naito Y, Mizushima K, Yoshikawa T. Global analysis of gene expression in gastric ischemia-reperfusion: a future therapeutic direction for mucosal protective drugs. Dig Dis Sci. 2005;50 Suppl 1:S45-55 pubmed
    ..This comprehensive approach enabled the simultaneous analysis of many genes, including transcriptional factors, as well as the generation of novel hypothesis on the mechanism of action of gastro-protective agents. ..
  4. Handa O, Naito Y, Okayama T, Yoshida N, Kamada K, Katada K, et al. Endoscopic diagnosis of small intestinal diseases. Clin J Gastroenterol. 2013;6:94-8 pubmed publisher
    ..The capsule endoscope is the best method for screening the small intestine; however, the development of supporting methods such as the patency capsule is eagerly desired. ..
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    Naito Y, Uchiyama K, Kuroda M, Mizushima K, Aoi W, Kokura S, et al. Laser capture microdissection/GeneChip analysis of gene expression in glomerular cells in diabetic db/db mice. Redox Rep. 2004;9:307-12 pubmed
    ..Although the precise involvement of these genes in diabetic nephropathy remains to be clarified, the data presented here will aid in the identification of genes that play a significant role in this pathological condition. ..
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    Naito Y, Kuroda M, Uchiyama K, Mizushima K, Akagiri S, Takagi T, et al. Inflammatory response of esophageal epithelium in combined-type esophagitis in rats: a transcriptome analysis. Int J Mol Med. 2006;18:821-8 pubmed
    ..This transcriptome approach provided insight into genes and putative genetic pathways thought to be affected by stimulation with gastroduodenal refluxates. ..
  7. Sakamoto N, Ishikawa T, Kokura S, Okayama T, Oka K, Ideno M, et al. Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer. J Transl Med. 2015;13:277 pubmed publisher
    ..We also determined that the expanded cells were safe to administer in a monotherapy and are suitable for the next round of clinical trials where their efficacy will be tested combined with other reagents. UMIN UMIN000007527. ..
  8. Naito Y, Yoshikawa T. Green tea and heart health. J Cardiovasc Pharmacol. 2009;54:385-90 pubmed publisher
  9. Naito Y, Uchiyama K, Kinoshita Y, Fukudo S, Joh T, Suzuki H, et al. A questionnaire-based survey on screening for gastric and colorectal cancer by physicians in East Asian countries in 2010. Digestion. 2012;86:94-106 pubmed publisher
    ..9%) and Indonesia. In other countries, sigmoidoscopy every 5 years and total colonoscopy every 10 years were the most popular methods. There are similarities and differences in the screening of GC and CRC among East Asian countries. ..

More Information


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    Naito Y, Takagi T, Kuroda M, Katada K, Ichikawa H, Kokura S, et al. An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice. Inflamm Res. 2004;53:462-8 pubmed
  2. Uchiyama K, Naito Y, Yagi N, Mizushima K, Higashimura Y, Hirai Y, et al. Selected reaction monitoring for colorectal cancer diagnosis using a set of five serum peptides identified by BLOTCHIP®-MS analysis. J Gastroenterol. 2018;: pubmed publisher
    ..In this case-control validation study, we confirmed high diagnostic performance for CRC using five peptides that were identified in our previous study as serum biomarker candidates for the detection of CRC. ..
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    Naito Y, Uchiyama K, Takagi T, Yoshikawa T. Therapeutic potential of carbon monoxide (CO) for intestinal inflammation. Curr Med Chem. 2012;19:70-6 pubmed
    ..These results indicate that CO may have a potential to be one of the therapeutic strategies in IBD patients. ..
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    Naito Y, Takagi T, Ichikawa H, Tomatsuri N, Kuroda M, Isozaki Y, et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004;10:170-7 pubmed
  5. Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4:261-70 pubmed publisher
    ..The aim of this article is to provide an update on the pharmacological and clinical profile of rebamipide and to explore further possibilities for additional indications. ..
  6. Higashimura Y, Naito Y, Takagi T, Uchiyama K, Mizushima K, Ushiroda C, et al. Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice. Am J Physiol Gastrointest Liver Physiol. 2016;310:G367-75 pubmed publisher
    ..Our results suggest that oral intake of AGO prevents HFD-induced gut dysbiosis, thereby inhibiting colon carcinogenesis. ..
  7. Naito Y, Takagi T, Uchiyama K, Katada K, Yoshikawa T. Multiple targets of carbon monoxide gas in the intestinal inflammation. Arch Biochem Biophys. 2016;595:147-52 pubmed publisher
    ..Finally, we have discussed the direction of translational research with respect to launching a novel agent for releasing CO in the intestine. ..
  8. Uchiyama K, Yagi N, Mizushima K, Higashimura Y, Hirai Y, Okayama T, et al. Serum metabolomics analysis for early detection of colorectal cancer. J Gastroenterol. 2017;52:677-694 pubmed publisher
    ..Our results show that benzoic acid exhibited excellent diagnostic power and could potentially serve as a novel disease biomarker for CRC diagnosis. ..
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    Naito Y, Takagi T, Oya Ito T, Okada H, Suzuki T, Hirata I, et al. Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal. J Physiol Pharmacol. 2009;60 Suppl 7:123-30 pubmed
  10. Naito Y, Takagi T, Okada H, Nukigi Y, Uchiyama K, Kuroda M, et al. Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa. J Gastroenterol Hepatol. 2008;23 Suppl 2:S250-7 pubmed publisher
    ..The proposed classification by chromoendoscopy is useful for screening patients for atrophic and iNOS-expressing gastric mucosa with NO-modified proteins in H. pylori-associated atrophic gastric mucosa. ..