Hiroki Kuniyasu

Summary

Country: Japan

Publications

  1. ncbi request reprint Differential effects between amphoterin and advanced glycation end products on colon cancer cells
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Int J Cancer 104:722-7. 2003
  2. ncbi request reprint Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Nara 734 8521, Japan
    Oncol Rep 10:1863-8. 2003
  3. pmc Novel missense mutation in the FH gene in familial renal cell cancer patients lacking cutaneous leiomyomas
    Masaomi Kuwada
    Department of Urology, Nara Medical University, 840, Shijyo cho, Kashihara, Japan
    BMC Res Notes 7:203. 2014
  4. pmc Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer
    T Sasahira
    Department of Molecular Pathology, Nara Medical University School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Br J Cancer 107:700-6. 2012
  5. pmc The Roles of Dietary PPARgamma Ligands for Metastasis in Colorectal Cancer
    Hiroki Kuniyasu
    Department of Molecular Pathology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    PPAR Res 2008:529720. 2008
  6. pmc Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma
    M Kurihara
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Br J Cancer 108:1460-9. 2013
  7. pmc A 49-year-old woman presenting with hepatoid adenocarcinoma of the urinary bladder: a case report
    Yohei Sekino
    Department of Urology, Miyoshi Central Hospital, 531 Higashisakaya, Hiroshima Prefecture, Miyoshi, Japan
    J Med Case Rep 7:12. 2013
  8. pmc Diagnostic markers of urothelial cancer based on DNA methylation analysis
    Yoshitomo Chihara
    Department of Molecular Pathology, Nara Medical University, 840, Shijyo cho, Kashihara, Japan
    BMC Cancer 13:275. 2013
  9. ncbi request reprint Increased phosphorylation of AKT in high-risk gastric mucosa
    Takamitsu Sasaki
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Anticancer Res 33:3295-300. 2013
  10. ncbi request reprint Depletion of tumor-infiltrating macrophages is associated with amphoterin expression in colon cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Japan
    Pathobiology 71:129-36. 2004

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Differential effects between amphoterin and advanced glycation end products on colon cancer cells
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Int J Cancer 104:722-7. 2003
    ..In contrast, production of inducible nitric oxide synthase and nuclear factor-kappaBp65 were increased to a greater degree by AGE-BSA than by amphoterin...
  2. ncbi request reprint Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Nara 734 8521, Japan
    Oncol Rep 10:1863-8. 2003
    ..These results suggest that androgen deprivation provides a paracrine interaction between cancer and stromal cells through the RAGE-amphoterin system in advanced prostate cancer...
  3. pmc Novel missense mutation in the FH gene in familial renal cell cancer patients lacking cutaneous leiomyomas
    Masaomi Kuwada
    Department of Urology, Nara Medical University, 840, Shijyo cho, Kashihara, Japan
    BMC Res Notes 7:203. 2014
    ..Germline mutation of the fumarate hydratase (FH) gene is known to be associated with HLRCC...
  4. pmc Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer
    T Sasahira
    Department of Molecular Pathology, Nara Medical University School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Br J Cancer 107:700-6. 2012
    ..MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial...
  5. pmc The Roles of Dietary PPARgamma Ligands for Metastasis in Colorectal Cancer
    Hiroki Kuniyasu
    Department of Molecular Pathology, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    PPAR Res 2008:529720. 2008
    ..The complicated roles of dietary PPARgamma ligands are needed to examine further...
  6. pmc Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma
    M Kurihara
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Br J Cancer 108:1460-9. 2013
    ..The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC)...
  7. pmc A 49-year-old woman presenting with hepatoid adenocarcinoma of the urinary bladder: a case report
    Yohei Sekino
    Department of Urology, Miyoshi Central Hospital, 531 Higashisakaya, Hiroshima Prefecture, Miyoshi, Japan
    J Med Case Rep 7:12. 2013
    ..Hepatoid adenocarcinoma is rare in the urinary bladder. Pathological diagnosis is based on a combination of histological features resembling hepatocellular carcinoma and positive immunostaining for α-fetoprotein...
  8. pmc Diagnostic markers of urothelial cancer based on DNA methylation analysis
    Yoshitomo Chihara
    Department of Molecular Pathology, Nara Medical University, 840, Shijyo cho, Kashihara, Japan
    BMC Cancer 13:275. 2013
    ..We aimed to establish diagnostic markers for UC based on DNA methylation...
  9. ncbi request reprint Increased phosphorylation of AKT in high-risk gastric mucosa
    Takamitsu Sasaki
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Anticancer Res 33:3295-300. 2013
    ..hTERT was detected only in CGA. These findings suggest that oxidative stress might be associated with AKT activation and hTERT induction and that mucosa in CGA might confer a high-risk status for gastric carcinogenesis...
  10. ncbi request reprint Depletion of tumor-infiltrating macrophages is associated with amphoterin expression in colon cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Japan
    Pathobiology 71:129-36. 2004
    ..Moreover, extracted amphoterin inhibited PMA-U937 monocyte infiltration in a dose-dependent manner. Thus, amphoterin may play an important role in the inhibition of macrophage infiltration into colon cancer...
  11. ncbi request reprint A role of histone H4 hypoacetylation in vascular endothelial growth factor expression in colon mucosa adjacent to implanted cancer in athymic mice cecum
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Pathobiology 70:348-52. 2002
    ..The subsequent suppression of protein ubiquitination leads to upregulation of VEGF production by HIF-1alpha retention...
  12. ncbi request reprint Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara 634 8521, Japan
    Clin Cancer Res 9:4802-10. 2003
    ..The purpose of this study was to identify a mediator produced by human colon cancer cells that is responsible for the induction of hyperplasia in the adjacent mucosa...
  13. ncbi request reprint Helicobactor pylori infection is closely associated with telomere reduction in gastric mucosa
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Oncology 65:275-82. 2003
    ..To investigate differential reduction in telomere DNA in tissue components of gastric mucosa with respect to Helicobactor pylori infection...
  14. doi request reprint Reg IV enhances peritoneal metastasis in gastric carcinomas
    H Kuniyasu
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Cell Prolif 42:110-21. 2009
    ..The role of Regenerating (Reg) IV on peritoneal metastasis was examined in gastric cancer using...
  15. ncbi request reprint Repression of MLH1 and MGMT genes in colon mucosa adjacent to implanted cancer in athymic mouse
    H Kuniyasu
    Dept of Molecular Pathology, Nara Medical University, Kashihara, Japan
    J Exp Clin Cancer Res 23:317-23. 2004
    ..These findings suggest that promoter CpG methylation affects expression of MLH1 MGMT genes in hyperplastic mucosa adjacent to colon cancer...
  16. pmc Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages
    Hiroki Kuniyasu
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Am J Pathol 166:751-60. 2005
    ..Phosphorylation of JNK and Rac1 was induced in PMA-U937 cells treated with HMGB1/amphoterin. These results suggest that HMGB1/amphoterin induces growth inhibition and apoptosis in macrophages through RAGE intracellular signaling pathway...
  17. doi request reprint CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver
    H Kuniyasu
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Gut 59:348-56. 2010
    ..To examine the role of CD10, a characteristic marker of liver metastasis of colorectal cancers (CRCs)...
  18. ncbi request reprint Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells
    Hiroki Kuniyasu
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Int J Cancer 118:571-6. 2006
    ..These findings suggest that CLA inhibits metastasis of human gastric and colon cancer cells...
  19. ncbi request reprint Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Oncol Rep 10:445-8. 2003
    ..The results suggest that co-expression of RAGE and amphoterin is closely associated with invasion and metastasis of colorectal cancer...
  20. ncbi request reprint Heparan sulfate enhances invasion by human colon carcinoma cell lines through expression of CD44 variant exon 3
    H Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, 840 Shijo Cho, Kashihara 634 8521, Japan
    Clin Cancer Res 7:4067-72. 2001
    ..Positive CD44v3 expression was associated with more advanced pathological stage and poorer prognosis than negative CD44v3 expression. These data support a role for CD44v3 in invasion and metastasis by colorectal carcinoma cells...
  21. ncbi request reprint Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Shijo cho, Kashihara, Japan
    Int J Mol Med 10:333-7. 2002
    ..0001). Concurrent expression of heparanase and CD44v3 might be a mechanism of cancer invasion and metastasis in colon cancer...
  22. ncbi request reprint Interleukin-15 expression is associated with malignant potential in colon cancer cells
    H Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Pathobiology 69:86-95. 2001
    ..0001). IL-15 may play important roles in cell proliferation, invasion, and metastasis of human colorectal cancer...
  23. ncbi request reprint Peritoneal metastasis inhibition by linoleic acid with activation of PPARgamma in human gastrointestinal cancer cells
    Takamitsu Sasaki
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Virchows Arch 448:422-7. 2006
    ..These findings suggest that LA inhibits invasion and metastasis of human gastric and colon cancer cells by nondietary administration...
  24. doi request reprint HMGB1 attenuates anti-metastatic defence of the liver in colorectal cancer
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Eur J Cancer 46:791-9. 2010
    ..These results suggest that HMGB1 secreted from primary tumours decreases the number of KCs and attenuates the anti-metastatic defence of the liver in patients with CRCs...
  25. doi request reprint Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet
    Takasumi Shimomoto
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    J Gastroenterol 47:1073-83. 2012
    ..Advanced glycation end products (AGE) and the receptor for advanced glycation end products (RAGE) are closely associated with colorectal cancer progression. The association between RAGE and AGE in colon carcinogenesis needs to be clarified...
  26. doi request reprint High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Japan
    Cancer Sci 99:1806-12. 2008
    ..These results suggest that MIA expression is enhanced by the interaction of intracellular HMGB1 and NFkBp65 and MIA is closely involved in tumor progression and nodal metastasis by the increments of VEGF-C and VEGF-D in OSCC...
  27. ncbi request reprint Accumulation of DNA methylation is associated with tumor stage in gastric cancer
    Naohide Oue
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Cancer 106:1250-9. 2006
    ....
  28. doi request reprint Linoleic-acid-induced growth suppression induces quiescent cancer cell nests in nude mice
    Hitoshi Ohmori
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Pathobiology 75:226-32. 2008
    ..In LA-treated MKN28 and Colo320 cells, protein production of Bcl-2 was increased, whereas Bak, EGFR and VEGF levels were decreased. These findings suggest that LA might induce quiescence and subsequent dormancy in cancer cells...
  29. doi request reprint Trks are novel oncogenes involved in the induction of neovascularization, tumor progression, and nodal metastasis in oral squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University School of Medicine, 840 Shijo Cho, Kashihara, Nara, Japan
    Clin Exp Metastasis 30:165-76. 2013
    ..Trks expression was inversely correlated with RUNX3 expression in the OSCC cases. These results suggested that Trks enhances progression of OSCC through angiogenesis and lymphangiogenesis...
  30. doi request reprint MIA-dependent angiogenesis and lymphangiogenesis are closely associated with progression, nodal metastasis and poor prognosis in tongue squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Eur J Cancer 46:2285-94. 2010
    ..MIA-dependent angiogenesis/lymphangiogenesis might be a useful therapeutic target in progressive and metastatic OSCC...
  31. ncbi request reprint Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment
    Takamitsu Sasaki
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Japan
    Int J Cancer 118:593-9. 2006
    ..These findings suggest that LA inhibited AOM-induced transformation of COX-2-negative IEC6 cells, which was possibly mediated with PPARgamma ligands generated by LOX15 from LA...
  32. doi request reprint Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1
    Hitoshi Ohmori
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Pathobiology 77:210-7. 2010
    ..High-mobility group box 1 (HMGB1) was closely associated with progression and metastasis of colorectal cancer...
  33. ncbi request reprint The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Virchows Arch 450:287-95. 2007
    ..The effect of HMGB-1 was abrogated by RAGE down-regulation by antisense S-oligodeoxynucleic acid. These results suggest that RAGE expression is closely associated to angiogenesis in OSCC...
  34. doi request reprint Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara 634 8521, Japan
    Hum Pathol 44:1098-106. 2013
    ..05), respectively. Both TrkB and TrkC showed antiapoptotic effect (P < .05). These results suggest that TrkB and TrkC have a tumor progressive function and may be a useful diagnostic and therapeutic target in CRC...
  35. ncbi request reprint Expression of receptor for advanced glycation end products during rat tongue carcinogenesis by 4-nitroquinoline 1-oxide and effect of a selective cyclooxygenase-2 inhibitor, etodolac
    Kazuhiko Yamamoto
    Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan
    Pathobiology 73:317-24. 2006
    ....
  36. ncbi request reprint Conjugated linoleic acid reduced metastasized LL2 tumors in mouse peritoneum
    Yasuha Sakai
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Japan
    Virchows Arch 449:341-7. 2006
    ..0010). CLA-treated LL2 tumors showed decrease of PPARgamma and EGFR proteins and increase of BAX protein in comparison with untreated tumors. These findings suggest that CLA possesses anti-tumor capability to peritoneal metastasis...
  37. doi request reprint Diabetes-associated angiotensin activation enhances liver metastasis of colon cancer
    Takasumi Shimomoto
    Department of Molecular Pathology, Nara Medical University, Shijo cho, Kashihara, Nara, Japan
    Clin Exp Metastasis 29:915-25. 2012
    ..These results suggest that diabetes-associated angiotensin activation enhances liver metastasis of CRC and may therefore provide a possible target for antimetastatic therapy in CRC...
  38. doi request reprint Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Pathobiology 76:267-73. 2009
    ..These findings suggest that CD10 is associated substantially with liver metastasis of CRC cells and might be a molecular target of CRC treatment...
  39. ncbi request reprint Heme oxygenase-1 accelerates protumoral effects of nitric oxide in cancer cells
    Takamitsu Sasaki
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 734 8521, Japan
    Virchows Arch 446:525-31. 2005
    ..These findings suggest that the NO/HO-1 system has protumoral effects...
  40. doi request reprint HMGB1 attenuates anti-metastatic defense of the lymph nodes in colorectal cancer
    Yukiko Moriwaka
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara, 634 8521, Japan
    Pathobiology 77:17-23. 2010
    ..Cancer-secreted high mobility group 1 (HMGB1) induces apoptosis of macrophages and suppresses the host anti-cancer immune system...
  41. doi request reprint High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Eur J Cancer 49:741-51. 2013
    ..These findings suggest that HMGB1 released from necrotic cancer cells treated with a necrosis inducer enhances regrowth and metastasis of remnant cancer cells via RAGE activation...
  42. ncbi request reprint Acetylated histone H4 is reduced in human gastric adenomas and carcinomas
    S Ono
    Dept of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    J Exp Clin Cancer Res 21:377-82. 2002
    ..These results suggest that low levels of histone acetylation may be closely associated with the development and progression of gastric carcinomas, possibly through alteration of gene expression...
  43. ncbi request reprint Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice
    Kaeko Hirai
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Japan
    Int J Cancer 120:500-5. 2007
    ..0003). In contrast, CoPPIX treatment increased HO-1 expression, enhanced tumorigenicity and MVD and reduced apoptosis. From these findings, inhibition of HO-1 by ZnPPIX provides relevant antitumoral effects...
  44. ncbi request reprint Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma
    Tomohiro Kondo
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Oncogene 24:157-64. 2005
    ..These results indicate that LOH of PINX1 locus and hypoacetylation of histone H4 in the 5' UTR of PINX1 are associated with reduced expression of PINX1 in GC...
  45. doi request reprint Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats
    Isao Kawahara
    Department of Physiology II, Nara Medical University School of Medicine, Kashihara, Japan
    Am J Physiol Gastrointest Liver Physiol 302:G588-97. 2012
    ..Mosapride induces nerve fiber tract growth across the anastomosis, mediated through enteric neural stem cells possibly from neural crest-derived stem cells or mesenchymal stem cells in the bone marrow...
  46. ncbi request reprint The plasticity of the defecation reflex pathway in the enteric nervous system of guinea pigs
    Renta Katsui
    Department of Physiology II, School of Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Japan
    J Smooth Muscle Res 45:1-13. 2009
    ..These results revealed the plasticity of enteric neurons, allowing the proposal of a new therapy for repairing enteric neural dysfunction at least after surgery...
  47. doi request reprint High matrix metalloproteinase-to-E-cadherin ratio measured by bicolor fluorescent in situ hybridization is associated with lymphangiogenesis and lymph node metastasis in prostate cancer
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Urol Oncol 30:306-13. 2012
    ..Another aim was examination of relation of MER by bicolor FISH with expression of vascular endothelial growth factor-C (VEGF-C)...
  48. ncbi request reprint Genes involved in invasion and metastasis of gastric cancer identified by array-based hybridization and serial analysis of gene expression
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Oncology 69:17-22. 2005
    ..We also discuss the significance of HMGB1/amphoterin in invasion and metastasis of GC...
  49. ncbi request reprint Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer
    Hiroki Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    J Pathol 196:163-70. 2002
    ..RAGE expression appears to be closely associated with invasion and metastasis in gastric cancer...
  50. doi request reprint Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer
    Shinya Ohara
    Department of Molecular Pathology, Hiroshima Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 99:1570-7. 2008
    ..In the LNCaP cell line, EGFR phosphorylation was induced by the addition of Reg IV-conditioned medium. These results suggest that Reg IV expression is an independent prognostic indicator of relapse after radical prostatectomy...
  51. doi request reprint Methionine-enkephalin secreted by human colorectal cancer cells suppresses T lymphocytes
    Hitoshi Ohmori
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Cancer Sci 100:497-502. 2009
    ..MENK expression was associated with tumor-infiltrating T lymphocytes, especially those belonging to the CD4(+) subset. These findings suggest that MENK secreted by CRC cells caused escape of the host from the effects of immunity...
  52. ncbi request reprint Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer
    Kiyomu Fujii
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Int J Mol Med 21:599-604. 2008
    ..05). Thus, Pot1 production was closely associated with telomere length in gastric mucosa and cancers. Pot1 might be a good in situ marker for the examination of cell-specific telomere length...
  53. doi request reprint Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer
    Akiko Kusume
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Pathobiology 76:155-62. 2009
    ..62 +/- 23 /mm(2), p = 0.0068) than those in metastasis-negative cases. These findings suggest that HMGB1 produced by colon cancer cells suppressed nodal dendritic cells to disturb host anti-cancer immunity...
  54. ncbi request reprint Discrepancy between E-cadherin protein expression and morphology in human gastric carcinoma cells
    Takamitsu Sasaki
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Hepatogastroenterology 52:1920-4. 2005
    ..The purpose of this study is to examine the effect of E-cadherin on morphogenesis of MKN28 human gastric carcinoma cell line in the course of E-cadherin antisense S-oligodeoxynucleotide (ODN) treatment...
  55. ncbi request reprint Interferon-alpha prevents selection of doxorubicin-resistant undifferentiated-androgen-insensitive metastatic human prostate cancer cells
    H Kuniyasu
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Prostate 49:19-29. 2001
    ..CONCLUSIONS: Treatment with IFN-alpha and DOX should be further explored as a therapeutic strategy for androgen-insensitive prostate cancer...
  56. ncbi request reprint Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
    Toshifumi Tsujiuchi
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Nara, Japan
    Mol Carcinog 40:241-6. 2004
    ..These results suggest that alterations of the Dutt1/Robo1 gene may be involved in the development of some lung adenocarcinomas induced by BHP in rats...
  57. doi request reprint Anti-angiotensin and hypoglycemic treatments suppress liver metastasis of colon cancer cells
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Pathobiology 78:285-90. 2011
    ..This scheme needs to be examined in a clinical setting...
  58. ncbi request reprint Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Virchows Arch 446:411-5. 2005
    ..These results suggest that RAGE expression, especially with membranous pattern, is associated with malignant potential of colorectal adenomas...
  59. ncbi request reprint Effect of Nma on growth inhibition by TGF-betaa in human gastric carcinoma cell lines
    Takamitsu Sasaki
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara 634 8521, Japan
    Oncol Rep 11:1219-23. 2004
    ....
  60. ncbi request reprint Induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells
    Ken Hayashi
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Pathobiology 70:40-6. 2002
    ..These results suggest that besides p53 activity, the induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells...
  61. doi request reprint Downregulation of runt-related transcription factor 3 associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Cancer Sci 102:492-7. 2011
    ..Recovery of the tumor suppressive function of RUNX3 might inhibit tumorigenesis and cancer progression in the human salivary gland...
  62. doi request reprint Determinants of the epithelial-muscular axis on embryonic stem cell-derived gut-like structures
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Pathobiology 77:253-9. 2010
    ..This implies that activin A upregulated the expression of sonic hedgehog and intestinal alkaline phosphatase in the embryoid bodies. These findings suggest that the motility of the ES gut depends on the domes' epithelial-muscular axis...
  63. doi request reprint Non-histone nuclear factor HMGB1 as a therapeutic target in colorectal cancer
    Hitoshi Ohmori
    Nara Medical University, Department of Molecular Pathology, 840 Shijo Cho, Kashihara, Nara, 634 8521, Japan
    Expert Opin Ther Targets 15:183-93. 2011
    ..HMGB1 is a relevant target for cancer treatment...
  64. pmc Expression of MAS1 in breast cancer
    Yi Luo
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Cancer Sci 106:1240-8. 2015
    ..These findings suggest that MAS1 might act as an inhibitory regulator of breast cancer and may be a possible molecular target for this malignancy...
  65. doi request reprint Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer
    Masaomi Kuwada
    Department of Molecular Pathology, Nara Medical University, Nara 634 8521, Japan Department of Urology, Nara Medical University, Nara 634 8521, Japan
    Cancer Lett 369:212-21. 2015
    ..The anti-tumor activity of the newly established 4D3 antibody suggests that it may be a powerful tool in CLDN4-targeting therapy, and in combination with chemotherapy. ..
  66. doi request reprint Transport and Golgi organisation protein 1 is a novel tumour progressive factor in oral squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara 634 8521, Japan
    Eur J Cancer 50:2142-51. 2014
    ..These findings suggest that TANGO might promote angiogenesis and lymphangiogenesis by upregulation of PDGFB and Neuropilin2 in OSCC. ..
  67. ncbi request reprint Anti-tumor effects of liposome-encapsulated titanium dioxide in nude mice
    Yoshitomo Chihara
    Department of Urology, Nara Medical University School of Medicine, Kashihara, Japan
    Pathobiology 74:353-8. 2007
    ..These findings suggest that LT might be more effective than noncoated TiO2 in the treatment of bladder cancer...
  68. doi request reprint Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high serum levels of Reg IV are associated with liver metastasis
    Naohide Oue
    Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Oncology 72:371-80. 2007
    ..The aim of this study was to investigate the diagnostic utility of Reg IV determination in sera from patients with CRC...
  69. ncbi request reprint Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice
    Ayumi Denda
    Department of Molecular Pathology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Nitric Oxide 16:164-76. 2007
    ..Results suggested no major determinant roles of the expressed iNOS in the development of liver tumors caused by the CDAA diet...
  70. pmc In vivo imaging of enteric neurogenesis in the deep tissue of mouse small intestine
    Kei Goto
    Department of Physiology II, Nara Medical University, School of Medicine, Kashihara, Nara, Japan
    PLoS ONE 8:e54814. 2013
    ..We conclude that in vivo 2PM imaging made it possible to perform high-resolution deep imaging of the living mouse whole gut and reveal formation of new enteric neurons promoted by 5-HT(4)-receptor activation...
  71. doi request reprint HuD promotes progression of oral squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Pathobiology 81:206-14. 2014
    ..These results suggest that HuD is a useful diagnostic and therapeutic target in OSCCs...
  72. pmc Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    PLoS ONE 9:e92534. 2014
    ..Our results suggested that Prox1 and FOXC2 play key roles in OSCC progression and that further studies focusing on these proteins may yield useful insights for diagnosis and therapy of OSCC. ..
  73. doi request reprint Cancer usurps skeletal muscle as an energy repository
    Yi Luo
    Authors Affiliations Department of Molecular Pathology, Nara Medical University, Shijo cho, Kashihara Institute for Innovation Ajinomoto Co, Inc, Suzuki cho, Kawasaki and Department of Gastrointestinal Surgery, Fukuoka University School of Medicine, Nanakuma, Minami Ku, Fukuoka, Japan
    Cancer Res 74:330-40. 2014
    ..Similar results were obtained in a mouse xenograft model of human colorectal cancer. Taken together, our findings suggest that HMGB1 released during tumorigenesis recruits muscle to supply glutamine to cancer cells as an energy source...
  74. doi request reprint Role of two types of angiotensin II receptors in colorectal carcinoma progression
    Linyan Zhou
    Department of Molecular Pathology, Nara Medical University, Kashihara, Japan
    Pathobiology 81:169-75. 2014
    ..Our findings suggest that a high angiotensinogen condition in the liver might evoke the antitumoral role of the AT2R in CRC cells...
  75. doi request reprint A new possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system
    Renta Katsui
    Dept of Physiology II, Nara Medical Univ, 840 Shijo Cho, Kashihara 634 8521, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G1084-93. 2008
    ..These results suggested a possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system with local application of BDNF...
  76. ncbi request reprint Effect of human noxa on irinotecan-induced apoptosis in human gastric carcinoma cell lines
    Takamitsu Sasaki
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara, Japan
    Hepatogastroenterology 51:912-5. 2004
    ..A protein BH3-only member bcl-2 family, Noxa is a proapoptotic mediator for p53-induced apoptosis. We analyzed the effect of Noxa on p53-induced apoptotic gastric carcinoma cell lines...
  77. doi request reprint In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation
    Miyako Takaki
    Department of Physiology II, Nara Medical University, School of Medicine, Kashihara, Nara 634 8521, Japan
    Biochem Biophys Res Commun 406:529-33. 2011
    ..5-HT per se exerted similar effects to those of SR4-agonist, though less potent. These results suggest SR4-agonist differentiated enteric neural networks, mediated via activation of SR4 in the ES gut...
  78. ncbi request reprint Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis
    H Friess
    Department of Medicine, University of California, Irvine 92717
    Int J Cancer 56:668-74. 1994
    ..These findings indicate that cripto expression may contribute to disease progression in pancreatic cancer, and implicate cripto in the histopathological alterations that occur in the pancreas both in cancer and in CP...
  79. ncbi request reprint Genetic and epigenetic changes in stomach cancer
    H Yokozaki
    First Department of Pathology, Hiroshima University School of Medicine, Japan
    Int Rev Cytol 204:49-95. 2001
    ..Interaction between cancer cells expressing c-met and hepatocyte growth factor from stromal cells is implicated in morphogenesis of gastric cancer...
  80. ncbi request reprint No mutations of the Bub1 gene in human gastric carcinomas
    H Shigeishi
    First Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Oncol Rep 8:791-4. 2001
    ..These results suggest that mutational inactivation of the Bub1 gene might not play a key role in human stomach carcinogenesis...
  81. ncbi request reprint PTEN expression is maintained in sporadic colorectal tumours
    K Taniyama
    Department of Clinical Pathology, Kure Kyosai Hospital, Kure, Japan
    J Pathol 194:341-8. 2001
    ..As with previous deletion and mutation analyses, the present study suggests that loss of PTEN expression is not prevalent in sporadic colon cancer...
  82. ncbi request reprint Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas
    N Matsutani
    First Department of Pathology, Hiroshima University School of Medicine, Hiroshima 734-8511, Japan
    Int J Oncol 19:507-12. 2001
    ....
  83. ncbi request reprint Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas
    N Matsutani
    First Department of Pathology, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
    Pathobiology 69:219-24. 2001
    ..05). These results suggest that gastric carcinomas with high TRF1 and TRF2 expression may need a large quantity of the MRE11 complex. Moreover, gastric carcinomas with high TRF1 expression may require a large quantity of hRap1...
  84. ncbi request reprint Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma
    S Nakatsuru
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:559-63. 1992
    ..Our results suggest that inactivation of APC plays a role in development of some gastric cancers, particularly very well differentiated adenocarcinomas and signet-ring cell carcinomas...
  85. ncbi request reprint Proton pump inhibitors reduce cell cycle abnormalities in Barrett's esophagus
    M Umansky
    GI Oncology Unit, Tel Aviv Medical Center and Tel Aviv University, Israel
    Oncogene 20:7987-91. 2001
    ..Increased expression of key cell cycle regulatory genes appears to occur early in the neoplastic progression associated with Barrett's esophagus. Treatment with proton pump inhibitors appears to alter this increased expression...
  86. ncbi request reprint Molecular diagnosis of gastric cancer: present and future
    W Yasui
    First Department of Pathology, Hiroshima University School of Medicine, Japan
    Gastric Cancer 4:113-21. 2001
    ..By analyzing the relationship between single-nucleotide polymorphisms and cancer susceptibility, we will be able to obtain information on cancer prevention from histopathology samples...
  87. ncbi request reprint Infrequent loss of heterozygosity of the major tumour suppressor genes in Indian oral cancers
    S Kannan
    Regional Cancer Centre, Kerala, India
    Int J Oral Maxillofac Surg 31:414-8. 2002
    ..The present preliminary study indicates that the gene aberration by LOH may be an insignificant mechanism in Indian oral cancers with respect to the tumour suppressor genes examined...
  88. ncbi request reprint Effect of Shimotsu-to (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized mice
    E Tahara
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    J Ethnopharmacol 68:219-28. 1999
    ..These findings indicate that the Shimotsu-to formulation is useful for the inhibition of cutaneous inflammatory diseases...