Yasuhiro Ito

Summary

Affiliation: Kuma Hospital
Country: Japan

Publications

  1. request reprint
    Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, et al. Prognostic significance of extrathyroid extension of papillary thyroid carcinoma: massive but not minimal extension affects the relapse-free survival. World J Surg. 2006;30:780-6 pubmed
  2. Ito Y, Miyauchi A. Active Surveillance as First-Line Management of Papillary Microcarcinoma. Annu Rev Med. 2018;: pubmed publisher
    ..Expected final online publication date for the Annual Review of Medicine Volume 70 is January 27, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates. ..
  3. Ito Y, Miyauchi A, Kihara M, Higashiiyama T, Fukushima M, Miya A. Static Prognostic Factors and Appropriate Surgical Designs for Patients with Medullary Thyroid Carcinoma: The Second Report from a Single-Institution Study in Japan. World J Surg. 2018;: pubmed publisher
    ..MTC patients had excellent prognosis in our institutions, indicating that our surgical strategies were appropriate. ..
  4. Goto H, Kiyota N, Otsuki N, Imamura Y, Chayahara N, Suto H, et al. Successful treatment switch from lenvatinib to sorafenib in a patient with radioactive iodine-refractory differentiated thyroid cancer intolerant to lenvatinib due to severe proteinuria. Auris Nasus Larynx. 2018;45:1249-1252 pubmed publisher
    ..This case may suggest that sorafenib does not exacerbate the proteinuria or renal impairment induced by lenvatinib, and may be an effective treatment option for RAI-refractory DTC patients who are unable to tolerate lenvatinib. ..
  5. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Expression of the components of the Cip/Kip family in malignant lymphoma of the thyroid. Pathobiology. 2004;71:164-70 pubmed
  6. Ito Y, Miyauchi A, Masuoka H, Fukushima M, Kihara M, Miya A. Excellent Prognosis of Central Lymph Node Recurrence-Free Survival for cN0M0 Papillary Thyroid Carcinoma Patients Who Underwent Routine Prophylactic Central Node Dissection. World J Surg. 2018;42:2462-2468 pubmed publisher
    ..However, future studies, including double-arm studies from Japan, should examine whether the omission of p-CND cN0M0 PTC is appropriate without RAI ablation in consideration of various factors, including the pros and cons of p-CND. ..
  7. request reprint
    Ito Y, Yoshida H, Shibahara K, Uruno T, Nakano K, Takamura Y, et al. Y-box binding protein expression in thyroid neoplasms: its linkage with anaplastic transformation. Pathol Int. 2003;53:429-33 pubmed
    ..These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma. ..
  8. request reprint
    Ito Y, Uramoto H, Funa K, Yoshida H, Jikuzono T, Asahi S, et al. Delta Np73 expression in thyroid neoplasms originating from follicular cells. Pathology. 2006;38:205-9 pubmed
    ..Our findings indicate that delta Np73 plays a role predominantly in the early phase of papillary carcinoma progression. ..
  9. request reprint
    Ito Y, Miyauchi A, Ishikawa H, Hirokawa M, Kudo T, Tomoda C, et al. Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients. Endocr J. 2011;58:685-9 pubmed
    ..FAP-associated CMV showed multiple tumors more frequently than sporadic CMV. Total thyroidectomy is recommended for FAP-associated CMV, but extensive lymph node dissection is not necessary. ..

More Information

Publications57

  1. request reprint
    Ito Y, Hirokawa M, Higashiyama T, Takamura Y, Miya A, Kobayashi K, et al. Prognosis and prognostic factors of follicular carcinoma in Japan: importance of postoperative pathological examination. World J Surg. 2007;31:1417-24 pubmed
    ..However, because poorly differentiated or widely invasive carcinomas showed a worse prognosis, postoperative pathological examination is important in predicting patient prognosis. ..
  2. Ito Y, Masuoka H, Fukushima M, Inoue H, Kihara M, Tomoda C, et al. Excellent prognosis of patients with solitary T1N0M0 papillary thyroid carcinoma who underwent thyroidectomy and elective lymph node dissection without radioiodine therapy. World J Surg. 2010;34:1285-90 pubmed publisher
    ..Regarding the extent of thyroidectomy, hemithyroidectomy is adequate for these patients, if a 1% risk of recurrence to the remnant thyroid is accepted. ..
  3. request reprint
    Ito Y, Hirokawa M, Jikuzono T, Higashiyama T, Takamura Y, Miya A, et al. Extranodal tumor extension to adjacent organs predicts a worse cause-specific survival in patients with papillary thyroid carcinoma. World J Surg. 2007;31:1194-201 pubmed
    ..Presence of nodal ex significantly reflects the biologically aggressive behaviors of papillary carcinoma and has a prognostic value, especially for cause-specific survival of patients. ..
  4. Ito Y, Kakudo K, Hirokawa M, Fukushima M, Yabuta T, Tomoda C, et al. Biological behavior and prognosis of familial papillary thyroid carcinoma. Surgery. 2009;145:100-5 pubmed publisher
    ..Although routine total thyroidectomy is recommended for familial papillary carcinoma, its therapeutic strategy can otherwise be the same as that for sporadic papillary carcinoma. ..
  5. request reprint
    Ito Y, Miyauchi A. Lateral and mediastinal lymph node dissection in differentiated thyroid carcinoma: indications, benefits, and risks. World J Surg. 2007;31:905-15 pubmed
    ..Node dissection of the lateral and mediastinal compartments must be performed aggressively and radically to prevent recurrence in previously dissected regions. ..
  6. Ito Y, Miyauchi A, Oda H, Kobayashi K, Kihara M, Miya A. Revisiting Low-Risk Thyroid Papillary Microcarcinomas Resected Without Observation: Was Immediate Surgery Necessary?. World J Surg. 2016;40:523-8 pubmed publisher
    ..However, for PMCs with high-risk features, immediate surgery after cytological diagnosis by a needle aspiration biopsy is recommended. ..
  7. request reprint
    Ito Y, Fukushima M, Tomoda C, Inoue H, Kihara M, Higashiyama T, et al. Prognosis of patients with papillary thyroid carcinoma having clinically apparent metastasis to the lateral compartment. Endocr J. 2009;56:759-66 pubmed
  8. request reprint
    Ito Y, Miyauchi A. Lateral lymph node dissection guided by preoperative and intraoperative findings in differentiated thyroid carcinoma. World J Surg. 2008;32:729-39 pubmed
    ..For follicular carcinoma, prophylactic node dissection is not mandatory but can be an option for tumors demonstrating aggressive characteristics or histologic types. ..
  9. Ito Y, Higashiyama T, Takamura Y, Kobayashi K, Miya A, Miyauchi A. Prognosis of patients with papillary thyroid carcinoma showing postoperative recurrence to the central neck. World J Surg. 2011;35:767-72 pubmed publisher
    ..However, patients initially showing recurrence to the thyroid bed or perithyroid tissue exhibited a worse prognosis; and careful second surgery and subsequent follow-up are thus mandatory. ..
  10. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, et al. Expression of S100A2 and S100A6 in thyroid carcinomas. Histopathology. 2005;46:569-75 pubmed
  11. request reprint
    Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, et al. Ultrasonographically and anatomopathologically detectable node metastases in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma. World J Surg. 2005;29:917-20 pubmed
    ..1-2.0 cm. These findings suggest that US-detectable lateral metastasis predicts a worse RFS for patients regardless of tumor size, and AP-detectable metastasis affects the RFS of patients with tumors >2 cm. ..
  12. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Caveolin-1 and 14-3-3 sigma expression in follicular variant of thyroid papillary carcinoma. Pathol Res Pract. 2005;201:545-9 pubmed
    ..0001). These findings suggest that caveolin-1 and 14-3-3 sigma positively or negatively regulate the development of FVPC but not that of FC, reflecting the difference of biological characteristics of these two types of carcinoma. ..
  13. request reprint
    Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, et al. Needle tract implantation of papillary thyroid carcinoma after fine-needle aspiration biopsy. World J Surg. 2005;29:1544-9 pubmed
    ..The incidence of implantation was low, and when it did occur, the tumors could be surgically removed without recurrence. ..
  14. request reprint
    Ito Y, Kihara M, Takamura Y, Kobayashi K, Miya A, Miyauchi A. Prognosis and prognostic factors of patients with papillary thyroid carcinoma requiring resection of recurrent laryngeal nerve due to carcinoma extension. Endocr J. 2012;59:247-52 pubmed
    ..Preoperative vocal cord paralysis reflected the aggressive characteristic of PTC to some extent, but did not have a significant prognostic value. ..
  15. request reprint
    Ito Y, Yoshida H, Motoo Y, Iovanna J, Nakamura Y, Kakudo K, et al. Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis. Anticancer Res. 2005;25:833-7 pubmed
    ..These results suggest that p8 plays a role in the early phase of breast carcinoma progression and especially in tumors of larger size, acting as an inhibitor of apoptosis of breast carcinoma cells. ..
  16. request reprint
    Ito Y, Yoshida H, Tomoda C, Miya A, Kobayashi K, Matsuzuka F, et al. Galectin-3 expression in follicular tumours: an immunohistochemical study of its use as a marker of follicular carcinoma. Pathology. 2005;37:296-8 pubmed
    ..Therefore, we must conclude that galectin-3 should only be considered an adjuvant marker for follicular carcinoma. ..
  17. request reprint
    Ito Y, Kobayashi K, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Ill-defined edge on ultrasonographic examination can be a marker of aggressive characteristic of papillary thyroid microcarcinoma. World J Surg. 2005;29:1007-11; discussion 1011-2 pubmed
    ..We should carefully follow such patients, regardless of the therapeutic strategy, observation, or surgical treatment chosen. ..
  18. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Expression of cdc25B and cdc25A in medullary thyroid carcinoma: cdc25B expression level predicts a poor prognosis. Cancer Lett. 2005;229:291-7 pubmed
    ..These findings suggest that cdc25B can be regarded as having prognostic significance and as a novel marker of biologically aggressive characteristics in this carcinoma. ..
  19. Ito Y, Miyauchi A, Kihara M, Fukushima M, Higashiyama T, Miya A. Overall Survival of Papillary Thyroid Carcinoma Patients: A Single-Institution Long-Term Follow-Up of 5897 Patients. World J Surg. 2018;42:615-622 pubmed publisher
    ..PTC of ?3 cm in young patients should be carefully followed, even in the absence of metastases, and these patients should undergo aggressive therapies for recurrent lesions and metastases. ..
  20. request reprint
    Ito Y, Arai K, Ryushi -, Nozawa -, Yoshida H, Tomoda C, et al. S100A9 expression is significantly linked to dedifferentiation of thyroid carcinoma. Pathol Res Pract. 2005;201:551-6 pubmed
    ..2%), and greater than 25% in six (31.6%) cases. It is therefore suggested that S100A4 protein plays an important role in thyroid carcinoma dedifferentiation, and can be considered a novel characteristic of undifferentiated carcinoma. ..
  21. Ito Y, Miyauchi A, Kudo T, Kihara M, Fukushima M, Miya A. The Effectiveness of Prophylactic Modified Neck Dissection for Reducing the Development of Lymph Node Recurrence of Papillary Thyroid Carcinoma. World J Surg. 2017;41:2283-2289 pubmed publisher
    ..Selective p-MND for high-risk cases improved lymph node recurrence-free survival. ..
  22. Ito Y, Miyauchi A, Inoue H, Fukushima M, Kihara M, Higashiyama T, et al. An observational trial for papillary thyroid microcarcinoma in Japanese patients. World J Surg. 2010;34:28-35 pubmed publisher
    ..Even though the primary tumor is small, careful surgical treatment including therapeutic modified neck dissection is necessary for N1b PMC patients. ..
  23. request reprint
    Ito Y, Arai K, Nozawa R, Yoshida H, Hirokawa M, Fukushima M, et al. S100A8 and S100A9 expression is a crucial factor for dedifferentiation in thyroid carcinoma. Anticancer Res. 2009;29:4157-61 pubmed
    ..S100A8 plays an important role in dedifferentiation of thyroid carcinoma possibly by forming a complex with S100A9. ..
  24. request reprint
    Ito Y, Yoshida H, Uruno T, Takamura Y, Miya A, Kuma K, et al. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Breast Cancer. 2004;11:295-300 pubmed
    ..6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters. These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression. ..
  25. request reprint
    Ito Y, Yoshida H, Uruno T, Nakano K, Takamura Y, Miya A, et al. Tie-1 tyrosine kinase expression in human thyroid neoplasms. Histopathology. 2004;44:318-22 pubmed
    ..These results suggest that tie-1 has a role in thyroid tumorigenesis, especially in the early phase of papillary carcinoma, but it is not important in the progression of anaplastic carcinoma or follicular tumour. ..
  26. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma. Thyroid. 2004;14:13-8 pubmed
    ..Further studies regarding the function of maspin in this carcinoma are required. ..
  27. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Polo-like kinase 1 (PLK1) expression is associated with cell proliferative activity and cdc2 expression in malignant lymphoma of the thyroid. Anticancer Res. 2004;24:259-63 pubmed
    ..These results suggest that PLK1 regulates the cell cycle progression of thyroid lymphoma cells in the G2-M-phase. ..
  28. request reprint
    Ito Y, Miyoshi E, Takeda T, Nagano H, Sakon M, Noda K, et al. Linkage of elevated ets-2 expression to hepatocarcinogenesis. Anticancer Res. 2002;22:2385-9 pubmed
    ..0009) and intrahepatic metastasis (p=0.0236) and shorter disease-free survival (p=0.0372). These findings suggest that ets-2 plays an important role predominantly in malignant transformation of the liver. ..
  29. request reprint
    Ito Y, Yoshida H, Nakano K, Kobayashi K, Yokozawa T, Hirai K, et al. Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues. Int J Mol Med. 2002;9:373-6 pubmed
    ..0001). These results suggest that the down-regulation of p57 may play a role in the dedifferentiation of thyroid carcinoma and in follicular carcinoma mutating to be more invasive. ..
  30. request reprint
    Ito Y, Yoshida H, Uruno T, Nakano K, Takamura Y, Miya A, et al. p130 expression in thyroid neoplasms: its linkage with tumor size and dedifferentiation. Cancer Lett. 2003;192:83-7 pubmed
    ..3% of cases overexpressed this protein. These findings suggest that: (1) reduced p130 expression may contribute to the aggressive character of anplastic carcinoma; and (2) p130 may specify the growth characteristics of microcarcinoma. ..
  31. request reprint
    Ito Y, Miyoshi E, Uda E, Yoshida H, Uruno T, Takamura Y, et al. 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid. Cancer Lett. 2003;200:161-6 pubmed
    ..These results suggest that 14-3-3 sigma plays a constitutive role in papillary carcinoma rather than acting as a cell cycle regulator, whereas it is not required for the occurrence and development of follicular tumor. ..
  32. Ito Y, Miyoshi E, Sasaki N, Kakudo K, Yoshida H, Tomoda C, et al. Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma. Br J Cancer. 2004;90:414-8 pubmed
  33. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, et al. S100A4 expression is an early event of papillary carcinoma of the thyroid. Oncology. 2004;67:397-402 pubmed
    ..0001) than that in papillary carcinoma. These findings suggest that (1) S100A4 plays a constitutive role in papillary carcinoma and (2) S100A4 may be a useful marker for early the detection of this carcinoma. ..
  34. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation. Int J Mol Med. 2004;13:431-5 pubmed
    ..These findings suggest that i) cdc25B plays a role in the early phase of thyroid lymphoma possibly including the malignant transformation from chronic thyroiditis, and ii) cdc25A may contribute to the progression of lymphoma. ..
  35. request reprint
    Ito Y, Masuoka H, Fukushima M, Inoue H, Kihara M, Tomoda C, et al. Prognosis and prognostic factors of patients with papillary carcinoma showing distant metastasis at surgery (M1 patients) in Japan. Endocr J. 2010;57:523-31 pubmed
    ..Locally curative surgery, RAI therapy, and TSH suppression therapy are actively recommended for M1 patients when conditions permit...
  36. request reprint
    Ito Y, Yoshida H, Tomoda C, Miya A, Kobayashi K, Matsuzuka F, et al. HBME-1 expression in follicular tumor of the thyroid: an investigation of whether it can be used as a marker to diagnose follicular carcinoma. Anticancer Res. 2005;25:179-82 pubmed
    ..HBME-1 has been recognized as a useful marker for diagnosing thyroid carcinoma. In this study, we investigated whether it has a diagnostic value for discriminating follicular carcinoma from adenoma...
  37. request reprint
    Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Telomerase activity in thyroid neoplasms evaluated by the expression of human telomerase reverse transcriptase (hTERT). Anticancer Res. 2005;25:509-14 pubmed
  38. Ito Y, Yoshida H, Kihara M, Kobayashi K, Miya A, Miyauchi A. BRAF(V600E) mutation analysis in papillary thyroid carcinoma: is it useful for all patients?. World J Surg. 2014;38:679-87 pubmed publisher
    ..BRAF mutation analysis is useful in estimating the CSS of high-risk PTC patients based on the representative classification systems. It was not related to the prognosis in non-high-risk patients, at least those living in Japan. ..
  39. request reprint
    Ito Y, Yoshida H, Matsuzuka F, Matsuura N, Nakamura Y, Nakamine H, et al. Jun activation domain-binding protein 1 expression in malignant lymphoma of the thyroid: its linkage to degree of malignancy and p27 expression. Anticancer Res. 2003;23:4121-5 pubmed
  40. request reprint
    Ito Y, Motoo Y, Yoshida H, Iovanna J, Nakamura Y, Kuma K, et al. High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid. Pathology. 2006;38:545-7 pubmed
  41. request reprint
    Ito Y, Yoshida H, Uruno T, Nakano K, Miya A, Kobayashi K, et al. Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma. Oncol Rep. 2003;10:1337-40 pubmed
    ..0001). These results suggest that survivin is strongly related to the dedifferentiation of thyroid carcinoma. ..
  42. request reprint
    Ito Y, Yoshida H, Nakamura Y, Tomoda C, Uruno T, Takamura Y, et al. Expression of Jun activation domain-binding protein 1 and p27 (Kip1) in thyroid medullary carcinoma. Pathology. 2005;37:216-9 pubmed
    ..In this study, we investigated the expression of these proteins in medullary thyroid carcinoma...
  43. Ito Y, Miyauchi A, Yabuta T, Fukushima M, Inoue H, Tomoda C, et al. Alternative surgical strategies and favorable outcomes in patients with medullary thyroid carcinoma in Japan: experience of a single institution. World J Surg. 2009;33:58-66 pubmed publisher
    ..Clinical outcomes of MTC patients in our series were better than those in Western countries, a result that might have resulted in part because of our routine MND regardless of whether clinically apparent node metastasis was detected. ..
  44. request reprint
    Ito Y, Arai K, Nozawa R, Yoshida H, Higashiyama T, Takamura Y, et al. S100A10 expression in thyroid neoplasms originating from the follicular epithelium: contribution to the aggressive characteristic of anaplastic carcinoma. Anticancer Res. 2007;27:2679-83 pubmed
    ..3% of these lesions were classified in the high group. These findings suggest that S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. ..
  45. Ito Y, Hirokawa M, Miyauchi A, Higashiyama T, Kihara M, Miya A. Prognostic Significance of the Proportion of Tall Cell Components in Papillary Thyroid Carcinoma. World J Surg. 2017;41:742-747 pubmed publisher
    ..Our findings indicate that the WHO definition of TCV is appropriate and that the prognostic impact of TCC-minor is limited. ..
  46. request reprint
    Ito Y, Miyauchi A, Yoshida H, Uruno T, Nakano K, Takamura Y, et al. Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation. Cancer Lett. 2003;200:167-72 pubmed
    ..These results suggest that FUT8 expression may be a key factor in the progression of thyroid papillary carcinomas, but not follicular carcinomas, and decreases in FUT8 expression might be linked to anaplastic transformation. ..
  47. request reprint
    Ito Y, Yoshida H, Motoo Y, Iovanna J, Tomoda C, Uruno T, et al. Expression of p8 protein in medullary thyroid carcinoma. Anticancer Res. 2005;25:3419-23 pubmed
    ..However, p8 expression was not linked to the apoptotic index. These findings suggest that p8 expression plays an important role in the progression of medullary carcinoma, but does not have an anti-apoptotic function. ..
  48. request reprint
    Ito Y, Nakamura Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, et al. Polo-like kinase 1 expression in medullary carcinoma of the thyroid: its relationship with clinicopathological features. Pathobiology. 2005;72:186-90 pubmed
    ..However, its protein expression in human carcinoma has not been studied in depth. In this study, we investigated PLK1 expression in medullary thyroid carcinoma by means of immunohistochemistry...