Mitsuru Ito

Summary

Affiliation: Kuma Hospital
Country: Japan

Publications

  1. pmc Biochemical markers reflecting thyroid function in athyreotic patients on levothyroxine monotherapy
    Mitsuru Ito
    Kuma Hospital, Internal Medicine, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Hyogo, Japan, 650 0011
    Thyroid . 2017
  2. doi request reprint Effect of the presence of remnant thyroid tissue on the serum thyroid hormone balance in thyroidectomized patients
    Mitsuru Ito
    Center for Excellence in Thyroid CareKuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, Hyogo 650 0011, Japan
    Eur J Endocrinol 173:333-40. 2015
  3. ncbi request reprint Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients
    Mitsuru Ito
    Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 60:65-71. 2013
  4. doi request reprint TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy
    Mitsuru Ito
    Center for Excellence in Thyroid Care, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, Hyogo 650 0011, Japan
    Eur J Endocrinol 167:373-8. 2012
  5. ncbi request reprint Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients
    Mitsuru Ito
    Kuma Hospital, Kobe 650 0011, Japan
    J Clin Endocrinol Metab 92:608-11. 2007
  6. doi request reprint The prevalence of polycystic thyroid disease in hypothyroid patients with negative thyroid autoantibodies
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Thyroid 20:1205-8. 2010
  7. doi request reprint Benefit of short-term iodide supplementation to antithyroid drug treatment of thyrotoxicosis due to Graves' disease
    Kazuna Takata
    Kuma Hospital, Kobe, Japan
    Clin Endocrinol (Oxf) 72:845-50. 2010
  8. doi request reprint The prevalence of transient thyrotoxicosis after antithyroid drug therapy in patients with Graves' disease
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:63-6. 2008
  9. ncbi request reprint Clinical characteristics of 852 patients with subacute thyroiditis before treatment
    Eijun Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe
    Intern Med 47:725-9. 2008
  10. ncbi request reprint Pathologic features of polycystic thyroid disease: comparison with benign nodular goiter
    Sumihisa Kubota
    Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    Endocr J 58:783-8. 2011

Collaborators

Detail Information

Publications43

  1. pmc Biochemical markers reflecting thyroid function in athyreotic patients on levothyroxine monotherapy
    Mitsuru Ito
    Kuma Hospital, Internal Medicine, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Hyogo, Japan, 650 0011
    Thyroid . 2017
    ..The objective of the present study was to clarify which of these three patient groups is closer to their preoperative euthyroid condition...
  2. doi request reprint Effect of the presence of remnant thyroid tissue on the serum thyroid hormone balance in thyroidectomized patients
    Mitsuru Ito
    Center for Excellence in Thyroid CareKuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, Hyogo 650 0011, Japan
    Eur J Endocrinol 173:333-40. 2015
    ..However, the effects of remnant thyroid tissue on these balances in thyroidectomized patients have not been established...
  3. ncbi request reprint Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients
    Mitsuru Ito
    Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 60:65-71. 2013
    ..Such altered serum levels of ApoB-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism...
  4. doi request reprint TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy
    Mitsuru Ito
    Center for Excellence in Thyroid Care, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, Hyogo 650 0011, Japan
    Eur J Endocrinol 167:373-8. 2012
    ..The objective of this study was to evaluate how the individual serum T(3) level changes between preoperative native thyroid function and postoperative L-T(4) therapy...
  5. ncbi request reprint Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients
    Mitsuru Ito
    Kuma Hospital, Kobe 650 0011, Japan
    J Clin Endocrinol Metab 92:608-11. 2007
    ..Recently, non-high-density lipoprotein cholesterol (non-HDL-C), a measure of total cholesterol minus HDL-C, has emerged as a predictor of cardiovascular disease...
  6. doi request reprint The prevalence of polycystic thyroid disease in hypothyroid patients with negative thyroid autoantibodies
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Thyroid 20:1205-8. 2010
    ..The aim of this study was to investigate the prevalence of PCTD in patients who visited our thyroid center. We hypothesized that patients with PCTD are not rare in a region with a high iodine intake...
  7. doi request reprint Benefit of short-term iodide supplementation to antithyroid drug treatment of thyrotoxicosis due to Graves' disease
    Kazuna Takata
    Kuma Hospital, Kobe, Japan
    Clin Endocrinol (Oxf) 72:845-50. 2010
    ..We compared methimazole (MMI) treatment with MMI + KI treatment in terms of rapid normalization of thyroid hormones during the early phase and examined the later induction of disease remission...
  8. doi request reprint The prevalence of transient thyrotoxicosis after antithyroid drug therapy in patients with Graves' disease
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:63-6. 2008
    ..When patients with transient hyperthyroidism are mistakenly regarded as recurrences, they receive unnecessary therapy. The aim of this study was to investigate the prevalence of transient thyrotoxicosis after ATD withdrawal...
  9. ncbi request reprint Clinical characteristics of 852 patients with subacute thyroiditis before treatment
    Eijun Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe
    Intern Med 47:725-9. 2008
    ..Subacute thyroiditis (SAT) is a transient inflammatory disease of the thyroid. We evaluated the clinical characteristics based on laboratory and imaging studies in patients with SAT before treatment...
  10. ncbi request reprint Pathologic features of polycystic thyroid disease: comparison with benign nodular goiter
    Sumihisa Kubota
    Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    Endocr J 58:783-8. 2011
    ..We believe that PCTD is a new entity of thyroid disease based on the pathological findings...
  11. doi request reprint Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease
    Mitsuru Ito
    Kuma Hospital, Kobe, Hyogo 650 0011, Japan
    Eur J Endocrinol 164:95-100. 2011
    ..Our objective was to evaluate the contribution of type 1 and type 2 iodothyronine deiodinase (D1 (or DIO1) and D2 (or DIO2) respectively) in the thyroid gland to the high serum T(3) level in T(3)-P-GD...
  12. pmc Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased constitutive activity
    Eijun Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    Thyroid 20:1307-14. 2010
    ..Here we report a family with hereditary subclinical hyperthyroidism caused by a constitutively activating germline mutation of the thyrotropin receptor (TSHR) gene...
  13. doi request reprint Kinetic analyses of changes in serum TSH receptor antibody values after total thyroidectomy in patients with Graves' disease
    Waka Yoshioka
    Departments of Internal Medicine, Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650 0011, Japan
    Endocr J 63:179-85. 2016
    ....
  14. ncbi request reprint Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan
    Eijun Nishihara
    Kuma Hospital, Chuo Ku, Kobe, Hyogo, Japan
    Endocr J 56:791-8. 2009
    ..In the present study, more than half of the cases with AFTN had a somatic activating mutation either of the TSHR or Gsalpha gene, despite their high iodine intake...
  15. doi request reprint Papillary carcinoma obscured by complication with subacute thyroiditis: sequential ultrasonographic and histopathological findings in five cases
    Eijun Nishihara
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
    Thyroid 18:1221-5. 2008
    ..The objective of the study was to assess sequential ultrasonographic and histopathological findings of SAT in the context of complicating thyroid carcinomas...
  16. doi request reprint Methimazole-induced agranulocytosis in patients with Graves' disease is more frequent with an initial dose of 30 mg daily than with 15 mg daily
    Kazuna Takata
    Department of Internal Medicine, Kuma Hospital, Chuo Ku, Kobe, Japan
    Thyroid 19:559-63. 2009
    ..This study was performed to determine if the prevalence of agranulocytosis is different depending on the starting dosage of ATDs in patients with Graves' disease...
  17. doi request reprint A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter
    Hidemi Ohye
    Department of Internal Medicine, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    Thyroid 18:561-6. 2008
    ..At the age of 56 years, goiter size remained the same. The perchlorate discharge rate was 72.8%, suggesting partial iodine organification defect. Thus, thyroid peroxidase (TPO) gene and DUOX2 gene were analyzed...
  18. ncbi request reprint Serum concentrations of remnant-like particles in hypothyroid patients before and after thyroxine replacement
    Mitsuru Ito
    The Kuma Hospital, Kobe, Hyogo, Japan
    Clin Endocrinol (Oxf) 58:621-6. 2003
    ....
  19. doi request reprint Multiple thyroid cysts may be a cause of hypothyroidism in patients with relatively high iodine intake
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Thyroid 20:205-8. 2010
    ..Here we present six patients from a region with relatively high iodine intake in whom multiple cysts of the thyroid were associated with hypothyroidism or the development of hypothyroidism...
  20. doi request reprint Initial treatment with 15 mg of prednisolone daily is sufficient for most patients with subacute thyroiditis in Japan
    Sumihisa Kubota
    Kuma Hospital, Chuo Ku, Kobe, Japan
    Thyroid 23:269-72. 2013
    ..In this study, we used 15 mg/day of PSL as the initial dosage and tapered it by 5 mg every 2 weeks. We assessed the effectiveness of this treatment protocol...
  21. ncbi request reprint A case of hypothyroid Graves' disease following external radiation therapy to the cervical region
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 53:357-61. 2006
    ..These results suggest that radiation-associated thyroidal injury might be associated with the etiology of hypothyroid Graves' disease...
  22. ncbi request reprint Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves' disease and painless thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:283-7. 2008
    ..However, a question arises whether such aggravation constitutes an adverse effect of the drugs or not...
  23. ncbi request reprint Sustained fever resolved promptly after total thyroidectomy due to huge Hashimoto's fibrous thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, 650 0011, Japan
    Endocrine 31:88-91. 2007
    ..We believed that fever was induced by inflammatory cytokines produced in thyroid. The case indicated that Hashimoto's thyroiditis with nontender goiter could cause idiopathic fever...
  24. ncbi request reprint Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature
    Eijun Nishihara
    Kuma Hospital, Shimoyamate dori, Chuo Ku, Kobe, Japan
    Endocrine 30:231-6. 2006
    ....
  25. doi request reprint Histopathological diagnoses of "accessory" thyroid nodules diagnosed as benign by fine-needle aspiration cytology and ultrasonography
    Takeo Kawai
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    Thyroid 22:299-303. 2012
    ..Most accessory nodules are diagnosed as benign based on preoperative US and FNAC. To evaluate the accuracy of US and FNAC for a group of nodules which were likely to be mostly benign we evaluated procedures to diagnose accessory nodules...
  26. ncbi request reprint Sporadic congenital hyperthyroidism due to a germline mutation in the thyrotropin receptor gene (Leu 512 Gln) in a Japanese patient
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 53:735-40. 2006
    ..To our knowledge, this is the first report of a germline mutation of TSHR causing sporadic congenital nonautoimmune hyperthyroidism in a Japanese patient...
  27. ncbi request reprint Effect of high dose methylprednisolone pulse therapy followed by oral prednisolone administration on the production of anti-TSH receptor antibodies and clinical outcome in Graves' disease
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Endocr J 52:735-41. 2005
    ..57%. There was no significant difference between the two. These results suggest that the immunosuppressive effect of pulse therapy was temporary, and that pulse therapy did not increase remission rate of Graves' disease...
  28. doi request reprint Thyroxine treatment may be useful for subclinical hypothyroidism in patients with female infertility
    Waka Yoshioka
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650 0011, Japan
    Endocr J 62:87-92. 2015
    ..High successful pregnancy rate and shorter duration of infertility until pregnancy after T4 treatment strongly suggest that T4 enhanced fertility in infertile patients with SCH...
  29. pmc A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter
    Eijun Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    Front Endocrinol (Lausanne) 7:131. 2016
    ..A germline mutation of KEAP1 gene was reported as a novel genetic abnormality associated with familial multinodular goiter. That report was limited, and the pathogenic features were not well established...
  30. doi request reprint Differentiation of postpartum Graves' thyrotoxicosis from postpartum destructive thyrotoxicosis using antithyrotropin receptor antibodies and thyroid blood flow
    Akane Ide
    Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
    Thyroid 24:1027-31. 2014
    ..We examined the usefulness of determining the time of onset postpartum and measurement of antithyrotropin (anti-TSH) receptor antibodies and thyroid blood flow...
  31. doi request reprint Occurrence of thyroxine tablet (Thyradin S(®)) - induced liver dysfunction in a patient with subclinical hypothyroidism
    Shino Kang
    Department of Internal Medicine, Kuma Hospital, Kobe, Japan
    Endocr J 62:719-24. 2015
    ..This is a rare case report of drug induced liver injury due to Fe2O3 free levothyroxine tablet form, and administration of L-T4 in powder form may be useful for treatment of cases similar to this one. ..
  32. pmc Graves' Disease Patients with Persistent Hyperthyroidism and Diffuse Lymphoplasmacytic Infiltration in the Thyroid Show No Histopathological Compatibility with IgG4-Related Disease
    Eijun Nishihara
    Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan
    PLoS ONE 10:e0134143. 2015
    ..The objective of this study was to elucidate the clinicopathological features of Graves' disease with diffuse lymphoplasmacytic infiltration in the thyroid...
  33. ncbi request reprint Prognosis and prognostic factors of differentiated thyroid carcinoma after the appearance of metastasis refractory to radioactive iodine therapy
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Kobe 650 0011, Japan
    Endocr J 61:821-4. 2014
    ..Further studies are necessary to clarify the appropriate indications for molecular-target therapy for RAI-refractory and progressive metastases. ..
  34. pmc Periodic Granulocyte Count Measuring Is Useful for Detecting Asymptomatic Agranulocytosis in Antithyroid Drug-Treated Patients with Graves' Disease
    Hirotoshi Nakamura
    Kuma Hospital, Kobe, Japan
    Eur Thyroid J 5:253-260. 2016
    ..Finding agranulocytosis (AG) at an early stage is important to improve outcome, but periodic granulocyte count monitoring is not generally recommended for patients with Graves' disease, because AG develops suddenly...
  35. ncbi request reprint Partial prediction of postpartum Graves' thyrotoxicosis by sensitive bioassay for thyroid-stimulating antibody measured in early pregnancy
    Akane Ide
    Department of Internal Medicine, Kuma Hospital, Kobe, Japan
    Endocr J 63:929-932. 2016
    ..These findings indicate that the third generation TRAb assay was not useful, but that the sensitive TSAb bioassay was moderately useful for predicting the postpartum onset of Graves' hyperthyroidism...
  36. doi request reprint Method-dependent HbA1c values in a family with hemoglobin Himeji
    Eijun Nishihara
    Kuma Hospital, Japan
    Clin Chim Acta 412:1689-92. 2011
    ..Hb Himeji is variant hemoglobin associated with increased glycation in a mutated β chain. We measured HbA1c using various methods in a family with Hb Himeji...
  37. doi request reprint Automated assay for determining cellular cholesterol using a random access chemistry analyser
    Satoshi Tada
    Department of Laboratory Medicine, Kagawa University, Kobe 650 0011, Japan
    Ann Clin Biochem 47:168-70. 2010
    ..Although this technique is reliable, the use of the assay has limitations due to the requirement for special equipment. It is therefore difficult to apply this assay for the routine determination of cellular cholesterol...
  38. doi request reprint Serial changes in liver function tests in patients with subacute thyroiditis
    Yuka Matsumoto
    Thyroid 18:815-6. 2008
  39. ncbi request reprint Two-day thionamide withdrawal prior to radioiodine uptake sufficiently increases uptake and does not exacerbate hyperthyroidism compared to 7-day withdrawal in Graves' disease
    Sumihisa Kubota
    Kuma Hospital
    Endocr J 53:603-7. 2006
    ..We believe that the 2-day ATD withdrawal method may be useful for patients undergoing treatment with ATD who are to undergo radioiodine therapy...
  40. ncbi request reprint Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosis
    Yasuhiro Murakami
    Comprehensive Medical Center for Health, Otemae Hospital, Osaka 584 0008, Japan
    Endocr J 51:579-85. 2004
    ....
  41. ncbi request reprint Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism
    Mitsuru Ito
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Am J Med 117:696-9. 2004
  42. ncbi request reprint High diagnostic value of a radioiodine uptake test with and without iodine restriction in Graves' disease and silent thyroiditis
    Tetsuya Hiraiwa
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Thyroid 14:531-5. 2004
    ..High diagnostic value of the RAIU test was confirmed, but not affected by the presence of iodine restriction in the differentiation between GD and ST, therefore, iodine restriction before the RAIU test was unnecessary...
  43. ncbi request reprint Isolated adrenocorticotropic hormone deficiency with transient thyroiditis inducing an adrenal crisis
    Tetsuya Hiraiwa
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Med Princ Pract 16:230-3. 2007
    ..It was the aim of this study to describe a patient with isolated adrenocorticotropic hormone deficiency presenting with a variety of involuntary movements who developed an adrenal crisis due to transient thyroiditis...