Hiroaki Kiyohara

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. doi request reprint Intestinal Peyer's patch-immunomodulating glucomannans from rhizomes of Anemarrhena asphodeloides Bunge
    Hiroaki Kiyohara
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo 108 8641, Japan Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108 8641, Japan Oriental Medicine Research Center, Kitasato University, Tokyo 108 8641, Japan Electronic address
    Phytochemistry 96:337-46. 2013
  2. doi request reprint Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth
    Hiroaki Kiyohara
    Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:55-61. 2012
  3. doi request reprint In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:377-82. 2012
  4. doi request reprint Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata
    Takayuki Nagai
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Int Immunopharmacol 10:655-61. 2010
  5. doi request reprint In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum)
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:558-61. 2012
  6. doi request reprint In vitro anti-influenza virus activity of a cardiotonic glycoside from Adenium obesum (Forssk.)
    Hiroaki Kiyohara
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Phytomedicine 19:111-4. 2012
  7. ncbi request reprint Antimalarial activity of biflavonoids from Ochna integerrima
    Chikara Ichino
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Planta Med 72:611-4. 2006
  8. doi request reprint Modulation of chemokine expression on intestinal epithelial cells by Kampo (traditional Japanese herbal) medicine, Hochuekkito, and its active ingredients
    Michiko Sekiya
    Graduate School of Infection Control Sciences, Kitasato University, Tokyo, 108 8641, Japan
    J Nat Med 67:626-35. 2013
  9. doi request reprint In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Phytochemistry 72:2024-30. 2011
  10. doi request reprint Different contributions of side-chains in beta-D-(1-->3,6)-galactans on intestinal Peyer's patch-immunomodulation by polysaccharides from Astragalus mongholics Bunge
    Hiroaki Kiyohara
    Department of Drug Discovery Science, Kitasato Institute for Life Sciences, Kitasato University, Minato ku, Tokyo 108 8641, Japan
    Phytochemistry 71:280-93. 2010

Collaborators

Detail Information

Publications20

  1. doi request reprint Intestinal Peyer's patch-immunomodulating glucomannans from rhizomes of Anemarrhena asphodeloides Bunge
    Hiroaki Kiyohara
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo 108 8641, Japan Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108 8641, Japan Oriental Medicine Research Center, Kitasato University, Tokyo 108 8641, Japan Electronic address
    Phytochemistry 96:337-46. 2013
    ..Structural analysis indicates that the long oligosaccharides from the active glucomannan contain mannanase-resistant complex structure comprising β-D-Man and β-D-Glc...
  2. doi request reprint Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth
    Hiroaki Kiyohara
    Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:55-61. 2012
    ..82 μM). Patchouli alcohol did not show inhibitory activity against influenza virus neuraminidase...
  3. doi request reprint In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:377-82. 2012
    ..Our finding represents the first report of the promising trypanocidal activity of these compounds. The research also provides valuable insight into structure-activity relationships and the possible mode of action of the compounds...
  4. doi request reprint Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata
    Takayuki Nagai
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Int Immunopharmacol 10:655-61. 2010
    ..The result of this study refutes the our previous study and suggests that the combination of 9S,12S,13S and 9S,12R,13R isomers is necessary for effective oral adjuvant activity when used in conjunction with nasal influenza vaccine...
  5. doi request reprint In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum)
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:558-61. 2012
    ..Our findings represent the first report of the promising trypanocidal activity of these compounds...
  6. doi request reprint In vitro anti-influenza virus activity of a cardiotonic glycoside from Adenium obesum (Forssk.)
    Hiroaki Kiyohara
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Phytomedicine 19:111-4. 2012
    ..The isolated glycoside showed reduction of virus titre by 69.3% inhibition at concentration of 1 μg/ml (IC(50)=0.86 μg/ml)...
  7. ncbi request reprint Antimalarial activity of biflavonoids from Ochna integerrima
    Chikara Ichino
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Planta Med 72:611-4. 2006
    ..The stereoisomer of 1 ( = compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1...
  8. doi request reprint Modulation of chemokine expression on intestinal epithelial cells by Kampo (traditional Japanese herbal) medicine, Hochuekkito, and its active ingredients
    Michiko Sekiya
    Graduate School of Infection Control Sciences, Kitasato University, Tokyo, 108 8641, Japan
    J Nat Med 67:626-35. 2013
    ....
  9. doi request reprint In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Phytochemistry 72:2024-30. 2011
    ..Present results also provide some valuable insight with regard to structure-activity relationships and the possible mode of action of the compounds...
  10. doi request reprint Different contributions of side-chains in beta-D-(1-->3,6)-galactans on intestinal Peyer's patch-immunomodulation by polysaccharides from Astragalus mongholics Bunge
    Hiroaki Kiyohara
    Department of Drug Discovery Science, Kitasato Institute for Life Sciences, Kitasato University, Minato ku, Tokyo 108 8641, Japan
    Phytochemistry 71:280-93. 2010
    ..Interestingly, the terminal GlcA was not required for activity of the arabinogalactan-enriched fractions, suggesting at least two different immunomodulating structures...
  11. pmc Polysaccharide-Containing Macromolecules in a Kampo (Traditional Japanese Herbal) Medicine, Hochuekkito: Dual Active Ingredients for Modulation of Immune Functions on Intestinal Peyer's Patches and Epithelial cells
    Hiroaki Kiyohara
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Minato ku, Tokyo 108 8641, Japan
    Evid Based Complement Alternat Med 2011:492691. 2011
    ....
  12. pmc Hochuekkito, a Kampo (Traditional Japanese Herbal) Medicine, and its Polysaccharide Portion Stimulate G-CSF Secretion from Intestinal Epithelial Cells
    Tsukasa Matsumoto
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108 8641, Oriental Medicine Research Center, The Kitasato Institute, Tokyo 108 8642 and Life Science Research Center, University of Toyama, Toyama 930 0194, Japan
    Evid Based Complement Alternat Med 7:331-40. 2010
    ..The enhanced G-CSF secretion by HET may partly contribute to the clinically observed various pharmacological activities of HET including immunomodulating activity...
  13. ncbi request reprint [Elucidation of structures and functions through Peyer's patches of responsible carbohydrate chains in intestinal immune system modulating polysaccharides from Japanese medicinal herbs]
    Hiroaki Kiyohara
    Graduate School of Infectious Control, Kitasato University, Tokyo, Japan
    Yakugaku Zasshi 128:709-16. 2008
    ..This review deals with recent results of our study on the structural clarification of responsible carbohydrate chains in modulating polysaccharides against functions of immunocompetent cells in Peyer's patches...
  14. doi request reprint Stimulatory effect of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L., on G-CSF secretion from intestinal epithelial cells
    Tsukasa Matsumoto
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108 8641, Japan
    Int Immunopharmacol 8:581-8. 2008
    ....
  15. ncbi request reprint Suppression of Fas-mediated apoptosis of keratinocyte cells by chikusetsusaponins isolated from the roots of Panax japonicus
    Kanako Hosono-Nishiyama
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
    Planta Med 72:193-8. 2006
    ..japonicus containing these saponins is expected to relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway...
  16. ncbi request reprint Structure of oligosaccharide side chains of an intestinal immune system modulating arabinogalactan isolated from rhizomes of Atractylodes lancea DC
    Ikue Taguchi
    Kitsato Institute for Life Sciences and Graduate school of Pharmaceutical Sciences, Kitasato University, Minato ku, Tokyo 108 8642, Japan
    Carbohydr Res 339:763-70. 2004
    ....
  17. doi request reprint Immunomodulating pectic polysaccharides from waste rose petals of Rosa damascena Mill
    Anton Slavov
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Int J Biol Macromol 59:192-200. 2013
    ..To our knowledge, this is a first report which explores the possibility for utilization of waste rose petals as a source of immunomodulating pectic polysaccharides...
  18. ncbi request reprint In vitro antimalarial activity of biflavonoids from Wikstroemia indica
    Shinyu Nunome
    The Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Planta Med 70:76-8. 2004
    ..This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR...
  19. ncbi request reprint A novel in vitro infection model of Helicobacter pylori using mucin-producing murine gastric surface mucous cells
    Tetsufumi Takahashi
    Graduate School of Pharmaceutical Sciences, Kitasato University, Minato ku, Tokyo, Japan
    Helicobacter 9:302-12. 2004
    ..pylori infection in vitro, although cancer cells have some abnormalities in cellular properties. The aim of this study was to develop an in vitro H. pylori infection model using normal gastric surface cells that produce gastric mucin...
  20. ncbi request reprint Total synthesis and adjuvant activity of all stereoisomers of pinellic acid
    Tatsuya Shirahata
    The Kitasato Institute for Life Science, School of Pharmaceutical Science, Kitasato University, Shirokane, Minatoku, Tokyo 108 8641, Japan
    Bioorg Med Chem Lett 13:937-41. 2003
    ..Among this series of isomers, 9S, 12S, 13S compound has the most potent adjuvant activity. Structure-activity relationships are discussed...