Tomoyuki Hishida

Summary

Country: Japan

Publications

  1. doi Does Repeated Lung Resection Provide Long-Term Survival for Recurrent Pulmonary Metastases of Colorectal Cancer? Results of a Retrospective Japanese Multicenter Study
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan Electronic address
    Ann Thorac Surg 103:399-405. 2017
  2. doi Lobe-Specific Nodal Dissection for Clinical Stage I and II NSCLC: Japanese Multi-Institutional Retrospective Study Using a Propensity Score Analysis
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan Electronic address
    J Thorac Oncol 11:1529-37. 2016
  3. doi Long-term outcome of surgical resection for residual or regrown advanced non-small cell lung carcinomas following EGFR-TKI treatment: report of four cases
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    Gen Thorac Cardiovasc Surg 64:429-33. 2016
  4. doi Postoperative oligo-recurrence of non-small-cell lung cancer: clinical features and survival†
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Centre Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 49:847-53. 2016
  5. doi Long-term outcome and prognostic factors of surgically treated thymic carcinoma: results of 306 cases from a Japanese Nationwide Database Study
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Centre Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 49:835-41. 2016
  6. doi Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6)
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba
    Jpn J Clin Oncol 45:499-501. 2015
  7. doi Surgical outcomes after initial surgery for clinical single-station N2 non-small-cell lung cancer
    Tomoyuki Hishida
    Division of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Jpn J Clin Oncol 44:85-92. 2014
  8. doi Prognostic impact of intratumoural microvascular invasion and microlymphatic permeation on node-negative non-small-cell lung cancer: which indicator is the stronger prognostic factor?
    Tomoyuki Hishida
    Division of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 43:772-7. 2013
  9. ncbi Is surgical resection indicated for a solitary non-small cell lung cancer recurrence?
    Tomoyuki Hishida
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 131:838-42. 2006
  10. ncbi Problems in the current diagnostic standards of clinical N1 non-small cell lung cancer
    T Hishida
    Department of Thoracic Oncology, National Cancer Centre Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577 Japan
    Thorax 63:526-31. 2008

Detail Information

Publications79

  1. doi Does Repeated Lung Resection Provide Long-Term Survival for Recurrent Pulmonary Metastases of Colorectal Cancer? Results of a Retrospective Japanese Multicenter Study
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan Electronic address
    Ann Thorac Surg 103:399-405. 2017
    ..The purpose of this study was to clarify the long-term survival outcomes after repeated lung resection (RLR) of pulmonary metastases from colorectal cancer (PM-CRC) using data from a Japanese nationwide investigation...
  2. doi Lobe-Specific Nodal Dissection for Clinical Stage I and II NSCLC: Japanese Multi-Institutional Retrospective Study Using a Propensity Score Analysis
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan Electronic address
    J Thorac Oncol 11:1529-37. 2016
    ..The purpose of this study was to assess the surgical outcomes according to the extent of mediastinal lymph node dissection for patients with NSCLC by using a nationwide registry database...
  3. doi Long-term outcome of surgical resection for residual or regrown advanced non-small cell lung carcinomas following EGFR-TKI treatment: report of four cases
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    Gen Thorac Cardiovasc Surg 64:429-33. 2016
    ..Although our series is small, the relatively favorable long-term survival indicates the need for further investigation of the role of surgery during molecular-targeted therapy for advanced NSCLC. ..
  4. doi Postoperative oligo-recurrence of non-small-cell lung cancer: clinical features and survival†
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Centre Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 49:847-53. 2016
    ..The aim of this study was to clarify clinical features and outcomes of patients with postoperative oligo-recurrence of NSCLC...
  5. doi Long-term outcome and prognostic factors of surgically treated thymic carcinoma: results of 306 cases from a Japanese Nationwide Database Study
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Centre Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 49:835-41. 2016
    ..Thymic carcinoma is a rare thymic malignancy. The purpose of this study was to evaluate the prognostic impact of clinicopathological variables and perioperative therapy for surgically treated thymic carcinoma using a nationwide database...
  6. doi Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6)
    Tomoyuki Hishida
    Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba
    Jpn J Clin Oncol 45:499-501. 2015
    ..The results of this cohort study will be useful for external validity of the results of clinical trial such as JCOG0707. ..
  7. doi Surgical outcomes after initial surgery for clinical single-station N2 non-small-cell lung cancer
    Tomoyuki Hishida
    Division of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Jpn J Clin Oncol 44:85-92. 2014
    ..The objective of this study was to clarify the surgical outcomes in clinical single-station N2 non-small-cell lung cancer patients...
  8. doi Prognostic impact of intratumoural microvascular invasion and microlymphatic permeation on node-negative non-small-cell lung cancer: which indicator is the stronger prognostic factor?
    Tomoyuki Hishida
    Division of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 43:772-7. 2013
    ..The aim of the current study was to clarify the prognostic impact of microvascular invasion and microlymphatic permeation on resected node-negative NSCLC by comparative analyses...
  9. ncbi Is surgical resection indicated for a solitary non-small cell lung cancer recurrence?
    Tomoyuki Hishida
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 131:838-42. 2006
    ..Some investigators have reported long-term survival after surgical resection of a solitary non-small cell lung cancer recurrence in various sites. However, the role and indications of the second operation remain unclear...
  10. ncbi Problems in the current diagnostic standards of clinical N1 non-small cell lung cancer
    T Hishida
    Department of Thoracic Oncology, National Cancer Centre Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577 Japan
    Thorax 63:526-31. 2008
    ..One possible reason may be that cN1disease diagnosed by current standard imaging modalities often contains unexpected N2 disease. This study was conducted to evaluate the surgical and pathological results of patients with cN1 NSCLC...
  11. doi Extraskeletal osteosarcoma arising in anterior mediastinum: brief report with a review of the literature
    Tomoyuki Hishida
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Oncol 4:927-9. 2009
    ..Complete surgical resection was successfully performed, and histologically the tumor contained osteoid formation consisting of round atypical cells. The literature concerning this rare tumor is reviewed...
  12. doi Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma
    Shinya Neri
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Surg Oncol 19:3953-62. 2012
    ..However, whether podoplanin(+)-CAFs also can be recruited into metastatic lymph nodes and influence the prognosis remains unclear...
  13. ncbi Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phe
    Shotaro Ono
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 143:963-70. 2013
    ..The purpose of this study was to analyze the prognostic markers of stage I squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both cancer cells and CAFs...
  14. doi Influence of cigarette smoking on survival and tumor invasiveness in clinical stage IA lung adenocarcinoma
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 93:1626-32. 2012
    ..The objective of this study was to investigate the association between cigarette smoking, cancer survival, and pathological features of clinical stage IA lung adenocarcinoma...
  15. doi Prognostic impact of node involvement pattern in pN1 non-small cell lung cancer patients
    Masayuki Nakao
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1576-82. 2010
    ..The purpose of this study was to evaluate the prognostic effect of node involvement patterns in pN1 non-small cell lung cancer (NSCLC) patients, with special attention given to any differences between SCC and adenocarcinoma (AD)...
  16. doi Prognostic impact of node involvement pattern in pulmonary pN1 squamous cell carcinoma patients
    Masayuki Nakao
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Oncol 5:504-9. 2010
    ..The purpose of this study was to evaluate the prognostic impact of lymph node involvement patterns in pulmonary pN1 SCC patients...
  17. doi Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation
    Keiju Aokage
    Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Int J Cancer 128:1585-95. 2011
    ..001) expression in comparison with cancer cells in BVBs. Our results suggested that in the early phase of metastatic tumor formation cancer cells undergo dynamic phenotypic change associated with EMT and subsequent MET...
  18. doi Long-term outcome and late recurrence in patients with completely resected stage IA non-small cell lung cancer
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, and daggerDepartment of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1246-50. 2010
    ..The purpose of this study was to quantify the risk of late recurrence in patients with stage IA non-small cell lung cancer (NSCLC) who remained recurrence-free for more than 5 years after resection...
  19. doi Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms
    Masakazu Kojika
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Mod Pathol 22:1341-50. 2009
    ....
  20. doi Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma
    Kaoru Kaseda
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    Cancer Sci 104:1262-9. 2013
    ....
  21. doi Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis
    Yuki Matsumura
    Pathology Division, Research Center for Innovative Oncology, Chiba, Japan
    Cancer Sci 103:1342-7. 2012
    ..The present study reveals that intralymphatic cancer cell and stromal cell phenotypes are susceptible to lymphogenic metastasis, suggesting that lymphogenic metastasis may be affected by the intralymphatic microenvironment they create...
  22. doi Risk factors for tumor recurrence in patients with early-stage (stage I and II) non-small cell lung cancer: patient selection criteria for adjuvant chemotherapy according to the seventh edition TNM classification
    Ryo Maeda
    Department of Thoracic Oncology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    Chest 140:1494-502. 2011
    ..The purpose of this study was to evaluate risk factors for tumor recurrence in patients with completely resected early-stage non-small cell lung cancer (NSCLC)...
  23. doi Late recurrence of non-small cell lung cancer more than 5 years after complete resection: incidence and clinical implications in patient follow-up
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    Chest 138:145-50. 2010
    ..The purpose of this study was to evaluate the risk of late recurrence in patients who had undergone complete resection for non-small cell lung cancer (NSCLC) and remained recurrence-free for > or = 5 years...
  24. doi Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients
    Junji Yoshida
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    J Thorac Oncol 5:546-50. 2010
    ..However, recently three of the 24 patients, with mixed GGO lesions intraoperatively diagnosed as type B, developed a solid lesion at the cut-end scar...
  25. doi Identification of prognostic immunophenotypic features in cancer stromal cells of high-grade neuroendocrine carcinomas of the lung
    Akiko Takahashi
    Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa City, Chiba, 277 8577, Japan
    J Cancer Res Clin Oncol 139:1869-78. 2013
    ....
  26. doi Distinctive histopathological features of lepidic growth predominant node-negative adenocarcinomas 3-5 cm in size
    Yusuke Takahashi
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Lung Cancer 79:118-24. 2013
    ..However, in large adenocarcinomas (3-5 cm in size), the clinicopathological significance of LG components remains unclear...
  27. doi Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma
    Tomonari Kinoshita
    Division of Pathology, Research Center for Innovative Oncology, Chiba, Japan
    Cancer Sci 104:409-15. 2013
    ..Our studies suggest the possibility that CAF expressing immunoregulatory cytokines may induce Treg in the stroma, creating a tumor-promoting microenvironment in lung adenocarcinoma that leads to a poor outcome...
  28. doi Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment
    Shunki Hirayama
    Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 7:1790-7. 2012
    ..The aim of this study was to clarify the correlation between CD204 (+) TAMs and the clinicopathological features of lung squamous cell carcinoma...
  29. doi Predictive factors of pathologically proven noninvasive tumor characteristics in T1aN0M0 peripheral non-small cell lung cancer
    Yoshihisa Shimada
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 141:1003-9. 2012
    ....
  30. doi Long-term survival and risk factors for recurrence in stage I non-small cell lung cancer patients with tumors up to 3 cm in maximum dimension
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Chest 138:357-62. 2010
    ....
  31. doi Low-fat diet management strategy for chylothorax after pulmonary resection and lymph node dissection for primary lung cancer
    Teruhisa Takuwa
    Division of Thoracic Surgery, Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 146:571-4. 2013
    ..We reviewed our experience of iatrogenic chylothorax after pulmonary resection for primary lung cancer to evaluate a low-fat diet management strategy...
  32. doi The clinical outcome of non-small cell lung cancer patients with adjacent lobe invasion: the optimal classification according to the status of the interlobar pleura at the invasion point
    Yoichi Ohtaki
    Division of Thoracic Surgery, National Cancer Centre Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 43:302-9. 2013
    ..The aim of this study was to analyse the survival of non-small cell lung cancer (NSCLC) patients with adjacent lobe invasion (ALI) with emphasis on the interlobar fissure status at the tumour invasion point...
  33. doi Characteristic immunophenotype of solid subtype component in lung adenocarcinoma
    Teruhisa Takuwa
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Surg Oncol 19:3943-52. 2012
    ..The aim of this study was to evaluate the characteristic immunophenotype of the solid subtype component compared with the immunophenotypes of other components...
  34. doi Long-term outcomes of 50 cases of limited-resection trial for pulmonary ground-glass opacity nodules
    Masayuki Nakao
    Department of Thoracic Oncology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Oncol 7:1563-6. 2012
    ..From 1998 to 2002, we performed a trial of prospective limited resection for pulmonary ground-glass opacity lesions 2 cm or smaller. This is the second report on the long-term outcome...
  35. doi Differences between squamous cell carcinoma and adenocarcinoma of the lung: are adenocarcinoma and squamous cell carcinoma prognostically equal?
    Akikazu Kawase
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 42:189-95. 2012
    ..We analyzed pulmonary squamous cell carcinoma and adenocarcinoma patient survival in our single institution database, to evaluate the relationship of histologic analysis to survival and tumor aggressiveness...
  36. doi Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma
    Masayuki Nakao
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer 115:2732-43. 2009
    ....
  37. doi Influence of cigarette smoking on histological subtypes of stage I lung adenocarcinoma
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 6:743-50. 2011
    ..The purpose of this study was to examine the association between cigarette smoking and histological subtypes of lung adenocarcinoma...
  38. doi Prognostic significance of a solid component in pulmonary adenocarcinoma
    Yoichi Ohtaki
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 91:1051-7. 2011
    ....
  39. doi Extratumoral vascular invasion is a significant prognostic indicator and a predicting factor of distant metastasis in non-small cell lung cancer
    Yoshihisa Shimada
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:970-5. 2010
    ....
  40. doi Subcarinal lymph node in upper lobe non-small cell lung cancer patients: is selective lymph node dissection valid?
    Keiju Aokage
    Division of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 70:163-7. 2010
    ..It appears valid to omit subcarinal node dissection in upper lobe NSCLC patients, especially in clinical N0 squamous cell carcinoma patients...
  41. doi Clinical features of unresectable high-grade lung neuroendocrine carcinoma diagnosed using biopsy specimens
    Yoshihisa Shimada
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Lung Cancer 75:368-73. 2012
    ..The aim of this study was to elucidate the clinical features of high-grade neuroendocrine carcinoma (HGNEC)-probable LCNEC diagnosed by biopsy, and compare therapeutic efficacy with patients with SCLC...
  42. doi The impact on survival of positive intraoperative pleural lavage cytology in patients with non-small-cell lung cancer
    Keiju Aokage
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 139:1246-52, 1252.e1. 2010
    ..The aim of this study was to analyze intraoperative pleural lavage cytology results in patients with non-small-cell lung cancer and quantify the impact on survival and recurrence...
  43. doi Reasonable extent of lymph node dissection in intentional segmentectomy for small-sized peripheral non-small-cell lung cancer: from the clinicopathological findings of patients who underwent lobectomy with systematic lymph node dissection
    Yuki Matsumura
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    J Thorac Oncol 7:1691-7. 2012
    ..The purpose of this study was to clarify the reasonable extent of dissection during intentional segmentectomy for peripheral cT1aN0M0 NSCLC...
  44. doi Pulmonary metastasis from encapsulated cervical ectopic type a thymoma
    Tomonari Kinoshita
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 94:e141-2. 2012
    ..There have been few reports on cervical ectopic thymoma metastasizing to a distant site and, to the best of our knowledge, this is the first case report of a cervical ectopic type A thymoma with distant metastasis...
  45. doi Number of circulating endothelial progenitor cells and intratumoral microvessel density in non-small cell lung cancer patients: differences in angiogenic status between adenocarcinoma histologic subtypes
    Ryo Maeda
    Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 7:503-11. 2012
    ....
  46. ncbi Two lung adenocarcinomas in the same lobe: multiple primaries or intrapulmonary metastasis?
    Kentaro Yoshimoto
    Department of Thoracic Oncolog, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Ann Thorac Cardiovasc Surg 17:584-7. 2011
    ..Although we expected EGFR gene mutation analysis would help us distinguish the 2 lesions from each other, it was of little help. Disease history can be more important in evaluating multiple pulmonary cancers...
  47. doi Tumor invasion of extralobar soft tissue beyond the hilar region does not affect the prognosis of surgically resected lung cancer patients
    Hajime Otsuka
    Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1571-5. 2010
    ..The purpose of this study is to evaluate the significance of tumor invasion of that region as a prognostic factor...
  48. doi Poor prognostic factors in patients with stage IB non-small cell lung cancer according to the seventh edition TNM classification
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277 8577, Japan
    Chest 139:855-61. 2011
    ..This study investigated poor prognostic factors in patients with stage IB non-small cell lung cancer (NSCLC) according to the seventh edition of the TNM classification...
  49. doi The difference in Ezrin-pAkt signaling axis between lepidic and papillary predominant invasive adenocarcinomas of the lung
    Kazunori Hata
    Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    J Cancer Res Clin Oncol 142:1421-30. 2016
    ..The purpose of this study was to clarify biological differences between PPA and LPA...
  50. ncbi Outcomes of segmentectomy and wedge resection for pulmonary metastases from colorectal cancer
    Satoshi Shiono
    Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Eur J Cardiothorac Surg . 2016
    ..Although wedge resection is the most common surgical procedure for pulmonary metastases from colorectal cancer, there are few reports about segmentectomy for colorectal metastasectomy...
  51. doi Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma
    Nao Aramaki
    Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    J Cancer Res Clin Oncol 142:37-46. 2016
    ..The aim of this study was to elucidate the morphological and phenotypical differences between micrometastatic and macrometastatic tumors...
  52. doi Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation
    Hideomi Ichinokawa
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 277 8577 Chiba, Japan Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277 8577 Chiba, Japan Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 277 8577 Chiba, Japan
    Hum Pathol 44:2636-42. 2013
    ..The current study clearly demonstrated that mucinous adenocarcinomas with KRAS mutations have clinicopathologic characteristics different from those of mucinous adenocarcinoma without such mutations. ..
  53. doi Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma
    Akikazu Kawase
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Int J Cancer 123:1053-9. 2008
    ..092). The results of this study highlight the importance of podoplanin expression by CAFs and provide new insights into the biology of the cancer microenvironment in adenocarcinoma of the lung...
  54. doi The recurrence of malignant pleural mesothelioma 14 years after extrapleural pneumonectomy: possible histological transformation
    Tomonari Kinoshita
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Pathol Int 62:754-7. 2012
    ..Although there have been some previous reports on the recurrence of MPM, to the best of our knowledge, this is the first clinical case which indicated that histological transformation of MPM might occur...
  55. doi Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma
    Yoichi Ohtaki
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1507-15. 2010
    ..Alternatively, activated macrophages (M2 phenotype) are known to be related to tumor progression and outcome, and CD204 has been reported to be expressed in M2 macrophages in some tumors...
  56. ncbi Late pulmonary metastasis of a rectal cancer resected 20 years after low anterior resection
    Kenji Takahashi
    Department of Thoracic Oncology, National Cancer Center Hospital East, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 14:386-9. 2008
    ..This shows that pulmonary metastasis from colorectal cancer is possible even 20 years after the initial operation...
  57. doi Visceral pleural invasion classification in non-small cell lung cancer
    Akikazu Kawase
    Division of Thoracic Surgery, National Cancer Center Hospital East, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1784-8. 2010
    ....
  58. doi Fibrous stroma is associated with poorer prognosis in lung squamous cell carcinoma patients
    Yusuke Takahashi
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 6:1460-7. 2011
    ..The aim of this study was to examine whether the histological properties of peritumoral stroma are correlated with squamous cell carcinoma (SqCC) aggressiveness and clinical outcome...
  59. doi Clinicopathological characteristics of primary lung adenocarcinoma predominantly composed of goblet cells in surgically resected cases
    Hideomi Ichinokawa
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba
    Pathol Int 61:423-9. 2011
    ..In conclusion, APGC formed a distinct subset and should be considered separately from lung adenocarcinoma based on frequent involvement of the left and lower lung and lack of central fibrosis...
  60. doi The prognostic impact of cigarette smoking on patients with non-small cell lung cancer
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    J Thorac Oncol 6:735-42. 2011
    ....
  61. doi Centrally located adenocarcinoma with endobronchial polypoid growth: clinicopathological analysis of five cases
    Tomoyuki Hishida
    Pathology Division, Research Center for Innovative Oncology, Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Pathol Int 61:73-9. 2011
    ....
  62. doi Histological progression of small intrapulmonary metastatic tumor from primary lung adenocarcinoma
    Keiju Aokage
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Pathol Int 60:765-73. 2010
    ..These findings suggest that implanted cancer cells display lepidic growth in the early metastatic phase and recapitulate the morphological heterogeneity of the original tumor as the metastasis enlarges...
  63. doi Ezrin-expressing lung adenocarcinoma cells and podoplanin-positive fibroblasts form a malignant microenvironment
    Shigeki Suzuki
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    J Cancer Res Clin Oncol 141:475-84. 2015
    ..So we identified the characteristic immunophenotype of lung adenocarcinoma cells coexisting with PDPN-expressing CAFs (PDPN-CAFs) and examined how it relates to an aggressive clinicopathological outcome...
  64. doi Prognostic impact of histology on early-stage non-small cell lung cancer
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 140:135-45. 2011
    ..The purpose of this study is to evaluate the significance of histology as a predictor of recurrence after resection in patients with early-stage non-small cell lung cancer...
  65. pmc Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma
    Yuki Matsumura
    Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan
    J Cancer Res Clin Oncol 141:2159-70. 2015
    ....
  66. doi The differences of biological behavior based on the clinicopathological data between resectable large-cell neuroendocrine carcinoma and small-cell lung carcinoma
    Tomonari Kinoshita
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Clin Lung Cancer 14:535-40. 2013
    ..However, there have been few reports focusing on the differences of clinicopathological prognostic factors between resectable LCNEC and SCLC...
  67. doi Prognostic impact of intratumoral vascular invasion in non-small cell lung cancer patients
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Thorax 65:1092-8. 2010
    ..The purpose of this study was to evaluate its significance as a risk factor for recurrence...
  68. doi Malignant granular cell tumor of the posterior mediastinum with dissemination
    Masayuki Nakao
    Division of Thoracic Surgery, Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Asian Cardiovasc Thorac Ann 20:71-3. 2012
    ..Histologically, the tumor was composed of cells with large eosinophilic and granular cytoplasm, which were strongly positive for S-100. Mediastinal malignant granular cell tumor with pleural dissemination is extremely unusual...
  69. doi Expression of podoplanin, CD44, and p63 in squamous cell carcinoma of the lung
    Yoshihisa Shimada
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer Sci 100:2054-9. 2009
    ....
  70. ncbi Complete left-sided pericardial defect in a lung cancer patient undergoing pneumonectomy without closure of the defect
    Yoshihisa Shimada
    Division of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Ann Thorac Cardiovasc Surg 17:67-70. 2011
    ..Complete pericardial defects usually do not endanger the lives of patients, and if the patient is asymptomatic, surgical repair of the defect may be unnecessary even during a left pneumonectomy...
  71. doi Prognostic impact of microscopic vessel invasion and visceral pleural invasion in non-small cell lung cancer: a retrospective analysis of 2657 patients
    Shinya Neri
    Division of Thoracic Surgery, National Cancer Center Hospital East Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Surg 260:383-8. 2014
    ..We aimed to assess the prognostic significance of microscopic vessel invasion (MVI) and visceral pleural invasion (VPI) in non-small cell lung cancer (NSCLC)...
  72. pmc Impact of extratumoral lymphatic permeation on postoperative survival of non-small-cell lung cancer patients
    Yuki Matsumura
    Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan and Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Oncol 9:337-44. 2014
    ..The purpose of this study was to determine the survival impact of extratumoral lymphatic permeation in patients with resected NSCLC by analyzing the long-term follow-up data...
  73. doi The role of pulmonary resection in tumors metastatic from head and neck carcinomas
    Hiroyuki Daiko
    Department of Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 40:639-44. 2010
    ..The purpose of this study was to determine the role of surgical treatment and to identify factors affecting the survival of patients undergoing pulmonary resection for tumors metastatic from head and neck carcinomas...
  74. doi Identification of early t1b lung adenocarcinoma based on thin-section computed tomography findings
    Keiju Aokage
    Divisions of Thoracic Surgery and Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 8:1289-94. 2013
    ..The aim of this study was to radiologically identify early lung adenocarcinoma in clinical T1bN0M0 lung cancer, based on pathological findings and long-term prognosis...
  75. ncbi Risk factors of postoperative respiratory infections in lung cancer surgery
    Satoshi Shiono
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 2:34-8. 2007
    ..Postoperative infections have been a major issue in lung cancer surgery. We changed our perioperative prophylactic antibiotic policy to a single dose of cefazolin before and after surgery in July 2002...
  76. ncbi Multiple sclerosing hemangiomas with a 10-year history
    Tomoyuki Hishida
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277 8577, Japan
    Jpn J Clin Oncol 35:37-9. 2005
    ..We followed this patient by annual chest CT scans for 10 years and demonstrated that all residual nodules remained unchanged. This is the first report of stable multiple pulmonary sclerosing hemangiomas observed for such a long period...
  77. ncbi Differences in clinicopathological and biological features between central-type and peripheral-type squamous cell carcinoma of the lung
    Takamoto Saijo
    Pathology Division, National Cancer Center Research Institute East, Kashiwa, Chiba, Japan
    Lung Cancer 52:37-45. 2006
    ..These results suggest that C-type and P-type SCC have different clinicopathological and biological features...
  78. ncbi Malignant glomus tumor of the lung
    Tomoyuki Hishida
    Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 53:632-6. 2003
    ..We believe that this is the fourth reported case of malignant glomus tumor of the lung...
  79. ncbi Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells
    Hakan Akca
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Lung Cancer 54:25-33. 2006
    ..This specific property due to EGFR mutation could be an important step of multistage lung cancer progression...