Affiliation: Hamamatsu University School of Medicine
Muregi F, Kino H, Ishih A. Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model. Exp Parasitol. 2008;120:286-9 pubmed publisher
..05). Our findings do not seem to support the hypothesis of selective de novo metabolism of DAP to AMP by the malarial parasite. ..
Muregi F, Kano S, Kino H, Ishih A. Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model. Exp Parasitol. 2009;121:376-80 pubmed publisher
..Drugs in a synergistic combination may exert less resistance selection pressure, thus FOA-PYR and FOA-DAP-ART warrant further evaluation with an ultimate object of possible clinical use against drug-resistant malaria. ..
Muregi F, Kirira P, Ishih A. Novel rational drug design strategies with potential to revolutionize malaria chemotherapy. Curr Med Chem. 2011;18:113-43 pubmed
..We thus explore malaria apoptosis machinery as a novel drug target, and also discuss the potential of hybrid molecules as well as prodrugs and double prodrugs in malaria chemotherapy. ..