R Ientile


Affiliation: University of Messina
Country: Italy


  1. request reprint
    Ientile R, Caccamo D, Marciano M, Currò M, Mannucci C, Campisi A, et al. Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia. Neurosci Lett. 2004;363:173-7 pubmed
    ..Our results suggest that increases in transglutaminases may be part of the tissue stress response in global brain ischemia. ..
  2. request reprint
    Ientile R, Caccamo D, Macaione V, Torre V, Macaione S. NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells. Neuroscience. 2002;115:723-9 pubmed
    ..Therefore, it is reasonable to hypothesize that if tissue transglutaminase levels and activity are up-regulated under such conditions, the protein cross-linking could be likely involved in excitotoxic response. ..
  3. request reprint
    Ientile R, Macaione V, Teletta M, Pedale S, Torre V, Macaione S. Apoptosis and necrosis occurring in excitotoxic cell death in isolated chick embryo retina. J Neurochem. 2001;79:71-8 pubmed
  4. Ientile R, Currò M, Caccamo D. Transglutaminase 2 and neuroinflammation. Amino Acids. 2015;47:19-26 pubmed publisher
    ..Together, evidence suggests that TG2 plays a role in neuroinflammation and contributes to the production of compounds that are potentially deleterious to neuronal cells. ..
  5. Matarese G, Currò M, Isola G, Caccamo D, Vecchio M, Giunta M, et al. Transglutaminase 2 up-regulation is associated with RANKL/OPG pathway in cultured HPDL cells and THP-1-differentiated macrophages. Amino Acids. 2015;47:2447-55 pubmed publisher
    ..Given the RANKL key role in NF-κB pathway and the observed up-regulation of pro-inflammatory cytokines, our data suggest that TG2 may be involved in molecular mechanisms of inflammatory response occurring in periodontal disease. ..
  6. Currò M, Di Mauro D, Bruschetta D, D Amico F, Vecchio M, Trimarchi F, et al. Influence of MTHFR polymorphisms on cardiovascular risk markers in elite athletes. Clin Biochem. 2016;49:183-5 pubmed publisher
    ..Elite hurdlers, having an unfavorable MTHFR genotype are exposed to increased cardiovascular risk, dependent on alterations of homocysteine and AOPP plasma levels. ..
  7. Currò M, Russo T, Ferlazzo N, Caccamo D, Antonuccio P, Arena S, et al. Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. Molecules. 2018;23: pubmed publisher
    ..A randomized clinical trial on a large number of children affected by BXO might be useful to verify the efficacy of topical treatment with OZOILE®. ..
  8. Caccamo D, Ricca S, Currò M, Ientile R. Health Risks of Hypovitaminosis D: A Review of New Molecular Insights. Int J Mol Sci. 2018;19: pubmed publisher
    ..This review will focus on the emerging evidence about non-classical biological functions of vitamin D in various disorders. ..
  9. Currò M, Gangemi C, Giunta M, Ferlazzo N, Navarra M, Ientile R, et al. Transglutaminase 2 is involved in amyloid-beta1-42-induced pro-inflammatory activation via AP1/JNK signalling pathways in THP-1 monocytes. Amino Acids. 2017;49:659-669 pubmed publisher
    ..Our preliminary findings first suggest that TG2 up-regulation is involved in the pro-inflammatory activation of THP-1 monocytes induced by Aβ1-42 via AP1/JNK signalling pathways. ..

More Information


  1. Ferlazzo N, Currò M, Zinellu A, Caccamo D, Isola G, Ventura V, et al. Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer. Int J Mol Sci. 2017;18: pubmed publisher
    ..The frequency of p16 and MGMT methylation was around 60% in patients with either the CT/AC or TT/AA genotype. Our results suggest that hypermethylation of cancer-related genes may be affected by MTHFR polymorphisms. ..
  2. Russo T, Currò M, Barbera A, Caccamo D, Antonuccio P, Arena S, et al. Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. Int J Mol Sci. 2016;17: pubmed publisher
    ..Increased expression of TG2 can be the result of chronic inflammation. TG2 overexpression can play a pivotal role in triggering and maintaining the inflammatory response in BXO patients. ..