Betti Giusti


Affiliation: University of Florence
Country: Italy


  1. Sticchi E, Giusti B, Cordisco A, Gori A, Sereni A, Sofi F, et al. Role of lipoprotein (a) and LPA KIV2 repeat polymorphism in bicuspid aortic valve stenosis and calcification: a proof of concept study. Intern Emerg Med. 2018;: pubmed publisher
    ..043] were also found. In conclusion, present data suggest the potential role for Lp(a) as a possible risk marker useful to stratify, among BAV patients, those with a higher chance to develop valvular calcifications and aortic stenosis. ..
  2. Giusti B, Galora S, Saracini C, Pratesi G, Gensini G, Pulli R, et al. Role of rs1466535 low density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism in carotid artery disease. Atherosclerosis. 2014;237:135-7 pubmed publisher
    ..Our result suggests this polymorphism in the LRP1 gene is not associated with atherosclerosis in general as it is not associated with CAS (this study), whereas it is strictly associated with AAA (our previous paper). ..
  3. Giusti B, Marini M, Rossi L, Lapini I, Magi A, Capalbo A, et al. Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection. BMC Genomics. 2009;10:342 pubmed publisher
  4. Magi A, D Aurizio R, Palombo F, Cifola I, Tattini L, Semeraro R, et al. Characterization and identification of hidden rare variants in the human genome. BMC Genomics. 2015;16:340 pubmed publisher
    ..For this reason, also future resequencing experiments, based on GRCh38, will benefit from RAREVATOR analysis results. RAREVATOR is freely available at . ..
  5. Giusti B, Gori A, Marcucci R, Abbate R. Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis. Expert Opin Drug Metab Toxicol. 2010;6:393-407 pubmed publisher
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    Giusti B, Gori A, Marcucci R, Sestini I, Saracini C, Paniccia R, et al. Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment. Atherosclerosis. 2008;196:341-8 pubmed
  7. Giusti B, Gori A, Marcucci R, Sestini I, Saracini C, Sticchi E, et al. Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility. PLoS ONE. 2007;2:e495 pubmed
    ..8 (1.68-4.54 95%CI) in Q2 to 12.9 (7.96-21.06 95%CI) in Q4. Our data demonstrated the four polymorphisms, although able, at least in part, to affect Hcy, were not associated with an increased risk of NVAF per se or in combination. ..
  8. Giusti B, Sestini I, Saracini C, Sticchi E, Bolli P, Magi A, et al. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. Biochem Genet. 2008;46:406-23 pubmed publisher
    ..2% concordance. We also performed a haplotype analysis. This approach could represent a useful tool to investigate the genotype-phenotype correlation and the association of these genes with hyperhomocysteinemia and correlated diseases. ..
  9. Giusti B, Rossi L, Lapini I, Magi A, Pratesi G, Lavitrano M, et al. Gene expression profiling of peripheral blood in patients with abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 2009;38:104-12 pubmed publisher
    ..Our data underline the power of microarrays in identifying further molecular perturbations associated with AAA. ..

More Information


  1. Giusti B, Gori A, Marcucci R, Saracini C, Sestini I, Paniccia R, et al. Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis. Am J Cardiol. 2009;103:806-11 pubmed publisher
    ..These findings could impact on the future design of pharmacogenetic antiaggregant strategies. ..
  2. Giusti B, Saracini C, Bolli P, Magi A, Martinelli I, Peyvandi F, et al. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Thromb Haemost. 2010;104:231-42 pubmed publisher
    ..This study identifies significant genetic associations between premature ischaemic stroke and haplotypes in BHMT, CBS, FOLH1, MTR, PON2, TCN2 and TYMS genes involved in methionine metabolism. ..
  3. Galora S, Saracini C, Pratesi G, Sticchi E, Pulli R, Pratesi C, et al. Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients. J Vasc Surg. 2015;61:787-92 pubmed publisher
  4. request reprint
    Giusti B, Gori A, Marcucci R, Saracini C, Sestini I, Paniccia R, et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet Genomics. 2007;17:1057-64 pubmed
    ..These findings can have a significant impact on the future design of pharmacogenetic antiaggregant strategies for high-risk vascular patients on dual antiplatelet treatment. ..
  5. De Cario R, Sticchi E, Lucarini L, Attanasio M, Nistri S, Marcucci R, et al. Role of TGFBR1 and TGFBR2 genetic variants in Marfan syndrome. J Vasc Surg. 2018;68:225-233.e5 pubmed publisher