Massimo Ghio

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation
    Paola Contini
    Department of Internal Medicine DIMI, University of Genova, Genova, Italy
    Eur J Immunol 33:125-34. 2003
  2. doi Immunomodulatory effects of blood transfusions: the synergic role of soluble HLA Class I free heavy-chain molecules detectable in blood components
    Massimo Ghio
    Department of Internal Medicine, University and San Martino Hospital of Genoa, Genoa, Italy
    Transfusion 48:1591-7. 2008
  3. doi sHLA-I contaminating molecules as novel mechanism of ex vivo/in vitro transcriptional and posttranscriptional modulation of transforming growth factor-beta in CD8+ T lymphocytes and neutrophils after intravenous immunoglobulin treatment
    Massimo Ghio
    Division of Clinical Immunology and Internal Medicine, University of Genoa Medical School, Genoa, Italy
    Transfusion 50:547-55. 2010
  4. doi sHLA-I Contamination, a novel mechanism to explain ex vivo/in vitro modulation of IL-10 synthesis and release in CD8(+) T lymphocytes and in neutrophils following intravenous immunoglobulin infusion
    Massimo Ghio
    Division of Clinical Immunology, Department of Internal Medicine, University of Genoa Medical School, 16132, Genoa, Italy
    J Clin Immunol 30:384-92. 2010
  5. ncbi Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function
    Gilberto Filaci
    Department of Internal Medicine, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    Hum Immunol 65:142-56. 2004
  6. ncbi IFN-gamma production in human NK cells through the engagement of CD8 by soluble or surface HLA class I molecules
    Grazia Maria Spaggiari
    Laboratory of Immunology, National Institute for Cancer Research IST, Genoa, Italy
    Eur J Immunol 33:3049-59. 2003
  7. ncbi CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers
    Gilberto Filaci
    Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    J Immunol 179:4323-34. 2007
  8. doi Brachial artery endothelial-dependent flow-mediated dilation identifies early-stage endothelial dysfunction in systemic sclerosis and correlates with nailfold microvascular impairment
    Daniela Rollando
    Academic Unit of Cardiovascular Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 37:1168-73. 2010
  9. ncbi Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-beta1 by neutrophils: role of the immunoglobulinlike transcript 1, sFasL, and sHLA-I
    Luciano Ottonello
    Divisions of Internal Medicine and Clinical Immunology, Department of Internal Medicine, University of Genoa Medical School, Viale Benedetto XV 6, I 16132 Genoa, Italy
    Transfusion 47:1395-404. 2007
  10. doi Lactulose breath test to assess oro-cecal transit delay and estimate esophageal dysmotility in scleroderma patients
    Lorenzo Gemignani
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Semin Arthritis Rheum 42:522-9. 2013

Collaborators

Detail Information

Publications32

  1. ncbi Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation
    Paola Contini
    Department of Internal Medicine DIMI, University of Genova, Genova, Italy
    Eur J Immunol 33:125-34. 2003
    ..In contrast, non-classical HLA class I molecules may exert immunomodulatory effects in particular conditions characterized by elevated sHLA-G levels such as pregnancy and some neoplastic diseases...
  2. doi Immunomodulatory effects of blood transfusions: the synergic role of soluble HLA Class I free heavy-chain molecules detectable in blood components
    Massimo Ghio
    Department of Internal Medicine, University and San Martino Hospital of Genoa, Genoa, Italy
    Transfusion 48:1591-7. 2008
    ..Moreover, the immunosuppressive potential of blood products grows with the time of their storage and becomes highest in nonleukoreduced blood products stored for a long time...
  3. doi sHLA-I contaminating molecules as novel mechanism of ex vivo/in vitro transcriptional and posttranscriptional modulation of transforming growth factor-beta in CD8+ T lymphocytes and neutrophils after intravenous immunoglobulin treatment
    Massimo Ghio
    Division of Clinical Immunology and Internal Medicine, University of Genoa Medical School, Genoa, Italy
    Transfusion 50:547-55. 2010
    ....
  4. doi sHLA-I Contamination, a novel mechanism to explain ex vivo/in vitro modulation of IL-10 synthesis and release in CD8(+) T lymphocytes and in neutrophils following intravenous immunoglobulin infusion
    Massimo Ghio
    Division of Clinical Immunology, Department of Internal Medicine, University of Genoa Medical School, 16132, Genoa, Italy
    J Clin Immunol 30:384-92. 2010
    ....
  5. ncbi Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function
    Gilberto Filaci
    Department of Internal Medicine, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    Hum Immunol 65:142-56. 2004
    ..These findings can be helpful for the better understanding of immune regulatory circuits and for the definition of new pathogenic aspects in autoimmunity and tumor immunology...
  6. ncbi IFN-gamma production in human NK cells through the engagement of CD8 by soluble or surface HLA class I molecules
    Grazia Maria Spaggiari
    Laboratory of Immunology, National Institute for Cancer Research IST, Genoa, Italy
    Eur J Immunol 33:3049-59. 2003
    ..Altogether, these findings indicate that CD8 engagement by sHLA-I activates a cyclosporin A-dependent pathway leading to production and secretion of IFN-gamma which may play a role in the regulation of innate immune responses in humans...
  7. ncbi CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers
    Gilberto Filaci
    Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    J Immunol 179:4323-34. 2007
    ..Collectively, these results have pathogenic relevance and implication for immunotherapy of cancer...
  8. doi Brachial artery endothelial-dependent flow-mediated dilation identifies early-stage endothelial dysfunction in systemic sclerosis and correlates with nailfold microvascular impairment
    Daniela Rollando
    Academic Unit of Cardiovascular Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 37:1168-73. 2010
    ..Evidence has shown that vascular impairment in SSc may be a sign of endothelial dysfunction involving both microvascular and macrovascular systems, although the pathological mechanisms of the dysfunction are poorly understood...
  9. ncbi Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-beta1 by neutrophils: role of the immunoglobulinlike transcript 1, sFasL, and sHLA-I
    Luciano Ottonello
    Divisions of Internal Medicine and Clinical Immunology, Department of Internal Medicine, University of Genoa Medical School, Viale Benedetto XV 6, I 16132 Genoa, Italy
    Transfusion 47:1395-404. 2007
    ..Such inhibitory activity is due to transforming growth factor (TGF)-beta1 contained in the supernatants that desensitize neutrophils to subsequent chemotaxic stimulation...
  10. doi Lactulose breath test to assess oro-cecal transit delay and estimate esophageal dysmotility in scleroderma patients
    Lorenzo Gemignani
    Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Genoa, Italy
    Semin Arthritis Rheum 42:522-9. 2013
    ..To assess the correlation between delayed oro-cecal transit time (OCTT) and esophageal motility abnormalities in a cohort of systemic sclerosis (SSc) patients...
  11. ncbi Immune homeostasis requires several biologic factors including glucocorticoid hormones
    Corraddo Cancedda
    Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:49-63. 2002
    ..Taken together, these data suggest the presence of a complex network of immunoregulatory mechanisms in which CTSs play a strong role supporting their recognized efficacy in the treatment of inflammatory and immunological diseases...
  12. doi Gastroesophageal reflux and pulmonary fibrosis in scleroderma: a study using pH-impedance monitoring
    Edoardo Savarino
    Division of Gastroenterology, University of Genoa, Genoa, Italy
    Am J Respir Crit Care Med 179:408-13. 2009
    ..Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with increased morbidity and mortality. Gastroesophageal reflux (GER) is considered a contributing factor in the pathogenesis of ILD...
  13. doi Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis
    Daniela Fenoglio
    Centre of Excellence for Biomedical Research CEBR, University of Genoa, Viale Benedetto XV, Genoa, Italy
    Clin Immunol 139:249-57. 2011
    ..Collectively, these data highlight the existence of an imbalanced ratio between Th17 and Treg cell subsets in SSc patients...
  14. doi Down regulation of human natural killer cell-mediated cytolysis induced by blood transfusion: role of transforming growth factor-β(1), soluble Fas ligand, and soluble Class I human leukocyte antigen
    Massimo Ghio
    Laboratory of Clinical Immunology, Azienda Ospedaliera Universitaria San Martino DIMI, Genoa, Italy
    Transfusion 51:1567-73. 2011
    ..The molecular mechanisms of down regulation of NK-cell activity observed after red blood cell (RBC) transfusion is still undefined...
  15. doi Immunomodulation due to plasma or plasma-platelet apheresis donation: Events occurring during donation procedures
    Massimo Ghio
    Department of Internal Medicine, I R C C S A O U San Martino IST, Genova, Italy
    J Clin Apher 30:204-11. 2015
    ..On this basis, it could be hypothesized that such events can cause immune modulation. It is uncertain which blood cell population is most impacted by these events. This study is focused on the effects on the T lymphocytes...
  16. doi Small intestinal bacterial overgrowth in patients suffering from scleroderma: clinical effectiveness of its eradication
    Andrea Parodi
    Di M I Unit of Gastroenterology, University of Genoa, Genoa, Italy
    Am J Gastroenterol 103:1257-62. 2008
    ..After the skin, the gastrointestinal tract is the second most common target of systemic sclerosis (SSc)...
  17. doi Granulocytes and monocytes apheresis induces upregulation of TGFβ1 in patients with active ulcerative colitis: A possible involvement of soluble HLA-I
    Paola Contini
    Department of Internal Medicine, I R C C S A O U San Martino IST and University of Genoa, Genova, Italy
    J Clin Apher . 2016
    ..J. Clin. Apheresis, 2016. © 2016 Wiley Periodicals, Inc...
  18. pmc Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients' plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?
    Massimo Ghio
    Department of Internal Medicine, I R C C S A O U San Martino IST and University of Genoa, Genoa
    Blood Transfus 12:s105-8. 2014
    ..As soluble CD8 (sCD8) molecules have been shown to capable of binding membrane and soluble HLA-I molecules, we focused on sCD8 as a possible modulator of sHLA-I-mediated TRIM...
  19. ncbi Soluble HLA class I molecules/CD8 ligation trigger apoptosis of CD8+ cells by Fas/Fas-ligand interaction
    Francesco Puppo
    Department of Internal Medicine DIMI, Viale Benedetto XV, N 6, 16132 Genoa, Italy
    ScientificWorldJournal 2:421-3. 2002
    ..Taken together, these data suggest that sHLA-I molecules are involved in a signal-transduction pathway leading to Fas-ligand expression, soluble Fas-ligand secretion, and CD8+ cells apoptosis...
  20. ncbi Emerging biologic drugs for the treatment of rheumatoid arthritis
    Francesco Puppo
    Department of Internal Medicine Di M I, University of Genoa, Viale Benedetto XV, n 6 16132 Genova, Italy
    Autoimmun Rev 4:537-41. 2005
    ..Moreover, promising results have been obtained in animal models utilizing suppressors of cytokine signaling (SOCS) and dominant-negative TNF variants to inactivate TNF signaling...
  21. ncbi [Possible connection between gastroesophageal reflux and interstitial pulmonary fibrosis in patients with systemic sclerosis]
    Edoardo Savarino
    DI M I, Dipartimento di Medicina Interna, Unità di Gastroenterologia con Endoscopia Digestiva, Universita Genova
    Recenti Prog Med 100:512-6. 2009
    ..Further larger controlled studies are necessary to evaluate whether or not the development of interstitial lung disease in systemic sclerosis patients can be prevented by treating gastroesophageal reflux...
  22. ncbi Frequency of telomerase-specific CD8+ T lymphocytes in patients with cancer
    Gilberto Filaci
    Department of Internal Medicine and Center of Excellence for Biomedical Research CEBR, University of Genoa, Viale Benedetto XV no 6, 16132 Genova, Italy
    Blood 107:1505-12. 2006
    ..However, they underline the necessity to study single patients immunologically before undergoing vaccination, to select the patients adequately, and to eventually adapt the immunization schedule to the patient's immunologic status...
  23. doi Flu vaccination with a virosomal vaccine does not affect clinical course and immunological parameters in scleroderma patients
    Maurizio Setti
    Clinic of Internal Medicine and Clinical Immunology, Department of Internal Medicine DIMI, San Martino Hospital, University of Genoa, Viale Benedetto XV 6, 16153 Genoa, Italy
    Vaccine 27:3367-72. 2009
    ..Inflexal was found effective in scleroderma patients. In no subject was worsening of clinical conditions, inflammation and immunological parameters observed...
  24. pmc Bio-modulators in platelet-rich plasma: a comparison of the amounts in products from healthy donors and patients produced with three different techniques
    Gianluca Ubezio
    Department of Internal Medicine, I R C C S A O U San Martino IST and University of Genoa, Genoa, Italy
    Blood Transfus 12:s214-20. 2014
    ..Since leucocyte contamination is technically unavoidable, we investigated whether platelet-rich plasma prepared from patients could contain different amounts of bio-modulators because of a possible activated status of the leucocytes...
  25. ncbi Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily
    Grazia Maria Spaggiari
    Laboratory of Immunology, National Cancer Research Institute, Genoa, Italy
    Blood 99:1706-14. 2002
    ..These findings suggest that interaction between sHLA-I and CD8 evokes an apoptotic signal that is down-regulated by inhibitory receptor superfamily that function as survival receptors in NK cells...
  26. ncbi Apoptotic DNA binds to HLA class II molecules inhibiting antigen presentation and participating in the development of anti-inflammatory functional behavior of phagocytic macrophages
    Gilberto Filaci
    Department of Internal Medicine and Centro di Eccellenza per le Ricerche Biomediche, University of Genoa, Genoa, Italy
    Hum Immunol 64:9-20. 2003
    ..These events are likely related to the preservation of healthy tissues from the onset of inflammation...
  27. doi High-resolution ultrasound of peripheral nerves in systemic sclerosis: a pilot study of computer-aided quantitative assessment of nerve density
    Bianca Bignotti
    Department of Health Sciences DISSAL, University of Genoa, Largo Rosanna Benzi 8, 16132, Genoa, Italy
    Skeletal Radiol 44:1761-7. 2015
    ..To quantitatively evaluate and compare nerve density in patients with limited cutaneous systemic sclerosis (lcSSc) and control subjects using high-resolution ultrasound (US) with a computer-aided assessment...
  28. doi Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of L-cystine and vitamin B6
    Francesco D'Agostini
    Section of Hygiene and Preventive Medicine, Department of Health Sciences, University of Genova, Genoa, Italy
    Arch Dermatol Res 305:25-34. 2013
    ..1 mg/kg body weight intravenously) in C57BL/6 mice...
  29. ncbi Cardiac magnetic resonance imaging detects subclinical right ventricular impairment in systemic sclerosis
    Gian Paolo Bezante
    Division of Cardiology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 34:2431-7. 2007
    ..To assess myocardial involvement in patients with systemic sclerosis (SSc) with no signs or symptoms of cardiac impairment (New York Heart Association functional class I)...
  30. ncbi Effect of clotting factors concentrates on lymphocyte and neutrophil function in vitro
    Massimo Ghio
    Department of Internal Medicine DIMI, University of Genova, Italy
    Thromb Haemost 89:365-73. 2003
    ....
  31. ncbi Transforming growth factor-beta1 in supernatants from stored red blood cells inhibits neutrophil locomotion
    Massimo Ghio
    Department of Internal Medicine and Center of Excellence for Biomedical Research CEBR, University of Genoa, Italy
    Blood 102:1100-7. 2003
    ..Consistently, the neutrophil chemotactic response to formyl peptide was inhibited by the plasma obtained from 5 transfusion patients...
  32. ncbi Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas ligand/Fas mediated: evidence for the involvement of p56lck, calcium calmodulin kinase II, and Calcium-independent protein kinase C signaling pa
    Paola Contini
    Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, Italy
    J Immunol 175:7244-54. 2005
    ..These findings clarify the intracellular signaling pathways triggering FasL up-regulation and apoptosis in CTL upon sHLA-I/CD8 ligation and suggest that sHLA-I molecules can be proposed as therapeutic tools to modulate immune responses...