Affiliation: University of Florence
Galli A, Svegliati Baroni G, Ceni E, Milani S, Ridolfi F, Salzano R, et al
. Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology. 2005;41:1074-84 pubmed
..In conclusion, our findings suggest that MMP-2 is required for the mitogenic and proinvasive effects of ROS on HSC and demonstrate that ERK1/2 and PI3K are the main signals involved in ROS-mediated MMP-2 expression. ..
Galli A, Ceni E, Crabb D, Mello T, Salzano R, Grappone C, et al
. Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms. Gut. 2004;53:1688-97 pubmed
..TZD treatment in pancreatic cancer cells has potent inhibitory effects on growth and invasiveness suggesting that these drugs may have application for prevention and treatment of pancreatic cancer in humans. ..
Cellai F, Munnia A, Viti J, Doumett S, Ravagli C, Ceni E, et al
. Magnetic Hyperthermia and Oxidative Damage to DNA of Human Hepatocarcinoma Cells. Int J Mol Sci. 2017;18: pubmed publisher
..Generation of oxidative lesions may be a mechanism by which magnetic hyperthermia induces cancer cell death. ..
Ceni E, Mello T, Polvani S, Vasseur Cognet M, Tarocchi M, Tempesti S, et al
. The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells. J Hepatol. 2017;66:754-764 pubmed publisher
..COUP-TFII expression in HSC controls the crosstalk between HSC and endothelial cells coordinating vascular remodelling during liver injury. ArrayExpress accession E-MTAB-1795. ..
Galli A, Ceni E, Mello T, Polvani S, Tarocchi M, Buccoliero F, et al
. Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus-transgenic mice by peroxisome proliferator-activated receptor gamma-independent regulation of nucleophosmin. Hepatology. 2010;52:493-505 pubmed publisher
..TZD inhibited NPM expression at protein and messenger RNA levels and decreased NPM promoter activity. TZD inhibition of NPM was associated with the induction of p53 phosphorylation and p21 expression...