R Ciccarelli

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi request reprint P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia
    P Ballerini
    Department of Biomedical Sciences, G D Annunzio University of Chieti, Italy
    Int J Immunopathol Pharmacol 18:255-68. 2005
  2. ncbi request reprint Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes
    Renata Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, University of Chieti, Medical School, Via dei Vestini 29, pal B, 66013 Chieti, Italy
    Mol Pharmacol 71:1369-80. 2007
  3. ncbi request reprint Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia
    R Ciccarelli
    Department of Biomedical Sciences, University of Chieti, Italy
    Glia 25:93-8. 1999
  4. ncbi request reprint Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia
    R Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology and Toxicology, School of Medicine, University of Chieti, Chieti, Italy
    Glia 29:202-11. 2000
  5. ncbi request reprint Involvement of astrocytes in purine-mediated reparative processes in the brain
    R Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, Via del Vestini Pal B, 66013, Chieti, Italy
    Int J Dev Neurosci 19:395-414. 2001
  6. ncbi request reprint Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway
    Renata Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, Medical School, G D Annunzio University of Chieti, Chieti, Italy
    Eur J Neurosci 20:1514-24. 2004
  7. ncbi request reprint P2Y2 receptor up-regulation induced by guanosine or UTP in rat brain cultured astrocytes
    P Ballerini
    Dept of Biomedical Sciences, Section of Pharmacology and Toxicology, Medical School, University G d Annunzio of Chieti Pescara, Via dei Vestini 29, 66013 Chieti, Italy
    Int J Immunopathol Pharmacol 19:293-308. 2006
  8. ncbi request reprint P2X7 receptor activation in rat brain cultured astrocytes increases the biosynthetic release of cysteinyl leukotrienes
    P Ballerini
    Dept of Biomedical Sciences, Section of Pharmacology and Toxicology, G D Annunzio University of Chieti, Medical School, Chieti, Italy
    Int J Immunopathol Pharmacol 18:417-30. 2005
  9. ncbi request reprint Activation of P2X(7) receptors stimulates the expression of P2Y(2) receptor mRNA in astrocytes cultured from rat brain
    I D'Alimonte
    Department of Biomedical Sciences, University of Chieti Pescara, Chieti, Italy
    Int J Immunopathol Pharmacol 20:301-16. 2007
  10. ncbi request reprint Guanine-based purines modulate the effect of L-NAME on learning and memory in rats
    P Giuliani
    Department of Experimental and Clinical Sciences, University of Chieti Pescara, Chieti, Italy
    Panminerva Med 54:53-8. 2012

Collaborators

Detail Information

Publications22

  1. ncbi request reprint P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia
    P Ballerini
    Department of Biomedical Sciences, G D Annunzio University of Chieti, Italy
    Int J Immunopathol Pharmacol 18:255-68. 2005
    ..In conclusion, the data of the present study suggest a cross talk between the purine and leukotriene systems in a possible autocrine/paracrine control of the microglia-mediated initiation and progression of an inflammatory response...
  2. ncbi request reprint Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes
    Renata Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, University of Chieti, Medical School, Via dei Vestini 29, pal B, 66013 Chieti, Italy
    Mol Pharmacol 71:1369-80. 2007
    ..These data suggest that pharmacological activation of A(1) and mGlu3 receptors protects astrocytes against hypoxic/ischemic damage by stimulating the PI3K and ERK1/2 MAPK pathways...
  3. ncbi request reprint Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia
    R Ciccarelli
    Department of Biomedical Sciences, University of Chieti, Italy
    Glia 25:93-8. 1999
    ..These data indicate that astrocytes are a major source of guanine-based purines, the release of which is markedly increased following hypoxia/hypoglycemia, permitting them to exert neurotrophic effects...
  4. ncbi request reprint Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia
    R Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology and Toxicology, School of Medicine, University of Chieti, Chieti, Italy
    Glia 29:202-11. 2000
    ..These data indicate that the mitogenic effects exerted by exogenous Guo on rat astrocytes are mediated via complex mechanisms involving extracellular Ado and microglia-derived soluble factors...
  5. ncbi request reprint Involvement of astrocytes in purine-mediated reparative processes in the brain
    R Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, Via del Vestini Pal B, 66013, Chieti, Italy
    Int J Dev Neurosci 19:395-414. 2001
    ..These data indicate that adenine- and guanine-based purines released in large amounts from injured or dying cells of CNS may act as signals to initiate brain repair mechanisms widely involving astrocytes...
  6. ncbi request reprint Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway
    Renata Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, Medical School, G D Annunzio University of Chieti, Chieti, Italy
    Eur J Neurosci 20:1514-24. 2004
    ..Thus, cys-LTs released from astrocytes might play an autocrine role in the induction of reactive astrogliosis that, in brain injuries, contributes to the formation of a reparative glial scar...
  7. ncbi request reprint P2Y2 receptor up-regulation induced by guanosine or UTP in rat brain cultured astrocytes
    P Ballerini
    Dept of Biomedical Sciences, Section of Pharmacology and Toxicology, Medical School, University G d Annunzio of Chieti Pescara, Via dei Vestini 29, 66013 Chieti, Italy
    Int J Immunopathol Pharmacol 19:293-308. 2006
    ....
  8. ncbi request reprint P2X7 receptor activation in rat brain cultured astrocytes increases the biosynthetic release of cysteinyl leukotrienes
    P Ballerini
    Dept of Biomedical Sciences, Section of Pharmacology and Toxicology, G D Annunzio University of Chieti, Medical School, Chieti, Italy
    Int J Immunopathol Pharmacol 18:417-30. 2005
    ..These data suggest that in rat brain cultured astrocytes P2X7ATP receptors may participate in the control of CysLT release thus further supporting a role for extracellular ATP as an integral component of the inflammatory brain response...
  9. ncbi request reprint Activation of P2X(7) receptors stimulates the expression of P2Y(2) receptor mRNA in astrocytes cultured from rat brain
    I D'Alimonte
    Department of Biomedical Sciences, University of Chieti Pescara, Chieti, Italy
    Int J Immunopathol Pharmacol 20:301-16. 2007
    ..We conclude that activation of P2X(7) receptors in astrocytes enhances P2Y(2) mRNA expression by a mechanism involving both calcium influx and PKC/MAPK signalling pathways...
  10. ncbi request reprint Guanine-based purines modulate the effect of L-NAME on learning and memory in rats
    P Giuliani
    Department of Experimental and Clinical Sciences, University of Chieti Pescara, Chieti, Italy
    Panminerva Med 54:53-8. 2012
    ....
  11. ncbi request reprint Protective activity of guanosine in an in vitro model of Parkinson's disease
    P Giuliani
    Department of Experimental and Clinical Sciences, University of Chieti Pescara, Chieti, Italy
    Panminerva Med 54:43-51. 2012
    ..In summary our results show that guanosine results to be neuroprotective in a recognized in vitro model of PD thus suggesting that it could represent a new potential pharmacological tool to be studied in the therapeutic approach to PD...
  12. ncbi request reprint Guanine-based purines modulate the effect of L-NAME on learning and memory in rats
    P Giuliani
    Department of Experimental and Clinical Sciences, University of Chieti Pescara, Chieti, Italy2 Department of Psychologic, Humanities and Territorial Sciences, University of Chieti Pescara, Chieti, Italy
    Panminerva Med . 2012
    ....
  13. ncbi request reprint AIT-082 is neuroprotective against kainate-induced neuronal injury in rats
    P Di Iorio
    Department of Biomedical Sciences, University of Chieti, Chieti, Italy
    Exp Neurol 169:392-9. 2001
    ..These data confirm that AIT-082 is of potential interest for the experimental therapy of neurodegenerative disorders...
  14. ncbi request reprint Tissue distribution and metabolism of guanosine in rats following intraperitoneal injection
    P Giuliani
    Department of Human Movement Sciences, University of Chieti Pescara, Italy
    J Biol Regul Homeost Agents 26:51-65. 2012
    ..Since guanosine has been shown to be neuroprotective and astrocytes have been reported to play critical roles in mediating neuronal survival and functions in different neurodegenerative disorders, we also performed uptake and release...
  15. ncbi request reprint Cultures of glial cells release purines under field electrical stimulation: the possible ionic mechanisms
    F Caciagli
    Institute of Neuroscience, University of Chieti, Medical School, Italy
    Pharmacol Res Commun 20:935-47. 1988
    ..These findings indicate that the frequency-dependent purine release from cultured glial cells is linked to ionic mechanisms, which calcium and potassium are mainly involved in...
  16. ncbi request reprint Changes in matrix extracellular phosphoglycoprotein expression before and during in vitro osteogenic differentiation of human dental papilla mesenchymal cells
    S Tete
    Department of Oral Sciences, Division of Oral Surgery, University Medical School, G D Annunzio University of Chieti, Via dei Vestini 29, Chieti, Italy
    Int J Immunopathol Pharmacol 21:309-18. 2008
    ..Therefore, these cells represent an optimal source to be conveniently used for dental tissue engineering and tooth regeneration...
  17. ncbi request reprint Vascular endothelial growth factor enhances in vitro proliferation and osteogenic differentiation of human dental pulp stem cells
    I D' Alimonte
    Department of Biomedical Sciences, University of Chieti, Italy
    J Biol Regul Homeost Agents 25:57-69. 2011
    ..These findings may have clinical implications possibly facilitating tissue repair and remodeling...
  18. ncbi request reprint Morphostructural analysis of human follicular stem cells on highly porous bone hydroxyapatite scaffold
    S Tete
    Dept of Stomatology and Oral Science, Division of Oral Surgery, University G D Annunzio, Chieti, Ialy
    Int J Immunopathol Pharmacol 20:819-26. 2007
    ..This approach would allow to personalize the scaffold for bone tissue engineering in order to accelerate the process of osteogenesis...
  19. doi request reprint Synergic development of pharmacokinetics and bioanalytical methods as support of pharmaceutical research
    M Marzo
    Department of Medical, Oral e Biotechnological Sciences, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, I 66013, Chieti, Italy
    Int J Immunopathol Pharmacol 29:168-79. 2016
    ..The baseline subtraction required by guidelines to define the net contribute to the exogenous absorbed drug in most cases is a non-solvable problem. ..
  20. ncbi request reprint Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture
    R Ciccarelli
    Institute of Pharmacology, University of Chieti, Italy
    Glia 21:390-8. 1997
    ..We conclude that activation of mGlu5 receptors enhances proliferation in cultured astrocytes, whereas activation of a receptor with pharmacological characteristics similar to those of mGlu2/3 receptors reduces proliferation...
  21. ncbi request reprint Cyanidin reduces preadipocyte differentiation and relative ChREBP expression
    A Pompei
    Institute of Molecular Genetics, National Research Council, Chieti, Italy
    J Biol Regul Homeost Agents 26:253-64. 2012
    ..These findings suggest that dietary cyanidin, may have inhibitory effects on adipogenesis...
  22. ncbi request reprint AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats
    S Jiang
    Department of Medicine, Division of Neurology, McMaster University Health Sciences Center, Hamilton, Canada
    Int J Immunopathol Pharmacol 17:353-66. 2004
    ..These results suggest that MPSS and AIT-082 may exert their beneficial effects through different and potentially antagonistic pathways...