M Mussap

Summary

Affiliation: San Martino University Hospital
Country: Italy

Publications

  1. doi Urine neutrophil gelatinase-associated lipocalin (uNGAL) and netrin-1: are they effectively improving the clinical management of sepsis-induced acute kidney injury (AKI)?
    Michele Mussap
    Department of Laboratory Medicine, University Hospital San Martino, Genova, Italy
    J Matern Fetal Neonatal Med 24:15-7. 2011
  2. doi Soluble CD14 subtype (sCD14-ST) presepsin in premature and full term critically ill newborns with sepsis and SIRS
    Michele Mussap
    Laboratory Medicine Service, IRCCS AOU San Martino IST, University Hospital, National Institute for Cancer Research, Genova, Italy Electronic address
    Clin Chim Acta 451:65-70. 2015
  3. pmc NGAL and metabolomics: the single biomarker to reveal the metabolome alterations in kidney injury
    A Noto
    Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Via Ospedale 119, 09124 Cagliari, Italy
    Biomed Res Int 2013:612032. 2013
  4. doi An alternative perspective on how laboratory medicine can contribute to solve the health care crisis: a model to save costs by acquiring excellence in diagnostic systems
    Michele Mussap
    Department of Laboratory Medicine, IRCCS AOU San Martino IST, University Hospital, Genoa, Italy National Institute for Cancer Research, Genoa, Italy Electronic address
    Clin Chim Acta 427:202-4. 2014
  5. doi Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges
    Michele Mussap
    Department of Laboratory Medicine, IRCCS University Hospital San Martino IST, National Institute for Cancer Research, Largo Rosanna Benzi 11, Genoa, Italy
    J Matern Fetal Neonatal Med 25:51-3. 2012
  6. doi The importance of biomarkers in neonatology
    M Mussap
    Department of Laboratory Medicine, IRCCS San Martino IST, University Hospital, National Institute for Cancer Research, Genoa 16132, Italy
    Semin Fetal Neonatal Med 18:56-64. 2013
  7. doi Laboratory medicine in neonatal sepsis and inflammation
    Michele Mussap
    Department of Laboratory Medicine, University Hospital IRCCS San Martino IST, National Institute for Cancer Research, Genoa, Italy
    J Matern Fetal Neonatal Med 25:32-4. 2012
  8. pmc Metabolic and cardiovascular risk in patients with a history of differentiated thyroid carcinoma: A case-controlled cohort study
    Massimo Giusti
    Clinica Endocrinologica, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Thyroid Res 1:2. 2008
  9. pmc Long-term outcome of low-activity radioiodine administration preceded by adjuvant recombinant human TSH pretreatment in elderly subjects with multinodular goiter
    Massimo Giusti
    Clinica Endocrinologica, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Thyroid Res 2:6. 2009
  10. pmc Antifungal susceptibility of invasive yeast isolates in Italy: the GISIA3 study in critically ill patients
    Giulia Morace
    Department of Public Health Microbiology Virology, Universita degli Studi di Milano, and Laboratory of Microbiology and Virology, Ospedale San Carlo Borromeo, Milan, Italy
    BMC Infect Dis 11:130. 2011

Collaborators

  • V Fanos
  • F Ansaldi
  • M Bassetti
  • C Viscoli
  • P Durando
  • E Righi
  • L Cataldi
  • Ferdinando Coghe
  • L Atzori
  • M Plebani
  • A Marra
  • R Russo
  • I Fontana
  • M Zaffanello
  • A Gallina
  • Leonardo Punzi
  • Massimo Giusti
  • A Noto
  • F Abdulraof Menesi
  • Giulia Morace
  • F Massaro
  • Diego Ferone
  • F Minuto
  • Francesco Minuto
  • M Giusti
  • F Cecoli
  • G M Andreozzi
  • M Testa
  • F Cibecchini
  • Elisabetta Tangorra
  • Claudio Farina
  • I Mannucci
  • G Garibotto
  • Gerardino Amato
  • Elisa Borghi
  • Patrizia Pecile
  • Gioconda Brigante
  • Ester Manso
  • Roberta Iatta
  • Gianluigi Lombardi
  • Roberto Rigoli
  • Giuliana Lo Cascio
  • Maria Valmarin
  • A Sofia
  • B Villaggio
  • D Verzola
  • Stefano Andreoni
  • Maria Teresa Montagna
  • Mariaclaudia Bagnara
  • D Ferone
  • Mauro Caputo
  • M Dolcino
  • Mara Schiavo
  • Marcello Bagnasco
  • Enrica Ceresola
  • R Degrandi
  • Iolanda Calamia
  • Guido Rodriguez
  • Lorenzo Mortara
  • Francesca Cecoli
  • L Briatore
  • G Andraghetti
  • Roberta Degrandi
  • C Ghiara
  • D Cavallero
  • V Martinelli
  • R Martini
  • G Salmistraro
  • M Stronati
  • R Cordova
  • M Del Zompo
  • A D'Eri

Detail Information

Publications30

  1. doi Urine neutrophil gelatinase-associated lipocalin (uNGAL) and netrin-1: are they effectively improving the clinical management of sepsis-induced acute kidney injury (AKI)?
    Michele Mussap
    Department of Laboratory Medicine, University Hospital San Martino, Genova, Italy
    J Matern Fetal Neonatal Med 24:15-7. 2011
    ..This concise review summarizes properties and perspectives of uNGAL and Netrin-1 for their appropriate clinical utilization...
  2. doi Soluble CD14 subtype (sCD14-ST) presepsin in premature and full term critically ill newborns with sepsis and SIRS
    Michele Mussap
    Laboratory Medicine Service, IRCCS AOU San Martino IST, University Hospital, National Institute for Cancer Research, Genova, Italy Electronic address
    Clin Chim Acta 451:65-70. 2015
    ..In conclusion, sCD14-ST presepsin could be introduced in clinical practice as a diagnostic tool for improving the management of neonatal sepsis and non-bacterial SIRS...
  3. pmc NGAL and metabolomics: the single biomarker to reveal the metabolome alterations in kidney injury
    A Noto
    Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Via Ospedale 119, 09124 Cagliari, Italy
    Biomed Res Int 2013:612032. 2013
    ..In this paper, we describe the role of NGAL for managing AKI and the potential benefits deriving from the combined clinical use of urine NGAL and metabolomics in kidney disease...
  4. doi An alternative perspective on how laboratory medicine can contribute to solve the health care crisis: a model to save costs by acquiring excellence in diagnostic systems
    Michele Mussap
    Department of Laboratory Medicine, IRCCS AOU San Martino IST, University Hospital, Genoa, Italy National Institute for Cancer Research, Genoa, Italy Electronic address
    Clin Chim Acta 427:202-4. 2014
    ....
  5. doi Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges
    Michele Mussap
    Department of Laboratory Medicine, IRCCS University Hospital San Martino IST, National Institute for Cancer Research, Largo Rosanna Benzi 11, Genoa, Italy
    J Matern Fetal Neonatal Med 25:51-3. 2012
    ..8 ng/L; the median value was 578 ng/L. Our results clearly suggest no correlation between GA and sCD14-ST presepsin blood level between 26 and 36 weeks and thus it is reasonable to adopt a unique reference range for preterm newborns...
  6. doi The importance of biomarkers in neonatology
    M Mussap
    Department of Laboratory Medicine, IRCCS San Martino IST, University Hospital, National Institute for Cancer Research, Genoa 16132, Italy
    Semin Fetal Neonatal Med 18:56-64. 2013
    ..Metabolomics represents the passage from a descriptive science to a predictive science, having the potential to translate benchtop research to real clinical benefits...
  7. doi Laboratory medicine in neonatal sepsis and inflammation
    Michele Mussap
    Department of Laboratory Medicine, University Hospital IRCCS San Martino IST, National Institute for Cancer Research, Genoa, Italy
    J Matern Fetal Neonatal Med 25:32-4. 2012
    ..As a consequence, costs can be significantly reduced over a full cycle of care by investing in high quality laboratory medicine...
  8. pmc Metabolic and cardiovascular risk in patients with a history of differentiated thyroid carcinoma: A case-controlled cohort study
    Massimo Giusti
    Clinica Endocrinologica, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Thyroid Res 1:2. 2008
    ..These findings underline the need for adequate L-T4 titration...
  9. pmc Long-term outcome of low-activity radioiodine administration preceded by adjuvant recombinant human TSH pretreatment in elderly subjects with multinodular goiter
    Massimo Giusti
    Clinica Endocrinologica, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Thyroid Res 2:6. 2009
    ..The long-term effect of radioiodine therapy on thyroid volume (TV) and function after recombinant human (rh) TSH pre-treatment was evaluated...
  10. pmc Antifungal susceptibility of invasive yeast isolates in Italy: the GISIA3 study in critically ill patients
    Giulia Morace
    Department of Public Health Microbiology Virology, Universita degli Studi di Milano, and Laboratory of Microbiology and Virology, Ospedale San Carlo Borromeo, Milan, Italy
    BMC Infect Dis 11:130. 2011
    ..We investigated the antifungal susceptibility of yeasts isolated over a 2-year period from hospitalised patients with invasive yeast infections...
  11. ncbi Laboratory investigation for the early diagnosis and monitoring of neonatal urinary tract infections: the present situation and future perspectives
    M Mussap
    Laboratory Medicine, University Hospital San Martino, Genova, Italy
    J Chemother 18:9-13. 2006
  12. doi Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old biomarkers
    Michele Mussap
    Department of Laboratory Medicine, University Hospital San Martino, Genova, Italy
    J Matern Fetal Neonatal Med 24:12-4. 2011
    ....
  13. doi Sequential outbreaks of multidrug-resistant Acinetobacter baumannii in intensive care units of a tertiary referral hospital in Italy: combined molecular approach for epidemiological investigation
    F Ansaldi
    Department of Health Sciences, University of Genoa, Genoa, Italy
    J Hosp Infect 79:134-40. 2011
    ..A molecular approach allowed the prompt introduction of infection control measures and the evaluation of data in a global epidemiological context...
  14. ncbi Impact of limited cephalosporin use on prevalence of methicillin-resistant Staphylococcus aureus in the intensive care unit
    M Bassetti
    Infectious Diseases Division, S Martino Hospital and University of Genoa School of Medicine, Genoa, Italy
    J Chemother 21:633-8. 2009
    ..5%). A significant reduction in the percentage of MRSA infections (-30%) and heterogeneous susceptibility patterns in Klebsiella pneumoniae and Pseudomonas aeruginosa were noted...
  15. ncbi Biochemical markers for the early assessment of neonatal sepsis: the role of procalcitonin
    M Mussap
    Laboratory Medicine, University Hospital San Martino, Genova, Italy
    J Chemother 19:35-8. 2007
    ..PCT may be useful in assessing the severity of infection, following the progress of treatment, and predicting outcomes...
  16. doi Metabolomics in neonatology: fact or fiction?
    V Fanos
    Department of Surgery, Section of Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Cagliari, Italy
    Semin Fetal Neonatal Med 18:3-12. 2013
    ..In any case, it is important for perinatologists to learn and understand this new technology to offer their patients the utmost in diagnostic and therapeutic opportunities...
  17. ncbi Laboratory management of neonatal sepsis and urinary tract infections: new perspectives
    M Mussap
    Department of Laboratory Medicine, Azienda Ospedaliera, Padova, Italy
    Pediatr Med Chir 24:119-21. 2002
  18. pmc Emerging biomarkers and metabolomics for assessing toxic nephropathy and acute kidney injury (AKI) in neonatology
    M Mussap
    Department of Laboratory Medicine, IRCCS San Martino IST, University Hospital, National Institute for Cancer Research, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Biomed Res Int 2014:602526. 2014
    ..To become routine tests, uNGAL and KIM-1 should be carefully tested in multicenter clinical trials and should be measured in biological fluids by robust, standardized analytical methods...
  19. doi Severe vitamin D deficiency is associated with frequently observed diseases in medical inpatients
    A Marra
    Department of Internal Medicine, IRCCS AOU San Martino IST, University of Genova, Genova, Italy
    Int J Clin Pract 68:647-52. 2014
    ..Medical inpatients are often vitamin D-deficient, but little information is available about the relation of vitamin D status with extra-skeletal disorders in this population...
  20. ncbi Nenatal drug induced nephrotoxicity : old and next generation biomarkers for early detection and management of neonatal drug-induced nephrotoxicity, with special emphasis on uNGAL and on metabolomics
    V Fanos
    Department of Surgery, Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Via Ospedale 119, 09124 Cagliari, Italy
    Curr Med Chem 19:4595-605. 2012
    ..Considerable expectations in terms of improvement of the management of newborns developing drug-induced nephropaties derive from the clinical application of metabolomics...
  21. doi Evaluation of metabolic acidosis in patients with a kidney graft: comparison of the bicarbonate-based and strong ion-based methods
    F Abdulraof Menesi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Transplant Proc 43:1055-62. 2011
    ..However, the bicarbonate-based approach has been questioned by intensivists using strong ion difference-based methods...
  22. ncbi Calcitonin assay in wash-out fluid after fine-needle aspiration biopsy in patients with a thyroid nodule and border-line value of the hormone
    F Massaro
    Department of Immuno Endocrinological Pathology, San Martino University Hospital, Genoa, Italy
    J Endocrinol Invest 32:308-12. 2009
    ..Our experience suggests that CT-FNAB does not have the same importance as that reported in the literature for thyroglobulin and PTH assay in wash-out fluid after FNAB in malignant thyroid and hyperfunctioning parathyroid lesions...
  23. ncbi Absence of thyrotropin-induced increase in leptin levels in patients with history of differentiated thyroid carcinoma undergoing recombinant human thyrotropin testing
    F Cecoli
    Department of Endocrinological and Metabolic Sciences, San Martino Hospital and University of Genoa, Genoa, Italy
    J Endocrinol Invest 31:888-92. 2008
    ..Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce interleukin-6 secretion by adipocytes. Leptin is the main protein secreted by adipose tissue...
  24. ncbi Laboratory medicine in nephrouropathies
    M Mussap
    Department Laboratory Medicine, University Hospital, Padua, Italy
    Pediatr Med Chir 27:74-7. 2005
  25. ncbi New diagnostic tools for neonatal sepsis: the role of a real-time polymerase chain reaction for the early detection and identification of bacterial and fungal species in blood samples
    M Mussap
    Laboratory Medicine, University Hospital San Martino, Genova, Italy
    J Chemother 19:31-4. 2007
    ..Real-time PCR can be easily incorporated into the hospital setting for term or near-term infants admitted to the neonatal intensive care unit for sepsis evaluation...
  26. doi Colistin and rifampicin in the treatment of multidrug-resistant Acinetobacter baumannii infections
    M Bassetti
    Infectious Disease Division, San Martino Hospital and University of Genoa School of Medicine, Genova, Italy
    J Antimicrob Chemother 61:417-20. 2008
    ..We describe the clinical and microbiological outcomes of patients infected with multidrug-resistant Acinetobacter baumannii who were treated with a combination of colistin and rifampicin...
  27. pmc Value of C reactive protein in the assessment of erosive osteoarthritis of the hand
    L Punzi
    Cattedra e Divisione di Reumatologia, Universita di Padova, Via Giustiniani, 235128 Padua, Italy
    Ann Rheum Dis 64:955-7. 2005
    ..To investigate the value of serum C reactive protein (CRP) as a marker of erosive osteoarthritis (EOA) of the hand...
  28. ncbi Urinary tract infections in infants and children
    L Cataldi
    Division of Neonatology, Catholic University of Sacred Heart, Rome, Italy
    J Chemother 18:5-8. 2006
  29. ncbi Circulating levels of cytokines (IL-6 and IL-1beta) in patients with intermittent claudication, at rest, after maximal exercise treadmill test and during restore phase. Could they be progression markers of the disease?
    G M Andreozzi
    Angiology Care Unit, University Hospital of Padua, Padua, Italy
    Int Angiol 26:245-52. 2007
    ..The aim of this study was to assess of the inflammatory pattern in claudicants and of the inflammatory response after maximal exercise and during the recovery from calf pain...
  30. ncbi Therapeutic drug monitoring of gentamicin in neonatal intensive care unit: experience in 68 newborns
    M Testa
    Istituto di Patologia e Terapia Intesiva Neonatale Puericultura e Nido Università de Cagliari, Italy
    J Chemother 19:39-41. 2007
    ..The aim of this work is to present our personal experience wtih TDM of gentamicin in 68 newborns and to compare it with data available in the literature...