Lior Gepstein

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint Atrial linear ablations in pigs. Chronic effects on atrial electrophysiology and pathology
    L Gepstein
    Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 100:419-26. 1999
  2. doi request reprint Cell and gene therapy strategies for the treatment of postmyocardial infarction ventricular arrhythmias
    Lior Gepstein
    The Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Bruce Rappaport Institute in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Ann N Y Acad Sci 1188:32-8. 2010
  3. ncbi request reprint Accurate linear radiofrequency lesions guided by a nonfluoroscopic electroanatomic mapping method during atrial fibrillation
    L Gepstein
    Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Pacing Clin Electrophysiol 24:1672-8. 2001
  4. doi request reprint Electrophysiologic implications of myocardial stem cell therapies
    Lior Gepstein
    Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Department of Biophysics and Physiology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Heart Rhythm 5:S48-52. 2008
  5. ncbi request reprint Derivation and potential applications of human embryonic stem cells
    Lior Gepstein
    Cardiovascular Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, and Rambam Medical Center, Haifa, Israel
    Circ Res 91:866-76. 2002
  6. doi request reprint Experimental molecular and stem cell therapies in cardiac electrophysiology
    Lior Gepstein
    The Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Ann N Y Acad Sci 1123:224-31. 2008
  7. ncbi request reprint Electromechanical characterization of chronic myocardial infarction in the canine coronary occlusion model
    L Gepstein
    Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 98:2055-64. 1998
  8. ncbi request reprint Stem cells as biological heart pacemakers
    Lior Gepstein
    Technion Israel Institute of Technology, The Rappaport Family Institute for Research in the Medical Sciences, Department of Biophysics and Physiology, Bruce Rappaport Faculty of Medicine, 31096 Haifa, Israel
    Expert Opin Biol Ther 5:1531-7. 2005
  9. ncbi request reprint Potential applications of human embryonic stem cell-derived cardiomyocytes
    Oren Caspi
    Cardiovascular Research Laboratory, Department of Physiology, Bruce Rapport Faculty of Medicine, Technion Israel Institute of Technology, Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 1015:285-98. 2004
  10. doi request reprint Cell therapy for modification of the myocardial electrophysiological substrate
    Lior Yankelson
    Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 117:720-31. 2008

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Atrial linear ablations in pigs. Chronic effects on atrial electrophysiology and pathology
    L Gepstein
    Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 100:419-26. 1999
    ..However, deployment and assessment of these lesions may be difficult, and there are few data regarding their short- and long-term effects on atrial electrophysiology and pathology...
  2. doi request reprint Cell and gene therapy strategies for the treatment of postmyocardial infarction ventricular arrhythmias
    Lior Gepstein
    The Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Bruce Rappaport Institute in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Ann N Y Acad Sci 1188:32-8. 2010
    ..Finally, we will also discuss the potential advantages and drawbacks of these strategies as well as a road map for future clinical use...
  3. ncbi request reprint Accurate linear radiofrequency lesions guided by a nonfluoroscopic electroanatomic mapping method during atrial fibrillation
    L Gepstein
    Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Pacing Clin Electrophysiol 24:1672-8. 2001
    ....
  4. doi request reprint Electrophysiologic implications of myocardial stem cell therapies
    Lior Gepstein
    Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Department of Biophysics and Physiology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Heart Rhythm 5:S48-52. 2008
    ..The potential advantages and shortcomings of each strategy are discussed, as are the obstacles that must be overcome before these exciting strategies can become a clinical reality...
  5. ncbi request reprint Derivation and potential applications of human embryonic stem cells
    Lior Gepstein
    Cardiovascular Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, and Rambam Medical Center, Haifa, Israel
    Circ Res 91:866-76. 2002
    ..However, many obstacles must still be overcome on the way to successful clinical utilization of these cells...
  6. doi request reprint Experimental molecular and stem cell therapies in cardiac electrophysiology
    Lior Gepstein
    The Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Ann N Y Acad Sci 1123:224-31. 2008
    ..Finally, we address the obstacles, challenges, and avenues for further research required to make these novel strategies a clinical reality...
  7. ncbi request reprint Electromechanical characterization of chronic myocardial infarction in the canine coronary occlusion model
    L Gepstein
    Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 98:2055-64. 1998
    ..A nonfluoroscopic, catheter-based mapping technique that can spatially associate endocardial mechanical and electrical data was used to quantify electromechanical changes in the canine chronic infarction model...
  8. ncbi request reprint Stem cells as biological heart pacemakers
    Lior Gepstein
    Technion Israel Institute of Technology, The Rappaport Family Institute for Research in the Medical Sciences, Department of Biophysics and Physiology, Bruce Rappaport Faculty of Medicine, 31096 Haifa, Israel
    Expert Opin Biol Ther 5:1531-7. 2005
    ..This review will describe each of these approaches, focusing mainly on the stem cell strategies, their possible advantages and shortcomings, as well as the avenues required to make biological pacemaking a clinical reality...
  9. ncbi request reprint Potential applications of human embryonic stem cell-derived cardiomyocytes
    Oren Caspi
    Cardiovascular Research Laboratory, Department of Physiology, Bruce Rapport Faculty of Medicine, Technion Israel Institute of Technology, Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 1015:285-98. 2004
    ....
  10. doi request reprint Cell therapy for modification of the myocardial electrophysiological substrate
    Lior Yankelson
    Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 117:720-31. 2008
    ..We present a novel approach for the modification of the myocardial electrophysiological substrate using cell grafts genetically engineered to express specific ionic channels...
  11. ncbi request reprint Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts
    Oren Caspi
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    J Am Coll Cardiol 50:1884-93. 2007
    ..We evaluated the ability of human embryonic stem cells (hESCs) and their cardiomyocyte derivatives (hESC-CMs) to engraft and improve myocardial performance in the rat chronic infarction model...
  12. doi request reprint Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells
    Oren Caspi
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Circ Cardiovasc Genet 6:557-68. 2013
    ..ARVC is characterized pathologically by fibrofatty infiltration and clinically by arrhythmias and sudden cardiac death. We aimed to establish a patient-/disease-specific human induced pluripotent stem cell (hiPSC) model of ARVC...
  13. ncbi request reprint Electromechanical integration of cardiomyocytes derived from human embryonic stem cells
    Izhak Kehat
    The Sohnis Family Research Laboratory for the Regeneration of Functional Myocardium, Department of Biophysics and Physiology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa, Israel
    Nat Biotechnol 22:1282-9. 2004
    ..These results demonstrate the potential of hES-cell cardiomyocytes to act as a rate-responsive biological pacemaker and for future myocardial regeneration strategies...
  14. doi request reprint A combined cell therapy and in-situ tissue-engineering approach for myocardial repair
    Manhal Habib
    Bruce Rappaport Faculty of Medicine and Technion Israel Institute of Technology, Haifa, Israel
    Biomaterials 32:7514-23. 2011
    ..We conclude that an injectable in-situ forming hydrogel can act as a cardiomyocyte cell-carrier and add to the beneficial effects of the grafted cells in preventing unfavorable post-infarction cardiac remodeling...
  15. doi request reprint Calcium handling in human embryonic stem cell-derived cardiomyocytes
    Jonathan Satin
    The Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Stem Cells 26:1961-72. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  16. doi request reprint Transplantation of a tissue-engineered human vascularized cardiac muscle
    Ayelet Lesman
    Department of Biomedical Engineering, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Tissue Eng Part A 16:115-25. 2010
    ..By utilizing a multicellular preparation we were able to increase biograft vascularization and to show that the preexisting human vessels can become functional and contribute to tissue perfusion...
  17. doi request reprint In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes
    Oren Caspi
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Department of Biophysics and Physiology, Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    Stem Cells Dev 18:161-72. 2009
    ....
  18. ncbi request reprint Identification and selection of cardiomyocytes during human embryonic stem cell differentiation
    Irit Huber
    Sohnis Family Research Laboratory for the Regeneration of Functional Myocardium and the Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    FASEB J 21:2551-63. 2007
    ....
  19. pmc Calcium handling in human induced pluripotent stem cell derived cardiomyocytes
    Ilanit Itzhaki
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 6:e18037. 2011
    ..In the current study, we investigated the Ca(2+)-handling properties of hiPSCs derived-cardiomyocytes (hiPSC-CMs)...
  20. doi request reprint A combined gene and cell therapy approach for restoration of conduction
    Anat Hofshi
    Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Heart Rhythm 8:121-30. 2011
    ..Abnormal conduction underlies both bradyarrhythmias and re-entrant tachyarrhythmias. However, no practical way exists for restoring or improving conduction in areas of conduction slowing or block...
  21. doi request reprint Vascularization shaping the heart
    Ayelet Lesman
    Department of Bio Medical Engineering, The Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    Ann N Y Acad Sci 1188:46-51. 2010
    ..Such muscle-constructs could contribute significantly to the emerging discipline of cardiovascular regenerative medicine as well as to the study of the important role of tissue vascularization...
  22. ncbi request reprint Development of cardiomyocytes from human ES cells
    Izhak Kehat
    Cardiovascular Research Laboratory, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 2 Efron Street, POB 9649, Haifa 31096, Israel
    Methods Enzymol 365:461-73. 2003
  23. doi request reprint Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients
    Limor Zwi-Dantsis
    Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur Heart J 34:1575-86. 2013
    ....
  24. doi request reprint Methods for human embryonic stem cells derived cardiomyocytes cultivation, genetic manipulation, and transplantation
    Gil Arbel
    The Bruce Rappaport Faculty of Medicine, Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Methods Mol Biol 660:85-95. 2010
    ..In this chapter, we will describe in detail methods related to the cultivation, genetic manipulation, selection, and in vivo transplantation of hESC-derived cardiomyocytes...
  25. ncbi request reprint Human embryonic stem cells for myocardial regeneration
    Izhak Kehat
    Cardiovascular Research Laboratory, Department of Physiology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and Rambam Medical Center, Haifa, Israel
    Heart Fail Rev 8:229-36. 2003
    ..The possible applications in several research and clinical areas are discussed as well as the steps required to fully harness the potential of this new technology in the fields of myocardial cell replacement and tissue engineering...
  26. doi request reprint Induced pluripotent stem cells for cardiac repair
    Limor Zwi-Dantsis
    The Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel
    Cell Mol Life Sci 69:3285-99. 2012
    ..We then detail the unique potential as well as the possible hurdles on the road to clinical utilizing of the iPSCs derived cardiomyocytes in the emerging field of cardiovascular regenerative medicine...
  27. doi request reprint Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells
    Ilanit Itzhaki
    The Sohnis Family Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    J Am Coll Cardiol 60:990-1000. 2012
    ..The goal of this study was to establish a patient-specific human-induced pluripotent stem cells (hiPSCs) model of catecholaminergic polymorphic ventricular tachycardia (CPVT)...
  28. doi request reprint Cardiomyocyte differentiation of human induced pluripotent stem cells
    Limor Zwi
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 120:1513-23. 2009
    ..In the present study, we aimed to characterize the cardiomyocyte differentiation potential of hiPS cells and to study the molecular, structural, and functional properties of the generated hiPS-derived cardiomyocytes...
  29. doi request reprint In vivo assessment of the electrophysiological integration and arrhythmogenic risk of myocardial cell transplantation strategies
    Lior Gepstein
    The Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Rappaport Institute, Technion Israel Institute of Technology, Haifa, Israel
    Stem Cells 28:2151-61. 2010
    ..In contrast, transplantation of cells that do not form gap junctions (skeletal myoblats) led to localized conduction disturbances and to the generation of a proarrhythmogenic substrate...
  30. ncbi request reprint High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction
    Izhak Kehat
    Cardiovascular Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circ Res 91:659-61. 2002
    ....
  31. ncbi request reprint Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes
    Mirit Snir
    Cardiovascular Research Laboratory, Department of Physiology and Biophysics, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Am J Physiol Heart Circ Physiol 285:H2355-63. 2003
    ..Moreover, the detailed characterization of the ES cell-derived cardiomyocyte may be crucial for the development of future cell replacement strategies aiming to regenerate functional myocardium...
  32. ncbi request reprint Tissue engineering of vascularized cardiac muscle from human embryonic stem cells
    Oren Caspi
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circ Res 100:263-72. 2007
    ..In summary, this is the first report of the construction of 3D vascularized human cardiac tissue that may have unique applications for studies of cardiac development, function, and tissue replacement therapy...
  33. ncbi request reprint Catheter ablation of cardiac arrhythmias guided by electroanatomic imaging (CARTO): a single-center experience
    Mahmoud Suleiman
    Electrophysiology and Invasive Cardiology Units, Rambam Medical Center, Haifa, Israel
    Isr Med Assoc J 9:260-4. 2007
    ..Conventional fluoroscopic catheter mapping has limited spatial resolution and involves prolonged fluoroscopy. The non-fluoroscopic electroanatomic mapping technique (CARTO) has been developed to overcome these drawbacks...
  34. ncbi request reprint Regenerating the heart using human embryonic stem cells--from cell to bedside
    Oren Caspi
    Research Laboratory for the Regeneration of Functional Myocardium, Department of Biophysics and Physiology, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Isr Med Assoc J 8:208-14. 2006
    ..Finally, the hurdles and challenges toward fully harnessing the potential clinical applications of these unique cells will be described...
  35. ncbi request reprint From gene therapy and stem cells to clinical electrophysiology
    Lior Yankelson
    Sohnis Family Research Laboratory for the Regeneration of Functional Myocardium, Department of Biophysics and Physiology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pacing Clin Electrophysiol 29:996-1005. 2006
    ....
  36. doi request reprint Scalable production of cardiomyocytes derived from c-Myc free induced pluripotent stem cells
    Limor Zwi-Dantsis
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Tissue Eng Part A 17:1027-37. 2011
    ..The result of this study should have important implications for several cardiovascular research areas and specifically for the emerging field of regenerative medicine...
  37. doi request reprint Modelling the long QT syndrome with induced pluripotent stem cells
    Ilanit Itzhaki
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, POB 9649, Haifa 31096, Israel
    Nature 471:225-9. 2011
    ..As such, it represents a promising paradigm to study disease mechanisms, optimize patient care (personalized medicine), and aid in the development of new therapies...
  38. doi request reprint Importance of ventricular tachycardia storms not terminated by implantable cardioverter defibrillators shocks in patients with CASQ2 associated catecholaminergic polymorphic ventricular tachycardia
    Ibrahim Marai
    Division of Pacing and Electrophysiology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Cardiol 110:72-6. 2012
    ..These patients may have recurrent ventricular tachycardia storms treated but not terminated by recurrent ICD shocks, without degeneration to ventricular fibrillation...
  39. doi request reprint A photopolymerizable hydrogel for 3-D culture of human embryonic stem cell-derived cardiomyocytes and rat neonatal cardiac cells
    Keren Shapira-Schweitzer
    Faculty of Biomedical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Mol Cell Cardiol 46:213-24. 2009
    ..These findings indicate that the PF hydrogel biomaterial can be used as an in situ polymerizable biomaterial for stem cells and their cardiomyocyte derivatives...
  40. doi request reprint Human embryonic stem cells for cardiomyogenesis
    Manhal Habib
    Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Mol Cell Cardiol 45:462-74. 2008
    ..Finally, the obstacles remaining on the road to clinical translation are described as well as the steps required to fully harness the potential of this new technology...
  41. ncbi request reprint Usefulness of electroanatomical mapping to differentiate between right ventricular outflow tract tachycardia and arrhythmogenic right ventricular dysplasia
    Monther Boulos
    Cardiology Department, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Cardiol 95:935-40. 2005
    ..This ability may have important clinical implications and supports the concept of different underlying mechanisms for these 2 entities...
  42. doi request reprint Novel Clinical Manifestation of the Known SCN5A D1790G Mutation
    Miry Blich
    Division of Pacing and Electrophysiology, Rambam Health Care Campus, Haifa, Israel
    Cardiology 132:228-32. 2015
    ..Moreover, this observation raises concern about the safety of class IC drug therapy in long QT type 3 patients and quinidine therapy in Brugada patients, and emphasizes the importance of a thorough clinical and genetic evaluation. ..
  43. doi request reprint Electrocardiographic comparison of ventricular premature complexes during exercise test in patients with CPVT and healthy subjects
    Miry Blich
    Division of Pacing and Electrophysiology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Pacing Clin Electrophysiol 38:398-402. 2015
    ..Although a standardized exercise stress test (ST) is the most reliable way to diagnose CPVT, in 30% only single ventricular premature beats (VPCs) were recorded...
  44. ncbi request reprint Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: a novel strategy to manipulate excitability
    Yair Feld
    Cardiovascular Research Laboratory, Department of Physiology, Technion, Israel
    Circulation 105:522-9. 2002
    ..To examine the feasibility of this concept, we tested the hypothesis that transfected fibroblasts expressing the voltage-sensitive potassium channel Kv1.3 can modify the electrophysiological properties of cardiomyocytic cultures...
  45. doi request reprint Modulation of excessive neuronal activity by fibroblasts: potential use in treatment of Parkinson's disease
    John P M Finberg
    Molecular Pharmacology Department, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Restor Neurol Neurosci 28:803-15. 2010
    ..Fibroblasts express gap junctions and ion channels, and so, when transplanted to brain tissue, can potentially modulate excessive electrical activity...
  46. ncbi request reprint Cardiovascular therapeutic aspects of cell therapy and stem cells
    Lior Gepstein
    Shonis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Institute in the Medical Sciences, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 32000, Israel
    Ann N Y Acad Sci 1080:415-25. 2006
    ....
  47. pmc Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives
    Shiran Yehezkel
    Molecular Medicine Laboratory, Faculty of Medicine and Research Institute, Rambam Health Care Campus and Rappaport, Technion Israel Institute of Technology, Haifa, Israel
    Epigenetics 6:63-75. 2011
    ..We suggest that TERRA may play a role in regulation of appropriate telomere function and length in hiPS cells...
  48. ncbi request reprint Differentiation pathways in human embryonic stem cell-derived cardiomyocytes
    Sophie Lev
    The B Rappaport Institute in the Medical Sciences, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Ann N Y Acad Sci 1047:50-65. 2005
    ....
  49. ncbi request reprint Calcium handling in embryonic stem cell-derived cardiac myocytes: of mice and men
    Ilanit Itzhaki
    Department of Physiology, The Bruce Rappaport Institute in the Medical Sciences, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 32000, Israel
    Ann N Y Acad Sci 1080:207-15. 2006
    ..Here we discuss the information gained from these models to describe the nexus of voltage-gated channel currents and Ca(2+) handling on rhythmic activity...
  50. doi request reprint Circadian pattern of life-threatening ventricular arrhythmia in patients with sleep-disordered breathing and implantable cardioverter-defibrillators
    Tawfiq Zeidan-Shwiri
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Heart Rhythm 8:657-62. 2011
    ..Sleep-disordered breathing (SDB) has been associated with various benign cardiac arrhythmias occurring during sleep...
  51. ncbi request reprint Electroanatomical mapping and radiofrequency ablation of an accessory pathway associated with a large aneurysm of the coronary sinus
    Monther Boulos
    Cardiology Department, Rambam Medical Center, Haifa, Israel
    Europace 6:608-12. 2004
    ....
  52. ncbi request reprint Controlling the cellular organization of tissue-engineered cardiac constructs
    Maya Gonen-Wadmany
    Department of Biomedical Engineering, Technion IIT, Haifa, Israel
    Ann N Y Acad Sci 1015:299-311. 2004
    ..e., in the circumferential direction). Hence, we demonstrate the importance of mechanical preconditioning as a means of promoting the in vitro development of engineered cardiac muscle for use with myocardial regeneration therapies...
  53. doi request reprint Cell tri-culture for cardiac vascularization
    Ayelet Lesman
    Department of Biomedical Engineering, Technion Israel Institute of Technology, Haifa, Israel
    Methods Mol Biol 1181:131-7. 2014
    ..Upon implantation, stable grafts were formed presenting intense vascularization, with evidence of anastomosis between the pre-formed endothelial capillaries and host neovessels. ..
  54. pmc Concise review: reprogramming strategies for cardiovascular regenerative medicine: from induced pluripotent stem cells to direct reprogramming
    Inbar Budniatzky
    Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine and Cardiology Department, Rambam Medical Center, Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Stem Cells Transl Med 3:448-57. 2014
    ..The advantages and shortcomings of each strategy for cardiac regeneration are discussed, along with the hurdles that need to be overcome on the road to clinical translation. ..
  55. ncbi request reprint Temporal changes in the endocardial ST segment during the evolution of myocardial infarction in dogs
    Jonathan Lessick
    Dept of Cardiology, Rambam Medical Center, P O Box 9602, Haifa, 31096, Irael
    Pacing Clin Electrophysiol 25:1616-23. 2002
    ..80), probably by correcting for pressure induced ST elevation. In conclusion, acute endocardial ST-segment changes occur in the infarct zone in the dog, showing a distinctive temporal evolution...
  56. ncbi request reprint Myocardial regeneration strategies using human embryonic stem cell-derived cardiomyocytes
    Oren Capi
    Sohnis Family Research Laboratory for the Regeneration of Functional Myocardium, Rappaport Family Institute for Research in the Medical Sciences, Israel
    J Control Release 116:211-8. 2006
    ....
  57. pmc Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes
    Jonathan Satin
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    J Physiol 559:479-96. 2004
    ..5; thus, the NaV1.5 Na+ channel is important for initiating spontaneous excitability in hES-derived heart cells...
  58. ncbi request reprint Electrophysiological coupling of transplanted cardiomyocytes
    Izhak Kehat
    Circ Res 101:433-5. 2007
  59. ncbi request reprint Somatic gene and cell therapy strategies for the treatment of cardiac arrhythmias
    Lior Gepstein
    Am J Physiol Heart Circ Physiol 286:H815-22. 2004