John J Mackrill

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. doi request reprint Ryanodine receptor calcium release channels: an evolutionary perspective
    John J Mackrill
    Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland
    Adv Exp Med Biol 740:159-82. 2012
  2. ncbi request reprint 'Shotgun immunological' approach for analysis of a complex subcellular system
    John J Mackrill
    Department of Physiology, NUI University College Cork, Cork, Ireland
    Int J Mol Med 23:399-405. 2009
  3. doi request reprint Ryanodine receptor calcium channels and their partners as drug targets
    John J Mackrill
    Department of Physiology, University College Cork, Biosciences Institute, Ireland
    Biochem Pharmacol 79:1535-43. 2010
  4. doi request reprint Oxysterols and calcium signal transduction
    John J Mackrill
    Department of Physiology, University College Cork, Cork, Ireland
    Chem Phys Lipids 164:488-95. 2011
  5. doi request reprint Calcium signalling in adult endothelial outgrowth cells
    William G Pierce
    Department of Physiology, University College Cork, Biosciences Institute, College Road, Cork, Ireland
    Biochem Biophys Res Commun 417:358-63. 2012
  6. doi request reprint Oxysterols modulate calcium signalling in the A7r5 aortic smooth muscle cell-line
    Yzzam Hammoud
    Department of Physiology, University College Cork, Biosciences Institute, College Road, Cork, Ireland
    Biochimie 95:568-77. 2013
  7. ncbi request reprint Activation of ryanodine receptor/Ca2+ release channels downregulates CD38 in the Namalwa B lymphoma
    Tommie V McCarthy
    Department of Biochemistry, Biosciences Institute, National University of Ireland, University College Cork, College Road, Cork, Ireland
    FEBS Lett 554:133-7. 2003
  8. ncbi request reprint Generation, use, and validation of receptor-selective antibodies
    John J Mackrill
    Department of Biochemistry, University College Cork, Ireland
    Methods Mol Biol 259:47-65. 2004
  9. ncbi request reprint CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss
    Frances J Drummond
    Department of Rheumatology and Medicine, Clinical Sciences Building, Cork University Hospital, National University of Ireland, Cork, Ireland
    J Bone Miner Metab 24:28-35. 2006

Collaborators

Detail Information

Publications9

  1. doi request reprint Ryanodine receptor calcium release channels: an evolutionary perspective
    John J Mackrill
    Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland
    Adv Exp Med Biol 740:159-82. 2012
    ....
  2. ncbi request reprint 'Shotgun immunological' approach for analysis of a complex subcellular system
    John J Mackrill
    Department of Physiology, NUI University College Cork, Cork, Ireland
    Int J Mol Med 23:399-405. 2009
    ..Such 'shotgun immunological' strategies will prove effective in characterising novel constituents of, as well as for investigating protein-protein interactions within, macromolecular structures isolated from biological systems...
  3. doi request reprint Ryanodine receptor calcium channels and their partners as drug targets
    John J Mackrill
    Department of Physiology, University College Cork, Biosciences Institute, Ireland
    Biochem Pharmacol 79:1535-43. 2010
    ..This commentary examines the possibility of manipulating the expression and function of such proteins in order develop new drugs acting on RyR channel complexes...
  4. doi request reprint Oxysterols and calcium signal transduction
    John J Mackrill
    Department of Physiology, University College Cork, Cork, Ireland
    Chem Phys Lipids 164:488-95. 2011
    ..This review examines the ways in which oxysterols could influence Ca(2+) signal transduction and the potential roles of this in health and disease...
  5. doi request reprint Calcium signalling in adult endothelial outgrowth cells
    William G Pierce
    Department of Physiology, University College Cork, Biosciences Institute, College Road, Cork, Ireland
    Biochem Biophys Res Commun 417:358-63. 2012
    ..These results indicate that EOCs possess sophisticated Ca(2+) signalling mechanisms, capable of generating distinct Ca(2+) waveforms in response to different physiologically relevant cues...
  6. doi request reprint Oxysterols modulate calcium signalling in the A7r5 aortic smooth muscle cell-line
    Yzzam Hammoud
    Department of Physiology, University College Cork, Biosciences Institute, College Road, Cork, Ireland
    Biochimie 95:568-77. 2013
    ..Overall, these data demonstrate that major oxysterol components of oxLDL cause long-term alterations in Ca(2+) signalling in a model aortic smooth muscle cell. Such effects could contribute to the pathology of atherosclerotic disease...
  7. ncbi request reprint Activation of ryanodine receptor/Ca2+ release channels downregulates CD38 in the Namalwa B lymphoma
    Tommie V McCarthy
    Department of Biochemistry, Biosciences Institute, National University of Ireland, University College Cork, College Road, Cork, Ireland
    FEBS Lett 554:133-7. 2003
    ..These findings indicate a novel negative feedback mechanism between RyR channel activity and CD38 abundance acts in cADPr signal transduction...
  8. ncbi request reprint Generation, use, and validation of receptor-selective antibodies
    John J Mackrill
    Department of Biochemistry, University College Cork, Ireland
    Methods Mol Biol 259:47-65. 2004
    ..Immunoblot and enzyme-linked immunosorbent assays for characterization of the selectivity and affinity of such antibodies are described. Finally, methods are given for improvement of the titer and specificity of PAbs...
  9. ncbi request reprint CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss
    Frances J Drummond
    Department of Rheumatology and Medicine, Clinical Sciences Building, Cork University Hospital, National University of Ireland, Cork, Ireland
    J Bone Miner Metab 24:28-35. 2006
    ..024), in postmenopausal women not taking hormone replacement therapy. We suggest that the CD38-PvuII polymorphism may influence the attainment and maintenance of peak BMD and postmenopausal bone loss...