Mohammad R Safarinejad


Affiliation: Urology and Nephrology Research Center
Country: Iran


  1. Safarinejad M, Shafiei N, Safarinejad S. Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility. Reprod Sci. 2011;18:304-15 pubmed publisher
    ..Further study on the biologic role that this polymorphism plays in the development of infertility may lead to better understanding of the etiology of impaired spermatogenesis. ..
  2. Safarinejad M, Khoshdel A, Shekarchi B, Taghva A, Safarinejad S. Association of the T-786C, G894T and 4a/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects. BJU Int. 2011;107:1994-2001 pubmed publisher
    ..Further studies in different ethnic populations are needed to better elucidate the role of eNOS gene polymorphism in the pathogenesis of ED. ..
  3. Safarinejad M, Shafiei N, Safarinejad S. Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men. Med Oncol. 2011;28 Suppl 1:S398-412 pubmed publisher
    ..01). There was no significant correlation between serum levels of tHcy and folate and bladder cancer risk. Further studies in larger samples size and different ethnicity are required to confirm our findings. ..
  4. Safarinejad M. Effect of pentoxifylline on semen parameters, reproductive hormones, and seminal plasma antioxidant capacity in men with idiopathic infertility: a randomized double-blind placebo-controlled study. Int Urol Nephrol. 2011;43:315-28 pubmed publisher
    ..003). The acrosome reaction was observed to be increased in PTX group (P = 0.01). Levels of reproductive hormones were also affected. PTX administration significantly improves semen parameters in infertile men with idiopathic OAT. ..
  5. Safarinejad M, Hosseini S. Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study. J Urol. 2008;179:1066-71 pubmed publisher
    ..Further studies with different dosages and treatment regimens are necessary to draw final conclusions on the efficacy of this drug in erectile dysfunction. ..
  6. Safarinejad M. Treatment of nonparaphilic hypersexuality in men with a long-acting analog of gonadotropin-releasing hormone. J Sex Med. 2009;6:1151-1164 pubmed publisher
    ..After 3 months, serum T, and fT levels decreased by 50% in 65 (85.5%) of patients (P = 0.01). Triptorelin was very effective and well tolerated in men with NPH. Further studies are needed to replicate our results. ..
  7. Safarinejad M, Hosseini S, Kolahi A. Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. J Urol. 2007;178:1398-403; discussion 1403 pubmed
    ..1). This study did not show significant improvement in pain, curvature or plaque size in patients with PD treated with vitamin E, propionyl-L-carnitine, or vitamin E plus propionyl-L-carnitine compared with those treated with placebo. ..
  8. Safarinejad M. Efficacy and safety of omega-3 for treatment of early-stage Peyronie's disease: A prospective, randomized, double-blind placebo-controlled study. J Sex Med. 2009;6:1743-1754 pubmed publisher
    ..Mean index of IIEF-5 in 6-month treatment period was 8.8 +/- 1.6 in the omega-3 group and 8.8 +/- 1.4 in the placebo group (P = 0.1). These data do not support a beneficial effect of omega-3 supplementation in early-chronic stage PD. ..
  9. Safarinejad M, Kolahi A, Hosseini L. The effect of the mode of delivery on the quality of life, sexual function, and sexual satisfaction in primiparous women and their husbands. J Sex Med. 2009;6:1645-1667 pubmed publisher
    ..In healthy women with normal singleton pregnancies at term, instrumental deliveries are associated with the highest and PCS associated with the lowest rate of long-term maternal and paternal sexual dysfunction. ..

More Information


  1. Safarinejad M, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. Phytother Res. 2011;25:508-16 pubmed publisher
    ..If medical professionals want to prescribe herbal remedies for male infertility, previous rigorous scientific investigations, documenting their safety and efficacy are required...
  2. Safarinejad M, Shafiei N, Safarinejad S. Relationship of insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) gene polymorphism with the susceptibility to development of prostate cancer and influence on serum levels of IGF-I, and IGFBP-3. Growth Horm IGF Res. 2011;21:146-54 pubmed publisher
    ..01, respectively) compared with controls. The AA genotype at IGFBP-3 gene polymorphism is associated with reduced risks of PCa and BPH. Both IGF-I and IGFBP-3 concentrations, are associated with modified risks of PCa and BPH. ..
  3. Safarinejad M. Infertility among couples in a population-based study in Iran: prevalence and associated risk factors. Int J Androl. 2008;31:303-14 pubmed
    ..Yet, further studies on the cause of primary and secondary infertility and geographical variations in the incidence and prevalence of infertility in Iran are needed...
  4. Safarinejad M, Shafiei N, Safarinejad S. Association of the (TAAAA)n repeat and Asp327Asn polymorphisms in the sex hormone-binding globulin (SHBG) gene with idiopathic male infertility and relation to serum SHBG concentrations. J Steroid Biochem Mol Biol. 2011;123:37-45 pubmed publisher
    ..Multicenter large scale studies are warranted to better elucidate the role of SHBG gene polymorphism in male infertility. ..
  5. Safarinejad M, Shafiei N, Safarinejad S. Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parameters. J Steroid Biochem Mol Biol. 2010;122:193-203 pubmed publisher
    ..Further studies are needed to replicate our findings as well as to better elucidate the biological mechanisms of the modulation of ESR-?, and ER-? on male infertility...
  6. Safarinejad M. Relationship between premature ejaculation and genetic polymorphisms of the dopamine transporter gene (SLC6A3). BJU Int. 2011;108:292-6 pubmed publisher
    ..Further studies are needed to replicate these results and to evaluate the role of inconsistency in the DAT genes and how this affects the development of PE. ..
  7. Safarinejad M, Shafiei N, Safarinejad S. Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran. Prostate Cancer Prostatic Dis. 2011;14:105-13 pubmed publisher
    ..62 (95% CI: 2.31-5.74; P=0.004). The results obtained demonstrated that simultaneous presence of three potentially risk alleles (GSTM1 null, GSTT1 null and GSTP1 Val) lead to a significant OR increase for PCa. ..
  8. Safarinejad M, Shafiei N, Safarinejad S. The association between bladder cancer and a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) gene. Arch Toxicol. 2011;85:1209-18 pubmed publisher
    ..10, P = 0.87). Genetic polymorphism of the IGFBP-3 gene may be involved in the etiology of bladder TCC, and our results need further confirmation by larger studies. ..
  9. Safarinejad M. Reversal of SSRI-induced female sexual dysfunction by adjunctive bupropion in menstruating women: a double-blind, placebo-controlled and randomized study. J Psychopharmacol. 2011;25:370-8 pubmed publisher
    ..2% (95% CI 44.7-82.6%, p = 0.001) in the bupropion group. Adjunctive treatment with bupropion sustained release during a 12-week period significantly improved key aspects of sexual function in women with SSRI-induced sexual dysfunction. ..
  10. Safarinejad M. The effect of coenzyme Q?? supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. Int Urol Nephrol. 2012;44:689-700 pubmed publisher
    ..7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months. CoQ(10) supplementation improves semen quality with beneficial effect on pregnancy rate. ..