Mohammad Hossein Nasr Esfahani


Affiliation: Royan Institute
Country: Iran


  1. Zadegan F, Ghaedi K, Kalantar S, Peymani M, Hashemi M, Baharvand H, et al. Cardiac differentiation of mouse embryonic stem cells is influenced by a PPAR γ/PGC-1α-FNDC5 pathway during the stage of cardiac precursor cell formation. Eur J Cell Biol. 2015;94:257-66 pubmed publisher
    ..We concluded that PPARγ agonist and antagonist induced up and down-regulation of PGC-1α and subsequently modulated the process of CPCs formation through an alteration in FNDC5 and mitochondrial markers expression. ..
  2. Hosseini Farahabadi S, Ghaedi K, Ghazvini Zadegan F, Karbalaie K, Rabiee F, Nematollahi M, et al. ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs. Neuroscience. 2015;297:252-61 pubmed publisher
    ..This led us to conclude that RA enhances Fndc5 expression through a non-genomic pathway via the ERK signaling pathway. ..
  3. Ghahrizjani F, Ghaedi K, Salamian A, Tanhaei S, Nejati A, Salehi H, et al. Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues. Gene. 2015;557:123-9 pubmed publisher
    ..Additional research is necessary to determine the major function of FDNC5 in this process. ..
  4. Rabiee F, Forouzanfar M, Ghazvini Zadegan F, Tanhaei S, Ghaedi K, Motovali Bashi M, et al. Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells. Gene. 2014;551:127-37 pubmed publisher
    ..These data suggest that Fndc5 may be involved in cardiomyocyte differentiation. Therefore, a new hope will be arisen for potential application of this myokine for regeneration of damaged cardiac tissues especially in cardiac failure. ..
  5. Ziaei A, Ardakani M, Hashemi M, Peymani M, Ghaedi K, Baharvand H, et al. Acute course of deferoxamine promoted neuronal differentiation of neural progenitor cells through suppression of Wnt/β-catenin pathway: a novel efficient protocol for neuronal differentiation. Neurosci Lett. 2015;590:138-44 pubmed publisher
    ..We concluded that suppression of Wnt/β-catenin pathway was induced through chelating of intracellular Iron due to DFO treatment. These findings help to understand therapeutic benefit of DFO as a neuroprotective agent. ..
  6. Darehgazani R, Peymani M, Hashemi M, Omrani M, Movafagh A, Ghaedi K, et al. PPARγ ameliorated LPS induced inflammation of HEK cell line expressing both human Toll-like receptor 4 (TLR4) and MD2. Cytotechnology. 2016;68:1337-48 pubmed publisher
    ..PPARγ was shown to negatively regulate TLR4 activity and therefore exerts its anti-inflammatory action against LPS induced inflammation. ..
  7. Kajabadi N, Ghoochani A, Peymani M, Ghaedi K, Kiani Esfahani A, Hashemi M, et al. The Synergistic Enhancement of Cloning Efficiency in Individualized Human Pluripotent Stem Cells by Peroxisome Proliferative-activated Receptor-γ (PPARγ) Activation and Rho-associated Kinase (ROCK) Inhibition. J Biol Chem. 2015;290:26303-13 pubmed publisher
    ..These effects were reversed by GW-9662, an irreversible peroxisome proliferative-activated receptor-γ antagonist. This novel setting provided a step toward hPSC manipulation and its biomedical applications. ..
  8. Taheri M, Salamian A, Ghaedi K, Peymani M, Izadi T, Nejati A, et al. A ground state of PPARγ activity and expression is required for appropriate neural differentiation of hESCs. Pharmacol Rep. 2015;67:1103-14 pubmed publisher
    ..However, high expression and activity of PPARγ could not enhance the required neural differentiation, whereas the PPARγ inactivation could negatively influence NP formation from hESCs by antagonist. ..
  9. Esmaeili M, Ghaedi K, Shoaraye Nejati A, Nematollahi M, Shiralyian H, Nasr Esfahani M. Pioglitazone significantly prevented decreased rate of neural differentiation of mouse embryonic stem cells which was reduced by Pex11β knock-down. Neuroscience. 2016;312:35-47 pubmed publisher

More Information


  1. Jodeiri Farshbaf M, Ghaedi K, Megraw T, Curtiss J, Shirani Faradonbeh M, Vaziri P, et al. Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?. Neuromolecular Med. 2016;18:1-15 pubmed publisher
    ..This review presents recent findings on the PGC1α/FNDC5/BDNF pathway and its role in neuroprotection, and discusses the controversial promise of irisin as a mediator of the positive benefits of exercise. ..
  2. Ghadiri N, Emamnia N, Ganjalikhani Hakemi M, Ghaedi K, Etemadifar M, Salehi M, et al. Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients. Gene. 2018;659:109-117 pubmed publisher
    ..Collectively, we showed a correlation between the four miRNAs with different phases of MS and their possible involvement in differentiation pathways of Th17 cells, as the most important players in MS. ..
  3. Ahmadian Elmi M, Bidmeshki Pour A, Naghavian R, Ghaedi K, Tanhaei S, Izadi T, et al. miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing-remitting multiple sclerosis. Immunogenetics. 2016;68:43-54 pubmed publisher
    ..Our data suggest that miR-27a may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation while miR-214 has an adverse effect. ..
  4. Jodeiri Farshbaf M, Forouzanfar M, Ghaedi K, Kiani Esfahani A, Peymani M, Shoaraye Nejati A, et al. Nurr1 and PPAR? protect PC12 cells against MPP(+) toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment. Mol Cell Biochem. 2016;420:29-42 pubmed publisher
    ..Moreover, production of intracellular ROS and MMP modulated by MPP(+) was decreased by PPAR? and Nurr1 agonists' treatment alone and in the combined form. ..
  5. Kashfi S, Ghaedi K, Baharvand H, Nasr Esfahani M, Javan M. A1 Adenosine Receptor Activation Modulates Central Nervous System Development and Repair. Mol Neurobiol. 2017;54:8128-8139 pubmed publisher
    ..Next, we summarize some of the most well-known biological effects of A1AR in the central nervous system (CNS) during development and adulthood, in addition to its role in nervous system regeneration and repair. ..
  6. Peymani M, Ghaedi K, Hashemi M, Ghoochani A, Kiani Esfahani A, Nasr Esfahani M, et al. Ameliorating the Effect of Pioglitazone on LPS-Induced Inflammation of Human Oligodendrocyte Progenitor Cells. Cell Mol Neurobiol. 2018;38:517-527 pubmed publisher
    ..Taken together, therapy with Pioglitazone represents a novel potential drug in alleviating the loss of OPCs in neurodegenerative conditions. ..
  7. Kashfi S, Peymani M, Ghaedi K, Baharvand H, Nasr Esfahani M, Javan M. Purinergic Receptor Expression and Potential Association with Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Development. Cell J. 2017;19:386-402 pubmed publisher
    ..Elucidation of the expression pattern of purinergic receptors and the effects of different subtypes of these receptors in hESC-OPCs may have a promising role in future cell-based therapy or drug design for demyelinating disease. ..