Affiliation: Royan Institute
Kajabadi N, Ghoochani A, Peymani M, Ghaedi K, Kiani Esfahani A, Hashemi M, et al
. The Synergistic Enhancement of Cloning Efficiency in Individualized Human Pluripotent Stem Cells by Peroxisome Proliferative-activated Receptor-Î³ (PPARÎ³) Activation and Rho-associated Kinase (ROCK) Inhibition. J Biol Chem. 2015;290:26303-13 pubmed publisher
..These effects were reversed by GW-9662, an irreversible peroxisome proliferative-activated receptor-Î³ antagonist. This novel setting provided a step toward hPSC manipulation and its biomedical applications. ..
Taheri M, Salamian A, Ghaedi K, Peymani M, Izadi T, Nejati A, et al
. A ground state of PPARÎ³ activity and expression is required for appropriate neural differentiation of hESCs. Pharmacol Rep. 2015;67:1103-14 pubmed publisher
..However, high expression and activity of PPARÎ³ could not enhance the required neural differentiation, whereas the PPARÎ³ inactivation could negatively influence NP formation from hESCs by antagonist. ..
Esmaeili M, Ghaedi K, Shoaraye Nejati A, Nematollahi M, Shiralyian H, Nasr Esfahani M. Pioglitazone significantly prevented decreased rate of neural differentiation of mouse embryonic stem cells which was reduced by Pex11Î² knock-down. Neuroscience. 2016;312:35-47 pubmed publisher
Jodeiri Farshbaf M, Ghaedi K, Megraw T, Curtiss J, Shirani Faradonbeh M, Vaziri P, et al
. Does PGC1Î±/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?. Neuromolecular Med. 2016;18:1-15 pubmed publisher
..This review presents recent findings on the PGC1Î±/FNDC5/BDNF pathway and its role in neuroprotection, and discusses the controversial promise of irisin as a mediator of the positive benefits of exercise. ..
Ahmadian Elmi M, Bidmeshki Pour A, Naghavian R, Ghaedi K, Tanhaei S, Izadi T, et al
. miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing-remitting multiple sclerosis. Immunogenetics. 2016;68:43-54 pubmed publisher
..Our data suggest that miR-27a may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation while miR-214 has an adverse effect. ..
Jodeiri Farshbaf M, Forouzanfar M, Ghaedi K, Kiani Esfahani A, Peymani M, Shoaraye Nejati A, et al
. Nurr1 and PPAR? protect PC12 cells against MPP(+) toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment. Mol Cell Biochem. 2016;420:29-42 pubmed publisher
..Moreover, production of intracellular ROS and MMP modulated by MPP(+) was decreased by PPAR? and Nurr1 agonists' treatment alone and in the combined form. ..
Peymani M, Ghaedi K, Hashemi M, Ghoochani A, Kiani Esfahani A, Nasr Esfahani M, et al
. Ameliorating the Effect of Pioglitazone on LPS-Induced Inflammation of Human Oligodendrocyte Progenitor Cells. Cell Mol Neurobiol. 2018;38:517-527 pubmed publisher
..Taken together, therapy with Pioglitazone represents a novel potential drug in alleviating the loss of OPCs in neurodegenerative conditions. ..
Safaeinejad Z, Nabiuni M, Peymani M, Ghaedi K, Nasr Esfahani M, Baharvand H. Resveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway. Eur J Cell Biol. 2017;96:665-672 pubmed publisher
..These findings provide a novel application of RSV for developing a defined medium for hESCs culture which could help to better understanding of the signaling events that govern self-renewal of hESCs. ..
Mazaheri N, Peymani M, Galehdari H, Ghaedi K, Ghoochani A, Kiani Esfahani A, et al
. Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells. Cell Mol Neurobiol. 2018;38:891-899 pubmed publisher
..Therefore OPN therapy may be considered as a feasible process to prevent progress of neurodegenerative diseases in human. ..