Gerasimos Siasos

Summary

Affiliation: University of Athens Medical School
Location: Athens, Greece
Publications:
1: Tousoulis D, Siasos G, Maniatis K, Oikonomou E, Vlasis K, Papavassiliou AG,
Stefanadis C. Novel Biomarkers Assessing the Calcium Deposition in Coronary
Artery Disease. Curr Med Chem. 2012 Jan 10. [Epub ahead of print] PubMed PMID:
.


2: Siasos G, Tousoulis D, Oikonomou E, Zaromitidou M, Stefanadis C, Papavassiliou
AG. Inflammatory markers in hyperlipidemia: from experimental models to clinical
practice. Curr Pharm Des. 2011 Dec;17(37):4132-46. PubMed PMID: .


3: Androulakis E, Tousoulis D, Papageorgiou N, Latsios G, Siasos G, Tsioufis C,
Giolis A, Stefanadis C. Inflammation in hypertension: current therapeutic
approaches. Curr Pharm Des. 2011 Dec;17(37):4121-31. PubMed PMID: .


4: Papageorgiou N, Tousoulis D, Androulakis E, Giotakis A, Siasos G, Latsios G,
Stefanadis C. Lifestyle Factors and Endothelial Function. Curr Vasc Pharmacol.
2011 Nov 21. [Epub ahead of print] PubMed PMID: .


5: Siasos G, Tousoulis D, Oikonomou E, Zaromitidou M, Verveniotis A, Plastiras A,
Kioufis S, Maniatis K, Miliou A, Siasou Z, Stefanadis C, Papavassiliou AG.
Effects of omega-3 fatty acids on endothelial function, arterial wall properties,
inflammatory and fibrinolytic status in smokers: A cross over study. Int J
Cardiol. 2011 Nov 17. [Epub ahead of print] PubMed PMID: .


6: Tousoulis D, Siasos G, Oikonomou E, Stougianos P, Papageorgiou N,
Papavassiliou AG, Stefanadis C. Asymmetric dimethylarginine (ADMA): is really a
biomarker for cardiovascular prognosis? Int J Cardiol. 2011 Dec 1;153(2):123-5.
Epub 2011 Sep 19. PubMed PMID: .


7: Tousoulis D, Papageorgiou N, Latsios G, Siasos G, Antoniades C, Stefanadis C.
C-reactive protein and endothelial dysfunction: gazing at the coronaries. Int J
Cardiol. 2011 Oct 6;152(1):1-3. Epub 2011 Aug 20. PubMed PMID: .


8: Avgerinou G, Tousoulis D, Siasos G, Oikonomou E, Maniatis K, Papageorgiou N,
Paraskevopoulos T, Miliou A, Koumaki D, Latsios G, Therianiou A, Trikas A,
Kampoli AM, Stefanadis C. Anti-tumor necrosis factor alpha treatment with
adalimumab improves significantly endothelial function and decreases inflammatory
process in patients with chronic psoriasis. Int J Cardiol. 2011 Sep
15;151(3):382-3. Epub 2011 Jul 18. PubMed PMID: .


9: Tousoulis D, Androulakis E, Papageorgiou N, Briasoulis A, Siasos G, Antoniades
C, Stefanadis C. From atherosclerosis to acute coronary syndromes: the role of
soluble CD40 ligand. Trends Cardiovasc Med. 2010 Jul;20(5):153-64. Review. PubMed
PMID: .


10: Papaoikonomou S, Tousoulis D, Tentolouris N, Papadogiannis D, Miliou A,
Hatzis G, Papageorgiou N, Siasos G, Tsioufis C, Latsios G, Stefanadis C.
Assessment of the effects of the A3872G polymorphism on the C-reactive protein
gene in patients with diabetes mellitus type 2. Int J Cardiol. 2011 Sep
1;151(2):243-5. Epub 2011 Jul 7. PubMed PMID: .


11: Chrysohoou C, Skoumas J, Pitsavos C, Masoura C, Siasos G, Galiatsatos N,
Psaltopoulou T, Mylonakis C, Margazas A, Kyvelou S, Mamatas S, Panagiotakos D,
Stefanadis C. Long-term adherence to the Mediterranean diet reduces the
prevalence of hyperuricaemia in elderly individuals, without known cardiovascular
disease: the Ikaria study. Maturitas. 2011 Sep;70(1):58-64. Epub 2011 Jul 2.
PubMed PMID: .


12: Panagiotakos DB, Chrysohoou C, Siasos G, Zisimos K, Skoumas J, Pitsavos C,
Stefanadis C. Sociodemographic and lifestyle statistics of oldest old people (>80
years) living in ikaria island: the ikaria study. Cardiol Res Pract. 2011 Feb
24;2011:679187. PubMed PMID: ; PubMed Central PMCID: PMC3051199.


13: Siasos G, Tousoulis D, Gialafos E, Oikonomou E, Zaromitidou M, Aggeli C,
Korompelis P, Kallianos A, Rapti A, Zisimos K, Marinos G, Stefanadis C,
Papavassiliou AG. Association of sarcoidosis with endothelial function, arterial
wall properties, and biomarkers of inflammation. Am J Hypertens. 2011
Jun;24(6):647-53. doi: 10.1038/ajh.2011.30. Epub 2011 Mar 3. PubMed PMID:
.


14: Papageorgiou N, Tousoulis D, Psaltopoulou T, Giolis A, Antoniades C, Tsiamis
E, Miliou A, Toutouzas K, Siasos G, Stefanadis C. Divergent anti-inflammatory
effects of different oil acute consumption on healthy individuals. Eur J Clin
Nutr. 2011 Apr;65(4):514-9. Epub 2011 Feb 16. PubMed PMID: .


15: Oikonomou E, Tousoulis D, Siasos G, Zaromitidou M, Papavassiliou AG,
Stefanadis C. The role of inflammation in heart failure: new therapeutic
approaches. Hellenic J Cardiol. 2011 Jan-Feb;52(1):30-40. Review. PubMed PMID:
.


16: Siasos G, Tousoulis D, Stefanadis C. CYP2C19 genotype and outcomes of
clopidogrel treatment. N Engl J Med. 2011 Feb 3;364(5):481-2. PubMed PMID:
.


17: Boutsikou M, Konstadoulakis M, Tousoulis D, Aggeli C, Bistola V, Doumba P,
Siasos G, Latsios G, Papageorgiou N, Tentolouris C, Stefanadis C. Lymphocyte
activation and apoptotic process in acute coronary syndromes. Int J Cardiol. 2011
Mar 17;147(3):449-50. Epub 2011 Jan 11. PubMed PMID: .


18: Gialafos E, Rapti A, Kouranos V, Aggeli K, Papaioannou TG, Kallianos A,
Siasos G, Kostopoulos C, Stefanadis C. Detection of right ventricular dysfunction
by tissue Doppler imaging in asymptomatic patients with pulmonary sarcoidosis.
Eur Respir J. 2011 Jan;37(1):212-5. PubMed PMID: .


19: Tousoulis D, Siasos G, Zaromytidou M, Papageorgiou N, Stefanadi E, Oikonomou
E, Stefanadis C. The role of the cytochrome P450 polymorphisms in clopidogrel
efficacy and clinical utility. Curr Med Chem. 2011;18(3):427-38. Review. PubMed
PMID: .


20: Tousoulis D, Andreou I, Tsiatas M, Miliou A, Tentolouris C, Siasos G,
Papageorgiou N, Papadimitriou CA, Dimopoulos MA, Stefanadis C. Effects of
rosuvastatin and allopurinol on circulating endothelial progenitor cells in
patients with congestive heart failure: the impact of inflammatory process and
oxidative stress. Atherosclerosis. 2011 Jan;214(1):151-7. Epub 2010 Nov 11.
PubMed PMID: .


21: Tousoulis D, Andreou I, Antoniades C, Siasos G, Stougiannos P, Trikas A,
Stefanadis C. Do endothelial progenitor cells modify our strategy to treat risk
factors? Int J Cardiol. 2011 Oct 6;152(1):95-7. Epub 2010 Nov 26. PubMed PMID:
.


22: Siasos G, Tousoulis D, Siasou G, Moschos MM, Oikonomou E, Zaromitidou M,
Marinos G, Korompelis P, Papavassiliou AG, Stefanadis C. The association between
glaucoma, vascular function and inflammatory process. Int J Cardiol. 2011 Jan
7;146(1):113-5. Epub 2010 Oct 29. PubMed PMID: .


23: Tousoulis D, Koutsogiannis M, Papageorgiou N, Siasos G, Antoniades C, Tsiamis
E, Stefanadis C. Endothelial dysfunction: potential clinical implications.
Minerva Med. 2010 Aug;101(4):271-84. Review. PubMed PMID: .


24: Tousoulis D, Antoniades C, Tsiamis E, Charakida M, Siasos G, Tsioufis C,
Stefanadis C. Gene therapy for dysfunctional endothelium: is dimethylarginine
dimethylaminohydrolase-2 a therapeutic target? Int J Cardiol. 2010 Oct
8;144(2):173-4. Epub 2010 Jun 9. PubMed PMID: .


25: Panas M, Gialafos E, Spengos K, Papaioannou TG, Aggeli K, Kladi A, Siasos G,
Gialafos J, Vassilopoulos D, Stefanadis C. Prevalence of interatrial block in
patients with Friedreichs ataxia. Int J Cardiol. 2010 Nov 19;145(2):386-7. Epub
2010 Mar 7. PubMed PMID: .


26: Papageorgiou N, Tousoulis D, Siasos G, Stefanadis C. Is fibrinogen a marker
of inflammation in coronary artery disease? Hellenic J Cardiol. 2010
Jan-Feb;51(1):1-9. PubMed PMID: .


27: Tousoulis D, Koniari K, Antoniades C, Papageorgiou N, Miliou A, Noutsou M,
Nikolopoulou A, Marinou K, Stefanadi E, Siasos G, Charakida M, Kamboli AM,
Stefanadis C. Combined effects of atorvastatin and metformin on glucose-induced
variations of inflammatory process in patients with diabetes mellitus. Int J
Cardiol. 2011 May 19;149(1):46-9. Epub 2009 Dec 24. PubMed PMID: .


28: Andreou I, Tousoulis D, Miliou A, Tentolouris C, Zisimos K, Gounari P, Siasos
G, Papageorgiou N, Papadimitriou CA, Dimopoulos MA, Stefanadis C. Effects of
rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a
randomized placebo-controlled study. Atherosclerosis. 2010 May;210(1):194-8. Epub
2009 Nov 10. PubMed PMID: .


29: Marinos G, Vasileiou I, Katsargyris A, Klonaris CP, Korombelis P, Michail O,
Valatsou A, Griniatsos J, Vlasis K, Siasos G, Souliotis K, Konstantopoulos K.
Management of minor medical problems and trauma: the role of general practice.
Rural Remote Health. 2009 Oct-Dec;9(4):1019. Epub 2009 Oct 19. PubMed PMID:
.


30: Tousoulis D, Kampoli AM, Siasos G, Stefanadi E, Antoniades C, Papavassiliou
AG, Stefanadis C. Circulating biomarkers for the diagnosis and prognosis of heart
failure. Curr Med Chem. 2009;16(29):3828-40. PubMed PMID: .


31: Kampoli AM, Tousoulis D, Antoniades C, Siasos G, Stefanadis C. Biomarkers of
premature atherosclerosis. Trends Mol Med. 2009 Jul;15(7):323-32. Epub 2009 Jul
3. Review. PubMed PMID: .


32: Stefanadi E, Tousoulis D, Androulakis ES, Papageorgiou N, Charakida M, Siasos
G, Tsioufis C, Stefanadis C. Inflammatory markers in essential hypertension:
potential clinical implications. Curr Vasc Pharmacol. 2010 Jul;8(4):509-16.
Review. PubMed PMID: .


33: Tousoulis D, Antonopoulos AS, Antoniades C, Saldari C, Stefanadi E, Siasos G,
Stougianos P, Plastiras A, Korompelis P, Stefanadis C. Role of depression in
heart failure--choosing the right antidepressive treatment. Int J Cardiol. 2010
Apr 1;140(1):12-8. Epub 2009 Jun 6. Review. PubMed PMID: .


34: Siasos G, Tousoulis D, Vlachopoulos C, Antoniades C, Stefanadi E, Ioakeimidis
N, Zisimos K, Siasou Z, Papavassiliou AG, Stefanadis C. The impact of oral
L-arginine supplementation on acute smoking-induced endothelial injury and
arterial performance. Am J Hypertens. 2009 Jun;22(6):586-92. Epub 2009 Mar 19.
PubMed PMID: .


35: Siasos G, Tousoulis D, Stefanadis C. Multiple mechanisms affect the
clopidogrel response. J Am Coll Cardiol. 2009 Mar 10;53(10):900-1; author reply
901. PubMed PMID: .


36: Gounari P, Tousoulis D, Antoniades C, Kampoli AM, Stougiannos P, Papageorgiou
N, Roulia G, Stefanadi E, Siasos G, Tsioufis C, Stefanadis C. Rosuvastatin but
not ezetimibe improves endothelial function in patients with heart failure, by
mechanisms independent of lipid lowering. Int J Cardiol. 2010 Jun
25;142(1):87-91. Epub 2009 Feb 6. PubMed PMID: .


37: Tousoulis D, Siasos G, Stefanadis C. Aspirin resistance: what the
cardiologist needs to know? Int J Cardiol. 2009 Feb 20;132(2):153-6. Epub 2009
Jan 22. PubMed PMID: .


38: Vasileiou I, Marinos G, Katsargyris A, Georgiou C, Vlasis K, Siasos G,
Gialafos E, Klonaris C, Konstantopoulos K, Giannopoulos A. Avian flu: how
informed are children in Greece? South Med J. 2008 Nov;101(11):1121-5. PubMed
PMID: .


39: Charakida M, Tousoulis D, Skoumas I, Pitsavos C, Vasiliadou C, Stefanadi E,
Antoniades C, Latsios G, Siasos G, Stefanadis C. Inflammatory and thrombotic
processes are associated with vascular dysfunction in children with familial
hypercholesterolemia. Atherosclerosis. 2009 Jun;204(2):532-7. Epub 2008 Oct 5.
PubMed PMID: .


40: Tousoulis D, Antoniades C, Marinou K, Vasiliadou C, Bouras G, Stefanadi E,
Latsios G, Siasos G, Toutouzas K, Stefanadis C. Methionine-loading rapidly
impairs endothelial function, by mechanisms independent of endothelin-1: evidence
for an association of fasting total homocysteine with plasma endothelin-1 levels.
J Am Coll Nutr. 2008 Jun;27(3):379-86. PubMed PMID: .


41: Tousoulis D, Zisimos K, Antoniades C, Stefanadi E, Siasos G, Tsioufis C,
Papageorgiou N, Vavouranakis E, Vlachopoulos C, Stefanadis C. Oxidative stress
and inflammatory process in patients with atrial fibrillation: the role of left
atrium distension. Int J Cardiol. 2009 Aug 21;136(3):258-62. Epub 2008 Jul 25.
PubMed PMID: .


42: Tousoulis D, Drolias A, Antoniades C, Vasiliadou C, Marinou K, Latsios G,
Stefanadi E, Gounari P, Siasos G, Papageorgiou N, Trikas A, Stefanadis C.
Antidepressive treatment as a modulator of inflammatory process in patients with
heart failure: effects on proinflammatory cytokines and acute phase protein
levels. Int J Cardiol. 2009 May 15;134(2):238-43. Epub 2008 Jun 24. PubMed PMID:
.


43: Tousoulis D, Kampoli AM, Stefanadi E, Antoniades C, Siasos G, Papavassiliou
AG, Stefanadis C. New biochemical markers in acute coronary syndromes. Curr Med
Chem. 2008;15(13):1288-96. Review. PubMed PMID: .


44: Nikolopoulou A, Tousoulis D, Antoniades C, Petroheilou K, Vasiliadou C,
Papageorgiou N, Koniari K, Stefanadi E, Latsios G, Siasos G, Stefanadis C. Common
community infections and the risk for coronary artery disease and acute
myocardial infarction: evidence for chronic over-expression of tumor necrosis
factor alpha and vascular cells adhesion molecule-1. Int J Cardiol. 2008 Nov
12;130(2):246-50. Epub 2007 Dec 11. PubMed PMID: .


45: Tousoulis D, Antoniades C, Nikolopoulou A, Koniari K, Vasiliadou C, Marinou
K, Koumallos N, Papageorgiou N, Stefanadi E, Siasos G, Stefanadis C. Interaction
between cytokines and sCD40L in patients with stable and unstable coronary
syndromes. Eur J Clin Invest. 2007 Aug;37(8):623-8. PubMed PMID: .


46: Siasos G, Tousoulis D, Vlachopoulos C, Antoniades C, Stefanadi E, Ioakeimidis
N, Andreou I, Zisimos K, Papavassiliou AG, Stefanadis C. Short-term treatment
with L-arginine prevents the smoking-induced impairment of endothelial function
and vascular elastic properties in young individuals. Int J Cardiol. 2008 Jun
6;126(3):394-9. Epub 2007 Jun 22. PubMed PMID: .


47: Siasos G, Tousoulis D, Siasou Z, Stefanadis C, Papavassiliou AG. Shear
stress, protein kinases and atherosclerosis. Curr Med Chem. 2007;14(14):1567-72.
Review. PubMed PMID: .


48: Antoniades C, Tousoulis D, Marinou K, Papageorgiou N, Bosinakou E, Tsioufis
C, Stefanadi E, Latsios G, Tentolouris C, Siasos G, Stefanadis C. Effects of
insulin dependence on inflammatory process, thrombotic mechanisms and endothelial
function, in patients with type 2 diabetes mellitus and coronary atherosclerosis.
Clin Cardiol. 2007 Jun;30(6):295-300. PubMed PMID: .


49: Tousoulis D, Böger RH, Antoniades C, Siasos G, Stefanadi E, Stefanadis C.
Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical
perspective. Nat Clin Pract Cardiovasc Med. 2007 May;4(5):274-83. Review. PubMed
PMID: .


50: Tousoulis D, Kourtellaris P, Antoniades C, Vasiliadou C, Papageorgiou N,
Tentolouris C, Siasos G, Stefanadi E, Stefanadis C. Effects of irbesartan and
perindopril on forearm reactive hyperemia and inflammatory process, in
normotensive patients with coronary artery disease. Int J Cardiol. 2008 Feb
20;124(1):127-9. Epub 2007 Mar 6. PubMed PMID: .


51: Tousoulis D, Charakida M, Stefanadi E, Siasos G, Latsios G, Stefanadis C.
Statins in heart failure. Beyond the lipid lowering effect. Int J Cardiol. 2007
Feb 7;115(2):144-50. Epub 2006 Dec 15. Review. Erratum in: Int J Cardiol. 2008
Jan 11;123(2):218. PubMed PMID: .


52: Tousoulis D, Antoniades C, Vasiliadou C, Kourtellaris P, Koniari K, Marinou
K, Charakida M, Ntarladimas I, Siasos G, Stefanadis C. Effects of atorvastatin
and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine
levels and the inflammatory process in patients with type 2 diabetes mellitus.
Heart. 2007 Feb;93(2):244-6. Epub 2006 Aug 16. PubMed PMID: ; PubMed
Central PMCID: PMC1861391.


53: Antoniades C, Tousoulis D, Marinou K, Stefanadi E, Ntarladimas I, Latsios G,
Konniari K, Papageorgiou N, Siasos G, Stefanadis C. Effects of lipid profile on
forearm hyperemic response in young subjects. Hellenic J Cardiol. 2006
May-Jun;47(3):152-7. PubMed PMID: .


54: Siasos G, Tousoulis D, Antoniades C, Stefanadi E, Stefanadis C. L-Arginine,
the substrate for NO synthesis: an alternative treatment for premature
atherosclerosis? Int J Cardiol. 2007 Apr 4;116(3):300-8. Epub 2006 Jul 24.
Review. PubMed PMID: .


55: Tousoulis D, Antoniades C, Charakida M, Toutouzas K, Trikas A, Stefanadi E,
Siasos G, Latsios G, Stefanadis C. Cold pressor test as a marker for the
detection of early stage coronary atherosclerosis. Int J Cardiol. 2007 Jan
31;115(1):120-2. Epub 2006 Jun 19. PubMed PMID: .


56: Vlachopoulos C, Kosmopoulou F, Alexopoulos N, Ioakeimidis N, Siasos G,
Stefanadis C. Acute mental stress has a prolonged unfavorable effect on arterial
stiffness and wave reflections. Psychosom Med. 2006 Mar-Apr;68(2):231-7. PubMed
PMID: .


57: Toutouzas K, Drakopoulou M, Stefanadi E, Siasos G, Stefanadis C.
Intracoronary thermography: does it help us in clinical decision making? J Interv
Cardiol. 2005 Dec;18(6):485-9. Review. PubMed PMID: .

Publications

  1. ncbi Circulating biomarkers for the diagnosis and prognosis of heart failure
    D Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Greece
    Curr Med Chem 16:3828-40. 2009
  2. ncbi Management of minor medical problems and trauma: the role of general practice
    George Marinos
    Laiko General Hospital, Athens, Greece
    Rural Remote Health 9:1019. 2009
  3. doi Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study
    Ioannis Andreou
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, 11528 Athens, Greece
    Atherosclerosis 210:194-8. 2010
  4. doi Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
  5. ncbi Prevalence of interatrial block in patients with Friedreich's Ataxia
    Marios Panas
    First Dept of Neurology, Medical School, National and Kapodistrian University of Athens, Greece
    Int J Cardiol 145:386-7. 2010
  6. ncbi Endothelial dysfunction: potential clinical implications
    D Tousoulis
    Hippokration Hospital, Athens University Medical School, Greece
    Minerva Med 101:271-84. 2010
  7. doi Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: the impact of inflammatory process and oxidative stress
    Dimitris Tousoulis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 214:151-7. 2011
  8. ncbi The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility
    D Tousoulis
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Curr Med Chem 18:427-38. 2011
  9. ncbi Acute mental stress has a prolonged unfavorable effect on arterial stiffness and wave reflections
    Charalambos Vlachopoulos
    Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    Psychosom Med 68:231-7. 2006
  10. doi Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals
    N Papageorgiou
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Eur J Clin Nutr 65:514-9. 2011

Collaborators

Detail Information

Publications70

  1. ncbi Circulating biomarkers for the diagnosis and prognosis of heart failure
    D Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Greece
    Curr Med Chem 16:3828-40. 2009
    ....
  2. ncbi Management of minor medical problems and trauma: the role of general practice
    George Marinos
    Laiko General Hospital, Athens, Greece
    Rural Remote Health 9:1019. 2009
    ..In Greece, recent reforms supporting urban primary healthcare have not been enacted, and long waiting times in Athens' emergency departments are common...
  3. doi Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study
    Ioannis Andreou
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, 11528 Athens, Greece
    Atherosclerosis 210:194-8. 2010
    ..Therefore in the present study we examined the effects of rosuvastatin and allopurinol on MPO levels in patients HF...
  4. doi Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
    ..We examined the effect of combined therapy with atorvastatin and metformin on glucose-induced variations of inflammatory molecules in patients with newly diagnosed diabetes mellitus type 2 (DM)...
  5. ncbi Prevalence of interatrial block in patients with Friedreich's Ataxia
    Marios Panas
    First Dept of Neurology, Medical School, National and Kapodistrian University of Athens, Greece
    Int J Cardiol 145:386-7. 2010
    ..Aim of the present study was to estimate the prevalence of interatrial block (IAB) in Friedreich's Ataxia (FA) compared to controls and correlate it with echocardiographic and genetic features...
  6. ncbi Endothelial dysfunction: potential clinical implications
    D Tousoulis
    Hippokration Hospital, Athens University Medical School, Greece
    Minerva Med 101:271-84. 2010
    ..Despite of the fact that there are several strategies aiming to improve endothelial dysfunction by enhancing nitric oxide bioavailability, it is still unclear whether they could be beneficial at a clinical level...
  7. doi Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: the impact of inflammatory process and oxidative stress
    Dimitris Tousoulis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 214:151-7. 2011
    ....
  8. ncbi The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility
    D Tousoulis
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Curr Med Chem 18:427-38. 2011
    ....
  9. ncbi Acute mental stress has a prolonged unfavorable effect on arterial stiffness and wave reflections
    Charalambos Vlachopoulos
    Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    Psychosom Med 68:231-7. 2006
    ..The purpose of this study was to assess the effect of acute mental stress on aortic stiffness and wave reflections...
  10. doi Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals
    N Papageorgiou
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Eur J Clin Nutr 65:514-9. 2011
    ..In this parallel study, we assessed the acute effects of extra virgin olive oil, soy oil, corn oil and cod liver oil on circulating soluble(s) forms of adhesion molecules and TNF-α...
  11. pmc Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in ikaria island: the ikaria study
    Demosthenes B Panagiotakos
    First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
    Cardiol Res Pract 2011:679187. 2011
    ..This concept must be further explored in order to understand how these factors relate and which are the most important in shaping prolonged life...
  12. doi Long-term adherence to the Mediterranean diet reduces the prevalence of hyperuricaemia in elderly individuals, without known cardiovascular disease: the Ikaria study
    Christina Chrysohoou
    1st Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
    Maturitas 70:58-64. 2011
    ..The purpose of this study was to evaluate the impact of adherence to Mediterranean diet on serum uric acid (UA) levels in elderly individuals, without known cardiovascular disease...
  13. doi From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 115 28 Athens, Greece
    Trends Cardiovasc Med 20:153-64. 2010
    ..Whether specific agents target the CD40/CD40L system as well as its pathogenic role in ACS remains to be elucidated by large-scale studies in the future...
  14. doi Effects of Ω-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study
    Gerasimos Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens Greece
    Int J Cardiol 166:340-6. 2013
    ..Supplementation of Ω-3 PUFAs is associated with better prognosis. Aim of this study was to evaluate the effects of Ω-3 polyunsaturated fatty acids (PUFAs) supplementation on smoking-induced impairment of arterial function...
  15. ncbi Lifestyle factors and endothelial function
    Nikolaos Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 10:94-106. 2012
    ..However, little is known about how individual's genetic background interacts with environmental influences on vascular health, thereby making the interpretation of the relative importance of lifestyle interventions more complicated...
  16. ncbi Inflammation in hypertension: current therapeutic approaches
    Emmanuel Androulakis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 17:4121-31. 2011
    ..Although the available data are encouraging, further large scale studies are required to evaluate the reported anti-inflammatory effects in management and treatment of arterial hypertension...
  17. ncbi Inflammatory markers in hyperlipidemia: from experimental models to clinical practice
    Gerasimos Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Curr Pharm Des 17:4132-46. 2011
    ..Although, cholesterol lowering treatment has several important beneficial effects, there is still little clinical experience or data from clinical trials, in order to treat patients with hyperlipidemia and impaired inflammatory status...
  18. ncbi Inflammatory markers in essential hypertension: potential clinical implications
    Elli Stefanadi
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:509-16. 2010
    ..However, further randomized studies are required to determine the potential favorable effects of suppression of inflammation in the management of arterial hypertension...
  19. ncbi Intracoronary thermography: does it help us in clinical decision making?
    Konstantinos Toutouzas
    1st Department of Cardiology, Medical School of Athens University, Hippokration Hospital, Athens, Greece
    J Interv Cardiol 18:485-9. 2005
    ....
  20. ncbi Cold pressor test as a marker for the detection of early stage coronary atherosclerosis
    Dimitris Tousoulis
    Int J Cardiol 115:120-2. 2007
  21. ncbi L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?
    Gerasimos Siasos
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga 69, Glifada, 16 675, Athens, Greece
    Int J Cardiol 116:300-8. 2007
    ..In conclusion, L-arginine administration may be useful in patients with premature atherosclerosis...
  22. ncbi Effects of lipid profile on forearm hyperemic response in young subjects
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 47:152-7. 2006
    ..In the present study we examined the effect of lipid profile on forearm vasodilatory response to reactive hyperemia, an index of endothelial function, in a cohort of young, low-risk adults...
  23. pmc Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus
    Dimitris Tousoulis
    Heart 93:244-6. 2007
  24. ncbi Statins in heart failure. Beyond the lipid lowering effect
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 115:144-50. 2007
    ..Finally the statin dose and the interaction with co-administered drugs need to be studied...
  25. ncbi Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease
    Dimitris Tousoulis
    Int J Cardiol 124:127-9. 2008
  26. ncbi Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective
    Dimitris Tousoulis
    Athens University Medical School, S Karagiorga 69, Glifada, 16675 Athens, Greece
    Nat Clin Pract Cardiovasc Med 4:274-83. 2007
    ..Here, we present a critique of the existing literature about the role of L-arginine in the prevention of atherosclerosis...
  27. ncbi Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
    ..Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity and abnormal inflammatory response...
  28. ncbi Shear stress, protein kinases and atherosclerosis
    Gerasimos Siasos
    Cardiology Unit, Hippokration Hospital, University of Athens Medical School, Greece
    Curr Med Chem 14:1567-72. 2007
    ..Targeted inhibition of many kinase types and subtypes is an immense research field as this may lead to novel therapeutic approaches to prevent atherogenesis...
  29. ncbi Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals
    Gerasimos Siasos
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 126:394-9. 2008
    ..Aim of the present study was to investigate in healthy smokers the effect of a short-term daily L-arginine administration on vascular function...
  30. ncbi Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes
    D Tousoulis
    Athens University Medical School, Athens, Greece
    Eur J Clin Invest 37:623-8. 2007
    ..Although sCD40L is part of immune response, the mechanisms regulating its release in different disease states remain unknown...
  31. ncbi New biochemical markers in acute coronary syndromes
    Dimitris Tousoulis
    Athens University Medical School, Cardiology Department, Hippokration Hospital, Athens, Greece
    Curr Med Chem 15:1288-96. 2008
    ..In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS...
  32. doi Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: effects on proinflammatory cytokines and acute phase protein levels
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 134:238-43. 2009
    ..In the present study we evaluated the impact of antidepressive medication on the expression of proinflammatory cytokines and acute phase response proteins, in patients with HF and major depression...
  33. doi Oxidative stress and inflammatory process in patients with atrial fibrillation: the role of left atrium distension
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens, Medical School, Athens, Greece
    Int J Cardiol 136:258-62. 2009
    ..We searched for clinical determinants of oxidative stress status, endothelial function and inflammatory process in patients with chronic atrial fibrillation...
  34. ncbi Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
    ..We also examined the role of endothelin-1 (ET-1) in the development of endothelial dysfunction in these two conditions...
  35. doi Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia
    Marietta Charakida
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 204:532-7. 2009
    ..However, it is unknown whether these abnormalities present in FH children and contribute to their vascular dysfunction...
  36. doi Avian flu: how informed are children in Greece?
    Ioanna Vasileiou
    First Department of Surgery, Athens University Medical School, Laiko Hospital, Athens, Greece
    South Med J 101:1121-5. 2008
    ..Dissemination of accurate information may be the cornerstone for proper community preparation. In the herein presented study, we attempted to asses the information level among Greek children regarding avian flu...
  37. doi Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering
    Panagiota Gounari
    1st Cardiology Department, Athens University Medical School, Vasilissis Sofias 114, 115 28, Athens, Greece
    Int J Cardiol 142:87-91. 2010
    ..However, its effect in patients with HF is not well studied. Therefore, in the present study we compared the effect of short-term treatment with rosuvastatin or ezetimibe on endothelial function in patients with HF...
  38. doi The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance
    Gerasimos Siasos
    Department of Biological Chemistry, Athens University Medical School, Athens, Greece
    Am J Hypertens 22:586-92. 2009
    ..We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking...
  39. doi Role of depression in heart failure--choosing the right antidepressive treatment
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 140:12-8. 2010
    ..Even though certain conclusions cannot be drawn yet, evidence suggests that the use of selective serotonin reuptake inhibitors may have a beneficial effect on clinical outcome of heart failure patients...
  40. doi Biomarkers of premature atherosclerosis
    Anna Maria Kampoli
    Athens University Medical School, 1 st Cardiology Department, Hippokration Hospital, Athens, Greece
    Trends Mol Med 15:323-32. 2009
    ..Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis...
  41. ncbi Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1
    Aggeliki Nikolopoulou
    Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 130:246-50. 2008
    ....
  42. doi Acute effects of different types of aerobic exercise on endothelial function and arterial stiffness
    Gerasimos Siasos
    First Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Greece Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, USA
    Eur J Prev Cardiol 23:1565-72. 2016
    ..Chronic aerobic exercise training is associated with improved endothelial function and arterial stiffness and favourable long-term cardiovascular effects...
  43. doi Role of endothelial dysfunction and arterial stiffness in the development of diabetic retinopathy.
    Gerasimos Siasos
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Diabetes Care 38:e9-e10. 2015
  44. doi Arterial Wall Elastic Properties and Endothelial Dysfunction in the Diabetic Foot Syndrome in Patients With Type 2 Diabetes.
    Alexios S Antonopoulos
    First Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece
    Diabetes Care 38:e180-1. 2015
  45. ncbi Basic Mechanisms in Atherosclerosis: The Role of Calcium
    Aimilios Kalampogias
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Vas Sophias 114, 115 28, Athens, Greece
    Med Chem 12:103-13. 2016
    ..5H2O] to the form of Hydroxylapatite [Ca10(PO4)6(OH)2]. This review is devoted to broaden the understanding regarding atherosclerosis and the central role of calcium in the development of the condition. ..
  46. ncbi Effects of CYP2C19 Polymorphism on Endothelial Function, Arterial Stiffness and Inflammation in Coronary Artery Disease Patients Under Clopidogrel Treatment
    Gerasimos Siasos
    Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Curr Pharm Des 21:5041-6. 2015
    ..Hence, we evaluated the impact of CYP2C19*2 genetic polymorphism on endothelial function, arterial stiffness and inflammation in coronary artery disease (CAD) patients receiving clopidogrel treatment...
  47. ncbi Circulating Biomarkers Determining Inflammation in Atherosclerosis Progression
    Gerasimos Siasos
    Vasilissis Sofias 114, TK 115 28, Hippokration Hospital, Athens, Greece
    Curr Med Chem 22:2619-35. 2015
    ..We also present recent data concerning the risk stratification of patients according to their inflammatory status and the possible anti-inflammatory treatment strategies. ..
  48. doi Vascular function and ocular involvement in sarcoidosis
    Gerasimos Siasos
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece Electronic address
    Microvasc Res 100:54-8. 2015
    ..These results strengthen the vascular theory which considers uveitis a consequence of vascular dysfunction in Sar patients and reveals a possible clinical importance of the use of endothelial function tests. ..
  49. ncbi The Role of Endothelial Dysfunction in Aortic Aneurysms
    Gerasimos Siasos
    Mikras Asias 75 str, 115 27, Athens, Greece
    Curr Pharm Des 21:4016-34. 2015
    ..Focusing on the emerging role of endothelial cells in AAA pathology may contribute in creating new therapeutic options in a disease which has not yet a well-accepted, implemented pharmaceutical treatment...
  50. ncbi Vitamin D3, D2 and arterial wall properties in coronary artery disease
    Gerasimos Siasos
    Vas Sophias 114 str, 115 28, Athens, Greece
    Curr Pharm Des 20:5914-8. 2014
    ..There are two major forms of vitamin D, vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). We studied the effect of the different vitamin D fractions (D3/D2) on arterial wall properties in coronary artery disease (CAD) patients...
  51. ncbi Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches
    Gerasimos Siasos
    Mikras Asias 75 str, 115 27, Athens, Greece
    Curr Med Chem 21:3936-48. 2014
    ....
  52. ncbi Novel biomarkers assessing renal function in heart failure: relation to inflammatory status and cardiac remodelling
    Gerasimos Siasos
    University of Athens Medical School, Vas Sophias 114, Athens, Greece
    Curr Med Chem 21:3976-83. 2014
    ..Patients with heart failure (HF) have a significant decline of renal function. We investigate the association between novel biomarkers of renal dysfunction and indices of inflammatory status and cardiac remodeling in patients with HF...
  53. ncbi MicroRNAs in cardiovascular therapeutics
    Gerasimos Siasos
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Curr Top Med Chem 13:1605-18. 2013
    ..Moreover, we discuss the therapeutic potential of miRNAs for treating cardiovascular diseases and we attempt to highlight future directions. ..
  54. ncbi MicroRNAs: Novel diagnostic and prognostic biomarkers in atherosclerosis
    Gerasimos Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens Greece
    Curr Top Med Chem 13:1503-17. 2013
    ..In the light of this evidence we will review the role of miRNAs in atherosclerosis. ..
  55. doi Consumption of a boiled Greek type of coffee is associated with improved endothelial function: the Ikaria study
    Gerasimos Siasos
    Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece
    Vasc Med 18:55-62. 2013
    ..Endothelial function is associated with cardiovascular risk. We examined the association between chronic coffee consumption and endothelium function in elderly inhabitants of the island of Ikaria...
  56. ncbi The impact of physical activity on endothelial function in middle-aged and elderly subjects: the Ikaria study
    Gerasimos Siasos
    First Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece
    Hellenic J Cardiol 54:94-101. 2013
    ..We examined the relationship between endothelial function and levels of habitual PA to evaluate the factors related to healthy ageing in this population...
  57. ncbi Novel risk factors related to stable angina
    Gerasimos Siasos
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Curr Pharm Des 19:1550-61. 2013
    ....
  58. ncbi Inflammatory mechanisms in atherosclerosis: the impact of matrix metalloproteinases
    Gerasimos Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Curr Top Med Chem 12:1132-48. 2012
    ..In this review, we will discuss the relationship between MMPs, inflammation and atherosclerosis under the topic of cardiovascular disease...
  59. ncbi Biomarkers determining cardiovascular risk in patients with kidney disease
    G Siasos
    Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Curr Med Chem 19:2555-71. 2012
    ....