Kyriakos E Kypreos

Summary

Affiliation: University of Patras
Country: Greece

Publications

  1. doi request reprint HDL particle functionality as a primary pharmacological target for HDL-based therapies
    Kyriakos E Kypreos
    The University of Patras Medical School, Department of Medicine, Pharmacology Laboratory, Rio Achaias, Greece
    Biochem Pharmacol 85:1575-8. 2013
  2. doi request reprint ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia
    Kyriakos E Kypreos
    Department of Medicine, Pharmacology Unit, University of Patras Medical School, Rio, TK 26500, Greece
    Biochemistry 47:10491-502. 2008
  3. doi request reprint Mechanisms of obesity and related pathologies: role of apolipoprotein E in the development of obesity
    Kyriakos E Kypreos
    Department of Medicine, Pharmacology Unit, University of Patras Medical School, Rio, Greece
    FEBS J 276:5720-8. 2009
  4. doi request reprint Lecithin/cholesterol acyltransferase modulates diet-induced hepatic deposition of triglycerides in mice
    Eleni A Karavia
    Pharmacology Unit, Department of Medicine, University of Patras Medical School, Panepistimioupolis, Rio, TK 26500, Greece
    J Nutr Biochem 24:567-77. 2013
  5. pmc Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice
    Eleni A Karavia
    Pharmacology Laboratory, Department of Medicine, University of Patras Medical School, Rio, Greece
    Mol Med 18:901-12. 2012
  6. doi request reprint Distinct Roles of Apolipoproteins A1 and E in the Modulation of High-Density Lipoprotein Composition and Function
    Serafoula Filou
    Department of Pharmacology, University of Patras Medical School, Rio Achaias, TK 26500, Greece
    Biochemistry 55:3752-62. 2016
  7. pmc The low density lipoprotein receptor modulates the effects of hypogonadism on diet-induced obesity and related metabolic perturbations
    Caterina Constantinou
    Department of Medicine, Pharmacology Unit, University of Patras Medical School, Rio Achaias, Greece
    J Lipid Res 55:1434-47. 2014
  8. doi request reprint Deficiency in apolipoprotein A-I ablates the pharmacological effects of metformin on plasma glucose homeostasis and hepatic lipid deposition
    Eleni A Karavia
    Pharmacology Department, University of Patras Medical School, Rio, Achaias TK 26500, Greece
    Eur J Pharmacol 766:76-85. 2015
  9. doi request reprint Scavenger Receptor Class B Type I Regulates Plasma Apolipoprotein E Levels and Dietary Lipid Deposition to the Liver
    Eleni A Karavia
    Pharmacology Department, Anatomy Histology and Embryology Department, Medical Physics Department, and Endocrinology Department, University of Patras Medical School, Rio Achaias, TK 26500, Greece
    Biochemistry 54:5605-16. 2015
  10. doi request reprint Advances in high-density lipoprotein physiology: surprises, overturns, and promises
    Caterina Constantinou
    Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece
    Am J Physiol Endocrinol Metab 310:E1-E14. 2016

Collaborators

  • Iordanes Karagiannides
  • Anatol Kontush
  • Ioannis Habeos
  • Jimmy F P Berbee
  • Maria Anastasiou-Nana
  • Stefan Lehr
  • Patrick C N Rensen
  • Yanan Wang
  • Peter J Voshol
  • Eleni A Karavia
  • Peristera Ioanna Petropoulou
  • Caterina Constantinou
  • Evangelia Zvintzou
  • Dionysios J Papachristou
  • Eva Xepapadaki
  • Serafoula Filou
  • Christina Kalogeropoulou
  • Aikaterini Hatziri
  • George C Sakellaropoulos
  • Vassilis Theodoropoulos
  • Nikolaos I Papachristou
  • Anastasios Natsos
  • Ioanna Kotsikogianni
  • Anthula E Kavo
  • Angeliki Lampropoulou
  • Peristera A Petropoulou
  • Eirini M Tsompanidi
  • Marilena Karavyraki
  • Marie Lhomme
  • George Panayiotakopoulos
  • Eugenia Papakosta
  • Shlomo Sasson
  • Eleni Papamichail
  • Alexandros Spyridonidis
  • Eugenia P Papakosta
  • Vassilios Theodoropoulos
  • Panagiota Stamou
  • Fotios Kalfarentzos
  • Abdulmaged M Traish
  • Diogenis Mpatsoulis
  • George Skroubis
  • Donald Gantz
  • Christina Gkolfinopoulou
  • Angelika Chroni
  • Ioanna Mihou
  • George Sakellaropoulos
  • Irene Eva Triantafyllidou
  • Juergen Eckel
  • Polyxeni I Bozatzi
  • Kassiani Liopeta
  • Irene Eva Triantaphyllidou
  • Odyssefs Dimitrakopoulos
  • Sonja Hartwig
  • Vassilis I Zannis
  • Loukianos S Rallidis
  • Panagiota Tsikrika
  • Ioanna Giopanou
  • Donald L Gantz
  • Maria S Brinkmeier
  • Elisavet H Fotiadou
  • Smaragda M Giakoumi

Detail Information

Publications19

  1. doi request reprint HDL particle functionality as a primary pharmacological target for HDL-based therapies
    Kyriakos E Kypreos
    The University of Patras Medical School, Department of Medicine, Pharmacology Laboratory, Rio Achaias, Greece
    Biochem Pharmacol 85:1575-8. 2013
    ..In this review we argue that HDL particle functionality rather than HDL-C levels should be the primary target in the rational design of new HDL-based pharmaceuticals aiming at successfully treating CHD...
  2. doi request reprint ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia
    Kyriakos E Kypreos
    Department of Medicine, Pharmacology Unit, University of Patras Medical School, Rio, TK 26500, Greece
    Biochemistry 47:10491-502. 2008
    ..Furthermore, the data establish that ABCA1 and apoCIII-containing HDL play key roles in the prevention of apoCIII-induced hypertriglyceridemia in mice...
  3. doi request reprint Mechanisms of obesity and related pathologies: role of apolipoprotein E in the development of obesity
    Kyriakos E Kypreos
    Department of Medicine, Pharmacology Unit, University of Patras Medical School, Rio, Greece
    FEBS J 276:5720-8. 2009
    ..In this minireview, we focus on the current literature pertinent to the involvement of apolipoprotein E in the development of pathologies associated with the metabolic syndrome...
  4. doi request reprint Lecithin/cholesterol acyltransferase modulates diet-induced hepatic deposition of triglycerides in mice
    Eleni A Karavia
    Pharmacology Unit, Department of Medicine, University of Patras Medical School, Panepistimioupolis, Rio, TK 26500, Greece
    J Nutr Biochem 24:567-77. 2013
    ..Our data extend the current knowledge on the functions of LCAT, indicating that LCAT activity is an important modulator of processes associated with diet-induced hepatic lipid deposition...
  5. pmc Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice
    Eleni A Karavia
    Pharmacology Laboratory, Department of Medicine, University of Patras Medical School, Rio, Greece
    Mol Med 18:901-12. 2012
    ..Our findings raise the interesting possibility that expression of therapeutic forms of apoA-I by gene therapy approaches may have a beneficial effect on NAFLD...
  6. doi request reprint Distinct Roles of Apolipoproteins A1 and E in the Modulation of High-Density Lipoprotein Composition and Function
    Serafoula Filou
    Department of Pharmacology, University of Patras Medical School, Rio Achaias, TK 26500, Greece
    Biochemistry 55:3752-62. 2016
    ..The distinct role of these two apolipoproteins in the modulation of HDL functionality may pave the way toward the development of novel pharmaceuticals that aim to improve HDL functionality. ..
  7. pmc The low density lipoprotein receptor modulates the effects of hypogonadism on diet-induced obesity and related metabolic perturbations
    Caterina Constantinou
    Department of Medicine, Pharmacology Unit, University of Patras Medical School, Rio Achaias, Greece
    J Lipid Res 55:1434-47. 2014
    ..Overall, our data reveal a novel role of Ldlr as functional modulator of metabolic alterations associated with hypogonadism. ..
  8. doi request reprint Deficiency in apolipoprotein A-I ablates the pharmacological effects of metformin on plasma glucose homeostasis and hepatic lipid deposition
    Eleni A Karavia
    Pharmacology Department, University of Patras Medical School, Rio, Achaias TK 26500, Greece
    Eur J Pharmacol 766:76-85. 2015
    ..Our data show that the role of ApoA-I in diabetes extends to the modulation of the pharmacological actions of metformin, a common drug for the treatment of type 2 diabetes...
  9. doi request reprint Scavenger Receptor Class B Type I Regulates Plasma Apolipoprotein E Levels and Dietary Lipid Deposition to the Liver
    Eleni A Karavia
    Pharmacology Department, Anatomy Histology and Embryology Department, Medical Physics Department, and Endocrinology Department, University of Patras Medical School, Rio Achaias, TK 26500, Greece
    Biochemistry 54:5605-16. 2015
    ..The elevated HDL-ApoE levels inhibit plasma LpL activity, blocking the clearance of triglyceride-rich lipoproteins and preventing the shuttling of dietary lipids to the liver. ..
  10. doi request reprint Advances in high-density lipoprotein physiology: surprises, overturns, and promises
    Caterina Constantinou
    Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece
    Am J Physiol Endocrinol Metab 310:E1-E14. 2016
    ....
  11. doi request reprint Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice
    Eleni A Karavia
    Department of Medicine, Pharmacology Unit, University of Patras School of Health Sciences, Rio Achaias, Greece
    FEBS J 278:3119-29. 2011
    ..Our findings suggest a new role of apoE as a key peripheral contributor to hepatic lipid homeostasis and the development of diet-induced NAFLD...
  12. doi request reprint Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice
    Peristera Ioanna Petropoulou
    Pharmacology Department, University of Patras Medical School, Rio Achaias TK 26500, Greece
    Biochim Biophys Acta 1852:2106-15. 2015
    ..We conclude that LCAT-deficiency increases LPS-induced inflammation in mice due to reduced LPS-neutralizing capacity of immature discoidal HDL and increased monocyte number. ..
  13. doi request reprint HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis
    Eirini M Tsompanidi
    University of Patras Medical School, Department of Medicine, Pharmacology Unit, Rio, TK, Greece
    Atherosclerosis 208:3-9. 2010
    ..In addition, we discuss the significance of both HDL quality and quantity in assessing cardiovascular risk...
  14. doi request reprint Pharmacodynamic and pharmacokinetic analysis of apoE4 [L261A, W264A, F265A, L268A, V269A], a recombinant apolipoprotein E variant with improved biological properties
    Angeliki Lampropoulou
    Department of Medicine, Pharmacology Unit, University of Patras Medical School, Greece
    Biochem Pharmacol 84:1451-8. 2012
    ..8h. Our data suggest that purified apoE4mut1 may be an attractive new candidate for the acute correction of hypercholesterolemia in subjects expressing functional LDL receptor...
  15. doi request reprint Effects of bariatric surgery on HDL structure and functionality: results from a prospective trial
    Evangelia Zvintzou
    Department of Pharmacology, University of Patras, School of Medicine, Rio Achaias, Greece
    J Clin Lipidol 8:408-17. 2014
    ..Despite that weight loss benefits these patients, its effects on HDL quality and functionality is currently poorly studied...
  16. doi request reprint Regulation of endothelial nitric oxide synthase and high-density lipoprotein quality by estradiol in cardiovascular pathology
    Kyriakos E Kypreos
    1Department of Medicine, University of Patras Medical School, Pharmacology Laboratory, Panepistimioupolis, Rio, Greece
    J Cardiovasc Pharmacol Ther 19:256-68. 2014
    ..This review focuses on recent findings from animal and human studies on the regulation of eNOS and HDL quality by estradiol in cardiovascular pathology. ..
  17. doi request reprint HDL quality and functionality: what can proteins and genes predict?
    Eleni A Karavia
    Department of Pharmacology, University of Patras, School of Medicine, Rio Achaias, TK 26500, Greece
    Expert Rev Cardiovasc Ther 12:521-32. 2014
    ....
  18. doi request reprint Qualitative characteristics of HDL in young patients of an acute myocardial infarction
    Anthula E Kavo
    Pharmacology Unit, Department of Medicine, University of Patras School of Health Sciences, Patras, Greece
    Atherosclerosis 220:257-64. 2012
    ....
  19. doi request reprint The aminoterminal 1-185 domain of human apolipoprotein E suffices for the de novo biogenesis of apoE-containing HDL-like particles in apoA-I deficient mice
    Peristera A Petropoulou
    Pharmacology Unit, University of Patras Medical School, Rio Achaias, TK 26500, Greece
    Atherosclerosis 219:116-23. 2011
    ..Here, we sought to identify the domain of apoE that is responsible for its functional interactions with ABCA1 and the formation of apoE-rich HDL-like particles...