Majeran W, Le Caer J, Ponnala L, Meinnel T, Giglione C. Targeted Profiling of Arabidopsis thaliana Subproteomes Illuminates Co- and Posttranslationally N-Terminal Myristoylated Proteins. Plant Cell. 2018;30:543-562 pubmed publisher
..In a few cases, MYR function extended beyond simple membrane association. This study identified hundreds of N-acylated proteins for which lipid modifications could control protein localization and expand protein function. ..
Apel C, Bignon J, Alvarez M, Ciccone S, Clerc P, Grondin I, et al
. N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë. Fitoterapia. 2018;: pubmed publisher
..This is the first report identifying natural products from a botanical source as inhibitors of HsNMT and PfNMT. ..
Castrec B, Dian C, Ciccone S, Ebert C, Bienvenut W, Le Caer J, et al
. Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern. Nat Chem Biol. 2018;14:671-679 pubmed publisher
..Together, the data extend the N-end rule concept for Gly-starting proteins to subcellular compartmentalization and reveal the main neighbors influencing protein modification profiles and consequent cell fate. ..
Breiman A, Fieulaine S, Meinnel T, Giglione C. The intriguing realm of protein biogenesis: Facing the green co-translational protein maturation networks. Biochim Biophys Acta. 2016;1864:531-50 pubmed publisher
..Particular attention has been accorded to the plant system, highlighting the similarities and differences with other organisms. ..
Grzela R, Nusbaum J, Fieulaine S, Lavecchia F, Bienvenut W, Dian C, et al
. The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation. Sci Rep. 2017;7:11041 pubmed publisher
..This residue fully compensates for the absence of the usual long C-domain. Taken together, these data elucidate an unexpected mechanism of enzyme natural evolution and adaptation within viral sequences. ..
Grzela R, Nusbaum J, Fieulaine S, Lavecchia F, Desmadril M, Nhiri N, et al
. Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts. Biochim Biophys Acta Proteins Proteom. 2018;1866:348-355 pubmed publisher
..We conclude that bacteriophage Vp16 PDF protein has functional peptide deformylase activity and we suggest that encoded phage PDFs might be important for viral fitness. ..
Bienvenut W, Scarpelli J, Dumestier J, Meinnel T, Giglione C. EnCOUNTer: a parsing tool to uncover the mature N-terminus of organelle-targeted proteins in complex samples. BMC Bioinformatics. 2017;18:182 pubmed publisher
..Such data processing allows the identification of the exact N-terminus position and the associated acetylation yield. ..