Genomes and Genes
Rory E Morty
Affiliation: University of Giessen
- Morty R, Morehead J. Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species. J Biol Chem. 2002;277:26057-65 pubmed..Lap was not secreted by Leishmania in vitro and was localized to the parasite cytosol. ..
- Morty R, Bulau P, Pelle R, Wilk S, Abe K. Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts. Biochem J. 2006;394:635-45 pubmed..The abnormal degradation of TRH and GnRH, and perhaps other neuropeptides N-terminally blocked with a pyroglutamyl moiety, by trypanosome PGP, may contribute to some of the endocrine lesions observed in African trypanosomiasis. ..
- Morty R, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri F, et al. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 2007;27:1072-8 pubmed..BMP signaling and BMP-regulated physiological phenomena are perturbed in MCT-treated rats, lending solid support to the proposed roles for BMP signaling in the pathogenesis of human PAH. ..
- Morty R, Eickelberg O, Seeger W. Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies?. Intensive Care Med. 2007;33:1229-1240 pubmed publisher..The failure of patients to resolve the alveolar edema associated with these conditions is a major contributing factor to mortality; hence there is continued interest to understand the mechanisms of alveolar edema fluid clearance...
- Surate Solaligue D, Rodríguez Castillo J, Ahlbrecht K, Morty R. Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00343.2017 pubmed publisher....
- Morty R. Accepting the challenge: maintaining AJP-Lung as the best place to publish basic and translational studies in lung biology and pathophysiology. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00488.2017 pubmed publisher....