Jens Einenkel

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Giant ovarian cysts: is a pre- and intraoperative drainage an advisable procedure?
    J Einenkel
    Department of Obstetrics, University of Leipzig, Leipzig, Germany
    Int J Gynecol Cancer 16:2039-43. 2006
  2. ncbi request reprint A misdiagnosed case of caesarean scar pregnancy
    Jens Einenkel
    Department of Obstetrics and Gynaecology, University of Leipzig, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Arch Gynecol Obstet 271:178-81. 2005
  3. ncbi request reprint 3-D analysis of the invasion front in squamous cell carcinoma of the uterine cervix: histopathologic evidence for collective invasion per continuitatem
    Jens Einenkel
    Department of Obstetrics and Gynecology, Interdisciplinary Center for Bioinformatics, Institute of Pathology, University Leipzig, Leipzig, Germany
    Anal Quant Cytol Histol 29:279-90. 2007
  4. ncbi request reprint [Topographical anatomy of the female pelvis in ultrasound]
    J Einenkel
    Universitätsfrauenklinik Leipzig
    Ultraschall Med 26:385-98. 2005
  5. ncbi request reprint Evaluation of the invasion front pattern of squamous cell cervical carcinoma by measuring classical and discrete compactness
    Jens Einenkel
    Department of Obstetrics and Gynecology, Leipzig University, Germany
    Comput Med Imaging Graph 31:428-35. 2007
  6. ncbi request reprint Combined three-dimensional microscopic visualisation of tumour-invasion front of cervical carcinoma
    Jens Einenkel
    Department of Obstetrics and Gynaecology, University of Leipzig, Leipzig, Germany
    Lancet Oncol 7:698. 2006
  7. doi request reprint Local spread of cervical cancer revisited: a clinical and pathological pattern analysis
    Michael Hockel
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Gynecol Oncol 117:401-8. 2010
  8. ncbi request reprint Three-dimensional reconstruction and quantification of cervical carcinoma invasion fronts from histological serial sections
    Ulf Dietrich Braumann
    Interdisciplinary Center for Bioinformatics, University Leipzig, Leipzig, Germany
    IEEE Trans Med Imaging 24:1286-307. 2005
  9. ncbi request reprint p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 10:193-6. 2006
  10. ncbi request reprint Combined serial section-based 3D reconstruction of cervical carcinoma invasion using H&E/p16INK4a/CD3 alternate staining
    Nicolas Wentzensen
    Division for Applied Tumor Biology, Institute of Pathology, University Heidelberg, 69120 Heidelberg, Germany
    Cytometry A 71:327-33. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Giant ovarian cysts: is a pre- and intraoperative drainage an advisable procedure?
    J Einenkel
    Department of Obstetrics, University of Leipzig, Leipzig, Germany
    Int J Gynecol Cancer 16:2039-43. 2006
    ..Based on a critical evaluation of the medical courses and the discussed miscellaneous advantages and complications, we conclude that a pre- and intraoperative drainage should be avoided...
  2. ncbi request reprint A misdiagnosed case of caesarean scar pregnancy
    Jens Einenkel
    Department of Obstetrics and Gynaecology, University of Leipzig, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Arch Gynecol Obstet 271:178-81. 2005
    ..For the first time, a strongly vascularised pelvic tumour developed while the titre of serum human chorionic gonadotrophin decreased after a curettage abortion for an unwanted pregnancy...
  3. ncbi request reprint 3-D analysis of the invasion front in squamous cell carcinoma of the uterine cervix: histopathologic evidence for collective invasion per continuitatem
    Jens Einenkel
    Department of Obstetrics and Gynecology, Interdisciplinary Center for Bioinformatics, Institute of Pathology, University Leipzig, Leipzig, Germany
    Anal Quant Cytol Histol 29:279-90. 2007
    ..To investigate spatial tumor invasion using ex vivo specimens and pursue a new morphometric approach for a quantitative assessment of the invasion front...
  4. ncbi request reprint [Topographical anatomy of the female pelvis in ultrasound]
    J Einenkel
    Universitätsfrauenklinik Leipzig
    Ultraschall Med 26:385-98. 2005
    ..The goal of the study was to define exact planes by means of cross-sectional anatomy and then to standardise the gynaecological ultrasound examination with the transabdominal, introital and transvaginal technique...
  5. ncbi request reprint Evaluation of the invasion front pattern of squamous cell cervical carcinoma by measuring classical and discrete compactness
    Jens Einenkel
    Department of Obstetrics and Gynecology, Leipzig University, Germany
    Comput Med Imaging Graph 31:428-35. 2007
    ..033). We conclude that the discrete compactness C(D) is a new and reproducible parameter for a computer assisted quantification of the invasion front pattern and, thus, defines a further phenotypic feature of SCC of the uterine cervix...
  6. ncbi request reprint Combined three-dimensional microscopic visualisation of tumour-invasion front of cervical carcinoma
    Jens Einenkel
    Department of Obstetrics and Gynaecology, University of Leipzig, Leipzig, Germany
    Lancet Oncol 7:698. 2006
  7. doi request reprint Local spread of cervical cancer revisited: a clinical and pathological pattern analysis
    Michael Hockel
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Gynecol Oncol 117:401-8. 2010
    ..However, this concept may lead to considerable treatment-related morbidity and does not prevent local relapse. We propose an alternative model of local tumor propagation involving permissive compartments related to embryonic development...
  8. ncbi request reprint Three-dimensional reconstruction and quantification of cervical carcinoma invasion fronts from histological serial sections
    Ulf Dietrich Braumann
    Interdisciplinary Center for Bioinformatics, University Leipzig, Leipzig, Germany
    IEEE Trans Med Imaging 24:1286-307. 2005
    ..By this, we achieved the most detailed 3-D reconstruction of the invasion of solid tumors so far. Once reconstructed, the invasion front of the segmented tumor is quantified using discrete compactness...
  9. ncbi request reprint p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 10:193-6. 2006
    ..Factors known to play a pathogenetic role in types 1 and 2 of endometrial carcinomas are not associated with primary ESCC. However, prognostically, ESCCs are more related to type 1 cancers...
  10. ncbi request reprint Combined serial section-based 3D reconstruction of cervical carcinoma invasion using H&E/p16INK4a/CD3 alternate staining
    Nicolas Wentzensen
    Division for Applied Tumor Biology, Institute of Pathology, University Heidelberg, 69120 Heidelberg, Germany
    Cytometry A 71:327-33. 2007
    ..The present study analyzes the spatial organization of a cervical cancer and the relation of the tumor invasion front and the infiltration with CD3(+) T-cells...
  11. doi request reprint Pattern analysis of regional spread and therapeutic lymph node dissection in cervical cancer based on ontogenetic anatomy
    Michael Hockel
    Department of Gynecology, University of Leipzig, Leipzig, Germany
    Gynecol Oncol 125:168-74. 2012
    ....
  12. doi request reprint A cut-off value of 2 cm in tumor size is of prognostic value in surgically treated FIGO stage IB cervical cancer
    Lars Christian Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Germany Electronic address
    Gynecol Oncol 134:42-6. 2014
    ..Limited knowledge exists about the value of tumor size in surgically treated cervical cancer (CX) using a tumor size of 2 cm as cut-off value...
  13. doi request reprint p16 methylation does not affect protein expression in cervical carcinogenesis
    Kristina Nehls
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Eur J Cancer 44:2496-505. 2008
    ..In cervical cancer, methylation of p16 does not seem to be an underlying pathogenic mechanism, but may be a result of increasing genetic and epigenetic instability...
  14. doi request reprint p53 signature and serous tubal in-situ carcinoma in cases of primary tubal and peritoneal carcinomas and serous borderline tumors of the ovary
    Karoline Leonhardt
    Division of Breast, Institute of Pathology, Gynecologic and Perinatal Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, Germany
    Int J Gynecol Pathol 30:417-24. 2011
    ..Immunohistochemistry for p53 and ki-67 may aid in the diagnosis, but is not necessary for routine investigation...
  15. ncbi request reprint Tumor hypoxia and expression of c-met in cervical cancer
    Cornelia Leo
    Department of Gynecology, Leipzig University, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Gynecol Oncol 104:181-5. 2007
    ..The aim of this study, therefore, was to investigate the expression of the c-met protooncogene in cervical cancers in relation to intratumoral hypoxia levels and to clinico-pathological parameters...
  16. ncbi request reprint Mixed small cell carcinomas of the uterine cervix: prognostic impact of focal neuroendocrine differentiation but not of Ki-67 labeling index
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Germany
    Ann Diagn Pathol 10:140-3. 2006
    ..8% vs 70.8%; P < .001). Even a small SmCC component in mixed carcinomas of the uterine cervix was associated with adverse outcome. Proliferative activity, determined by Ki-67 labeling index, is of no prognostic value...
  17. doi request reprint (Laterally) extended endopelvic resection: surgical treatment of locally advanced and recurrent cancer of the uterine cervix and vagina based on ontogenetic anatomy
    Michael Hockel
    Department of Gynecology, University of Leipzig, Leipzig, Germany
    Gynecol Oncol 127:297-302. 2012
    ..To improve locoregional tumor control we have proposed to establish cancer surgery on ontogenetic anatomy and, consequently, we have developed the (Laterally) Extended Endopelvic Resection ((L)EER)...
  18. ncbi request reprint p16, p14, p53, and cyclin D1 expression and HPV analysis in small cell carcinomas of the uterine cervix
    Lars Christian Horn
    Institute of Pathology, Division of Gynecopathology, and Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 25:182-6. 2006
    ..p14 inactivation is of high prevalence in SmCCs and detection rate of p53 is similar to other histologic types of cervical carcinomas...
  19. doi request reprint Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic Pathology, Leipzig University, Leipzig, Germany
    Int J Gynecol Pathol 27:288-91. 2008
    ..However, further molecular studies are required...
  20. doi request reprint Suitability of infrared microspectroscopic imaging for histopathology of the uterine cervix
    Jens Einenkel
    Department of Obstetrics and Gynaecology, Centre for Women s and Children s Health, Leipzig University, Liebigstrasse 20a, Leipzig, Germany
    Histopathology 60:1084-98. 2012
    ..This study aimed to determine the accuracy of IR-MSP-based histopathology of cervical carcinoma sections with complex tissue architecture under practically relevant testing conditions...
  21. doi request reprint Resection of the embryologically defined uterovaginal (Müllerian) compartment and pelvic control in patients with cervical cancer: a prospective analysis
    Michael Hockel
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Lancet Oncol 10:683-92. 2009
    ..The aim of our study was to test these hypotheses...
  22. doi request reprint Characteristics and management of diaphragm involvement in patients with primary advanced-stage ovarian, fallopian tube, or peritoneal cancer
    Jens Einenkel
    Department of Obstetrics and Gynecology, Translational Centre for Regenerative Medicine, Leipzig University, Leipzig, Germany
    Int J Gynecol Cancer 19:1288-97. 2009
    ....
  23. ncbi request reprint Clonal history of papillomavirus-induced dysplasia in the female lower genital tract
    Svetlana Vinokurova
    Department of Molecular Pathology Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Natl Cancer Inst 97:1816-21. 2005
    ....
  24. doi request reprint CD34(low) and SMA(high) represent stromal signature in uterine cervical cancer and are markers for peritumoral stromal remodeling
    Lars Christian Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Leipzig, Germany Electronic address
    Ann Diagn Pathol 17:531-5. 2013
    ..9 vs 81.0%; P=0.025 and 64.6 vs 81.1%; P=0.243). Peritumoral stromal response in cervical carcinoma is immunohistochemically characterized by CD34(low)/SMA(high) and associated reduced overall survival...
  25. pmc Ultrasound plays a key role in imaging and management of genital angiomyofibroblastoma: a case report
    Benjamin Wolf
    Department of Obstetrics and Gynecology, Leipzig University, Liebigstrasse 20a, 04103, Leipzig, Germany
    J Med Case Rep 9:248. 2015
    ..The vast majority of angiomyofibroblastomas arise from the vulva and appear as solid cystic masses on ultrasound images...
  26. ncbi request reprint Histopathology of endometrial hyperplasia and endometrial carcinoma: an update
    Lars Christian Horn
    Division of Gynecologic Pathology, Institute of Pathology, Leipzig University, D 04103 Leipzig, Germany
    Ann Diagn Pathol 11:297-311. 2007
    ..Finally, a short practical description for the handling of surgical specimens from fractional curetting and hysterctomies is given...
  27. doi request reprint Serous tubal in situ carcinoma (STIC) in primary peritoneal serous carcinomas
    Lars Christian Horn
    Division of Breast, Gynecologic and Perinatal Pathology, Institute of Trier, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 32:339-44. 2013
    ..There might be the 2 different carcinogenetic pathways within PPC, and further studies are required to identify the source of serous cancer in cases without an STIC lesion...
  28. doi request reprint Monoclonal origin of peritoneal implants and lymph node deposits in serous borderline ovarian tumors (s-BOT) with high intratumoral homogeneity
    Lars Christian Horn
    Institute of Pathology L C H, A K H, Division of Breast, Gynecologic and Perinatal Pathology Department of Obstetrics and Gynecology J E, Institute of Trier Institute of Pathology U S, Division Molecular Pathology, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 33:592-7. 2014
    ..In addition, a high intratumoral genetic homogeneity can be suggested. In conclusion, the results of the present study support the monoclonal origin of s-BOT and their peritoneal implants and lymph node deposits. ..
  29. ncbi request reprint Hormone replacement therapy (HRT) and endometrial morphology under consideration of the different molecular pathways in endometrial carcinogenesis
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig D 04103, Germany
    Eur J Obstet Gynecol Reprod Biol 122:4-12. 2005
    ..The use of tibolone leaves the endometrium unaffected...
  30. ncbi request reprint Delimitation of squamous cell cervical carcinoma using infrared microspectroscopic imaging
    Wolfram Steller
    Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
    Anal Bioanal Chem 384:145-54. 2006
    ....
  31. ncbi request reprint A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques
    Corina Ziegert
    Institute of Molecular Pathology, Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Oncogene 22:3977-84. 2003
    ..Disruption of cellular genes might support malignant transformation in rare cases; however, it is not a pathogenic prerequisite. The main function of HPV integration seems to be the stabilization of oncogene transcription...