Christian Rube

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi request reprint The value of radiation therapy in the management of aggressive non-Hodgkin's lymphomas
    Ch Rübe
    Abteilung für Strahlentherapie, Universitatskliniken des Saarlandes, Homburg Saar
    Onkologie 25:214-20. 2002
  2. ncbi request reprint Combined-modality treatment of non-small-cell lung cancer stages I-III (take home messages)
    Christian Rube
    Department of Radiotherapy and Radiation Oncology, Saarland Medical University, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Lung Cancer 45:S139-41. 2004
  3. pmc Study protocol of the German "Registry for the detection of late sequelae after radiotherapy in childhood and adolescence" (RiSK)
    Tobias Bolling
    Department of Radiotherapy, University Hospital of Munster, Germany
    Radiat Oncol 3:10. 2008
  4. ncbi request reprint Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL
    Michael Pfreundschuh
    Saarland University Medical School, Homburg Saar, Germany
    Blood 104:634-41. 2004
  5. doi request reprint F-18-FDG-PET confined radiotherapy of locally advanced NSCLC with concomitant chemotherapy: results of the PET-PLAN pilot trial
    Jochen Fleckenstein
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg, Germany
    Int J Radiat Oncol Biol Phys 81:e283-9. 2011
  6. ncbi request reprint Comparison of early pulmonary changes in 18FDG-PET and CT after combined radiochemotherapy for advanced non-small-cell lung cancer: a study in 15 patients
    Ursula Nestle
    Department of Nuclear Medicine, University Hospital of the Saarland, Homburg Saar, Germany
    Front Radiat Ther Oncol 37:26-33. 2002
  7. doi request reprint DNA repair alterations in children with pediatric malignancies: novel opportunities to identify patients at risk for high-grade toxicities
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 78:359-69. 2010
  8. ncbi request reprint The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation
    Claudia E Rübe
    Department of Radiotherapy and Radiooncology, Saarland University, Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 61:1482-92. 2005
  9. doi request reprint Nonrigid versus rigid registration of thoracic 18F-FDG PET and CT in patients with lung cancer: an intraindividual comparison of different breathing maneuvers
    Aleksandar Grgic
    Department of Nuclear Medicine, Saarland University Medical Center, Homburg Saar, Germany
    J Nucl Med 50:1921-6. 2009
  10. ncbi request reprint Target volume definition for 18F-FDG PET-positive lymph nodes in radiotherapy of patients with non-small cell lung cancer
    Ursula Nestle
    Department of Nuclear Medicine, Saarland University Medical Centre, 66421, Homburg Saar, Germany
    Eur J Nucl Med Mol Imaging 34:453-62. 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint The value of radiation therapy in the management of aggressive non-Hodgkin's lymphomas
    Ch Rübe
    Abteilung für Strahlentherapie, Universitatskliniken des Saarlandes, Homburg Saar
    Onkologie 25:214-20. 2002
    ..This article reviews the available data concerning combined-modality treatment in localized stages and treatment of bulky lesions and residual lymphomas after chemotherapy with emphasis on the role of radiation therapy...
  2. ncbi request reprint Combined-modality treatment of non-small-cell lung cancer stages I-III (take home messages)
    Christian Rube
    Department of Radiotherapy and Radiation Oncology, Saarland Medical University, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Lung Cancer 45:S139-41. 2004
    ....
  3. pmc Study protocol of the German "Registry for the detection of late sequelae after radiotherapy in childhood and adolescence" (RiSK)
    Tobias Bolling
    Department of Radiotherapy, University Hospital of Munster, Germany
    Radiat Oncol 3:10. 2008
    ..The study protocol and the documentation forms are given in this publication...
  4. ncbi request reprint Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL
    Michael Pfreundschuh
    Saarland University Medical School, Homburg Saar, Germany
    Blood 104:634-41. 2004
    ..Due to its favorable efficacy and toxicity profile, CHOP-14 should be considered the new standard chemotherapy regimen for patients ages 60 or older with aggressive lymphoma...
  5. doi request reprint F-18-FDG-PET confined radiotherapy of locally advanced NSCLC with concomitant chemotherapy: results of the PET-PLAN pilot trial
    Jochen Fleckenstein
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg, Germany
    Int J Radiat Oncol Biol Phys 81:e283-9. 2011
    ..The aim of this prospective pilot trial was to evaluate the therapeutic safety of FDG-PET-based RT treatment planning with an autocontour-derived delineation of the primary tumor...
  6. ncbi request reprint Comparison of early pulmonary changes in 18FDG-PET and CT after combined radiochemotherapy for advanced non-small-cell lung cancer: a study in 15 patients
    Ursula Nestle
    Department of Nuclear Medicine, University Hospital of the Saarland, Homburg Saar, Germany
    Front Radiat Ther Oncol 37:26-33. 2002
  7. doi request reprint DNA repair alterations in children with pediatric malignancies: novel opportunities to identify patients at risk for high-grade toxicities
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 78:359-69. 2010
    ..To evaluate, in a pilot study, the phosphorylated H2AX (γH2AX) foci approach for identifying patients with double-strand break (DSB) repair deficiencies, who may overreact to DNA-damaging cancer therapy...
  8. ncbi request reprint The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation
    Claudia E Rübe
    Department of Radiotherapy and Radiooncology, Saarland University, Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 61:1482-92. 2005
    ..To study in detail the temporal and spatial release of the pro-inflammatory cytokines tumor necrosis factor alpha, interleukin (IL)-1alpha, and IL-6 in the lung tissue of C57BL/6 mice after thoracic irradiation with 12 Gy...
  9. doi request reprint Nonrigid versus rigid registration of thoracic 18F-FDG PET and CT in patients with lung cancer: an intraindividual comparison of different breathing maneuvers
    Aleksandar Grgic
    Department of Nuclear Medicine, Saarland University Medical Center, Homburg Saar, Germany
    J Nucl Med 50:1921-6. 2009
    ..The aim of this study was to investigate by an intraindividual analysis whether, in comparison with a rigid algorithm, a nonrigid registration algorithm improves the quality of fusion between (18)F-FDG PET and CT...
  10. ncbi request reprint Target volume definition for 18F-FDG PET-positive lymph nodes in radiotherapy of patients with non-small cell lung cancer
    Ursula Nestle
    Department of Nuclear Medicine, Saarland University Medical Centre, 66421, Homburg Saar, Germany
    Eur J Nucl Med Mol Imaging 34:453-62. 2007
    ..J Nucl Med 2005;46:1342-8). This paper focusses on FDG-positive mediastinal lymph nodes (LN(PET))...
  11. ncbi request reprint Modulation of radiation-induced tumour necrosis factor alpha (TNF-alpha) expression in the lung tissue by pentoxifylline
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, D 66421 Homburg Saar, Germany
    Radiother Oncol 64:177-87. 2002
    ..In addition, we evaluated the ability of PTX to reduce the radiation-induced TNF-alpha release in this animal model of thoracic irradiation...
  12. doi request reprint The impact of individual in vivo repair of DNA double-strand breaks on oral mucositis in adjuvant radiotherapy of head-and-neck cancer
    Jochen Fleckenstein
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg, Germany
    Int J Radiat Oncol Biol Phys 81:1465-72. 2011
    ..To evaluate the impact of individual in vivo DNA double-strand break (DSB) repair capacity on the incidence of severe oral mucositis in patients with head-and-neck cancer undergoing adjuvant radiotherapy (RT) or radiochemotherapy (RCT)...
  13. ncbi request reprint Ewing's sarcoma and peripheral primitive neuroectodermal tumor cells produce large quantities of bioactive tumor necrosis factor-alpha (TNF-alpha) after radiation exposure
    Claudia E Rübe
    Department of Radiotherapy Radiooncology, Saarland University, Homburg Saar, Germany
    Int J Radiat Oncol Biol Phys 56:1414-25. 2003
    ..On the other hand, radiation-induced tumor cell production of TNF-alpha may adversely affect the normal tissue...
  14. pmc Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy
    Yvonne Lorat
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    PLoS ONE 7:e38165. 2012
    ..An essential step in DSB processing by non-homologous end joining is the high-affinity binding of Ku70-Ku80 and DNA-PKcs to double-stranded DNA ends that holds the ends in physical proximity for subsequent repair...
  15. doi request reprint DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    Clin Cancer Res 14:6546-55. 2008
    ..Using a preclinical mouse model, the highly sensitive gammaH2AX-foci approach was tested to verify even subtle, genetically determined DSB repair deficiencies known to be associated with increased normal tissue radiosensitivity...
  16. pmc Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    PLoS ONE 6:e17487. 2011
    ..Here we tested this hypothesis in healthy individuals of different ages by examining unrepaired DNA double-strand breaks (DSBs) in hematopoietic stem/progenitor cells matured in their physiological microenvironment...
  17. ncbi request reprint HDAC inhibition radiosensitizes human normal tissue cells and reduces DNA Double-Strand Break repair capacity
    Jan C Purrucker
    Division of Immunotherapy and Gene Therapy, Department of Internal Medicine I, José Carreras Research Center, Saarland University Medical Center, Homburg Saar, Germany
    Oncol Rep 23:263-9. 2010
    ....
  18. doi request reprint Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Saarland University, Homburg Saar, Germany
    DNA Repair (Amst) 10:159-68. 2011
    ..By evaluating SSCs within their stem cell niche, we show that DNA repair, cell-cycle checkpoints, and apoptosis function together to maintain the integrity of the heritable genome...
  19. ncbi request reprint Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury
    Kunyu Yang
    Department of Radiotherapy and Radiooncology, Saarland University, Homburg Saar, Germany
    Int J Radiat Biol 83:665-76. 2007
    ..On this background, we investigated the effect of irradiation on the MMP/TIMP system in the lung tissue of normal and transgenic TGF-beta1 mice, in which TGF-beta1 is overexpressed in the liver resulting in high TGF-beta1 plasma levels...
  20. pmc mARC Treatment of Hypopharynx Carcinoma with Flat and Flattening-Filter-Free Beam Energies - A Planning Study
    Katharina Bell
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str Geb 6 5, D 66421, Homburg Saar, Germany
    PLoS ONE 11:e0164616. 2016
    ..For the case of hypopharynx cancer plans we evaluate whether the mARC can achieve an advantage in treatment time in comparison to IMRT. These plans consider two arcs with flat and flattening filter free (FFF) beam energies...
  21. doi request reprint mARC prostate treatment planning with Varian Eclipse for flat vs. FFF beams
    Katharina Bell
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str Geb 6 5, D 66421 Homburg Saar, Germany Electronic address
    Phys Med 32:474-8. 2016
    ..Therefore, for prostate treatment with Eclipse we compare mARC with IMRT using flat (6MV) and flattening-filter-free (FFF, 7MV) beam energies...
  22. doi request reprint IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC: A direct comparison of PET-based treatment planning
    Jochen Fleckenstein
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, 66421, Homburg Saar, Germany
    Strahlenther Onkol 192:75-82. 2016
    ..elective nodal irradiation (ENI)...
  23. pmc DNA-damage foci to detect and characterize DNA repair alterations in children treated for pediatric malignancies
    Nadine Schuler
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    PLoS ONE 9:e91319. 2014
    ..In one patient with Fanconi anemia (FA) suffering relapsing squamous cell carcinomas of the oral cavity we also characterized the repair defect in biopsies of skin, mucosa and tumor...
  24. doi request reprint DNA double-strand break rejoining in complex normal tissues
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Saarland, Germany
    Int J Radiat Oncol Biol Phys 72:1180-7. 2008
    ....
  25. doi request reprint DNA repair in the context of chromatin: new molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    DNA Repair (Amst) 10:427-37. 2011
    ..Collectively, this TEM approach provides fascinating insights into the dynamic events of the DSB repair process that depend decisively upon the actual chromatin structure around the break...
  26. doi request reprint VMAT to arclet plan conversion in a treatment planning system : Feasibility and dosimetric relationship between VMAT, arclet, and stationary fields
    Yvonne Dzierma
    Department of Radiotherapy, Saarland University Medical Center, Kirrberger Straße 6 5, 66421, Homburg Saar, Germany
    Strahlenther Onkol 191:961-9. 2015
    ....
  27. ncbi request reprint Radiosensitivity of tumor cell lines after pretreatment with the EGFR tyrosine kinase inhibitor ZD1839 (Iressa)
    Susanne Burdak-Rothkamm
    Department of Radiotherapy, Saarland University Hospital, Homburg Saar, Germany
    Strahlenther Onkol 181:197-204. 2005
    ..The aim of this study was to identify cellular events that are associated with the modulation of radiosensitivity by ZD1839...
  28. ncbi request reprint [The relevance of cytokines in the radiation-induced lung reaction. Experimental basis and clinical significance]
    Claudia E Rübe
    Abteilung für Strahlentherapie, Radiologische Klinik, Universitat des Saarlandes, Homburg Saar
    Strahlenther Onkol 180:541-9. 2004
    ..Another potential cause of increased cytokine levels in the blood of oncologic patients is the secretion of cytokines in the blood circulation by tumor specimens...
  29. pmc The Impact of Diffusion-Weighted MRI on the Definition of Gross Tumor Volume in Radiotherapy of Non-Small-Cell Lung Cancer
    Jochen Fleckenstein
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center, Homburg, Germany
    PLoS ONE 11:e0162816. 2016
    ..The study was designed to evaluate diffusion-weighted magnetic resonance imaging (DWI) vs. PET-CT of the thorax in the determination of gross tumor volume (GTV) in radiotherapy planning of non-small-cell lung cancer (NSCLC)...
  30. pmc Influence of daily imaging on plan quality and normal tissue toxicity for prostate cancer radiotherapy
    Katharina Bell
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical Centre, Kirrberger Str Geb 6 5, D 66421, Homburg Saar, Germany
    Radiat Oncol 12:7. 2017
    ..Different clinically relevant IGRT (image guided radiotherapy) scenarios were considered with regard to their influence on dosimetric plan quality and normal tissue complication probability (NTCP)...
  31. pmc Dose distribution and tumor control probability in out-of-field lymph node stations in intensity modulated radiotherapy (IMRT) vs 3D-conformal radiotherapy (3D-CRT) of non-small-cell lung cancer: an in silico analysis
    Jochen Fleckenstein
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, 66421, Homburg, Germany
    Radiat Oncol 10:178. 2015
    ....
  32. pmc Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number
    Yvonne Dzierma
    Department of Radiation Oncology, Saarland University Medical Center, Homburg Saar, Germany
    PLoS ONE 9:e94371. 2014
    ....
  33. pmc Toxicity after radiochemotherapy for glioblastoma using temozolomide--a retrospective evaluation
    Marcus Niewald
    Department of Radiotherapy, Saarland University Hospital, Kirrberger Strasse, D 66421 Homburg, Germany
    Radiat Oncol 6:141. 2011
    ..Retrospective evaluation of toxicity and results after radiochemotherapy for glioblastoma...
  34. ncbi request reprint Comparison of different methods for delineation of 18F-FDG PET-positive tissue for target volume definition in radiotherapy of patients with non-Small cell lung cancer
    Ursula Nestle
    Department for Nuclear Medicine, Saarland University Medical Center, Homburg Saar, Germany
    J Nucl Med 46:1342-8. 2005
    ..This investigation compared the gross tumor volumes (GTVs) resulting from 4 methods used for this purpose in a set of clinical cases...
  35. pmc Long-term outcomes in radically treated synchronous vs. metachronous oligometastatic non-small-cell lung cancer
    Jochen Fleckenstein
    Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center, Homburg, Germany
    BMC Cancer 16:348. 2016
    ..The present retrospective study was designed to examine the relevance of synchronous vs. metachronous manifestations as a potential prognostic factor when ablative treatments are performed in oligometastatic disease...
  36. ncbi request reprint Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL
    Michael Pfreundschuh
    Saarland University Medical School, Homburg Saar, Germany
    Blood 104:626-33. 2004
    ..Although the CHOEP regimens induced more myelosuppression, all regimens were well tolerated. CHOEP should be the preferred chemotherapy regimen for young patients with good-prognosis (normal LDH level) aggressive lymphoma...
  37. ncbi request reprint Increased expression of pro-inflammatory cytokines as a cause of lung toxicity after combined treatment with gemcitabine and thoracic irradiation
    Claudia E Rübe
    Department of Radiotherapy Radiooncology, Saarland University, Kirrbergerstr, D 66421 Homburg Saar, Germany
    Radiother Oncol 72:231-41. 2004
    ....