- Ilko D, Steiger C, Keller R, Holzgrabe U, Meinel L. Tamper-proof tablets for distinction between counterfeit and originator drugs through PEG coding. Eur J Pharm Biopharm. 2016;99:1-6 pubmed publisher..The approach is limited to cases in which PEGs are not present for formulation purposes as excipients, as coding against this background was unfeasible. ..
- Wahl O, Holzgrabe U. Amino acid analysis for pharmacopoeial purposes. Talanta. 2016;154:150-63 pubmed publisher..Production methods and possible impurities as well as separation and detection methods suitable for said impurities are subject to this review. ..
- Hiltensperger G, Hecht N, Kaiser M, Rybak J, Hoerst A, Dannenbauer N, et al. Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity. Antimicrob Agents Chemother. 2016;60:4442-52 pubmed publisher..Spray-dried GHQ168 demonstrated exciting antitrypanosomal efficacy. ..
- Unger N, Holzgrabe U. Stability and assessment of amino acids in parenteral nutrition solutions. J Pharm Biomed Anal. 2018;147:125-139 pubmed publisher..This review focuses on amino acid stability in pure amino acid solution and name methods of assessment. Incompatibilities of amino acids with the other ingredients are matter of concern in clinical practice and evaluated for relevance. ..
- Skaf J, Hamarsheh O, Berninger M, Balasubramanian S, Oelschlaeger T, Holzgrabe U. Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima. Fitoterapia. 2018;125:191-198 pubmed publisher..1. Toxicity of 26 and 27 was assessed using the greater wax moth Galleria mellonella larvae as an in vivo model. No significant toxicity was observed for the concentration range of 1.25-20mM. ..
- Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville I, et al. Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei. Bioorg Med Chem. 2016;24:5134-5147 pubmed publisher..Synthesis and evaluation of the compounds in PPIase assays resulted in highly active inhibitors. The activities can be interpreted in terms of a common binding mode obtained by docking calculations. ..
- Schmidt I, Göllner S, Fuß A, Stich A, Kucharski A, Schirmeister T, et al. Bistacrines as potential antitrypanosomal agents. Bioorg Med Chem. 2017;25:4526-4531 pubmed publisher..In addition, the inhibition of trypanothione reductase by bistacrines was found. This flavoprotein oxidoreductase is the main defense against oxidative stress in the thiol redox system unique for protozoa. ..
- Wahl J, Holzgrabe U. Capillary electrophoresis separation of phenethylamine enantiomers using amino acid based ionic liquids. J Pharm Biomed Anal. 2018;148:245-250 pubmed publisher..The best results for the separation of all enantiomers were achieved using 125mmol/L tetrabutylammonium l-argininate in a 75mmol/L phosphate buffer pH 1.5 containing 30mmol/L ?-cyclodextrin. ..
- Wahl O, Cleynhens J, Verbruggen A, Holzgrabe U. Impurity profiling of N,N'-ethylenebis-l-cysteine diethyl ester (Bicisate). J Pharm Biomed Anal. 2018;150:132-136 pubmed publisher..A new degradation product of bicisate, bicisate lactam, was identified during sample solution stability assessment. ..
- Zilker M, Sorgel F, Holzgrabe U. A stability-study of expired ampoules manufactured more than 40 years ago. J Pharm Biomed Anal. 2018;150:318-326 pubmed publisher..In Suprarenin and Adrenalin in Oil, both containing epinephrine, Impletol (procaine), and Persantin® (dipyridamole) contents were decreased to 70%, 74%, 79%, and 86%, respectively, and therefore out of specification. ..
- Schmidt M, Skaf J, Gavril G, Polednik C, Roller J, Kessler M, et al. The influence of Osmunda regalis root extract on head and neck cancer cell proliferation, invasion and gene expression. BMC Complement Altern Med. 2017;17:518 pubmed publisher..Thin layer chromatography identified ferulic acid to be present in the extract. The presented results justify the use of royal fern extracts as an anti-cancer remedy in history and imply a further analysis of ingredients. ..