Michael T Heneka
Heneka M, Ramanathan M, Jacobs A, Dumitrescu Ozimek L, Bilkei Gorzo A, Debeir T, et al
. Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci. 2006;26:1343-54 pubmed
..We postulate that LC degeneration substantially contributes to AD development. ..
Heneka M, Sastre M, Dumitrescu Ozimek L, Dewachter I, Walter J, Klockgether T, et al
. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J Neuroinflammation. 2005;2:22 pubmed
Heneka M, Landreth G. PPARs in the brain. Biochim Biophys Acta. 2007;1771:1031-45 pubmed
..Less is known about the physiological role of PPARs for brain development, maintenance and function. Lesions from transgenic mouse models, however, provide evidence that PPARs may play pivotal roles for CNS development and function. ..