Affiliation: Frankfurt am Main
- Niederberger E, Geisslinger G. The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?. FASEB J. 2008;22:3432-42 pubmed publisher..Therefore, a modulation of specific participants in the NF-kappaB signal transduction might exert a useful approach for the development of new painkillers. ..
- Niederberger E, Moser C, Kynast K, Geisslinger G. The non-canonical I?B kinases IKK? and TBK1 as potential targets for the development of novel therapeutic drugs. Curr Mol Med. 2013;13:1089-97 pubmed..In this review, we summarize the roles of IKK? and TBK1 in different diseases and outline therapeutic options for modulation of these kinases. ..
- King Himmelreich T, Schramm S, Wolters M, Schmetzer J, Möser C, Knothe C, et al. The impact of endurance exercise on global and AMPK gene-specific DNA methylation. Biochem Biophys Res Commun. 2016;474:284-290 pubmed publisher..Taken together, these results suggest that exercise influences AMPK?2 gene methylation in human blood and eminently in the skeletal muscle of mice and therefore might repress AMPK?2 gene expression. ..
- King Himmelreich T, Möser C, Wolters M, Schmetzer J, Schreiber Y, Ferreirós N, et al. AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids. Neuropharmacology. 2017;124:134-142 pubmed publisher..In conclusion, our data suggest that AMPK is an intermediate effector in endocannabinoid-mediated exercise-induced antinociception. This article is part of the Special Issue entitled "A New Dawn in Cannabinoid Neurobiology". ..
- Niederberger E, Schmidtko A, Gao W, Kühlein H, Ehnert C, Geisslinger G. Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB. Eur J Pharmacol. 2007;559:55-60 pubmed..The participation to persistent pain might rely on activation of NF-kappaB by inflammatory stimuli while the contribution to acute pain responses might be related to constitutive NF-kappaB activity in neurons of the nociceptive system. ..
- Niederberger E, Ehnert C, Gao W, Coste O, Schmidtko A, Popp L, et al. The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception. Biochem Biophys Res Commun. 2007;362:75-80 pubmed..Thus, our data confirm that CREB is essential for spinal nociceptive processing. However, prevention of phosphorylation only at serine 142 is not sufficient to modulate the nociceptive response. ..