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- Ostos M, Recalde D, Baroukh N, Callejo A, Rouis M, Castro G, et al. Fructose intake increases hyperlipidemia and modifies apolipoprotein expression in apolipoprotein AI-CIII-AIV transgenic mice. J Nutr. 2002;132:918-23 pubmed..Our data suggest that long-term fructose consumption had strong adverse effects in this hyperlipidemic mouse model. ..