Genomes and Genes

Species

Gael Chetelat

Summary

Affiliation: GIP Cyceron
Country: France

Publications

  1. Chetelat G. Alzheimer disease: A?-independent processes-rethinking preclinical AD. Nat Rev Neurol. 2013;9:123-4 pubmed publisher
    ..Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-?, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies. ..
  2. Chetelat G, Ossenkoppele R, Villemagne V, Perrotin A, Landeau B, Mézenge F, et al. Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer's disease. Brain. 2016;139:2528-39 pubmed publisher
    ....
  3. Chetelat G, Villemagne V, Pike K, Baron J, Bourgeat P, Jones G, et al. Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain. 2010;133:3349-58 pubmed publisher
    ..Our complementary analyses tend to support the latter hypotheses. Overall, our findings suggest that the deleterious effects of ?-amyloid on cognition may be delayed in those subjects with larger brain (temporal) volume. ..
  4. Chetelat G, Villemagne V, Villain N, Jones G, Ellis K, Ames D, et al. Accelerated cortical atrophy in cognitively normal elderly with high ?-amyloid deposition. Neurology. 2012;78:477-84 pubmed publisher
    ..The aim of the present study was to assess whether A? influences the rate of atrophy in cognitively normal elderly individuals...
  5. Chetelat G, Mézenge F, Tomadesso C, Landeau B, Arenaza Urquijo E, Rauchs G, et al. Reduced age-associated brain changes in expert meditators: a multimodal neuroimaging pilot study. Sci Rep. 2017;7:10160 pubmed publisher
    ..Pending replication in a larger cohort of elderly expert meditators and longitudinal studies, these findings suggest that meditation practice could reduce age-associated structural and functional brain changes. ..
  6. Wirth M, Bejanin A, La Joie R, Arenaza Urquijo E, Gonneaud J, Landeau B, et al. Regional patterns of gray matter volume, hypometabolism, and beta-amyloid in groups at risk of Alzheimer's disease. Neurobiol Aging. 2017;: pubmed publisher
    ..Our findings highlight that regional AD-like biomarker patterns may vary across different at-risk populations, potentially reflecting differential mediators of these risks. ..

Detail Information

Publications6

  1. Chetelat G. Alzheimer disease: A?-independent processes-rethinking preclinical AD. Nat Rev Neurol. 2013;9:123-4 pubmed publisher
    ..Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-?, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies. ..
  2. Chetelat G, Ossenkoppele R, Villemagne V, Perrotin A, Landeau B, Mézenge F, et al. Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer's disease. Brain. 2016;139:2528-39 pubmed publisher
    ....
  3. Chetelat G, Villemagne V, Pike K, Baron J, Bourgeat P, Jones G, et al. Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain. 2010;133:3349-58 pubmed publisher
    ..Our complementary analyses tend to support the latter hypotheses. Overall, our findings suggest that the deleterious effects of ?-amyloid on cognition may be delayed in those subjects with larger brain (temporal) volume. ..
  4. Chetelat G, Villemagne V, Villain N, Jones G, Ellis K, Ames D, et al. Accelerated cortical atrophy in cognitively normal elderly with high ?-amyloid deposition. Neurology. 2012;78:477-84 pubmed publisher
    ..The aim of the present study was to assess whether A? influences the rate of atrophy in cognitively normal elderly individuals...
  5. Chetelat G, Mézenge F, Tomadesso C, Landeau B, Arenaza Urquijo E, Rauchs G, et al. Reduced age-associated brain changes in expert meditators: a multimodal neuroimaging pilot study. Sci Rep. 2017;7:10160 pubmed publisher
    ..Pending replication in a larger cohort of elderly expert meditators and longitudinal studies, these findings suggest that meditation practice could reduce age-associated structural and functional brain changes. ..
  6. Wirth M, Bejanin A, La Joie R, Arenaza Urquijo E, Gonneaud J, Landeau B, et al. Regional patterns of gray matter volume, hypometabolism, and beta-amyloid in groups at risk of Alzheimer's disease. Neurobiol Aging. 2017;: pubmed publisher
    ..Our findings highlight that regional AD-like biomarker patterns may vary across different at-risk populations, potentially reflecting differential mediators of these risks. ..