Marja Riitta Taskinen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Diabetic dyslipidaemia: from basic research to clinical practice
    M R Taskinen
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    Diabetologia 46:733-49. 2003
  2. ncbi request reprint LDL-cholesterol, HDL-cholesterol or triglycerides--which is the culprit?
    Marja Riitta Taskinen
    Division of Cardiology, Department of Medicine, University of Helsinki, Biomedicum, Haartmaninkatu 8, Helsinki 00290, Finland
    Diabetes Res Clin Pract 61:S19-26. 2003
  3. ncbi request reprint Diabetic dyslipidemia
    Marja Riitta Taskinen
    University of Helsinki, Meilahti Hospital, Helsinki, Finland
    Atheroscler Suppl 3:47-51. 2002
  4. ncbi request reprint Pathogenesis of dyslipidemia in type 2 diabetes
    M R Taskinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Exp Clin Endocrinol Diabetes 109:S180-8. 2001
  5. ncbi request reprint Oestrogen replacement therapy and coronary heart disease
    M R Taskinen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Ann Med 30:443-51. 1998
  6. ncbi request reprint Carotid artery intima-media thickness in Finnish families with familial combined hyperlipidemia
    Kati Ylitalo
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, PO Box 340, Floor 11, Haartmaninkatu 4, 0029 HUS, Finland
    Atherosclerosis 162:171-8. 2002
  7. ncbi request reprint Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families
    Ming Lin Liu
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Stroke 33:1255-60. 2002
  8. doi request reprint Cardiac steatosis in patients with dilated cardiomyopathy
    Marit Graner
    Division of Cardiology, Diabetes and Obesity Research Program, Heart and Lung Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Heart 100:1107-12. 2014
  9. ncbi request reprint Association of carotid intima-media thickness with angiographic severity and extent of coronary artery disease
    Marit Graner
    Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Am J Cardiol 97:624-9. 2006
  10. ncbi request reprint Decreased high-density lipoprotein (HDL) particle size, prebeta-, and large HDL subspecies concentration in Finnish low-HDL families: relationship with intima-media thickness
    Hiroshi Watanabe
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital and Biomedicum, Finland
    Arterioscler Thromb Vasc Biol 26:897-902. 2006

Detail Information

Publications100

  1. ncbi request reprint Diabetic dyslipidaemia: from basic research to clinical practice
    M R Taskinen
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    Diabetologia 46:733-49. 2003
    ..These observations suggest these factors as a new target to tailor more efficient drugs to treat diabetic dyslipidaemia...
  2. ncbi request reprint LDL-cholesterol, HDL-cholesterol or triglycerides--which is the culprit?
    Marja Riitta Taskinen
    Division of Cardiology, Department of Medicine, University of Helsinki, Biomedicum, Haartmaninkatu 8, Helsinki 00290, Finland
    Diabetes Res Clin Pract 61:S19-26. 2003
    ..Additional strategies for treating the cluster of risk factors in dyslipidaemia are necessary to further reduce atherosclerotic disease in this population...
  3. ncbi request reprint Diabetic dyslipidemia
    Marja Riitta Taskinen
    University of Helsinki, Meilahti Hospital, Helsinki, Finland
    Atheroscler Suppl 3:47-51. 2002
    ..Lowering of LDL-cholesterol is a very attractive target for the reduction of coronary heart disease in type 2 diabetic people...
  4. ncbi request reprint Pathogenesis of dyslipidemia in type 2 diabetes
    M R Taskinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Exp Clin Endocrinol Diabetes 109:S180-8. 2001
    ..The clinical implication is that the concentration of plasma triglycerides should be maintained as low as possible to avoid these deleterious consequences of hypertriglyceridemia...
  5. ncbi request reprint Oestrogen replacement therapy and coronary heart disease
    M R Taskinen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Ann Med 30:443-51. 1998
    ..Consequently, the picture on cardiovascular effects of oestrogen and HRT has become more complicated, and research in this field has extended to novel areas...
  6. ncbi request reprint Carotid artery intima-media thickness in Finnish families with familial combined hyperlipidemia
    Kati Ylitalo
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, PO Box 340, Floor 11, Haartmaninkatu 4, 0029 HUS, Finland
    Atherosclerosis 162:171-8. 2002
    ..This study is aimed to evaluate whether there is a difference in carotid artery wall thickness between asymptomatic FCHL family members who are affected and those who are unaffected according to the currently used lipid criteria...
  7. ncbi request reprint Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families
    Ming Lin Liu
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Stroke 33:1255-60. 2002
    ....
  8. doi request reprint Cardiac steatosis in patients with dilated cardiomyopathy
    Marit Graner
    Division of Cardiology, Diabetes and Obesity Research Program, Heart and Lung Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Heart 100:1107-12. 2014
    ..The aim of the study was to examine the components of cardiac steatosis and their relationship to LV structure and function in non-diabetic DCM patients...
  9. ncbi request reprint Association of carotid intima-media thickness with angiographic severity and extent of coronary artery disease
    Marit Graner
    Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Am J Cardiol 97:624-9. 2006
    ..Carotid IMT seems to be a weaker predictor of coronary atherosclerosis in the proximal parts of the coronary tree than in the mid and distal parts...
  10. ncbi request reprint Decreased high-density lipoprotein (HDL) particle size, prebeta-, and large HDL subspecies concentration in Finnish low-HDL families: relationship with intima-media thickness
    Hiroshi Watanabe
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital and Biomedicum, Finland
    Arterioscler Thromb Vasc Biol 26:897-902. 2006
    ..We studied the relationship between carotid intima-media thickness (IMT) and HDL subspecies distribution in Finnish families with low HDL cholesterol and premature CHD...
  11. ncbi request reprint Susceptibility of LDL to oxidation in vitro and antioxidant capacity in familial combined hyperlipidemia: comparison of patients with different lipid phenotypes
    Ming Lin Liu
    Department of Medicine, Helsinki University Central Hospital, Finland
    Ann Med 34:48-54. 2002
    ..There is increasing evidence that oxidation of low-density lipoprotein (LDL) plays an important role in atherogenesis...
  12. ncbi request reprint Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia
    Juha Vakkilainen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Hum Genet 10:547-52. 2002
    ..Our results suggest a polygenic background for LDL size with a recessive major gene that may contribute to large LDL peak particle size in women. Serum TG and HDL-C concentrations predict the majority of variations in LDL particle size...
  13. ncbi request reprint Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes
    Eeva Leinonen
    Department of Internal Medicine, Helsinki University Central Hospital, Biomedicum, Haartmaninkatu 8, P O Box 700, 00029 HUS Helsinki, Finland
    Atherosclerosis 166:387-94. 2003
    ..To investigate the relationship of inflammation and endothelial activation with insulin resistance and adiposity in type 2 diabetes...
  14. ncbi request reprint LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins
    Juha Vakkilainen
    Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, P O Box 340, 00029 HUCH, Helsinki, Finland
    J Lipid Res 43:598-603. 2002
    ..642). We conclude that serum triglyceride concentration is strongly correlated with LDL size in affected FCHL subjects. After adjustment for serum triglycerides, HL and CETP activities are associated with LDL size in FCHL...
  15. ncbi request reprint Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families
    Ming Lin Liu
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 24:1492-7. 2004
    ..This study aimed to investigate the determinants of the circulating Ox-LDL and the association between Ox-LDL and carotid intima-media thickness (IMT) in asymptomatic members of FCHL families...
  16. ncbi request reprint Determinants of low HDL levels in familial combined hyperlipidemia
    Aino Soro
    Department of Medicine, University of Helsinki, Finland
    J Lipid Res 44:1536-44. 2003
    ..We suggest that in FCHL, TG enrichment of HDL particles and enhanced HL activity lead to the reduction of HDL cholesterol and HDL2 cholesterol...
  17. ncbi request reprint Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL
    Aino Soro-Paavonen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland
    Ann Med 38:229-38. 2006
    ..Inhibition of cytokine-induced expression of adhesion molecules is one of the atheroprotective mechanisms of high-density lipoprotein (HDL)...
  18. ncbi request reprint Relationships between low-density lipoprotein particle size, plasma lipoproteins, and progression of coronary artery disease: the Diabetes Atherosclerosis Intervention Study (DAIS)
    Juha Vakkilainen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Circulation 107:1733-7. 2003
    ..We determined whether on-treatment plasma lipid concentrations and LDL particle size contribute to the favorable effect of fenofibrate on the progression of coronary artery disease (CAD)...
  19. ncbi request reprint Reduced IGFBP-1 is associated with thickening of the carotid wall in type 2 diabetes
    Eeva S Leinonen
    Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 25:1807-12. 2002
    ..The aim of the present study was to assess the role of the insulin-like growth factor (IGF) system and lipids in predicting the carotid intima-media thickness (IMT) in type 2 diabetes...
  20. ncbi request reprint Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL
    Aino Soro-Paavonen
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Lipid Res 48:1409-16. 2007
    ..These results suggest that defective ABCA1 function in cholesterol-loaded macrophages is one potential contributor to the impaired RCT process and the increased coronary heart disease risk in subjects with familial low HDL...
  21. doi request reprint Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol
    Pirkka Pekka Laurila
    Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 33:847-57. 2013
    ....
  22. doi request reprint Macrophage cholesterol efflux to plasma and HDL in subjects with low and high homocysteine levels: a FIELD substudy
    Marianna Maranghi
    Helsinki University Central Hospital, Biomedicum, Haartmaninkatu 8 PO Box 700, FIN 00029 Helsinki, Finland
    Atherosclerosis 219:259-65. 2011
    ....
  23. doi request reprint Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects
    Marja Riitta Taskinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 31:2144-50. 2011
    ..However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjects...
  24. ncbi request reprint A candidate gene study in low HDL-cholesterol families provides evidence for the involvement of the APOA2 gene and the APOA1C3A4 gene cluster
    Heidi E Lilja
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Atherosclerosis 164:103-11. 2002
    ....
  25. ncbi request reprint Lipoprotein metabolism in subjects with hepatic lipase deficiency
    Marju Tilly-Kiesi
    Helsinki University Central Hospital, Helsinki, Finland
    Metabolism 53:520-5. 2004
    ..HL deficiency may result in a lipoprotein pattern associated with low heart disease risk...
  26. ncbi request reprint The increase of apolipoprotein A-V during postprandial lipemia parallels the response of triglyceride-rich lipoproteins in type 2 diabetes: no relationship between apoA-V and postheparin plasma lipolytic activity
    Juhani Kahri
    Division of Cardiology, Helsinki University Hospital, Biomedicum, Helsinki, Finland
    Diabetes Care 30:2083-5. 2007
  27. ncbi request reprint Postprandial lipemia associates with liver fat content
    Niina Matikainen
    Department of Medicine, University of Helsinki, P O Box 700, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 92:3052-9. 2007
    ..Postprandial lipemia and low adiponectin represent novel risk factors for vascular disease. This study aimed to determine whether liver fat content and adiponectin are predictors of postprandial triglyceride (TG)-rich lipoproteins (TRL)...
  28. pmc ApoE polymorphism is associated with C-reactive protein in low-HDL family members and in normolipidemic subjects
    Juhani Kahri
    Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 340, 00029 HUS, Finland
    Mediators Inflamm 2006:12587. 2006
    ..We conclude that apoE phenotype has a strong influence on serum CRP values...
  29. doi request reprint Cardiac steatosis associates with visceral obesity in nondiabetic obese men
    Marit Graner
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290 HUCH, Finland
    J Clin Endocrinol Metab 98:1189-97. 2013
    ..The aim of this study was to explore components of cardiac steatosis and their relationship to intra-abdominal ectopic fat deposits and cardiometabolic risk factors in nondiabetic obese men...
  30. doi request reprint Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 Tesla: validation by gas chromatography
    Jesper Lundbom
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    NMR Biomed 23:466-72. 2010
    ..569, p = 0.017, n = 17), but serum lipid levels showed no apparent relation to SAT FA composition. We conclude that long TE (1)H-MRS provides a robust non-invasive method for characterizing adipose tissue triglycerides in vivo...
  31. doi request reprint Ectopic fat depots and left ventricular function in nondiabetic men with nonalcoholic fatty liver disease
    Marit Graner
    From the Diabetes and Obesity Research Program, Division of Cardiology, Heart and Lung Center, Helsinki University Central Hospital M G, M O P, M S N, M R T, Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital K N, J L, A H, K L, N L, and Department of General Practice and Primary Health Care, Health Center of City of Helsinki R S, University of Helsinki, Helsinki, Finland
    Circ Cardiovasc Imaging 8:. 2015
    ..The aim of the study was to assess the effect of different ectopic fat depots on left ventricular (LV) function in subjects with nonalcoholic fatty liver disease...
  32. ncbi request reprint Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes
    Anne Hiukka
    Department of Medicine, Division of Cardiology, Helsinki University Hospital and Biomedicum, Haartmaninkatu 8, 00029, Helsinki, Finland
    Diabetologia 48:1207-15. 2005
    ..The aim of the study was to examine the distribution and composition of VLDL subspecies in type 2 diabetes...
  33. ncbi request reprint Hypertriglyceridemia is associated with prebeta-HDL concentrations in subjects with familial low HDL
    Sanni Soderlund
    Division of Cardiology, Department of Medicine, University of Helsinki, Helsinki, Finland
    J Lipid Res 46:1643-51. 2005
    ..Our results support the hypothesis that impaired RCT is one mechanism behind the increased risk for CHD in subjects with familial low HDL...
  34. doi request reprint Long-TE 1H MRS suggests that liver fat is more saturated than subcutaneous and visceral fat
    Jesper Lundbom
    Department of Medicine, Division of Cardiology, University of Helsinki, Helsinki, Finland
    NMR Biomed 24:238-45. 2011
    ..The results suggest that liver fat is more saturated than subcutaneous or visceral adipose tissue, which may be attributed to differences in de novo lipogenesis...
  35. doi request reprint Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus
    Anne Hiukka
    Department of Medicine, University of Helsinki, Helsinki University Central Hospital and Biomedicum, Helsinki, Finland
    J Am Coll Cardiol 52:2190-7. 2008
    ..The aim of this substudy was to ascertain whether long-term treatment with fenofibrate reduces surrogate measures of atherosclerosis, biomarkers of inflammation, and endothelial activation in patients with type 2 diabetes...
  36. pmc Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes
    Jussi Naukkarinen
    FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Finland
    PLoS Genet 6:e1000976. 2010
    ..This study presents a new approach to utilizing gene expression studies for informing choice of candidate genes for complex human phenotypes, such as obesity...
  37. doi request reprint Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study
    Jan Boren
    From the Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden J B, M A Lipid Disorders Clinic, Metabolic Research Centre, Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology G F W, D C C, P H R B and Faculty of Engineering, Computing and Mathematics P H R B, University of Western Australia, Perth, Australia Heart and Lung Centre, Helsinki University Central Hospital and Research Programs Unit, Diabetes and Obesity S S, N M, M R T and Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital A H, N L, University of Helsinki, Helsinki, Finland Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland N M, J K and Department of Endocrinology Diabetology, University Hospital and INSERM CRI 866, Dijon, France B V
    Arterioscler Thromb Vasc Biol 35:2218-24. 2015
    ..The aim of this study was to clarify determinants of plasma triglyceride concentration. We focused on factors that predict the kinetics of very-low density lipoprotein 1 (VLDL1) triglycerides...
  38. ncbi request reprint Insulin resistance as predictor of the angiographic severity and extent of coronary artery disease
    Marit Graner
    Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 39:137-44. 2007
    ..Insulin resistance (IR) is frequently observed in patients with coronary artery disease (CAD). Aim. To examine the association between IR and severity and extent of CAD...
  39. doi request reprint Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias
    Jussi Naukkarinen
    Institute for Molecular Medicine Finland FIMM, National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
    Circ Cardiovasc Genet 2:522-9. 2009
    ..Typical of complex disease-associated genes, neither the explicit mutations have been described nor the functional consequences for risk allele carriers been reported at the cellular or tissue level...
  40. ncbi request reprint Serum homocysteine concentrations, gemfibrozil treatment, and progression of coronary atherosclerosis
    Mikko Syvanne
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, P O Box 340, Haartmaninkatu 4, Helsinki, 00029 HUS, Finland
    Atherosclerosis 172:267-72. 2004
    ..The MTHFR genotype was not associated with extent or progression of coronary atherosclerosis. We conclude that gemfibrozil causes a significant elevation in tHcy levels, but the clinical relevance of this is unknown at present...
  41. ncbi request reprint Effects of nateglinide and glibenclamide on postprandial lipid and glucose metabolism in type 2 diabetes
    Juha Vakkilainen
    Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Metab Res Rev 18:484-90. 2002
    ....
  42. ncbi request reprint Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study)
    Lena M Thorn
    Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, POB 63, FIN 00014, Helsinki, Finland
    Diabetes Care 28:2019-24. 2005
    ..The aim of this study was to estimate the prevalence of the metabolic syndrome in Finnish type 1 diabetic patients and to assess whether it is associated with diabetic nephropathy or poor glycemic control...
  43. pmc Effects of long-term fenofibrate treatment on markers of renal function in type 2 diabetes: the FIELD Helsinki substudy
    Carol Forsblom
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum, Helsinki, Finland
    Diabetes Care 33:215-20. 2010
    ..We explored if there were changes in commonly available markers of renal function during fenofibrate treatment in the FIELD Helsinki cohort excluding statin users...
  44. ncbi request reprint Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition
    Matti Hero
    Hospital for Children and Adolescents, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Eur J Endocrinol 155:453-60. 2006
    ..In the current study, we explored the effects of aromatase inhibition on lipid metabolism, insulin sensitivity, body composition and serum adiponectin in peripubertal boys...
  45. ncbi request reprint Association of paraoxonase-1 activity and concentration with angiographic severity and extent of coronary artery disease
    Marit Graner
    Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    J Am Coll Cardiol 47:2429-35. 2006
    ..The goal of this study was to examine the association between paraoxonase-1 (PON1) activity and concentration and the severity and extent of coronary artery disease (CAD)...
  46. ncbi request reprint Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease
    Marit Graner
    Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290 HUCH, Helsinki, Finland
    Nutr Metab Cardiovasc Dis 18:271-7. 2008
    ..Therefore, the aim of the present study was to examine the association between apoE polymorphism and carotid intima-media thickness (IMT), and severity and extent of coronary artery disease (CAD)...
  47. doi request reprint Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci
    Taru Tukiainen
    Institute for Molecular Medicine Finland FIMM, Helsinki University Hospital, FI 00014 University of Helsinki, Helsinki, Finland
    Hum Mol Genet 21:1444-55. 2012
    ..Further understanding of the rich variability in genetic effects on metabolites provides insights into the biological processes modifying lipid levels...
  48. doi request reprint Decrease in circulating fibroblast growth factor 21 after an oral fat load is related to postprandial triglyceride-rich lipoproteins and liver fat
    Niina Matikainen
    Division of Cardiology Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, University of Helsinki, PO Box 700, FIN 00029 Helsinki, Finland
    Eur J Endocrinol 166:487-92. 2012
    ..How FGF21 responds to an oral fat load in man is unknown...
  49. doi request reprint Dietary omega-3 polyunsaturated fatty acid intake is related to a protective high-density lipoprotein subspecies profile independent of genetic effects: a monozygotic twin pair study
    Leonie H Bogl
    The Finnish Twin Cohort Study, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Atherosclerosis 219:880-6. 2011
    ..Studies on diet and high-density lipoprotein (HDL) subspecies distribution are limited...
  50. doi request reprint Reviewing statin therapy in diabetes--towards the best practise
    Niina Matikainen
    Department of Medicine, University of Helsinki, Finland
    Prim Care Diabetes 4:9-15. 2010
    ..This review updates the current knowledge of statin therapy in preventing micro- and macrovascular complications in both type 1 and type 2 diabetes...
  51. doi request reprint Increased apolipoprotein E level and reduced high-density lipoprotein mean particle size associate with low high-density lipoprotein cholesterol and features of metabolic syndrome
    Sanni Soderlund
    Division of Cardiology, Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Biomedicum, Helsinki, Finland
    Metabolism 59:1502-9. 2010
    ..Apolipoprotein E, although generally considered antiatherogenic, associates with MetS and low HDL-C. Our results emphasize the need for a better understanding of apo E metabolism in HDL particles...
  52. pmc A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol
    Ida Surakka
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    PLoS Genet 7:e1002333. 2011
    ..However, more refined measures of both body-fat distribution and metabolic measures are needed to understand how their joint dynamics are modified by the newly found locus...
  53. pmc Effect of HDL composition and particle size on the resistance of HDL to the oxidation
    Nakanishi Shuhei
    Division of Cardiology, Department of Medicine, University of Helsinki, Helsinki, Finland
    Lipids Health Dis 9:104. 2010
    ..To study the resistance of HDL particles to direct oxidation in respect to the distribution of HDL particles...
  54. ncbi request reprint Metabolic effects of metformin in patients with impaired glucose tolerance
    M Lehtovirta
    Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    Diabet Med 18:578-83. 2001
    ..Obviously large multicentre studies are needed to establish whether these effects are sufficient to prevent progression to manifest Type 2 diabetes and associated cardiovascular morbidity and mortality. Diabet. Med. 18, 578-583 (2001)..
  55. pmc The Contribution of GWAS Loci in Familial Dyslipidemias
    Pietari Ripatti
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    PLoS Genet 12:e1006078. 2016
    ..Polygenic SNP panels improve identification of individuals affected with FCH, but their clinical utility remains to be defined. ..
  56. pmc Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men
    Niina Matikainen
    Research Programs Unit, Diabetes and Obesity, University of Helsinki and Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland
    PLoS ONE 11:e0145890. 2016
    ..Glucose and lipids stimulate the gut-hormones glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) but the effect of these on human postprandial lipid metabolism is not fully clarified...
  57. doi request reprint Hepatic lipogenesis and a marker of hepatic lipid oxidation, predict postprandial responses of triglyceride-rich lipoproteins
    Niina Matikainen
    Department of Medicine, Cardiovascular Research Unit, Diabetes and Obesity Research Program, Heart and Lung Center, University of Helsinki, Finland Division of Endocrinology, Helsinki University Central Hospital, University of Helsinki, Finland
    Obesity (Silver Spring) 22:1854-9. 2014
    ..The mechanisms are still unclear. Here it was tested if hepatic de novo lipogenesis (DNL) and lipid oxidation influence the postprandial responses of triglyceride-rich lipoproteins (TRL) in humans...
  58. doi request reprint Diagnostic efficacy of myeloperoxidase to identify acute coronary syndrome in subjects with chest pain
    Marit Graner
    Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 45:322-7. 2013
    ..Early diagnosis of acute coronary syndrome (ACS) is frequently a challenging task...
  59. ncbi request reprint Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis
    Robert Bergholm
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 22:1637-41. 2002
    ..We determined whether endothelial dysfunction characterizes patients with newly diagnosed RA (n=10) compared with normal subjects (control group, n=33) and whether it is reversible with 6 months of anti-inflammatory therapy...
  60. ncbi request reprint Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample
    Minna T Jänis
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    J Lipid Res 45:2303-9. 2004
    ..The present data on PLTP activity and concentration reveal novel connections of the two PLTP forms to lipid and carbohydrate metabolism...
  61. doi request reprint PPARalpha: an emerging therapeutic target in diabetic microvascular damage
    Anne Hiukka
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital and Biomedicum, Haartmaninkatu 8, 00029 Helsinki, Finland
    Nat Rev Endocrinol 6:454-63. 2010
    ..This Review focuses on the role of PPARalpha activation in diabetic microvascular disease and highlights the available experimental and clinical evidence from studies of PPARalpha agonists...
  62. doi request reprint Measuring short-term liver metabolism non-invasively: postprandial and post-exercise ¹H and ³¹P MR spectroscopy
    Antti Hakkarainen
    Department of Radiology, HUS Medical Imaging Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    MAGMA 28:57-66. 2015
    ..The objective of this study was to determine the effects of a standardized fat rich meal and subsequent exercise on liver fat content by ¹H MRS and on liver adenosine triphosphate (ATP) content by ³¹P MRS in healthy subjects...
  63. doi request reprint Interrelationships between the kinetics of VLDL subspecies and HDL catabolism in abdominal obesity: a multicenter tracer kinetic study
    Bruno Verges
    Departments of Endocrinology Diabetology B V, I R and Medical Biology L D, University Hospital, and INSERM CRI 866 B V, L D, 21000 Dijon, France Departments of Molecular and Clinical Medicine M A, J B and Mathematical Sciences M A, University of Gothenburg, S 405 30 Gothenburg, Sweden Faculty of Engineering, Computing, and Mathematics H B, University of Western Australia, Perth, Western Australia 6872, Australia Lipid Disorders Clinic H B, G F W, D C, Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia and Heart and Lung Centre S S, N M, M R T, Helsinki University Central Hospital and Research Programs Unit, Department of Diabetes and Obesity, University of Helsinki, and Department of Medicine N M, J K, Helsinki University Central Hospital, 00290 Helsinki, Finland
    J Clin Endocrinol Metab 99:4281-90. 2014
    ....
  64. pmc Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects
    Niina Matikainen
    HUCH Heart and Lung Centre, Cardiovascular Research Group, Helsinki University Central Hospital, Diabetes and Obesity, University of Helsinki, Helsinki, Finland
    PLoS ONE 8:e79473. 2013
    ..The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway is important for the hepatic clearance of remnant TRLs in mice, but its relevance in humans is unclear...
  65. ncbi request reprint The role of PPAR-alpha agonists in the prevention of CVD in diabetes
    Marja Riitta Taskinen
    Department of Medicine, Division of Cardiology, Helsinki University Hospital, Biomedicum, Haartmaninkatu 8, P O Box 700, 00029 Helsinki, Finland
    Curr Diab Rep 7:83-5. 2007
  66. ncbi request reprint C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients
    Kati Ylitalo
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 4, 00029 HYKS, Helsinki, Finland
    Metabolism 51:664-70. 2002
    ..However, defects in adipose tissue expression of these genes are not likely to play a primarily role in the pathogenesis of FCHL in Finnish FCHL families...
  67. doi request reprint Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity
    Shuhei Nakanishi
    Division of Cardiology, Department of Medicine, University of Helsinki, Helsinki, Finland
    J Lipid Res 50:183-92. 2009
    ..However, sera from low-HDL subjects have poorer cholesterol acceptor ability as compared with sera from high-HDL subjects...
  68. ncbi request reprint Type 2 diabetes as a lipid disorder
    M R Taskinen
    Department of Medicine, University of Helsinki, Finland
    Curr Mol Med 5:297-308. 2005
    ..Future discoveries hopefully will delineate the regulatory steps to allow more targeted treatment of diabetic dyslipidemia...
  69. ncbi request reprint Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus
    H Yki-Jarvinen
    Department of Medicine, University of Helsinki, Finland
    J Clin Endocrinol Metab 82:4037-43. 1997
    ....
  70. doi request reprint Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study
    M R Taskinen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Diabetes Obes Metab 13:65-74. 2011
    ..To evaluate the efficacy and safety of the potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin administered as add-on therapy to metformin in patients with type 2 diabetes with inadequate glycaemic control...
  71. ncbi request reprint Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients
    J Westerbacka
    Department of Medicine, University of Helsinki, Finland
    Diabetologia 48:1654-62. 2005
    ..The aim of this study was to determine the relationships between intima-media thickness (IMT), an established marker of atherosclerosis, large artery function and other determinants of cardiovascular risk in type 2 diabetic patients...
  72. ncbi request reprint Associations between lipoproteins and the progression of coronary and vein-graft atherosclerosis in a controlled trial with gemfibrozil in men with low baseline levels of HDL cholesterol
    M Syvanne
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Findland
    Circulation 98:1993-9. 1998
    ....
  73. ncbi request reprint Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women
    S Vehkavaara
    Department of Medicine, University of Helsinki, Finland
    Thromb Haemost 85:619-25. 2001
    ....
  74. doi request reprint Ability of traditional lipid ratios and apolipoprotein ratios to predict cardiovascular risk in people with type 2 diabetes
    M R Taskinen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Biomedicum, Haartmaninkatu 8, Helsinki, Finland
    Diabetologia 53:1846-55. 2010
    ....
  75. doi request reprint Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes
    N Tolonen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, University of Helsinki, Biomedicum Helsinki C318b, Haartmaninkatu 8, PO Box 63, 00014, Helsinki, Finland
    Diabetologia 52:2522-30. 2009
    ..We studied the impact of baseline lipid variables on the progression of renal disease in a large nationwide prospective cohort of patients with type 1 diabetes...
  76. ncbi request reprint Long-term effects of fenofibrate on VLDL and HDL subspecies in participants with type 2 diabetes mellitus
    A Hiukka
    Department of Medicine, Division of Cardiology, Helsinki University Hospital and Biomedicum, Haartmaninkatu 8, 00290, Helsinki, Finland
    Diabetologia 50:2067-75. 2007
    ..We explored the changes in VLDL and HDL subspecies during fenofibrate treatment in a statin-free FIELD cohort...
  77. ncbi request reprint Determinants of the severity and extent of coronary artery disease in patients with type-2 diabetes and in nondiabetic subjects
    M Syvanne
    Department of Medicine, Helsinki University Central Hospital, Finland
    Coron Artery Dis 12:99-106. 2001
    ....
  78. doi request reprint Different lipid variables predict incident coronary artery disease in patients with type 1 diabetes with or without diabetic nephropathy: the FinnDiane study
    Nina Tolonen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, University of Helsinki, Helsinki, FinlandDivision of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, FinlandResearch Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland
    Diabetes Care 37:2374-82. 2014
    ..To study the ability of lipid variables to predict incident coronary artery disease (CAD) events in patients with type 1 diabetes at different stages of nephropathy...
  79. doi request reprint Management of dyslipidemias in the presence of the metabolic syndrome or type 2 diabetes
    Niina Matikainen
    Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, University of Helsinki, Finland
    Curr Cardiol Rep 14:721-31. 2012
    ..The position of niacin and ezetimibe and omega-3 fatty acids in treatment of dyslipidemia in the metabolic syndrome and type 2 diabetes is even less clear and remains to be established in future clinical trials...
  80. doi request reprint Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate
    Marja Riitta Taskinen
    Department of Medicine, Division of Cardiology, Helsinki University Hospital, Biomedicum, Haartmaninkatu 8, 00029 Helsinki, Finland
    Arterioscler Thromb Vasc Biol 29:950-5. 2009
    ....
  81. doi request reprint PRESS echo time behavior of triglyceride resonances at 1.5T: detecting omega-3 fatty acids in adipose tissue in vivo
    Jesper Lundbom
    Department of Medicine, Division of Cardiology, University of Helsinki, 00029 HUS Helsinki, Finland
    J Magn Reson 201:39-47. 2009
    ..The feasibility of (1)H NMR spectroscopy to detect these resonances was also evaluated in human adipose tissue in vivo...
  82. ncbi request reprint Phenotype expression in familial combined hyperlipidemia
    K V Porkka
    Department of Medicine, HUCH, University of Helsinki, Finland
    Atherosclerosis 133:245-53. 1997
    ..Our data emphasizes the need for re-evaluation of FCHL diagnostic criteria. Preferably, the diagnosis should be based on a single, reliable metabolic marker...
  83. ncbi request reprint Impact of postprandial lipaemia on low-density lipoprotein (LDL) size and oxidized LDL in patients with coronary artery disease
    M Graner
    Helsinki University Central Hospital, Helsinki, Finland
    Eur J Clin Invest 36:764-70. 2006
    ....
  84. ncbi request reprint Controlling lipid levels in diabetes
    M R Taskinen
    University of Helsinki, Department of Medicine, Finland
    Acta Diabetol 39:S29-34. 2002
    ..An increasing number of primary and secondary prevention trials have shown that lipid-lowering therapy with statins can significantly reduce the risk of CHD events in patients with diabetic dyslipidaemia...
  85. ncbi request reprint Strategies for the management of diabetic dyslipidaemia
    M R Taskinen
    Department of Medicine, University of Helsinki, Finland
    Drugs 58:47-51; discussion 75-82. 1999
    ....
  86. pmc OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism
    Julia Perttilä
    National Institute for Health and Welfare Public Health Genomics Unit, Biomedicum, 00251 Helsinki, Finland
    J Mol Med (Berl) 87:825-35. 2009
    ..The data introduces OSBPL10 as a gene whose variation may contribute to high triglyceride levels in dyslipidemic Finnish subjects and provides evidence for ORP10 as a regulator of cellular lipid metabolism...
  87. doi request reprint Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations
    A Kotronen
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
    Diabetologia 52:684-90. 2009
    ....
  88. ncbi request reprint Effects of acipimox on serum lipids, lipoproteins and lipolytic enzymes in hypertriglyceridemia
    M R Taskinen
    Second Department of Medicine, University of Helsinki, Finland
    Atherosclerosis 69:249-55. 1988
    ..LPL activity was markedly reduced in adipose tissue at 9 months. No significant changes occurred in postheparin plasma LPL activity. In contrast, hepatic lipase activity showed a reduction of about 25% from 6 months of treatment onwards...
  89. ncbi request reprint Associations between HDL oxidation and paraoxonase-1 and paraoxonase-1 gene polymorphisms in families affected by familial combined hyperlipidemia
    M L Liu
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland
    Nutr Metab Cardiovasc Dis 14:81-7. 2004
    ..The aim of this study was to investigate the associations between in vitro HDL oxidation parameters, endogenous PON1 and PON1 genotypes in families affected by asymptomatic FCHL...
  90. doi request reprint A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study
    B Isomaa
    Folkhälsan Genetic Institute, Helsinki, Finland
    Diabetologia 53:1709-13. 2010
    ..We studied the impact of a family history of type 2 diabetes on physical fitness, lifestyle factors and diabetes-related metabolic factors...
  91. ncbi request reprint Cholesterol efflux capacity in vitro predicts the severity and extent of coronary artery disease in patients with and without type 2 diabetes
    P Pajunen
    Department of Medicine, Helsinki University Central Hospital, Finland
    Scand Cardiovasc J 35:96-100. 2001
    ..In the diabetic group this association was independent of LpA-I levels, suggesting impaired antiatherogenic potential of these particles in type 2 diabetic patients...
  92. ncbi request reprint A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127
    H Tenkanen
    National Public Health Institute, First Department of Medicine, Helsinki, Finland
    Biochim Biophys Acta 1138:27-33. 1992
    ..There was also no association between the history of previous myocardial infarction and any of the apoA-IV alleles...
  93. doi request reprint HDL subspecies in young adult twins: heritability and impact of overweight
    Kirsi H Pietiläinen
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 17:1208-14. 2009
    ..Overweight associated with significant lipid profile changes, particularly, small HDL3c increased in overweight independent of genetic influences...
  94. pmc ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan
    Anne Hiukka
    Department of Medicine, Helsinki University Central Hospital and Biomedicum, Helsinki, Finland
    Diabetes 58:2018-26. 2009
    ..We investigated potential proatherogenic properties of apoCIII-containing LDL from hypertriglyceridemic patients with type 2 diabetes...
  95. ncbi request reprint USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study
    K Auro
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Haartmaninkatu 8, 00290 Helsinki, Finland
    Diabetologia 51:464-72. 2008
    ..Our aim was to further address the role of USF1 in metabolic syndrome and cardiovascular traits at the population level in a large Swedish male cohort (n=2,322) with multiple measurements for risk factors during 32 years of follow-up...
  96. ncbi request reprint Relationship between lipid profiles and kidney function in patients with type 1 diabetes
    N Tolonen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki C318b, University of Helsinki, Haartmaninkatu 8, P O Box 63, 00014, Helsinki, Finland
    Diabetologia 51:12-20. 2008
    ....
  97. ncbi request reprint Serum C3 but not plasma acylation-stimulating protein is elevated in Finnish patients with familial combined hyperlipidemia
    K Ylitalo
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland
    Arterioscler Thromb Vasc Biol 21:838-43. 2001
    ..The present data do not support the hypothesis that defects of the ASP pathway are reflected in plasma lipoproteins or in impaired plasma lipid clearance postprandially...
  98. pmc Tamoxifen treatment reverses the adverse effects of chemotherapy-induced ovarian failure on serum lipids
    L Vehmanen
    Department of Oncology, Helsinki University Central Hospital, PO Box 180, HUCH, FIN 00290, Helsinki, Finland
    Br J Cancer 91:476-81. 2004
    ..Our current study suggests that adjuvant tamoxifen therapy reverses the adverse effects of chemotherapy-induced ovarian failure on total and LDL cholesterol and even lowers their serum levels below the baseline...
  99. ncbi request reprint No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families
    P Pajukanta
    National Public Health Institute, Department of Human Molecular Genetics, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 17:841-50. 1997
    ..Data obtained by the affected sib-pair method supported these findings, suggesting that the LPL, HL, or HSL genes do not represent major loci influencing the expression of the FCHL phenotype...
  100. ncbi request reprint Role of apolipoproteins E and C in type V hyperlipoproteinemia
    T Kuusi
    Second Department Medicine, University of Helsinki, Finland
    J Lipid Res 29:293-8. 1988
    ..The apolipoprotein C-II and C-III distribution was similar to that in normolipidemic subjects. The results suggest that apoE4 may be involved in the development of type V hyperlipoproteinemia...