Affiliation: King Faisal University - Ain Shams University
El Sayed W, Aboul Fadl T, Lamb J, Roberts J, Franklin M. Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice. Toxicology. 2006;220:179-88 pubmed
El Sayed W, Aboul Fadl T, Roberts J, Lamb J, Franklin M. Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxicol In Vitro. 2007;21:157-64 pubmed
..Thus, Hepa1c1c7 cells appear to provide a viable platform for the study of protective enzyme regulation by selenocompounds, and with the exception of Ugt1a6, the mRNA elevations from selenazolidines are transcriptionally dependent. ..
Li L, Xie Y, El Sayed W, Szakacs J, Roberts J. Characteristics of selenazolidine prodrugs of selenocysteine: toxicity, selenium levels, and glutathione peroxidase induction in A/J mice. Life Sci. 2004;75:447-59 pubmed
..Increased activity of selenium-dependent glutathione peroxidase (GPx) in blood and liver illustrated that the selenazolidines provided a source of biologically-available selenium. ..
Li L, Xie Y, El Sayed W, Szakacs J, Franklin M, Roberts J. Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse. J Biochem Mol Toxicol. 2005;19:396-405 pubmed
..The two compounds showing significant tumor reduction (OSCA and selenocystine) were the only two compounds that showed ubiquity of changes, elevating both selenium levels and GPx activity in both liver and RBC. ..
El Sayed W, Franklin M. Hepatic chemoprotective enzyme responses to 2-substituted selenazolidine-4(R)-carboxylic acids. J Biochem Mol Toxicol. 2006;20:292-301 pubmed
..Thus, although constituting a closely related series of compounds, each 2-substituted SCA produced its own unique pattern of changes, and for most members, changes were predominant following i.p. administration. ..
El Sayed W, Hussin W, Franklin M. The antimutagenicity of 2-substituted selenazolidine-4-(R)-carboxylic acids. Mutat Res. 2007;627:136-45 pubmed
Franklin M, Moos P, El Sayed W, Aboul Fadl T, Roberts J. Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. Chem Biol Interact. 2007;168:211-20 pubmed
..Thus, several 2-aryl/alkyl selenazolidines possess chemopreventive activity against NNK-induced lung tumors, and variously demonstrate pre-initiation and post-initiation efficacy. ..
Ramadan G, Al Kahtani M, El Sayed W. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. 2011;34:291-301 pubmed publisher
..05), respectively. The present study proves the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model...
El Sayed W. Effect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice. Eur J Pharmacol. 2011;660:291-7 pubmed publisher
..This study not only filled the void about the murine PXR-induction profile but also will help in the course of drug development research with respect to extrapolation to human risk assessment. ..