Luc Dupuis

Summary

Publications

  1. Dupuis L, Pradat P, Ludolph A, Loeffler J. Energy metabolism in amyotrophic lateral sclerosis. Lancet Neurol. 2011;10:75-82 pubmed publisher
    ..Altogether, these results have clinical consequences for the management of defective energy metabolism in patients with ALS and pave the way for future therapeutic interventions. ..
  2. Dupuis L, Gonzalez de Aguilar J, Echaniz Laguna A, Eschbach J, Rene F, Oudart H, et al. Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. PLoS ONE. 2009;4:e5390 pubmed publisher
    ....
  3. Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller H, Rasche V, et al. Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration. Hum Mol Genet. 2015;24:2228-40 pubmed publisher
    ..Collectively, our data suggest that stimulating the autophagy/lysosomal system through appropriate nutritional intervention has significant beneficial effects on motor symptoms of dynein/dynactin diseases even after symptom onset. ..
  4. El Oussini H, Bayer H, Scekic Zahirovic J, Vercruysse P, Sinniger J, Dirrig Grosch S, et al. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta Neuropathol. 2016;131:465-80 pubmed publisher
    ..Thus, the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in ALS. Targeting this receptor might be therapeutically useful. ..
  5. Scekic Zahirovic J, Oussini H, Mersmann S, Drenner K, Wagner M, Sun Y, et al. Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis. Acta Neuropathol. 2017;133:887-906 pubmed publisher
    ..In all, we show that mutant FUS triggers toxic events in both motor neurons and neighboring cells to elicit motor neuron disease. ..

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Detail Information

Publications5

  1. Dupuis L, Pradat P, Ludolph A, Loeffler J. Energy metabolism in amyotrophic lateral sclerosis. Lancet Neurol. 2011;10:75-82 pubmed publisher
    ..Altogether, these results have clinical consequences for the management of defective energy metabolism in patients with ALS and pave the way for future therapeutic interventions. ..
  2. Dupuis L, Gonzalez de Aguilar J, Echaniz Laguna A, Eschbach J, Rene F, Oudart H, et al. Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. PLoS ONE. 2009;4:e5390 pubmed publisher
    ....
  3. Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller H, Rasche V, et al. Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration. Hum Mol Genet. 2015;24:2228-40 pubmed publisher
    ..Collectively, our data suggest that stimulating the autophagy/lysosomal system through appropriate nutritional intervention has significant beneficial effects on motor symptoms of dynein/dynactin diseases even after symptom onset. ..
  4. El Oussini H, Bayer H, Scekic Zahirovic J, Vercruysse P, Sinniger J, Dirrig Grosch S, et al. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta Neuropathol. 2016;131:465-80 pubmed publisher
    ..Thus, the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in ALS. Targeting this receptor might be therapeutically useful. ..
  5. Scekic Zahirovic J, Oussini H, Mersmann S, Drenner K, Wagner M, Sun Y, et al. Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis. Acta Neuropathol. 2017;133:887-906 pubmed publisher
    ..In all, we show that mutant FUS triggers toxic events in both motor neurons and neighboring cells to elicit motor neuron disease. ..