Søren E Degn

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. Degn S, Jensen L, Gal P, Dobó J, Holmvad S, Jensenius J, et al. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J Immunol Methods. 2010;361:37-50 pubmed publisher
    ..Thus, neither of the two proteins behaves as a classical acute phase protein. ..
  2. Degn S, Jensenius J, Thiel S. Disease-causing mutations in genes of the complement system. Am J Hum Genet. 2011;88:689-705 pubmed publisher
    ..Here, we compare the functional immunologic consequences of "conventional" complement deficiencies with these newly described developmental roles. ..
  3. Degn S, Thiel S, Nielsen O, Hansen A, Steffensen R, Jensenius J. MAp19, the alternative splice product of the MASP2 gene. J Immunol Methods. 2011;373:89-101 pubmed publisher
    ..Immunohistochemical analyses combined with qRT-PCR revealed that both MAp19 and MASP-2 were mainly expressed in hepatocytes. High levels of MAp19 were found in urine, where MASP-2 was absent. ..
  4. Degn S, Jensen L, Hansen A, Duman D, Tekin M, Jensenius J, et al. Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function. J Immunol. 2012;189:3957-69 pubmed publisher
    ..Hence, in functional terms, it appears that MASP-1 and MASP-2 act in a manner analogous to that of C1r and C1s of the classical pathway. ..
  5. Degn S, Jensen L, Olszowski T, Jensenius J, Thiel S. Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. J Immunol. 2013;191:1334-45 pubmed publisher
    ..We present support for this contention. ..

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Detail Information

Publications5

  1. Degn S, Jensen L, Gal P, Dobó J, Holmvad S, Jensenius J, et al. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J Immunol Methods. 2010;361:37-50 pubmed publisher
    ..Thus, neither of the two proteins behaves as a classical acute phase protein. ..
  2. Degn S, Jensenius J, Thiel S. Disease-causing mutations in genes of the complement system. Am J Hum Genet. 2011;88:689-705 pubmed publisher
    ..Here, we compare the functional immunologic consequences of "conventional" complement deficiencies with these newly described developmental roles. ..
  3. Degn S, Thiel S, Nielsen O, Hansen A, Steffensen R, Jensenius J. MAp19, the alternative splice product of the MASP2 gene. J Immunol Methods. 2011;373:89-101 pubmed publisher
    ..Immunohistochemical analyses combined with qRT-PCR revealed that both MAp19 and MASP-2 were mainly expressed in hepatocytes. High levels of MAp19 were found in urine, where MASP-2 was absent. ..
  4. Degn S, Jensen L, Hansen A, Duman D, Tekin M, Jensenius J, et al. Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function. J Immunol. 2012;189:3957-69 pubmed publisher
    ..Hence, in functional terms, it appears that MASP-1 and MASP-2 act in a manner analogous to that of C1r and C1s of the classical pathway. ..
  5. Degn S, Jensen L, Olszowski T, Jensenius J, Thiel S. Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. J Immunol. 2013;191:1334-45 pubmed publisher
    ..We present support for this contention. ..