Søren E Degn
Affiliation: University of Aarhus
- Degn S, Jensen L, Gal P, Dobó J, Holmvad S, Jensenius J, et al. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J Immunol Methods. 2010;361:37-50 pubmed publisher..Thus, neither of the two proteins behaves as a classical acute phase protein. ..
- Degn S, Jensenius J, Thiel S. Disease-causing mutations in genes of the complement system. Am J Hum Genet. 2011;88:689-705 pubmed publisher..Here, we compare the functional immunologic consequences of "conventional" complement deficiencies with these newly described developmental roles. ..
- Degn S, Thiel S, Nielsen O, Hansen A, Steffensen R, Jensenius J. MAp19, the alternative splice product of the MASP2 gene. J Immunol Methods. 2011;373:89-101 pubmed publisher..Immunohistochemical analyses combined with qRT-PCR revealed that both MAp19 and MASP-2 were mainly expressed in hepatocytes. High levels of MAp19 were found in urine, where MASP-2 was absent. ..
- Degn S, Jensen L, Hansen A, Duman D, Tekin M, Jensenius J, et al. Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function. J Immunol. 2012;189:3957-69 pubmed publisher..Hence, in functional terms, it appears that MASP-1 and MASP-2 act in a manner analogous to that of C1r and C1s of the classical pathway. ..
- Degn S, Jensen L, Olszowski T, Jensenius J, Thiel S. Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. J Immunol. 2013;191:1334-45 pubmed publisher..We present support for this contention. ..