CoppedÃ¨ F, Denaro M, Tannorella P, Migliore L. Increased MTHFR promoter methylation in mothers of Down syndrome individuals. Mutat Res. 2016;787:1-6 pubmed publisher
Coppede F. Risk factors for Down syndrome. Arch Toxicol. 2016;90:2917-2929 pubmed
CoppedÃ¨ F, Migliore L. DNA damage in neurodegenerative diseases. Mutat Res. 2015;776:84-97 pubmed publisher
..We will address those issues in the context of Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis, which represent three of the most common neurodegenerative pathologies in humans. ..
Coppede F, Tannorella P, Stoccoro A, Chico L, Siciliano G, Bonuccelli U, et al
. Methylation analysis of DNA repair genes in Alzheimer's disease. Mech Ageing Dev. 2017;161:105-111 pubmed publisher
..Collectively, present data do not support an increased promoter methylation of some of the major DNA repair genes in blood DNA of AD patients. ..
Lopomo A, Ricciardi R, Maestri M, De Rosa A, Melfi F, Lucchi M, et al
. Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis. Int J Mol Sci. 2016;17: pubmed publisher
..The present study suggests that MTHFR methylation is increased in thymomas obtained from MG patients; furthermore, some degrees of methylation of the DNMT3A gene were observed in thymic tissue with respect to blood. ..
Lopomo A, Ricciardi R, De Rosa A, Guida M, Maestri M, Lucchi M, et al
. The thymidylate synthase enhancer region (TSER) polymorphism increases the risk of thymic lymphoid hyperplasia in patients with Myasthenia Gravis. Gene. 2018;642:376-380 pubmed publisher
..The present study suggests that the TYMS TSER 3R allele increases the risk of thymic lymphoid hyperplasia in AChR+ MG patients. ..