And Lin Sen Zan

Summary

Country: China

Publications

  1. Hong J, Wang X, Mei C, Zan L. Competitive regulation by transcription factors and DNA methylation in the bovine SIRT5 promoter: Roles of E2F4 and KLF6. Gene. 2018;: pubmed publisher
    ..This study focused on the mechanism underlying the methylation and transcriptional regulation of SIRT5 expression in bovine adipocytes. ..
  2. Ma X, Wei D, Cheng G, Li S, Wang L, Wang Y, et al. Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle. Mol Cell Probes. 2018;: pubmed publisher
    ..Our result provides a reference for illustrating how noncoding RNAs affects beef quality traits in cattle. ..
  3. Hong J, Mei C, Li S, Wang H, Zhao C, Zan L. Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes. Arch Biochem Biophys. 2018;659:1-12 pubmed publisher
    ..Taken together, this study illuminated the underlying mechanism of methylation and transcription regulation of SIRT6 expression in bovine adipocytes. ..
  4. Mei C, Wang H, Liao Q, Khan R, Raza S, Zhao C, et al. Genome-wide analysis reveals the effects of artificial selection on production and meat quality traits in Qinchuan cattle. Genomics. 2018;: pubmed publisher
    ..and production or meat quality traits in QNS (PLCD3, MB, PPARGC1A, etc.). These results revealed the efforts of selective breeding for Chinese Qinchuan cattle, and will be helpful for future cattle breeding. ..
  5. Luoreng Z, Wang X, Mei C, Zan L. Expression profiling of peripheral blood miRNA using RNAseq technology in dairy cows with Escherichia coli-induced mastitis. Sci Rep. 2018;8:12693 pubmed publisher
    ..coli-induced mastitis. The results of this study lay the foundation for molecular network analysis of mastitis and molecular breeding of dairy cows. ..
  6. Guo H, Raza S, Schreurs N, Khan R, Wei D, Wang L, et al. Genetic variants in the promoter region of the KLF3 gene associated with fat deposition in Qinchuan cattle. Gene. 2018;672:50-55 pubmed publisher
  7. Liu Y, Gao J, Yang Y, Ku T, Zan L. Novel extraction method of genomic DNA suitable for long-fragment amplification from small amounts of milk. J Dairy Sci. 2014;97:6804-9 pubmed publisher
    ..The specific PCR amplification of 1,019- and 729-bp bovine DNA fragments was successfully carried out. This novel method can be used as a practical, fast, and economical mean for long genomic DNA extraction from a small amount of milk. ..
  8. Zhang Y, Li Y, Fu C, Wang J, Wang H, Zan L. Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle. Genet Mol Res. 2014;13:8105-17 pubmed publisher
    ..05). Therefore, the SMO gene could be used as a candidate gene to alter BMTs and MQTs in Qinchuan cattle or for marker-assisted selection to breed cattle with superior BMTs and MQTs. ..
  9. Khan R, Guo H, Raza S, Rahman A, Ayaz M, Linsen Z. Halal slaughtering, welfare, and empathy in farm animals: a review. Trop Anim Health Prod. 2018;: pubmed publisher

More Information

Publications47

  1. Li P, Wang Y, Zhang L, Ning Y, Zan L. The Expression Pattern of PLIN2 in Differentiated Adipocytes from Qinchuan Cattle Analysis of Its Protein Structure and Interaction with CGI-58. Int J Mol Sci. 2018;19: pubmed publisher
  2. Zhao X, Li Y, Cao S, Hu J, Wang W, Hao R, et al. Protective effects of ascorbic acid and vitamin E on antioxidant enzyme activity of freeze-thawed semen of Qinchuan bulls. Genet Mol Res. 2015;14:2572-81 pubmed publisher
    ..05). Therefore, we inferred that the combination of Vc (1400 IU/mL) and VE (0.12 IU/mL) protected the sperm quality in the freeze-thaw process. ..
  3. Wu S, Wang Y, Ning Y, Guo H, Wang X, Zhang L, et al. Genetic Variants in STAT3 Promoter Regions and Their Application in Molecular Breeding for Body Size Traits in Qinchuan Cattle. Int J Mol Sci. 2018;19: pubmed publisher
    ..Therefore, variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle. ..
  4. Guo H, Khan R, Raza S, Ning Y, Wei D, Wu S, et al. KLF15 promotes transcription of KLF3 gene in bovine adipocytes. Gene. 2018;659:77-83 pubmed publisher
    ..These findings conclude that KLF15 promotes the transcriptional activity of KLF3 in bovine adipocytes. This mechanism to provides a new direction for further study of adipogenesis by internal regulation of members within KLF family. ..
  5. Wei D, Feng L, Zhang W, Ma X, Cheng G, Li S, et al. Characterization of the promoter region of bovine SIX4: Roles of E-box and MyoD in the regulation of basal transcription. Biochem Biophys Res Commun. 2018;496:44-50 pubmed publisher
    ..Taken together, these interactions provide insight into the regulatory mechanisms of SIX4 transcription in mediating skeletal muscle growth in cattle. ..
  6. Li Y, Fu C, Zhang Y, Zan L. Efficient construction of recombinant adenovirus expression vector of the Qinchuan cattle LYRM1 gene. Genet Mol Res. 2015;14:9469-77 pubmed publisher
  7. Xu H, Gui L, Song N, Zhang Y, Wang H, Zan L. Association of CRTC2 gene polymorphisms with growth and meat quality traits of Qinchuan cattle. Genet Mol Res. 2015;14:12912-20 pubmed publisher
  8. Wei D, Li A, Zhao C, Wang H, Mei C, Khan R, et al. Transcriptional Regulation by CpG Sites Methylation in the Core Promoter Region of the Bovine SIX1 Gene: Roles of Histone H4 and E2F2. Int J Mol Sci. 2018;19: pubmed publisher
    ..The results of this study provide the foundation for a better understanding of the regulation of bovine SIX1 expression via methylation and muscle developmental in beef cattle. ..
  9. Yang W, Tang K, Wang Y, Zan L. MiR-27a-5p Increases Steer Fat Deposition Partly by Targeting Calcium-sensing Receptor (CASR). Sci Rep. 2018;8:3012 pubmed publisher
    ..These results obtained in the liver indicate that miR-27a-5p may increase fat deposition partly by targeting CASR in steers. ..
  10. Zhang Y, Wang H, Gui L, Wang H, Mei C, Zhang Y, et al. Profile of muscle tissue gene expression specific to water buffalo: Comparison with domestic cattle by genome array. Gene. 2016;577:24-31 pubmed publisher
    ..These results establish the groundwork for further studies on buffalo meat quality and will be beneficial in improving water buffalo breeding by molecular biotechnology. ..
  11. Gui L, Jia C, Zhang Y, Zhao C, Zan L. Association studies on the bovine lipoprotein lipase gene polymorphism with growth and carcass quality traits in Qinchuan cattle. Mol Cell Probes. 2016;30:61-5 pubmed publisher
    ..91C > T and g.18377T > C) were significantly correlated with some growth and carcass quality traits. These results demonstrate that LPL might be a potential candidate gene for marker-assisted selection (MAS). ..
  12. Wang X, Luoreng Z, Zan L, Li F, Li N. Bovine miR-146a regulates inflammatory cytokines of bovine mammary epithelial cells via targeting the TRAF6 gene. J Dairy Sci. 2017;100:7648-7658 pubmed publisher
    ..This study presents a potential regulatory mechanism of bta-miR-146a on immune responses in bovine mammary infection and may provide a potential therapeutic target for mastitis. ..
  13. Gui L, Hao R, Zhang Y, Zhao X, Zan L. Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus). Mol Cell Probes. 2015;29:167-71 pubmed publisher
    ..05) except g.4062C > T (SIRT2) (P > 0.05). These results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding. ..
  14. Zhang Y, Gui L, Li Y, Jiang B, Wang H, Zhang Y, et al. Molecular Characterization of Bovine SMO Gene and Effects of Its Genetic Variations on Body Size Traits in Qinchuan Cattle (Bos taurus). Int J Mol Sci. 2015;16:16966-80 pubmed publisher
    ..Therefore, our results could be helpful for marker-assisted selection in beef cattle breeding programs. ..
  15. Yang W, Tang K, Fu C, Riaz H, Zhang Q, Zan L. Melatonin regulates the development and function of bovine Sertoli cells via its receptors MT1 and MT2. Anim Reprod Sci. 2014;147:10-6 pubmed publisher
    ..These findings were consistent with inhibin B levels detected in the culture medium. In conclusion, exogenous melatonin acts via its receptors and appears to play regulatory roles in the development and function of bovine SCs. ..
  16. Jiang B, Shen H, Chen Z, Yin L, Zan L, Rui L. Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury. J Biol Chem. 2015;290:11704-14 pubmed publisher
    ..Defects in CHIP regulation of NIK may result in aberrant NIK activation in the liver, contributing to live injury, inflammation, and disease. ..
  17. Wei D, Raza S, Zhang J, Gui L, Rahman S, Khan R, et al. Polymorphism in promoter of SIX4 gene shows association with its transcription and body measurement traits in Qinchuan cattle. Gene. 2018;656:9-16 pubmed publisher
    ..These potential transcription factor information and combined genotypes H3-H3 of the SIX4 gene can be used as a molecular marker for selection of economic traits in Qinchuan cattle. ..
  18. Zhang L, Zhao Y, Ning Y, Wang H, Zan L. Ectopical expression of FABP4 gene can induce bovine muscle-derived stem cells adipogenesis. Biochem Biophys Res Commun. 2017;482:352-358 pubmed publisher
    ..Our findings may provide a unique new model for studying the molecular control of cattle cross-talk between adipose and skeletal muscle. ..
  19. Wei D, Ma X, Zhang S, Hong J, Gui L, Mei C, et al. Characterization of the promoter region of the bovine SIX1 gene: Roles of MyoD, PAX7, CREB and MyoG. Sci Rep. 2017;7:12599 pubmed publisher
    ..In addition, MyoG drives SIX1 transcription indirectly via the MEF3 motif. Taken together these interactions suggest a key functional role for SIX1 in mediating skeletal muscle growth in cattle...
  20. Wei D, Gui L, Raza S, Zhang S, Khan R, Wang L, et al. NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle. Sci Rep. 2017;7:7867 pubmed publisher
    ..This information may be useful for molecular marker-assisted selection (MAS) in cattle breeding. ..
  21. Song N, Wang X, Gui L, Raza S, Luoreng Z, Zan L. MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRAF3. Mol Cell Probes. 2017;35:27-33 pubmed publisher
    ..Taken together, our data revealed miR-214 regulated immunity-related genes by targeting NFATc3 and TRAF3, which provides insight into the molecular basis of immunity. ..
  22. Gui L, Zhang Y, Liu G, Zan L. Expression of the SIRT2 gene and its relationship with body size traits in Qinchuan cattle (Bos taurus). Int J Mol Sci. 2015;16:2458-71 pubmed publisher
    ..These results indicated that the variations in the SIRT2 gene and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding. ..
  23. Wang G, Zhang S, Wei S, Zhang Y, Li Y, Fu C, et al. Novel polymorphisms of SIX4 gene and their association with body measurement traits in Qinchuan cattle. Gene. 2014;539:107-10 pubmed publisher
    ..05). Hence, based on results obtained from this study, we conjectured that SIX4 gene may have potential effects on body measurement traits in Qinchuan cattle population and could be used for marker-assisted selection. ..
  24. Wang X, Luoreng Z, Zan L, Raza S, Li F, Li N, et al. Expression patterns of miR-146a and miR-146b in mastitis infected dairy cattle. Mol Cell Probes. 2016;30:342-344 pubmed publisher
    ..Potential target genes are involved in multiple immunological pathways. These results suggest a regulatory function of both miRNAs for the bovine inflammatory response in mammary tissue. ..
  25. Huang Y, Wang L, Zan A. ARN: analysis and prediction by adipogenic professional database. BMC Syst Biol. 2016;10:57 pubmed publisher
    ..This platform can support ongoing adipogenesis research and contribute to the discovery of key regulatory genes and pathways. ..
  26. Li A, Wu L, Wang X, Xin Y, Zan L. Tissue expression analysis, cloning and characterization of the 5'-regulatory region of the bovine FABP3 gene. Mol Biol Rep. 2016;43:991-8 pubmed publisher
    ..These results provide further understanding of the function and regulation mechanism of bovine FABP3. ..
  27. Huangfu Y, Zan L, Adoligbe C, Wang H, Wang H, Gao J. Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle. Genet Mol Res. 2015;14:4890-5 pubmed publisher
    ..In comparison, at the T335C locus, individuals with the TC genotype had greater back fat thickness and a larger loin muscle area. Therefore, these 2 SNPs could be used as genetic markers to enhance Qinchuan cattle breeding programs. ..
  28. Fu C, Tian W, Li Y, Wei S, Cheng G, Wang H, et al. Novel polymorphisms of the PRKAG2 gene and their association with body measurement and meat quality traits in Qinchuan cattle. Genet Mol Res. 2015;14:3669-79 pubmed publisher
    ..It is inferred that the PRKAG2 gene can be used for marker-assisted selection to improve the body measurement and meat quality traits in the Qinchuan cattle population. ..
  29. Li Y, Huangpu Y, Gao J, Yang N, Fu C, Wang H, et al. New polymorphisms in the novel LYRM1 gene are associated with body measurement and meat quality traits in Qinchuan cattle. Genet Mol Res. 2014;13:6926-36 pubmed publisher
    ..We suggest that the LYRM1 gene can be used for marker-assisted selection to improve body measurement and meat quality traits in the Qinchuan cattle population. ..
  30. Liu Y, Wang H, Cheng G, Jiang B, Zan L. Expression analysis of Gli1 and Gli2 in different tissues and muscle-derived cells of Qinchuan cattle. Genet Mol Res. 2014;13:8767-75 pubmed publisher
    ..The increased expression of Gli1 and Gli2 in the early days of myogenic differentiation suggested that Hh signaling would be activated when the quiescent bovine myoblast was stimulated to initiate myogenic differentiation. ..
  31. Gui L, Yang W, Zhao C, Wei S, Zhao Z, Zan L. Association of SIRT2 gene polymorphisms with body measurement and growth traits of Qinchuan cattle. Genet Mol Res. 2014;13:8834-44 pubmed publisher
  32. Gui L, Jiang B, Zhang Y, Zan L. Sequence variants in the bovine silent information regulator 6, their linkage and their associations with body measurements and carcass quality traits in Qinchuan cattle. Gene. 2015;559:16-21 pubmed publisher
    ..Our results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS) and management in beef cattle breeding programs. ..
  33. Gui L, Wang H, Liu G, Zan L. Polymorphisms in the SIRT5 gene and their association with body measurement and ultrasound traits in Qinchuan cattle. Genet Mol Res. 2015;14:3843-53 pubmed publisher
    ..Our results demonstrate that SIRT5 may be a candidate for marker-assisted selection in future breeding programs for Qinchuan cattle. ..
  34. Gui L, Hong J, Raza S, Zan L. Genetic variants in SIRT3 transcriptional regulatory region affect promoter activity and fat deposition in three cattle breeds. Mol Cell Probes. 2017;32:40-45 pubmed publisher
    ..The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle. ..
  35. request reprint
    Wang Y, Yang W, Gui L, Wang H, Zan L. Association and expression analyses of the Ucp2 and Ucp3 gene polymorphisms with body measurement and meat quality traits in Qinchuan cattle. J Genet. 2016;95:939-946 pubmed
    ..These results suggest that the diplotype P3P3 (GG-GG-CC) could be used as a molecular marker of the combined genotypes for future selection of body measurement traits and meat quality traits in Qinchuan cattle. ..
  36. Raza S, Gui L, Khan R, Schreurs N, Xiaoyu W, Wu S, et al. Association between FASN gene polymorphisms ultrasound carcass traits and intramuscular fat in Qinchuan cattle. Gene. 2018;645:55-59 pubmed publisher
    ..Variations in the FASN genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding. ..
  37. Yang W, Tang K, Wang Y, Zhang Y, Zan L. Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes. Sci Rep. 2017;7:15080 pubmed publisher
    ..These results reveal that melatonin promotes TAG accumulation via MT2 receptor during differentiation in BIPs. ..
  38. Tang K, Wang Y, Zan L, Yang W. miR-27a controls triacylglycerol synthesis in bovine mammary epithelial cells by targeting peroxisome proliferator-activated receptor gamma. J Dairy Sci. 2017;100:4102-4112 pubmed publisher
    ..In summary, these results indicate that miR-27a has the ability to control TAG synthesis in BMEC via targeting PPARG, suggesting that miR-27a could potentially be used to improve beneficial milk components in dairy cows. ..