Andy Peng Xiang

Summary

Affiliation: Sun Yat-sen University
Country: China

Publications

  1. ncbi Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host
    Andy Peng Xiang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
    Hum Mol Genet 17:27-37. 2008
  2. pmc Contribution of nestin positive esophageal squamous cancer cells on malignant proliferation, apoptosis, and poor prognosis
    Beilong Zhong
    Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat Sen University, Zhuhai, Guangdong 519000, China
    Cancer Cell Int 14:57. 2014
  3. ncbi Neural differentiation of embryonic stem cells induced by conditioned medium from neural stem cell
    Jia Qing Zhang
    Centre for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, Guangdong, China
    Neuroreport 17:981-6. 2006
  4. doi Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors
    Weiqiang Li
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Cell Transplant 19:1181-93. 2010
  5. doi Isolation, characterization and gene modification of fetal neural stem/progenitor cells from cynomolgus monkey
    Peng Wang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangdong, PR China
    Neuroreport 19:419-24. 2008
  6. ncbi Mathematical models for the proliferation of neural stem/progenitor cells in clonogenic culture
    Bao Feng Ma
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
    Rejuvenation Res 10:205-14. 2007
  7. pmc Multiple mesodermal lineage differentiation of Apodemus sylvaticus embryonic stem cells in vitro
    Tao Wang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, 510080, China
    BMC Cell Biol 11:42. 2010
  8. doi Generation of functional hepatocytes from mouse induced pluripotent stem cells
    Weiqiang Li
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, P R China
    J Cell Physiol 222:492-501. 2010
  9. doi Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts
    Mengfei Chen
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 51:5970-8. 2010
  10. doi Generation and neuronal differentiation of induced pluripotent stem cells in Cdyl-/- mice
    Li Wan
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    Neuroreport 24:114-9. 2013

Collaborators

Detail Information

Publications49

  1. ncbi Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host
    Andy Peng Xiang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
    Hum Mol Genet 17:27-37. 2008
    ..Furthermore, our study demonstrates that mammalian evolution can proceed at two starkly contrasting levels: significant divergence in genome and proteome sequence, yet striking conservation in developmental programs...
  2. pmc Contribution of nestin positive esophageal squamous cancer cells on malignant proliferation, apoptosis, and poor prognosis
    Beilong Zhong
    Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat Sen University, Zhuhai, Guangdong 519000, China
    Cancer Cell Int 14:57. 2014
    ....
  3. ncbi Neural differentiation of embryonic stem cells induced by conditioned medium from neural stem cell
    Jia Qing Zhang
    Centre for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, Guangdong, China
    Neuroreport 17:981-6. 2006
    ..Thus, neural stem cell conditioned medium is a highly potent reagent for inducing the development of mouse embryonic stem cells into the neural lineage, especially neural progenitor cells...
  4. doi Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors
    Weiqiang Li
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Cell Transplant 19:1181-93. 2010
    ..This approach will provide a useful tool for both gene function studies and in vivo cell tracking of stem cells...
  5. doi Isolation, characterization and gene modification of fetal neural stem/progenitor cells from cynomolgus monkey
    Peng Wang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangdong, PR China
    Neuroreport 19:419-24. 2008
    ....
  6. ncbi Mathematical models for the proliferation of neural stem/progenitor cells in clonogenic culture
    Bao Feng Ma
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
    Rejuvenation Res 10:205-14. 2007
    ..These models provide a powerful tool to explain and predict the experimental outcome and clarify the cell growth characteristics of neural stem/progenitor cells...
  7. pmc Multiple mesodermal lineage differentiation of Apodemus sylvaticus embryonic stem cells in vitro
    Tao Wang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, 510080, China
    BMC Cell Biol 11:42. 2010
    ..In addition, recently, AS-ES1 cells derived from Apodemus sylvaticus were established and identified by our laboratory as a new mammalian ES cell line. Hence further research, in the application of AS-ES1 cells, is warranted...
  8. doi Generation of functional hepatocytes from mouse induced pluripotent stem cells
    Weiqiang Li
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, P R China
    J Cell Physiol 222:492-501. 2010
    ....
  9. doi Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts
    Mengfei Chen
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 51:5970-8. 2010
    ..This study was conducted to determine whether induced pluripotent stem (iPS) cells express retinal progenitor cell (RPC)-related genes and whether iPS cells can directly differentiate into retinal ganglion cells (RGCs)...
  10. doi Generation and neuronal differentiation of induced pluripotent stem cells in Cdyl-/- mice
    Li Wan
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    Neuroreport 24:114-9. 2013
    ..These results provide some insight into the molecular function of the Cdyl gene, showing that it inhibited the neuronal differentiation of iPS cells...
  11. doi Derivation, characterization and gene modification of cynomolgus monkey mesenchymal stem cells
    Hui Ke
    Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat Sen University, Ministry of Education, Guangzhou 510080, China
    Differentiation 77:256-62. 2009
    ....
  12. pmc A stem cell-based tool for small molecule screening in adipogenesis
    Jie Qin
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    PLoS ONE 5:e13014. 2010
    ..By testing another two small molecules in adipogenesis--Troglitazone and CHIR99021, we proved that this is a simple and sensitive method, which could be applied in adipocyte biology, drug discovery and toxicological study in the future...
  13. doi Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells
    Fei Chen
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong 510080, PR China
    Biomaterials 34:1701-11. 2013
    ..Our approach will render the clinical application of human pluripotent stem cells increasingly possible...
  14. doi A novel biomimetic composite scaffold hybridized with mesenchymal stem cells in repair of rat bone defects models
    Caixia Xu
    Center for Stem Cell Biology and Tissue Engineering, SunYat sen University, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Guangzhou, Guangdong 510080, People s Republic of China
    J Biomed Mater Res A 95:495-503. 2010
    ..The results demonstrated that the BG-COL-HYA-PS scaffold was biocompatible and osteoconductive and the transplanted MSCs with the scaffold enhanced the healing of the bone defect...
  15. doi IFN-γ-primed human bone marrow mesenchymal stem cells induce tumor cell apoptosis in vitro via tumor necrosis factor-related apoptosis-inducing ligand
    Jingchun Du
    Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou 510080, PR China
    Int J Biochem Cell Biol 44:1305-14. 2012
    ..Thus, more attention needs to be paid when seeking to exploit mesenchymal stem cells as a therapeutic option under the condition of malignant tumor...
  16. ncbi Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells
    Ai Xia Zhang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, No 74, Zhongshan Road 2, Guangzhou 510080, China
    Mol Cell Biochem 304:167-79. 2007
    ..This study clarifies the global proteome during osteoblast differentiation. Our results will play an important role in better elucidating the underlying molecular mechanism in hMSC differentiation into osteoblasts...
  17. doi PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells
    Wei Hua Yu
    Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China
    Int J Biochem Cell Biol 44:377-84. 2012
    ..Together, these results suggest that PPARγ is not the master factor regulating mesenchymal lineage determination in human bone marrow...
  18. pmc Human mesenchymal stromal cells enhance the immunomodulatory function of CD8(+)CD28(-) regulatory T cells
    Qiuli Liu
    Cell gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
    Cell Mol Immunol 12:708-18. 2015
    ..In summary, this study shows that MSCs can enhance the regulatory function of CD8(+)CD28(-) Treg cells, shedding new light on MSCs-mediated immune regulation...
  19. doi Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells
    Yanwen Peng
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China
    Cell Biol Int 32:1265-71. 2008
    ..These findings provide a powerful model for studying T cell development and may open new venues for the clinical application of Talpha-1...
  20. ncbi Establishment and characterization of two new human embryonic stem cell lines, SYSU-1 and SYSU-2
    Guo Huang
    Centre for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
    Chin Med J (Engl) 120:589-94. 2007
    ..However, further investigation requires additional cell lines with varying genetic background. Therefore, efforts to derive and establish more human embryonic stem cell lines are highly warranted...
  21. doi Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients
    Zhenguang Chen
    Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510080, P R China
    Hum Pathol 41:737-44. 2010
    ..The results demonstrated that nestin expressed in most tumor cells of non-small cell lung cancer tissue and had a direct linkage to lymph node metastasis and tumor-induced lymphangiogenesis, independent of COX-2 signal pathway...
  22. doi Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity
    Junxia Lei
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou 510080, PR China
    Cell Immunol 271:147-56. 2011
    ..These data indicate that TLR2 and TLR4 ligation had different effects on immunomodulatory capability of murine BMSCs, which should be considered in their use for treating inflammatory diseases...
  23. doi Nestin regulates neural stem cell migration via controlling the cell contractility
    Sunxing Yan
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Int J Biochem Cell Biol 78:349-60. 2016
    ..Together, our results indicate that nestin may increase NSC motility via elevating MLCK activity through direct binding and provide new insight into the roles of nestin in NSC migration and repair. ..
  24. pmc Mesenchymal Stromal Cells Mitigate Experimental Colitis via Insulin-like Growth Factor Binding Protein 7-mediated Immunosuppression
    Yan Liao
    Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children s Hospital, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Mol Ther 24:1860-1872. 2016
    ..These results suggest that IGFBP7 may act as a novel MSC-secreted immunomodulatory factor...
  25. doi Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells
    Weiqiang Li
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong, PR China Department of Biochemistry, Zhongshan Medical School, Sun Yat Sen University, Guangzhou, Guangdong, PR China Key Laboratory of Reproductive Medicine of Guangdong Province, Guangzhou, Guangdong, PR China
    Biomaterials 39:75-84. 2015
    ....
  26. pmc Role of the stem cell-associated intermediate filament nestin in malignant proliferation of non-small cell lung cancer
    Zhenguang Chen
    Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China Department of Cardiothoracic Surgery, Huangpu Division of The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China Lung Cancer Research Center of Sun Yat sen University, Guangzhou, Guangdong, China
    PLoS ONE 9:e85584. 2014
    ..Considering that proliferation is necessary for malignant behavior, we investigated the mechanism of nestin action in association with the proliferative properties of non-small cell lung cancer (NSCLC)...
  27. pmc Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice
    Xiao Li Yao
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    PLoS ONE 8:e64720. 2013
    ..The present study provides evidence that ALS-iPS cells can be used as disease models in high-throughput screening and mechanistic studies due to their ability to efficiently differentiate into specific neuronal subtypes...
  28. doi Protecting against wayward human induced pluripotent stem cells with a suicide gene
    Fuyi Cheng
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou 510080, PR China
    Biomaterials 33:3195-204. 2012
    ..This approach may help to develop safety strategies for clinical application of hiPSCs in regenerative medicine in the future...
  29. doi Overexpression of Gremlin1 in Mesenchymal Stem Cells Improves Hindlimb Ischemia in Mice by Enhancing Cell Survival
    Qiuling Xiang
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Cell Physiol . 2016
    ..J. Cell. Physiol. 9999: 1-12, 2016. © 2016 Wiley Periodicals, Inc...
  30. pmc TALEN-based generation of a cynomolgus monkey disease model for human microcephaly
    Qiong Ke
    Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children s Hospital, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510623, China
    Cell Res 26:1048-61. 2016
    ..This monkey model may help us elucidate the role of MCPH1 in the pathogenesis of human microcephaly and better understand the function of this protein in the evolution of primate brain size. ..
  31. pmc Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction
    Mei Hua Jiang
    1 Cell gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong 510630, China 2 Key Laboratory for Stem Cells and Tissue Engineering, Center for Stem Cell Biology and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong 510080, China 3 Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong 510080, China
    Cell Res 24:1466-85. 2014
    ..Taken together, these results suggest that Nes-GFP+ cells from the testis have the characteristics of SLCs, and our study would shed new light on developing stem cell replacement therapy for testosterone deficiency...
  32. doi Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test
    Rui Chen
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong PR China 510080
    Toxicol Mech Methods 20:112-8. 2010
    ..These results may provide a valuable attempt to expand the application of EST to the cosmetics field...
  33. doi Donor-derived mesenchymal stem cells combined with low-dose tacrolimus prevent acute rejection after renal transplantation: a clinical pilot study
    Yanwen Peng
    Center for Stem Cell Biology and Tissue Engineering, SunYat sen University, 74, Zhongshan 2 Road, Guangzhou, Guangdong, China, 510080
    Transplantation 95:161-8. 2013
    ..Mesenchymal stem cells (MSCs) represent a unique cell population with immunosuppressive function and prolong allograft survival in experimental organ transplant models...
  34. doi Comparative study of myocytes from normal and mdx mice iPS cells
    Fei Chen
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    J Cell Biochem 113:678-84. 2012
    ..More importantly, treatment of a pan-caspase inhibitor (Z-VAD) produced a significant decrease in apoptotic cells. This study might add some insight to the biology study of dystrophin gene...
  35. doi Evaluation of human mesenchymal stem cells response to biomimetic bioglass-collagen-hyaluronic acid-phosphatidylserine composite scaffolds for bone tissue engineering
    Caixia Xu
    Center for Stem Cell Biology and Tissue Engineering, SunYat sen University, Guangzhou, Guangdong, China
    J Biomed Mater Res A 88:264-73. 2009
    ..These findings suggest that the BG-COL-HYA-PS composite porous scaffolds have high potential for use as scaffolds in bone tissue engineering and repair...
  36. pmc ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells
    Jianye Cai
    Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children s Hospital, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Cell Death Dis 7:e2459. 2016
    ..These findings suggest that the ability of MSCs to trigger Drp1 activation-induced changes in mitochondrial dynamics is crucial to their ability to protect cells against chemotherapeutic agents...
  37. pmc Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells
    Zhenguang Chen
    Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat Sen University, Lung Cancer Research Center of Sun Yat sen University, Guangzhou, Guangdong, China
    J Exp Clin Cancer Res 31:10. 2012
    ..The purpose of this study was to assess the prognostic value of Oct-4 expression after surgery in primary non-small cell lung cancer (NSCLC) and investigate its possible molecular mechanism...
  38. doi Nestin(+) kidney resident mesenchymal stem cells for the treatment of acute kidney ischemia injury
    Mei Hua Jiang
    Cell gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, China Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Biomaterials 50:56-66. 2015
    ....
  39. doi Involvement of extracellular factors in maintaining self-renewal of neural stem cell by nestin
    Chun Guang Di
    aCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangdong, China bThe Sixth Affiliated Hospital, Sun Yat Sen University, Guangdong, China cDepartment of Neuroscience, Ohio State University Medical Center, Columbus, Ohio, USA
    Neuroreport 25:782-7. 2014
    ..In addition, the Akt signaling pathway is altered at low density and reversed by conditioned medium. Our data show that secreted factors contribute toward maintaining self-renewal of NSCs by nestin, potentially through Akt signaling. ..
  40. pmc Safeguarding clinical translation of pluripotent stem cells with suicide genes
    Weiqiang Li
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, Guangdong P R China
    Organogenesis 9:34-9. 2013
    ..Safety-enhancing strategies that can selectively ablate undifferentiated cells without inducing virus infection or insertional mutations may greatly aid in translating human pluripotent stem cells into cell therapies in the future...
  41. doi Heterogeneity of the biological properties and gene expression profiles of murine bone marrow stromal cells
    Junxia Lei
    Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat Sen University, Guangzhou, PR China
    Int J Biochem Cell Biol 45:2431-43. 2013
    ..This study provides novel information about the heterogeneity of MSCs and insight into the selection of optimal cell sources for therapeutic applications. ..
  42. pmc Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer
    Jiancheng Wang
    The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
    Oncotarget 6:42825-37. 2015
    ..Taken together, these findings suggest that IL-8 secreted by MSCs promotes CRC angiogenesis and growth and can therefore serve as a potential novel therapeutic target. ..
  43. pmc Alteration of naïve and memory B-cell subset in chronic graft-versus-host disease patients after treatment with mesenchymal stromal cells
    Yanwen Peng
    Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Medical Science Experimentation Center, and Department of Biochemistry, Zhongshan Medical School, Sun Yat Sen University, Guangzhou, People s Republic of China Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, People s Republic of China Department of Rehabilitation Medicine Science and Cell Gene Therapy Translational Medicine Research Center, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, People s Republic of China Organ Transplant Center, First Affiliated Hospital of Sun Yat sen University, Guangzhou, People s Republic of China
    Stem Cells Transl Med 3:1023-31. 2014
    ..Overall, our findings imply that MSCs might exert therapeutic effects in cGVHD patients, accompanied by alteration of naïve and memory B-cell subsets, modulating plasma BAFF levels and BAFF-R expression on B lymphocytes...
  44. ncbi Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells
    Weihua Yu
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China
    Mol Cell Biochem 310:11-8. 2008
    ..In conclusion, our data suggest that the PI3K/Akt and mTOR/p70S6K signaling pathways are essential for adipogenesis of human MSCs...
  45. ncbi Slower cycling of nestin-positive cells in neurosphere culture
    Bao Feng Ma
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou, China
    Neuroreport 17:377-81. 2006
    ..Using the relative proliferation ratio and relative division ratio analysis, we concluded that the slower cycling of nestin-positive cells was responsible for this decrease...
  46. doi Islet-1 overexpression in human mesenchymal stem cells promotes vascularization through monocyte chemoattractant protein-3
    Jia Liu
    Department of Cardiology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China Heart Center, The Affiliated Futian Hospital of Guangdong Medical College, Shenzhen, People s Republic of China
    Stem Cells 32:1843-54. 2014
    ..Our data suggest that overexpression of ISL1 in hMSCs promotes angiogenesis in vitro and in vivo through increasing secretion of paracrine factors, smooth muscle differentiation ability, and enhancing the survival of HUVECs...
  47. doi The effects of gradients of nerve growth factor immobilized PCLA scaffolds on neurite outgrowth in vitro and peripheral nerve regeneration in rats
    Shuo Tang
    DSAPM Lab, PCFM Lab, School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    Biomaterials 34:7086-96. 2013
    ..Our results demonstrated the significant role of introducing NGF gradients into scaffolds in promoting nerve regeneration. ..
  48. doi Role of MEF feeder cells in direct reprogramming of mousetail-tip fibroblasts
    Mengfei Chen
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China
    Cell Biol Int 33:1268-73. 2009
    ..These data will facilitate the generation of human iPS cells without animal feeders for regenerative medicine...
  49. ncbi Evolutionary and biomedical insights from the rhesus macaque genome
    Richard A Gibbs
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 316:222-34. 2007
    ..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species...